Hengjun Gao
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View article: Single‐cell RNA sequencing revealed the T‐cell heterogeneity and exhaustion subsets of <i>Helicobacter pylori</i> ‐induced gastritis‐to‐cancer transformation
Single‐cell RNA sequencing revealed the T‐cell heterogeneity and exhaustion subsets of <i>Helicobacter pylori</i> ‐induced gastritis‐to‐cancer transformation Open
Gastric cancer (GC) is the third leading cause of cancer‐related deaths worldwide. Helicobacter pylori ( H. pylori ) infection is a crucial initiative factor for the Correa cascade occurrence of GC. However, the immunological mechanisms of…
View article: Single-cell RNA sequencing revealed the T cell heterogeneity and exhaustion subsets of Helicobacter pylori-induced gastritis - cancer transformation
Single-cell RNA sequencing revealed the T cell heterogeneity and exhaustion subsets of Helicobacter pylori-induced gastritis - cancer transformation Open
View article: Clinical outcomes of hepaticojejunostomy and ERCP endoscopic bile duct stent implantation in the treatment of malignant obstructive jaundice: a retrospective analysis
Clinical outcomes of hepaticojejunostomy and ERCP endoscopic bile duct stent implantation in the treatment of malignant obstructive jaundice: a retrospective analysis Open
Purpose Malignant obstructive jaundice (MOJ) refers to intrahepatic or extrahepatic bile ducts obstruction caused by the compression or infiltrative growth of malignant tumors, followed by cholestasis and jaundice. Hepaticojejunostomy (HJ)…
View article: Living biobank: Standardization of organoid construction and challenges
Living biobank: Standardization of organoid construction and challenges Open
In multiple areas such as science, technology, and economic activities, it is necessary to unify the management of repetitive tasks or concepts by standardization to obtain the best order and high efficiency. Organoids, as living tissue mo…
View article: The Benefit of the Optimized Formula of Yinxieling in Psoriasis Vulgaris via Regulation on Autophagy Based on microRNA Expression Profile and Network Pharmacology Analysis
The Benefit of the Optimized Formula of Yinxieling in Psoriasis Vulgaris via Regulation on Autophagy Based on microRNA Expression Profile and Network Pharmacology Analysis Open
Yue Lu,1â 3,* Simin Pan,4,* Wenzhen Li,5 Yao Qi,6,7 Li Li,1â 3 Yu-Hong Yan,1â 3 Jianan Wei,1â 3 Dan-Ni Yao,1â 3 Jingjing Wu,1â 3 Hao Deng,1â 3 Shuyan Ye,1â 3 Haiming Chen,1â 3 Qubo Chen,1â 3 Hengjun Gao,…
View article: Considerations from the organoid perspective of hepatocytes: culture organoid of bone or cartilage
Considerations from the organoid perspective of hepatocytes: culture organoid of bone or cartilage Open
View article: Circulating tumor cell-derived exosome–transmitted long non-coding RNA TTN-AS1 can promote the proliferation and migration of cholangiocarcinoma cells
Circulating tumor cell-derived exosome–transmitted long non-coding RNA TTN-AS1 can promote the proliferation and migration of cholangiocarcinoma cells Open
View article: Intraductal papillary mucinous neoplasm of the biliary tract in the caudate lobe of the liver: a case report and literature review
Intraductal papillary mucinous neoplasm of the biliary tract in the caudate lobe of the liver: a case report and literature review Open
An intraductal papillary mucinous neoplasm of the biliary tract (BT-IPMN) in the caudate lobe of the liver is a rare tumor originating from the bile duct. Approximately 40% of the intraductal papillary neoplasms of the biliary tract (IPNB)…
View article: Short-term clinical outcomes of laparoscopic duodenum-preserving pancreatic head resection for the management of pancreatic-head cystic neoplasms
Short-term clinical outcomes of laparoscopic duodenum-preserving pancreatic head resection for the management of pancreatic-head cystic neoplasms Open
View article: Esophageal cancer-related gene 4 inhibits gastric cancer growth and metastasis by upregulating Krüppel-like factor 2 expression
Esophageal cancer-related gene 4 inhibits gastric cancer growth and metastasis by upregulating Krüppel-like factor 2 expression Open
Our findings show that ECRG4 promotes GC progression via Krüppel-like factor 2 signaling and highlight ECRG4 as a potential GC biomarker and therapeutic target.
View article: Benchmark for establishment of organoids from gastrointestinal epithelium and cancer based on available consumables and reagents
Benchmark for establishment of organoids from gastrointestinal epithelium and cancer based on available consumables and reagents Open
Gastrointestinal cancers are a public health problem that threatens the lives of human being. A good experimental model is a powerful tool to promote the uncovering pathogenesis and establish novel treatment methods. High-quality biomedica…
View article: Prognostic analysis of radical resection for iCCAphl and iCCApps: A retrospective cohort study
Prognostic analysis of radical resection for iCCAphl and iCCApps: A retrospective cohort study Open
Backgroud At present, there is no definitive conclusion about the relative prognostic factors on intrahepatic cholangiocarcinoma perihilar large duct type (iCCA phl ) and iCCA peripheral small duct type (iCCA pps ). Aim of the study To com…
View article: Clinical utility of the pancreatitis activity scoring system in severe acute pancreatitis
Clinical utility of the pancreatitis activity scoring system in severe acute pancreatitis Open
Objective: To analyze clinical utility of pancreatitis activity scoring system (PASS) in prediction of persistent organ failure, poor prognosis, and in-hospital mortality in patients with moderately severe acute pancreatitis (MSAP) or seve…
View article: The Gene Expression Analysis of Peripheral Blood Monocytes From Psoriasis Vulgaris Patients With Different Traditional Chinese Medicine Syndromes
The Gene Expression Analysis of Peripheral Blood Monocytes From Psoriasis Vulgaris Patients With Different Traditional Chinese Medicine Syndromes Open
Psoriasis is chronic skin disease and an important health concern. Traditional Chinese Medicine (TCM) has shown great promise in the treatment of psoriasis. However, the correlation between TCM Syndromes and genomics of psoriasis has not b…
View article: Clinical Application Value of Blood Urea Nitrogen in Evaluating the Prognosis of Severe Acute Pancreatitis
Clinical Application Value of Blood Urea Nitrogen in Evaluating the Prognosis of Severe Acute Pancreatitis Open
View article: Gene Expression of PSORI-CM01 and Yinxieling in the Treatment of Psoriasis Vulgaris
Gene Expression of PSORI-CM01 and Yinxieling in the Treatment of Psoriasis Vulgaris Open
Background. This study aimed to explore the mechanisms of action of the PSORI-CM01 and Yinxieling formulas in the treatment of patients with psoriasis vulgaris by analyzing gene expression in peripheral blood mononuclear cells (PBMCs). Met…
View article: Identification of the ASPM-miR-26b-5p network associated with the aggressive traits of HCC cells
Identification of the ASPM-miR-26b-5p network associated with the aggressive traits of HCC cells Open
Background: Even though earlier reports have revealed that abnormal spindle-like microcephaly associated (ASPM) exert essential roles in diverse malignancies, its relationship between specific microRNAs (miRNAs) in regulation of hepatocell…
View article: Exploration of the Regulatory Effects of PSORI-CM01 and Yin Xie Ling on microRNAs in the Peripheral Blood Monocytes of Patients with Blood Stasis Syndrome of Psoriasis Vulgaris
Exploration of the Regulatory Effects of PSORI-CM01 and Yin Xie Ling on microRNAs in the Peripheral Blood Monocytes of Patients with Blood Stasis Syndrome of Psoriasis Vulgaris Open
Background: Traditional Chinese medicines (TCMs) have been used to manage psoriasis since thousands of years and are associated with advantages such as long remission period and few side effects. PSORI-CM01 is a clinical TCM formula for tr…
View article: Analysis of microRNA expression in peripheral blood monocytes of three Traditional Chinese Medicine (TCM) syndrome types in psoriasis patients
Analysis of microRNA expression in peripheral blood monocytes of three Traditional Chinese Medicine (TCM) syndrome types in psoriasis patients Open
View article: Inter- and intratumor DNA methylation heterogeneity associated with lymph node metastasis and prognosis of esophageal squamous cell carcinoma
Inter- and intratumor DNA methylation heterogeneity associated with lymph node metastasis and prognosis of esophageal squamous cell carcinoma Open
Background: Esophageal squamous cell carcinoma (ESCC), one of the leading causes of cancer mortality worldwide, is a heterogeneous cancer with diverse clinical manifestations. However, little is known about the epigenetic heterogene…
View article: Epidermal growth factor‐containing fibulin‐like extracellular matrix protein 1 (<scp>EFEMP</scp>1) suppressed the growth of hepatocellular carcinoma cells by promoting Semaphorin 3B(<scp>SEMA</scp>3B)
Epidermal growth factor‐containing fibulin‐like extracellular matrix protein 1 (<span>EFEMP</span>1) suppressed the growth of hepatocellular carcinoma cells by promoting Semaphorin 3B(<span>SEMA</span>3B) Open
Aim Epidermal growth factor‐containing fibulin‐like extracellular matrix protein 1( EFEMP 1) has been found to be involved in the occurrence and development of many cancers. The relationship between EFEMP 1 and the development of hepatocel…
View article: Prognostic value of the metastatic lymph node ratio in patients with pancreatic cancer.
Prognostic value of the metastatic lymph node ratio in patients with pancreatic cancer. Open
The purpose of the study was to analyze the prognostic value of metastatic lymph node ratio (LNR) in pancreatic cancer (PC) patients undergoing surgical operation. We retrospectively reviewed 615 patients with PC who underwent surgical ope…
View article: Correction: LncRNA-SVUGP2 suppresses progression of hepatocellular carcinoma
Correction: LncRNA-SVUGP2 suppresses progression of hepatocellular carcinoma Open
[This corrects the article DOI: 10.18632/oncotarget.18279.].
View article: Genetic variants in the platelet‐derived growth factor subunit B gene associated with pancreatic cancer risk
Genetic variants in the platelet‐derived growth factor subunit B gene associated with pancreatic cancer risk Open
The platelet‐derived growth factor (PDGF) signaling pathway plays important roles in development and progression of human cancers. In our study, we aimed to identify genetic variants of the PDGF pathway genes associated with pancreatic can…
View article: LncRNA-SVUGP2 suppresses progression of hepatocellular carcinoma
LncRNA-SVUGP2 suppresses progression of hepatocellular carcinoma Open
Numerous studies indicate that long noncoding RNAs (lncRNAs) are dysregulated in hepatocellular carcinoma (HCC) and might serve as potential diagnostic biomarkers and therapeutic targets of HCC. Therefore, it is interesting to globally ide…
View article: Decreased expression of miR-193a-3p is associated with poor prognosis in colorectal cancer
Decreased expression of miR-193a-3p is associated with poor prognosis in colorectal cancer Open
Epithelial-mesenchymal transition (EMT) is an early and key process in the metastatic cascade during the progression of colorectal cancer (CRC). The aim of the present study was to identify deregulated EMT-related microRNAs (miRNAs/miRs) o…
View article: miRNA-338-3p/CDK4 signaling pathway suppressed hepatic stellate cell activation and proliferation
miRNA-338-3p/CDK4 signaling pathway suppressed hepatic stellate cell activation and proliferation Open
We found miR-338-3p is an anti-fibrotic miRNA which inhibits cell activation and proliferation. Our findings suggest that miR-338-3p/CDK4 signaling pathway participates in the regulation of HSC activation and growth and may act as a novel …
View article: Application of AFP whole blood one-step rapid detection kit in screening for HCC in Qidong.
Application of AFP whole blood one-step rapid detection kit in screening for HCC in Qidong. Open
Hepatocellular carcinoma (HCC) is a big problem in China where the Hepatitis B (HBV) infection patients are near to 120 million. Early screening and diagnosis is the key to reduce the incidence and mortality of HCC. Serum AFP detection is …
View article: Intravascular NK/T-cell lymphoma in the testis: a novel case report and review of the literature.
Intravascular NK/T-cell lymphoma in the testis: a novel case report and review of the literature. Open
Intravascular NK/T-cell lymphoma (IVNKTL) is an extremely rare type of lymphoma that frequently affects the skin. To date, only 14 cases of IVNKTL have been described. To the best of our knowledge, this is the first case report of IVNKTL i…
View article: 5‐Hydroxytryptamine promotes hepatocellular carcinoma proliferation by influencing β‐catenin
5‐Hydroxytryptamine promotes hepatocellular carcinoma proliferation by influencing β‐catenin Open
5‐Hydroxytryptamine (5‐HT), a neurotransmitter and vasoactive factor, has been reported to promote proliferation of serum‐deprived hepatocellular carcinoma (HCC) cells but the detailed intracellular mechanism is unknown. As Wnt/β‐catenin s…