Explanipedia

Opportunity Screening for Early Detection of Gestational Diabetes: Results from the MERGD Study Open

Manju Mamtani, Kunal Kurhe, Ashwini A. Patel, Manisha T. Jaisinghani, Kanchan V. Pipal , et al. · 2025

Background: The definitions and approaches used to diagnose gestational diabetes (GD) are varied. The two-step approach recommended by the American College of Obstetricians and Gynecologists (ACOG) combines the sensitivity of a glucose cha…

Early-Life Exposure to Organic Chemical Pollutants as Assessed in Primary Teeth and Cardiometabolic Risk in Mexican American Children: A Pilot Study Open

Vidya S. Farook, Feroz Akhtar, Rector Arya, Alice Yau, Srinivas Mummidi , et al. · 2025

Early-life exposure to organic chemicals (OCs) may influence childhood obesity and associated cardiometabolic risk. These conditions have been shown to disproportionately affect minority populations such as Mexican Americans (MAs). However…

Opportunity Screening for Early Detection of Gestational Diabetes: Results from the MERGD Study Open

Manju Mamtani, Kunal Kurhe, Ashwini A. Patel, Manisha T. Jaisinghani, Kanchan V Pipal , et al. · 2025

Background: The definitions and approaches used to diagnose gestational diabetes (GD) are varied. The two-step approach recommended by the American College of Obstetricians and Gynecologists (ACOG) combines the sensitivity of a glucose cha…

Rationale and design of the Renal Lifecycle trial assessing the effect of dapagliflozin on cardiorenal outcomes in severe chronic kidney disease Open

W Bakker, Hiddo J.L. Heerspink, Stefan P. Berger, Christoph Wanner, Sunil V. Badve , et al. · 2025

Background Several clinical trials have shown beneficial effects of sodium–glucose co-transporter 2 (SGLT2) inhibitors on kidney disease progression and cardiovascular morbidity and mortality in patients with chronic kidney disease (CKD) w…

Computation of Separate Product and Ratio Exponential Estimators Under Neutrosophic Stratified Sampling: Application to Climate Data Open

Abhishek Singh, Vedangee Gunesh Patkar, Hemant Kulkarni, Gajendra K. Vishwakarma · 2024

Within the confines of this article, we unveil a ground-breaking methodology, introducing for the first time product, product and ratio exponential estimators within the framework of neutrosophic stratified sampling an endeavour that integ…

#1342 Updated results from the RUBY-3 study of povetacicept, an enhanced dual BAFF/APRIL antagonist, in autoantibody-associated glomerulonephritis Open

Arvind Madan, Inwhee Park, Rajesh Yalavarthy, Sreedhar Mandayam, Hemant Kulkarni , et al. · 2024

Background and Aims Inhibition of BAFF and/or APRIL has shown promise in IgA nephropathy (IgAN), systemic lupus erythematosus (SLE), lupus nephritis (LN), and primary membranous nephropathy (pMN), and has the potential to exert a disease-m…

WCN24-762 UPDATED RESULTS FROM THE RUBY-3 STUDY OF POVETACICEPT, AN ENHANCED DUAL BAFF/APRIL ANTAGONIST, IN AUTOANTIBODY-ASSOCIATED GLOMERULONEPHRITIS Open

James A. Tumlin, Sreedhar Mandayam, Arvind Madan, Frank B. Cortazar, Sang-Woong Han , et al. · 2024

BAFF and APRIL are clinically validated targets in multiple autoantibody-associated diseases. Their inhibition has shown promise in IgA nephropathy (IgAN), lupus nephritis (LN), and primary membranous nephropathy (pMN), with the potential …

WCN24-756 POVETACICEPT, AN ENHANCED DUAL BAFF/APRIL ANTAGONIST, IN AUTOANTIBODY-ASSOCIATED GLOMERULONEPHRITIS Open

James A. Tumlin, Sreedhar Mandayam, Arvind Madan, Frank B. Cortazar, Sang-Woong Han , et al. · 2024

The cytokines BAFF and APRIL are clinically validated targets in multiple autoantibody-associated diseases. Their inhibition has shown promise in IgA nephropathy (IgAN), lupus nephritis (LN), and primary membranous nephropathy (pMN), with …

Hepatitis B vaccination in patients with stage 4/5 chronic kidney disease – a scoping review Open

Casey Light, Karen Heslop, Hemant Kulkarni · 2023

Aim This scoping review aims to identify and map the extent of published literature on Hepatitis B vaccination in stage 4/5 chronic kidney disease (CKD) and dialysis patients, the availability of standardised practice guidelines, the optim…

Protocol for CLASSIC PBB: comparison of lower airway sampling strategies in children with protracted bacterial bronchitis Open

Francis Gilchrist, Mathew Aspey, Robert Bowler, Malcolm Brodlie, Seema Desai , et al. · 2022

Background Protracted bacterial bronchitis (PBB) is an endobronchial infection and a the most common cause of chronic wet cough in young children. It is treated with antibiotics, which can only be targeted if the causative organism is know…

Machine-learning algorithm to non-invasively detect diabetes and pre-diabetes from electrocardiogram Open

Anoop R Kulkarni, Ashwini A Patel, Kanchan V Pipal, Sujeet G Jaiswal, Manisha T Jaisinghani , et al. · 2022

Objectives Early detection is of crucial importance for prevention of type 2 diabetes and pre-diabetes. Diagnosis of these conditions relies on the oral glucose tolerance test and haemoglobin A1c estimation which are invasive and challengi…

Susceptibility Loci for Type 2 Diabetes in the Ethnically Endogamous Indian Sindhi Population: A Pooled Blood Genome-Wide Association Study Open

Kanchan V. Pipal, Manju Mamtani, Ashwini A. Patel, Sujeet G. Jaiswal, Manisha T. Jaisinghani , et al. · 2022

Type 2 diabetes (T2D) is a complex metabolic derangement that has a strong genetic basis. There is substantial population-specificity in the association of genetic variants with T2D. The Indian urban Sindhi population is at a high risk of …

Improving radiographic triaging of COVID-19 patients using artificial intelligence Open

Hemant Kulkarni · 2022

Genetic association of anthropometric traits with type 2 diabetes in ethnically endogamous Sindhi families Open

Manju Mamtani, Manisha T. Jaisinghani, Sujeet G. Jaiswal, Kanchan V. Pipal, Ashwini A. Patel , et al. · 2021

Background Ethnically endogamous populations can shed light on the genetics of type 2 diabetes. Such studies are lacking in India. We conducted this study to determine the genetic and environmental contributions of anthropometric traits to…

Transradial Access for High-Risk Percutaneous Coronary Intervention: Implications of the Risk-Treatment Paradox Open

Amit P. Amin, Sunil V. Rao, Arnold H. Seto, Manoj Thangam, Richard G. Bach , et al. · 2021

Background: Transradial percutaneous coronary intervention (PCI; TRI) reduces adverse outcomes when compared with transfemoral PCI (TFI). However, TRI is also used less in high-risk patients. It remains unknown how baseline patient risk in…

Costs associated with transradial access and same-day discharge after percutaneous coronary intervention: a systematic review and meta-analysis Open

Hemant Kulkarni, Manoj Thangam, Spencer Liu, James T. DeVries, Eric Rothstein , et al. · 2021

Transradial access for PCI (TRI) along with same day discharge (SDD) is associated with varying estimates of cost savings depending on the population studied, the clinical scenario and application to low-risk vs high-risk patients. A summa…

Development and Validation of a Deep Learning Model to Quantify Interstitial Fibrosis and Tubular Atrophy From Kidney Ultrasonography Images Open

Ambarish M. Athavale, Peter D. Hart, M. Itteera, David Cimbaluk, Tushar Patel , et al. · 2021

These findings suggest that a DL algorithm can accurately and independently predict IFTA from kidney ultrasonography images.

A Machine-Learning Framework to Identify Distinct Phenotypes of Aortic Stenosis Severity Open

Partho P. Sengupta, Sirish Shrestha, Nobuyuki Kagiyama, Yasmin S. Hamirani, Hemant Kulkarni , et al. · 2021

Association of hyperglycaemia with hospital mortality in nondiabetic COVID-19 patients: A cohort study Open

Manju Mamtani, Ambarish M. Athavale, Miriam Abraham, Jane Vernik, Amatur Amarah , et al. · 2021

CCL3L1-CCR5 genotype influences durability of immune recovery during antiretroviral therapy of HIV-1–infected individuals Open

Sunil K. Ahuja, Hemant Kulkarni, Gabriel Catano, Brian K. Agan, José F. Camargo , et al. · 2020

The basis for the extensive variability seen in the reconstitution of CD4+ T cell counts in HIV-infected individuals receiving highly active antiretroviral therapy (HAART) is not fully known. Here, we show that variations in CCL3L1 gene do…

Independent association of meteorological characteristics with initial spread of Covid-19 in India Open

Hemant Kulkarni, Harshwardhan Khandait, Uday Narlawar, Pragati Rathod, Manju Mamtani · 2020

ASSOCIATION OF HYPERGLYCEMIA WITH HOSPITAL MORTALITY IN COVID-19 PATIENTS WITHOUT DIABETES: A COHORT STUDY Open

Manju Mamtani, Ambarish M. Athavale, Mohan Abraham, Jane Vernik, Amatur Amarah , et al. · 2020

Objective Diabetes is a known risk factor for mortality in Coronavirus disease 2019 (COVID-19) patients. Our objective was to identify prevalence of hyperglycemia in COVID-19 patients with and without diabetes and quantify its association …

Early identification of preterm neonates at birth with a Tablet App for the Simplified Gestational Age Score (T-SGAS) when ultrasound gestational age dating is unavailable: A validation study Open

Archana Patel, Hemant Kulkarni, Kunal Kurhe, Amber Prakash, Savita Bhargav , et al. · 2020

The Tablet App for the Simplified Gestational Age Score (T-SGAS) study was registered at ClinicalTrials.gov NCT02408783.

A Deep Learning Model to Predict the Need for Mechanical Ventilation Using Chest X-Ray Images in Hospitalized COVID-19 Patients Open

Anoop C. Kulkarni, Ambarish M. Athavale, Ashima Sahni, Shashvat Sukhal, Abhimanyu Sahni , et al. · 2020

Purpose Early identification of a potentially deteriorating clinical course in hospitalized COVID-19 patients is critical since there exists a resource-demand gap for the ventilators. Materials We aimed to develop and validate a deep learn…

DEEP LEARNING TO PREDICT DEGREE OF INTERSTITIAL FIBROSIS AND TUBULAR ATROPHY FROM KIDNEY ULTRASOUND IMAGES – AN ARTIFICIAL INTELLIGENCE APPROACH Open

Ambarish M. Athavale, Peter D. Hart, M. Itteera, David Cimbaluk, Tushar Patel , et al. · 2020

Background Interstitial fibrosis and tubular atrophy (IFTA) is a strong predictor of decline in kidney function. Non-invasive test to assess IFTA is not available. Methods We trained, validated and tested a deep learning (DL) system to cla…

ARTIFICIAL INTELLIGENCE IN PERCUTANEOUS CORONARY INTERVENTION: IMPROVED PREDICTION OF PCI-RELATED COMPLICATIONS USING AN ARTIFICIAL NEURAL NETWORK Open

Hemant Kulkarni, Amit P. Amin · 2020

Importance Complications after percutaneous coronary intervention (PCI) are common and costly. Risk models for predicting the likelihood of acute kidney injury (AKI), bleeding, stroke and death are limited by accuracy and inability to use …

COSTS ASSOCIATED WITH TRANSRADIAL ACCESS AND SAME-DAY DISCHARGE AFTER PERCUTANEOUS CORONARY INTERVENTION: A SYSTEMATIC REVIEW AND META-ANALYSIS Open

Hemant Kulkarni, Manoj Thangam, Samuel M. Lindner, Christian McNeely, Amit P. Amin · 2020

Introduction Transradial access for PCI (TRI) along with same day discharge (SDD) is associated with varying estimates of cost savings depending on the population studied, the clinical scenario and application to low-risk vs high-risk pati…

Response by Amin et al to Letters Regarding Article, “The Evolving Landscape of Impella Use in the United States Among Patients Undergoing Percutaneous Coronary Intervention With Mechanical Circulatory Support” Open

Amit P. Amin, Sunil V. Rao, Richard G. Bach, Jeptha P. Curtis, Nihar R. Desai , et al. · 2020

INDEPENDENT ASSOCIATION OF METEOROLOGICAL CHARACTERISTICS WITH INITIAL SPREAD OF COVID-19 IN INDIA Open

Hemant Kulkarni, Harshwardhan Khandait, Uday Narlawar, Pragati Rathod, Manju Mamtani · 2020

Whether weather plays a part in the transmissibility of the novel COronaVIrus Disease-19 (COVID-19) is still not established. We tested the hypothesis that meteorological factors (air temperature, relative humidity, air pressure, wind spee…

Incremental Prognostic Value of Anemia in Acute Coronary Syndrome from A Rural Hospital in India Open

Anjalee Chiwhane, Shreerang Burchundi, Gajendra Manakshe, Hemant Kulkarni · 2020

Inclusion of baseline anemia in addition to the GRACE score improves prognostication of ACS patients.

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