Hemalatha G. Rangarajan
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View article: Hematopoietic Cell Transplantation for Wiskott-Aldrich syndrome: A PIDTC Report
Hematopoietic Cell Transplantation for Wiskott-Aldrich syndrome: A PIDTC Report Open
Wiskott-Aldrich syndrome (WAS), an X-linked disorder characterized by immunodeficiency, thrombocytopenia, autoimmunity, and malignancy, can be effectively treated with allogeneic hematopoietic cell transplantation (HCT). Older age at HCT a…
View article: Primary and Secondary Stroke Prophylaxis in Children with Sickle Cell Anemia: A Meta-Analysis
Primary and Secondary Stroke Prophylaxis in Children with Sickle Cell Anemia: A Meta-Analysis Open
We conducted a pooled analysis to evaluate the effectiveness of hydroxyurea (HU), chronic blood transfusions (CBT), myeloablative allogeneic hematopoietic stem cell transplants (HCT) with a matched related donor, and revascularization surg…
View article: Real-world outcomes of infections following tisagenlecleucel in patients with B-cell ALL: a CIBMTR analysis
Real-world outcomes of infections following tisagenlecleucel in patients with B-cell ALL: a CIBMTR analysis Open
Tisagenlecleucel (tisa-cel) is a CD19-directed chimeric antigen receptor T-cell therapy for relapsed/refractory precursor B-cell acute lymphoblastic leukemia (R/R B-ALL). We report infectious complications for 100 days (D100) following tis…
View article: Efficacy of Total‐Body Irradiation‐based Intensified Myeloablative Regimens for Acute Leukemia—An International Collaborative Study
Efficacy of Total‐Body Irradiation‐based Intensified Myeloablative Regimens for Acute Leukemia—An International Collaborative Study Open
Background In this study, we compared outcomes of intensified myeloablative conditioning regimens using large registry data from Japan (Japanese Society for Transplantation and Cellular Therapy) and the United States (Center for Internatio…
View article: Infection after CD19 chimeric antigen receptor T-cell therapy for large B-cell lymphoma: real-world analysis from CIBMTR
Infection after CD19 chimeric antigen receptor T-cell therapy for large B-cell lymphoma: real-world analysis from CIBMTR Open
Infection is increasingly recognized as a significant cause of morbidity and mortality in patients with relapsed/refractory (R/R) large B-cell lymphoma (LBCL) receiving CD19 chimeric antigen receptor (CAR) T-cell therapy. The current study…
View article: The Nationwide Children’s Hospital Blood and Marrow Transplant Index: A Quality Improvement Approach to Assess the Performance of a Pediatric Blood and Marrow Transplant Program
The Nationwide Children’s Hospital Blood and Marrow Transplant Index: A Quality Improvement Approach to Assess the Performance of a Pediatric Blood and Marrow Transplant Program Open
Introduction: To design and test a metric that reflects the overall quality and safety performance of our blood and marrow transplant program (BMT) and use this metric to enhance the quality of care provided to patients. Methods: The BMT i…
View article: Trends in volumes and survival after hematopoietic cell transplantation in racial/ethnic minorities
Trends in volumes and survival after hematopoietic cell transplantation in racial/ethnic minorities Open
There has been an increase in volume as well as an improvement in overall survival (OS) after hematopoietic cell transplantation (HCT) for hematologic disorders. It is unknown if these changes have affected racial/ethnic minorities equally…
View article: Ibrutinib for therapy of steroid-refractory chronic graft-versus-host disease: a multicenter real-world analysis
Ibrutinib for therapy of steroid-refractory chronic graft-versus-host disease: a multicenter real-world analysis Open
To examine the activity of ibrutinib in steroid-refractory chronic graft-versus-host disease (SR-cGVHD) after the US Food and Drug Administration approval, we conducted a multicenter retrospective study. Data were standardly collected (N =…
View article: Incremental eligibility criteria for the BMT CTN 1507 haploidentical trial for children with sickle cell disease
Incremental eligibility criteria for the BMT CTN 1507 haploidentical trial for children with sickle cell disease Open
The Blood and Marrow Transplant Clinical Trials Network (BMT CTN) 1507 leadership and the data safety monitoring board (DSMB) established incremental entry criteria for children aged 5 to 14.99 years with sickle cell disease (SCD) enrollin…
View article: Virtual 3D planning in Maxillofacial surgery : The journey so far and the way ahead
Virtual 3D planning in Maxillofacial surgery : The journey so far and the way ahead Open
View article: Racial, ethnic, and socioeconomic diversity and outcomes of patients with graft-versus-host disease: a CIBMTR analysis
Racial, ethnic, and socioeconomic diversity and outcomes of patients with graft-versus-host disease: a CIBMTR analysis Open
Socioeconomic status (SES) and race/ethnicity have been associated with the outcomes of allogeneic hematopoietic stem cell transplantation (allo-HCT). Certain aspects of graft-versus-host disease (GVHD) management, such as the need for lon…
View article: Trends in volumes and survival after hematopoietic cell transplantation in racial/ethnic minorities
Trends in volumes and survival after hematopoietic cell transplantation in racial/ethnic minorities Open
There has been an increase in volume as well as an improvement in overall survival (OS) after hematopoietic cell transplantation (HCT) for hematologic disorders. It is unknown if these changes have affected racial/ethnic minorities equally…
View article: No impact of CD34+ cell dose on outcome among children undergoing autologous hematopoietic stem cell transplant for high-risk neuroblastoma
No impact of CD34+ cell dose on outcome among children undergoing autologous hematopoietic stem cell transplant for high-risk neuroblastoma Open
View article: Comparison of physics forceps to conventional forceps in simple dental extraction
Comparison of physics forceps to conventional forceps in simple dental extraction Open
Background: In this study, Conventional forceps & Physics forceps were compared in simple dental extractions with respect to crown and root fracture of tooth during extraction, alveolar bone plate fracture, gingival laceration, requirement…
View article: Genotype, oxidase status, and preceding infection or autoinflammation do not affect allogeneic HCT outcomes for CGD
Genotype, oxidase status, and preceding infection or autoinflammation do not affect allogeneic HCT outcomes for CGD Open
Chronic granulomatous disease (CGD) is a primary immunodeficiency characterized by life-threatening infections and inflammatory conditions. Hematopoietic cell transplantation (HCT) is the definitive treatment for CGD, but questions remain …
View article: Racial and Socioeconomic Disparities in Long-Term Outcomes in ≥1 Year Allogeneic Hematopoietic Cell Transplantation Survivors: A CIBMTR Analysis
Racial and Socioeconomic Disparities in Long-Term Outcomes in ≥1 Year Allogeneic Hematopoietic Cell Transplantation Survivors: A CIBMTR Analysis Open
Racial/ethnic minorities have demonstrated worse survival after allogeneic hematopoietic cell transplantation (HCT) compared to whites. Whether the racial disparity in HCT outcomes persists in long-term survivors and possibly may be even e…
View article: Peritoneal and Pleural Drains in Pediatric Hematopoietic Cell Transplant Recipients with Veno-Occlusive Disease are Safe and Do Not Adversely Impact Clinical Outcomes
Peritoneal and Pleural Drains in Pediatric Hematopoietic Cell Transplant Recipients with Veno-Occlusive Disease are Safe and Do Not Adversely Impact Clinical Outcomes Open
There is a lack of data on the safety and efficacy of peritoneal drain (PD) and chest tube (CT) in the management of effusions in stem cell transplant recipients with veno-occlusive disease (VOD). In this retrospective pediatric study, cli…
View article: CD34 Stem Cell Boost in Pediatric Allogeneic Stem Cell Transplant Recipients: A Case Series and Review of Literature
CD34 Stem Cell Boost in Pediatric Allogeneic Stem Cell Transplant Recipients: A Case Series and Review of Literature Open
Patients with poor graft function (PGF) or declining donor chimerism (DC) post allogeneic hematopoietic cell transplantation (HCT) may benefit from a CD34-selected stem cell boost (SCB). We retrospectively studied outcomes of fourteen pedi…
View article: Effect of Autograft CD34+ Dose on Outcome in Pediatric Patients Undergoing Autologous Hematopoietic Stem Cell Transplant for Central Nervous System Tumors
Effect of Autograft CD34+ Dose on Outcome in Pediatric Patients Undergoing Autologous Hematopoietic Stem Cell Transplant for Central Nervous System Tumors Open
View article: “Bridging the Breach”: Cranioplasties Using Different Reconstruction Materials—An Institutional Experience
“Bridging the Breach”: Cranioplasties Using Different Reconstruction Materials—An Institutional Experience Open
View article: Diagnostic Dilemma of Vanishing Bone Disease - A Case Report and Review of Literature
Diagnostic Dilemma of Vanishing Bone Disease - A Case Report and Review of Literature Open
Rationale: Vanishing bone disease (VBD) is a rare bone disorder in which progressive osteolysis may lead to complete disappearance of involved bones. The diagnosis of this disease requires a high degree of clinical suspicion. We present a …
View article: Role of abatacept in the prevention of graft-<i>versus</i>-host disease: current perspectives
Role of abatacept in the prevention of graft-<i>versus</i>-host disease: current perspectives Open
Administration of abatacept following transplantation has been reported to inhibit graft rejection and graft- versus-host-disease (GvHD) in mouse models associated with allogeneic hematopoietic stem cell transplant (HSCT). This strategy ha…
View article: Neuropsychiatric disorders in adults undergoing chimeric antigen receptor T cells therapy for aggressive lymphomas and acute lymphoblastic leukemia
Neuropsychiatric disorders in adults undergoing chimeric antigen receptor T cells therapy for aggressive lymphomas and acute lymphoblastic leukemia Open
Female gender and ALL were risk factors for NPD.
View article: Refractory, fatal autoimmune hemolytic anemia due to ineffective thymic‐derived T‐cell reconstitution following allogeneic hematopoietic cell transplantation for hypomorphic RAG1 deficiency
Refractory, fatal autoimmune hemolytic anemia due to ineffective thymic‐derived T‐cell reconstitution following allogeneic hematopoietic cell transplantation for hypomorphic RAG1 deficiency Open
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View article: Human CARMIL2 deficiency underlies a broader immunological and clinical phenotype than CD28 deficiency
Human CARMIL2 deficiency underlies a broader immunological and clinical phenotype than CD28 deficiency Open
Patients with inherited CARMIL2 or CD28 deficiency have defective T cell CD28 signaling, but their immunological and clinical phenotypes remain largely unknown. We show that only one of three CARMIL2 isoforms is produced and functional acr…
View article: Correction to: CD34-selected stem cell boost as therapy for late graft rejection following allogeneic transplantation for sickle cell disease
Correction to: CD34-selected stem cell boost as therapy for late graft rejection following allogeneic transplantation for sickle cell disease Open
View article: Characteristics of Graft-Versus-Host Disease (GvHD) After Post-Transplantation Cyclophosphamide Versus Conventional GvHD Prophylaxis
Characteristics of Graft-Versus-Host Disease (GvHD) After Post-Transplantation Cyclophosphamide Versus Conventional GvHD Prophylaxis Open
View article: Clinical Characteristics and Outcomes of COVID-19 in Pediatric and Early Adolescent and Young Adult Hematopoietic Stem Cell Transplant Recipients: A Cohort Study
Clinical Characteristics and Outcomes of COVID-19 in Pediatric and Early Adolescent and Young Adult Hematopoietic Stem Cell Transplant Recipients: A Cohort Study Open
Adult hematopoietic stem cell transplantation (HSCT) recipients are at a high risk of adverse outcomes after COVID-19. Although children have had better outcomes after COVID-19 compared to adults, data on risk factors and outcomes of COVID…
View article: Tacrolimus-Induced Systemic Drug Related Intertriginous and Flexural Exanthema after Hematopoietic Stem Cell Transplantation
Tacrolimus-Induced Systemic Drug Related Intertriginous and Flexural Exanthema after Hematopoietic Stem Cell Transplantation Open
Symmetrical drug-related intertriginous and flexural exanthema (SDRIFE), previously known as “Baboon Syndrome,” is diagnosed if four or more of the following criteria are met: symmetry, involvement of at least one intertriginous zone, eryt…
View article: An Exploration of COVID-19 Distress and Vaccine Hesitancy in Parents of Children Post Hematopoietic Stem Cell Transplant
An Exploration of COVID-19 Distress and Vaccine Hesitancy in Parents of Children Post Hematopoietic Stem Cell Transplant Open