Henna-Kaisa Jyrkkänen
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View article: Association between postoperative thromboembolic and hemorrhagic complications and clinical outcomes after surgery for chronic subdural hematoma in patients with anticoagulation therapy for atrial fibrillation
Association between postoperative thromboembolic and hemorrhagic complications and clinical outcomes after surgery for chronic subdural hematoma in patients with anticoagulation therapy for atrial fibrillation Open
Purpose A substantial proportion of patients undergoing surgery for chronic subdural hematoma (CSDH) use anticoagulation medication due to atrial fibrillation (AF). We assessed the risk of postoperative thromboembolic and hemorrhagic compl…
View article: Outcome and complications of operatively treated subaxial cervical spine injuries: A population-based retrospective cohort study
Outcome and complications of operatively treated subaxial cervical spine injuries: A population-based retrospective cohort study Open
View article: Long-term outcome of operated Chiari I patients between 2005 and 2020 in Eastern Finland
Long-term outcome of operated Chiari I patients between 2005 and 2020 in Eastern Finland Open
View article: Potent dual MAGL/FAAH inhibitor AKU-005 engages endocannabinoids to diminish meningeal nociception implicated in migraine pain
Potent dual MAGL/FAAH inhibitor AKU-005 engages endocannabinoids to diminish meningeal nociception implicated in migraine pain Open
View article: In vivo assessment of Lewy body and beta-amyloid copathologies in idiopathic normal pressure hydrocephalus: prevalence and associations with clinical features and surgery outcome
In vivo assessment of Lewy body and beta-amyloid copathologies in idiopathic normal pressure hydrocephalus: prevalence and associations with clinical features and surgery outcome Open
View article: Incidence and risk factors of spinal cord stimulation for persistent or recurrent pain after lumbar spine surgery: a population-based study
Incidence and risk factors of spinal cord stimulation for persistent or recurrent pain after lumbar spine surgery: a population-based study Open
View article: Surgically Treated C1 Fractures: A Population-Based Study
Surgically Treated C1 Fractures: A Population-Based Study Open
For unstable C1 fractures, surgery is safe treatment with good outcomes. Fractures initially determined as stable may require surgery if alignment is worsened in follow-up imaging. Magnetic resonance imaging is recommended to better detect…
View article: Upper limb dysfunction and activities in daily living in idiopathic normal pressure hydrocephalus
Upper limb dysfunction and activities in daily living in idiopathic normal pressure hydrocephalus Open
View article: Gabapentinoids Associated With Lower Explantation Rate in 203 Patients With Spinal Cord Stimulation for Failed Back Surgery Syndrome
Gabapentinoids Associated With Lower Explantation Rate in 203 Patients With Spinal Cord Stimulation for Failed Back Surgery Syndrome Open
BACKGROUND Spinal cord stimulation (SCS) is an effective treatment in failed back surgery syndrome (FBSS). The effect of neuropathic pain medication use on SCS outcome is poorly understood. OBJECTIVE To study the effect of gabapentinoid us…
View article: Long-Term Outcome of Spinal Cord Stimulation in Complex Regional Pain Syndrome
Long-Term Outcome of Spinal Cord Stimulation in Complex Regional Pain Syndrome Open
BACKGROUND Spinal cord stimulation (SCS) is an effective treatment in chronic neuropathic pain, but its efficacy in complex regional pain syndrome (CRPS) needs to be proven. OBJECTIVE To study the outcome of SCS in CRPS as measured by tria…
View article: Transcription factor Nrf2 mediated gene regulation and signaling in the endothelium
Transcription factor Nrf2 mediated gene regulation and signaling in the endothelium Open
View article: Higher Preimplantation Opioid Doses Associated With Long-Term Spinal Cord Stimulation Failure in 211 Patients With Failed Back Surgery Syndrome
Higher Preimplantation Opioid Doses Associated With Long-Term Spinal Cord Stimulation Failure in 211 Patients With Failed Back Surgery Syndrome Open
Higher preimplantation opioid doses were associated with SCS failure, suggesting the need for opioid tapering before implantation. With continuous SCS therapy and no explantation or revision due to inadequate pain relief, 39% of FBSS patie…
View article: A hybrid SWOT analysis of the neuromodulation process for chronic pain
A hybrid SWOT analysis of the neuromodulation process for chronic pain Open
Background: Spinal cord stimulation is an efficient treatment for selected patients with chronic neuropathic pain. Since 2015, neuromodulation nurses at Kuopio University Hospital have been responsible for patient education and stimulator …
View article: Psychiatric disorders are a common prognostic marker for worse outcome in patients with idiopathic intracranial hypertension
Psychiatric disorders are a common prognostic marker for worse outcome in patients with idiopathic intracranial hypertension Open
Psychiatric disorders are highly prevalent in patients with IIH and associate with worse subjective outcomes. These findings advocate for monitoring the mental health of patients with IIH and warrant further multidisciplinary research to u…
View article: Nrf2 and SQSTM1/p62 jointly contribute to mesenchymal transition and invasion in glioblastoma
Nrf2 and SQSTM1/p62 jointly contribute to mesenchymal transition and invasion in glioblastoma Open
View article: NRF2 regulates endothelial glycolysis and proliferation with miR-93 and mediates the effects of oxidized phospholipids on endothelial activation
NRF2 regulates endothelial glycolysis and proliferation with miR-93 and mediates the effects of oxidized phospholipids on endothelial activation Open
Phospholipids, such as 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine (PAPC), are the major components of cell membranes. Their exposure to reactive oxygen species creates oxidized phospholipids, which predispose to the development…