Hengxing Chen
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View article: SPP1 is required for maintaining mesenchymal cell fate in pancreatic cancer
SPP1 is required for maintaining mesenchymal cell fate in pancreatic cancer Open
Elucidating the complex network of communication between tumour cells is central to understanding cell fate decisions and progression of pancreatic ductal adenocarcinoma (PDAC)1,2. We previously showed that constant suppression …
View article: NPR1 Promotes Lipid Droplet Lipolysis to Enhance Mitochondrial Oxidative Phosphorylation and Fuel Gastric Cancer Metastasis
NPR1 Promotes Lipid Droplet Lipolysis to Enhance Mitochondrial Oxidative Phosphorylation and Fuel Gastric Cancer Metastasis Open
Metabolic reprogramming driven by oncogenes plays a critical role in promoting and sustaining multiple steps of gastric cancer metastasis. However, the key metabolic driver of metastasis that can lead to the development of targeted therapi…
View article: Hp1 Enhances Radio- and Chemotherapy Resistance in Osteosarcoma Via Parp1-Dependent Transcriptional Repression and Hr Repair
Hp1 Enhances Radio- and Chemotherapy Resistance in Osteosarcoma Via Parp1-Dependent Transcriptional Repression and Hr Repair Open
View article: superTMB: A Refined Deep Learning-Based Tumor Mutation Burden Model in Prediction of Immunotherapy Response in Head and Neck Squamous Cell Carcinoma
superTMB: A Refined Deep Learning-Based Tumor Mutation Burden Model in Prediction of Immunotherapy Response in Head and Neck Squamous Cell Carcinoma Open
View article: Novel DNA damage repair signature for immunotherapy and a proposed molecular subtyping scheme in gastric cancer
Novel DNA damage repair signature for immunotherapy and a proposed molecular subtyping scheme in gastric cancer Open
The DNA damage repair (DDR) mechanisms is closely related to the occurrence and progression of cancer cells. The diversity and complexity of DNA repair mechanisms also affect the tumor immune microenvironment. In this study, we analyzed ga…
View article: Exosome circATP8A1 induces macrophage M2 polarization by regulating the miR-1-3p/STAT6 axis to promote gastric cancer progression
Exosome circATP8A1 induces macrophage M2 polarization by regulating the miR-1-3p/STAT6 axis to promote gastric cancer progression Open
Circular RNAs (circRNAs) play important roles in gastric cancer progression but the regulatory role of circRNAs in controlling macrophage function remains elusive. Exosomes serve as cargo for circRNAs and play a crucial role as mediators i…
View article: Transcription factor EHF interacting with coactivator AJUBA aggravates malignancy and acts as a therapeutic target for gastroesophageal adenocarcinoma
Transcription factor EHF interacting with coactivator AJUBA aggravates malignancy and acts as a therapeutic target for gastroesophageal adenocarcinoma Open
View article: Data from PINK1-Mediated Mitophagy Promotes Oxidative Phosphorylation and Redox Homeostasis to Induce Drug-Tolerant Persister Cancer Cells
Data from PINK1-Mediated Mitophagy Promotes Oxidative Phosphorylation and Redox Homeostasis to Induce Drug-Tolerant Persister Cancer Cells Open
The drug-tolerant persister (DTP) state enables cancer cells to evade cytotoxic stress from anticancer therapy. However, the mechanisms governing DTP generation remain poorly understood. Here, we observed that lung adenocarcinoma (LUAD) ce…
View article: Data from PINK1-Mediated Mitophagy Promotes Oxidative Phosphorylation and Redox Homeostasis to Induce Drug-Tolerant Persister Cancer Cells
Data from PINK1-Mediated Mitophagy Promotes Oxidative Phosphorylation and Redox Homeostasis to Induce Drug-Tolerant Persister Cancer Cells Open
The drug-tolerant persister (DTP) state enables cancer cells to evade cytotoxic stress from anticancer therapy. However, the mechanisms governing DTP generation remain poorly understood. Here, we observed that lung adenocarcinoma (LUAD) ce…
View article: Supplementary Data from PINK1-Mediated Mitophagy Promotes Oxidative Phosphorylation and Redox Homeostasis to Induce Drug-Tolerant Persister Cancer Cells
Supplementary Data from PINK1-Mediated Mitophagy Promotes Oxidative Phosphorylation and Redox Homeostasis to Induce Drug-Tolerant Persister Cancer Cells Open
Figures S1-S12;Tables S1-S4
View article: Supplementary Data from PINK1-Mediated Mitophagy Promotes Oxidative Phosphorylation and Redox Homeostasis to Induce Drug-Tolerant Persister Cancer Cells
Supplementary Data from PINK1-Mediated Mitophagy Promotes Oxidative Phosphorylation and Redox Homeostasis to Induce Drug-Tolerant Persister Cancer Cells Open
Figures S1-S12;Tables S1-S4
View article: Mitophagy is a novel protective mechanism for drug-tolerant persister (DTP) cancer cells
Mitophagy is a novel protective mechanism for drug-tolerant persister (DTP) cancer cells Open
Drug-tolerant persister (DTP) cancer cells drive residual tumor and relapse. However, the mechanisms underlying DTP state development are largely unexplored. In a recent study, we determined that PINK1-mediated mitophagy favors DTP generat…
View article: Identification and validation of a PD-L1-related signature from mass spectrometry in gastric cancer
Identification and validation of a PD-L1-related signature from mass spectrometry in gastric cancer Open
View article: On-Demand Generation of Peroxynitrite from an Integrated Two-Dimensional System for Enhanced Tumor Therapy
On-Demand Generation of Peroxynitrite from an Integrated Two-Dimensional System for Enhanced Tumor Therapy Open
Nanosystem-mediated tumor radiosensitization strategy combining the features of X-ray with infinite penetration depth and high atomic number elements shows considerable application potential in clinical cancer therapy. However, it is diffi…
View article: Cycloruthenated Self‐Assembly with Metabolic Inhibition to Efficiently Overcome Multidrug Resistance in Cancers
Cycloruthenated Self‐Assembly with Metabolic Inhibition to Efficiently Overcome Multidrug Resistance in Cancers Open
The synthesis and the evaluation of the efficacy of a cycloruthenated complex, RuZ, is reported, to overcome multi‐drug resistance (MDR) in cancer cells. RuZ can self‐assemble into nanoaggregates in the cell culture medium, resulting in a …
View article: Cross-Talk of Focal Adhesion-Related Gene Defines Prognosis and the Immune Microenvironment in Gastric Cancer
Cross-Talk of Focal Adhesion-Related Gene Defines Prognosis and the Immune Microenvironment in Gastric Cancer Open
Background: Focal adhesion, as the intermediary between tumor cells and extracellular matrix communication, plays a variety of roles in tumor invasion, migration, and drug resistance. However, the potential role of focal adhesion-related g…
View article: Table of Contents
Table of Contents Open
The research on binocular ranging technology for transmission lines based
View article: Pyruvate Kinase M2 Tetramerization Protects against Hepatic Stellate Cell Activation and Liver Fibrosis
Pyruvate Kinase M2 Tetramerization Protects against Hepatic Stellate Cell Activation and Liver Fibrosis Open
View article: PARK2 promotes mitochondrial pathway of apoptosis and antimicrotubule drugs chemosensitivity <i>via</i> degradation of phospho-BCL-2
PARK2 promotes mitochondrial pathway of apoptosis and antimicrotubule drugs chemosensitivity <i>via</i> degradation of phospho-BCL-2 Open
Rationale: Neoadjuvant chemotherapy has become the standard treatment of locally advanced breast cancer. Antimicrotubule drugs and DNA-damaging drugs are the most popular medicines used for neoadjuvant chemotherapy. However, we are …
View article: Transcription factor NFYA promotes G1/S cell cycle transition and cell proliferation by transactivating cyclin D1 and CDK4 in clear cell renal cell carcinoma.
Transcription factor NFYA promotes G1/S cell cycle transition and cell proliferation by transactivating cyclin D1 and CDK4 in clear cell renal cell carcinoma. Open
NFYA (nuclear transcription factor Y, subunit A) is a CCAAT-binding transcription factor. Accumulating evidence suggests that NFYA plays an important role in breast, ovarian, lung and gastric cancer. However, the role of NFYA in clear cell…
View article: Poly( <scp>ADP</scp> ‐ribosyl)ation of <scp>BRD</scp> 7 by <scp>PARP</scp> 1 confers resistance to <scp>DNA</scp> ‐damaging chemotherapeutic agents
Poly( <span>ADP</span> ‐ribosyl)ation of <span>BRD</span> 7 by <span>PARP</span> 1 confers resistance to <span>DNA</span> ‐damaging chemotherapeutic agents Open
View article: Correction to: High-performance gene expression and knockout tools using sleeping beauty transposon system
Correction to: High-performance gene expression and knockout tools using sleeping beauty transposon system Open
View article: RCC2 promotes breast cancer progression through regulation of Wnt signaling and inducing EMT
RCC2 promotes breast cancer progression through regulation of Wnt signaling and inducing EMT Open
Regulator of chromosome condensation 2 (RCC2), also known as TD-60, is an RCC1 family member and plays an essential role in mitosis. However, the roles of RCC2 in breast cancer are still unclear. In this study, RCC2 was found to exert onco…
View article: High-performance gene expression and knockout tools using sleeping beauty transposon system
High-performance gene expression and knockout tools using sleeping beauty transposon system Open
Our study demonstrated that the pSB series vectors are convenient and powerful tools for gene overexpression and knockout in mammalian cells, providing a new alternative approach for molecular cell biology research.