Hengcheng Zhang
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View article: IL-6/IL-6R Signaling Blockade Alleviates Chronic Allograft Rejection by Modulating Germinal Center B Cells and Allograft Inflammation in Murine Cardiac Transplantation
IL-6/IL-6R Signaling Blockade Alleviates Chronic Allograft Rejection by Modulating Germinal Center B Cells and Allograft Inflammation in Murine Cardiac Transplantation Open
IL-6/IL-6R signaling represents a pivotal therapeutic target for CR, and its blockade offers a promising strategy for improving long-term allograft outcomes.
View article: Neuropilin-2 functions as a coinhibitory receptor to regulate antigen-induced inflammation and allograft rejection
Neuropilin-2 functions as a coinhibitory receptor to regulate antigen-induced inflammation and allograft rejection Open
Coinhibitory receptors function as central modulators of the immune response to resolve T effector activation and/or to sustain immune homeostasis. Here, using humanized SCID mice, we found that neuropilin-2 (NRP2) is inducible on late eff…
View article: Performance Measurement and Analysis of Multi-layer Insulation Material (MLI) From 20 K-300 K
Performance Measurement and Analysis of Multi-layer Insulation Material (MLI) From 20 K-300 K Open
This paper introduces a cryogen-free high vacuum multi-layer insulation material (MLI) measurement system based on a G-M cryocooler, which uses the steady-state axial heat flux method for heat measurement. The system enables cold boundary …
View article: A cryogenic temperature edge dislocation motion model of FCC 316LN stainless steel based on molecular dynamics
A cryogenic temperature edge dislocation motion model of FCC 316LN stainless steel based on molecular dynamics Open
The dislocation slip patterns and micro-stress fields generated by accumulation at cryogenic temperature are the main reasons for the formation of twins or structural phase transformations in metallic materials during deformation. A unit c…
View article: Design of near-field radiative heat transfer measurement system for superconducting films in cryogenic temperature
Design of near-field radiative heat transfer measurement system for superconducting films in cryogenic temperature Open
With the miniaturization and increased efficiency of electronic devices, near-field radiative heat transfer (NFRHT) has become a crucial factor in thermal management studies. In recent studies, the strong suppression of NFRHT through super…
View article: Follicular regulatory T cells restrain kidney allograft rejection in mice by suppressing alloreactive B cells
Follicular regulatory T cells restrain kidney allograft rejection in mice by suppressing alloreactive B cells Open
View article: #1843 Deletion of IL17-producing follicular helper T cells restrains the germinal center reaction in systemic lupus erythematosus
#1843 Deletion of IL17-producing follicular helper T cells restrains the germinal center reaction in systemic lupus erythematosus Open
Background and Aims Systemic lupus erythematosus (SLE) is an autoimmune disorder in which autoantibody formation can lead to severe kidney pathology. Interleukin (IL)17-producing T cells have been suggested to play an important role in the…
View article: QuantEcon.py: A community based Python library forquantitative economics
QuantEcon.py: A community based Python library forquantitative economics Open
Economics traditionally relied on tractable mathematical models, diagrams, and simple regression methods to analyze and understand economic phenomena.However, in recent decades, economists have increasingly shifted towards more computation…
View article: A Novel Timoshenko Beam-Based Crankshaft Model with Non-Linear Breathing Cracks and Experimental Study
A Novel Timoshenko Beam-Based Crankshaft Model with Non-Linear Breathing Cracks and Experimental Study Open
View article: Stepwise differentiation of follicular helper T cells reveals distinct developmental and functional states
Stepwise differentiation of follicular helper T cells reveals distinct developmental and functional states Open
Follicular helper T (Tfh) cells are essential for the formation of high affinity antibodies after vaccination or infection. Although the signals responsible for initiating Tfh differentiation from naïve T cells have been studied, the signa…
View article: A narrow T cell receptor repertoire instructs thymic differentiation of MHC class Ib–restricted CD8+ regulatory T cells
A narrow T cell receptor repertoire instructs thymic differentiation of MHC class Ib–restricted CD8+ regulatory T cells Open
Although most CD8+ T cells are equipped to kill infected or transformed cells, a subset may regulate immune responses and preserve self-tolerance. Here, we describe a CD8 lineage that is instructed to differentiate into CD8 T regulatory ce…
View article: IL-21–producing effector Tfh cells promote B cell alloimmunity in lymph nodes and kidney allografts
IL-21–producing effector Tfh cells promote B cell alloimmunity in lymph nodes and kidney allografts Open
Follicular helper T (Tfh) cells have been implicated in controlling rejection after allogeneic kidney transplantation, but the precise subsets, origins, and functions of Tfh cells in this process have not been fully characterized. Here we …
View article: Single-nucleotide polymorphisms of matrix metalloproteinase genes are associated with graft fibrosis after kidney transplantation
Single-nucleotide polymorphisms of matrix metalloproteinase genes are associated with graft fibrosis after kidney transplantation Open
The SNP rs9059 is associated with significant kidney allograft pathological changes by promoting EMT progression. Our findings provide insights into the etiology of renal allograft interstitial fibrosis and the MMP9 could be used as a pote…
View article: Clapping Triboelectric Nanogenerators as Self-Powered, Frequency-Insensitive and Gravity-Independent Vibration Sensors
Clapping Triboelectric Nanogenerators as Self-Powered, Frequency-Insensitive and Gravity-Independent Vibration Sensors Open
View article: Design and Uncertainty Analysis of Cryogenic Spectral Emissivity Measurement System
Design and Uncertainty Analysis of Cryogenic Spectral Emissivity Measurement System Open
View article: Delivery of costimulatory blockade to lymph nodes promotes transplant acceptance in mice
Delivery of costimulatory blockade to lymph nodes promotes transplant acceptance in mice Open
The lymph node (LN) is the primary site of alloimmunity activation and regulation during transplantation. Here, we investigated how fibroblastic reticular cells (FRCs) facilitate the tolerance induced by anti-CD40L in a murine model of hea…
View article: Author Correction: BTLA suppress acute rejection via regulating TCR downstream signals and cytokines production in kidney transplantation and prolonged allografts survival
Author Correction: BTLA suppress acute rejection via regulating TCR downstream signals and cytokines production in kidney transplantation and prolonged allografts survival Open
This Article contains errors in Figure 3.In Figure 3A, the immunohistochemical staining figure in the Normal+NC group is incorrect.In addition, Figure 3C was incomplete.The days 0 to 7 are added.The correct Figure 3 and accompanying legend…
View article: Microstructure evolution of austenitic stainless steels under high-cycle-fatigue loading at deep cryogenic temperature
Microstructure evolution of austenitic stainless steels under high-cycle-fatigue loading at deep cryogenic temperature Open
In this work, the microstructure evolution and magnetic properties of the 316LN austenitic stainless steels under high-cycle-fatigue loading at liquid helium temperature (4.2 K) were assessed by using the X-ray diffractometer (XRD), electr…
View article: Transcriptionally Distinct B Cells Infiltrate Allografts After Kidney Transplantation
Transcriptionally Distinct B Cells Infiltrate Allografts After Kidney Transplantation Open
Background. Following allogeneic kidney transplantation, a substantial proportion of graft loss is attributed to the formation of donor-specific antibodies and antibody-mediated rejection. B cells infiltrate kidney grafts during antibody-m…
View article: Role of T follicular helper and T follicular regulatory cells in antibody-mediated rejection: new therapeutic targets?
Role of T follicular helper and T follicular regulatory cells in antibody-mediated rejection: new therapeutic targets? Open
Purpose of review Antibody-mediated rejection (AbMR) after solid organ transplantation is tightly controlled by multiple cells of the immune system. Tfh and Tfr cells are essential controllers of antibody responses making them putative tar…
View article: T cell depletion increases humoral response by favoring T follicular helper cells expansion
T cell depletion increases humoral response by favoring T follicular helper cells expansion Open
View article: Follicular T cells optimize the germinal center response to SARS-CoV-2 protein vaccination in mice
Follicular T cells optimize the germinal center response to SARS-CoV-2 protein vaccination in mice Open
Follicular helper T (Tfh) cells promote, whereas follicular regulatory T (Tfr) cells restrain, germinal center (GC) reactions. However, the precise roles of these cells in the complex GC reaction remain poorly understood. Here, we perturb …
View article: Everolimus Alleviates Renal Allograft Interstitial Fibrosis by Inhibiting Epithelial-to-Mesenchymal Transition Not Only via Inducing Autophagy but Also via Stabilizing IκB-α
Everolimus Alleviates Renal Allograft Interstitial Fibrosis by Inhibiting Epithelial-to-Mesenchymal Transition Not Only via Inducing Autophagy but Also via Stabilizing IκB-α Open
Chronic allograft dysfunction (CAD) is the major cause of late graft loss in long-term renal transplantation. In our previous study, we found that epithelial–mesenchymal transition (EMT) is a significant event in the progression of renal a…
View article: Microstructure Evolution of Austenitic Stainless Steels Under High-Cycle-Fatigue Loading at Deep Cryogenic Temperature
Microstructure Evolution of Austenitic Stainless Steels Under High-Cycle-Fatigue Loading at Deep Cryogenic Temperature Open
View article: Single Nucleotide Polymorphisms of IL-33 Gene Correlated with Renal Allograft Fibrosis in Kidney Transplant Recipients
Single Nucleotide Polymorphisms of IL-33 Gene Correlated with Renal Allograft Fibrosis in Kidney Transplant Recipients Open
Background. Nowadays, renal allograft survival is confined by the development of allograft fibrosis. Previous studies have reported interleukin-33 (IL-33) upregulated significantly in patients with chronic renal allograft dysfunction, and …
View article: Efficacy and Safety of Iguratimod Supplement to the Standard Immunosuppressive Regimen in Highly Mismatched Renal Transplant Recipients: A Pilot Study
Efficacy and Safety of Iguratimod Supplement to the Standard Immunosuppressive Regimen in Highly Mismatched Renal Transplant Recipients: A Pilot Study Open
Iguratimod (IGU) can mitigate the symptoms of rheumatoid arthritis through its anti-inflammatory effects. The objective of this study was to investigate the clinical efficacy and safety of IGU in highly HLA-mismatched renal transplant reci…
View article: Bearing run-to-failure datasets of UNSW
Bearing run-to-failure datasets of UNSW Open
The run-to-failure experiments data were collected at the University of New South Wales in 2019-2020, regarding the development of bearing fault severity assessment methods. The following journal paper [1] contains the description of the e…
View article: Combined Immunotherapy With Belatacept and BTLA Overexpression Attenuates Acute Rejection Following Kidney Transplantation
Combined Immunotherapy With Belatacept and BTLA Overexpression Attenuates Acute Rejection Following Kidney Transplantation Open
Background Costimulatory blockade provides new therapeutic opportunities for ensuring the long-term survival of kidney grafts. The adoption of the novel immunosuppressant Belatacept has been limited, partly due to concerns regarding higher…
View article: Follicular T cells mediate donor-specific antibody and rejection after solid organ transplantation
Follicular T cells mediate donor-specific antibody and rejection after solid organ transplantation Open
View article: Measurement of thermal expansions of closed-cell polyurethane rigid foams at cryogenic temperatures with an extensometer technique
Measurement of thermal expansions of closed-cell polyurethane rigid foams at cryogenic temperatures with an extensometer technique Open
The database of thermal expansion behavior of closed-cell polyurethane rigid foam at very low temperatures is required for designing and manufacturing thermal insulation components of various cryogenic systems. In the present work, thermal…