Hemant Chandru Naik
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View article: <i>Xist</i> upstream deletion leads to dysregulation of <i>Xist</i> and autosomal gene expression
<i>Xist</i> upstream deletion leads to dysregulation of <i>Xist</i> and autosomal gene expression Open
Xist long noncoding RNA is the master regulator of the X-Chromosome inactivation (XCI) process. Xist is expressed from the inactive X and coats the inactive X to facilitate XCI. Cis -regulation of Xist expression remains poorly understood …
View article: Single-cell allelic transcriptomic analysis unravels intratumoral gene expression heterogeneity linked to TNBC pathogenesis
Single-cell allelic transcriptomic analysis unravels intratumoral gene expression heterogeneity linked to TNBC pathogenesis Open
Triple-negative breast cancer (TNBC) is the most aggressive subclass of breast cancer, which exhibits high intratumoral heterogeneity. Intratumoral heterogeneity often drives the evolution of drug resistance towards tumour therapy in TNBC.…
View article: The role of m6A RNA methylation in the maintenance of X-chromosome inactivation and X to autosome dosage compensation in early embryonic lineages
The role of m6A RNA methylation in the maintenance of X-chromosome inactivation and X to autosome dosage compensation in early embryonic lineages Open
In therian mammals, inactivation of one of the X-chromosomes in females balances the dosage of X-linked gene expression between the sexes. On the other hand, upregulation of active-X balances the dosage of monoallelically expressed X-linke…
View article: Epigenomic states contribute to coordinated allelic transcriptional bursting in iPSC reprogramming
Epigenomic states contribute to coordinated allelic transcriptional bursting in iPSC reprogramming Open
Two alleles of a gene can be transcribed independently or coordinatedly, which can lead to temporal expression heterogeneity with potentially distinct impacts on cell fate. Here, we profiled genome-wide allelic transcriptional burst kineti…
View article: Single-cell analysis reveals X upregulation is not global in pre-gastrulation embryos
Single-cell analysis reveals X upregulation is not global in pre-gastrulation embryos Open
In mammals, transcriptional inactivation of one X chromosome in female compensates for the dosage of X-linked gene expression between the sexes. Additionally, it is believed that the upregulation of active X chromosome in male and female b…
View article: Lineage-specific dynamics of erasure of X-upregulation during inactive-X reactivation
Lineage-specific dynamics of erasure of X-upregulation during inactive-X reactivation Open
In mammals, sex chromosome dosage is compensated through X-chromosome inactivation and active-X upregulation. It is believed that during early development, X-chromosome inactivation and active X upregulation happen in a highly coordinated …