Henna Khalid
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View article: Association of Osteopontin (OPN) Level in Diabetic Nephropathy Patients as an Early Diagnostic Marker
Association of Osteopontin (OPN) Level in Diabetic Nephropathy Patients as an Early Diagnostic Marker Open
OBJECTIVES The study aimed to find an association between OPN levels and diabetic nephropathy as a serum marker in DM patients for early detection. METHODOLOGY A cross-sectional study was conducted for 6 months on 277 diagnosed cases of DM…
View article: Molecular characterization of Streptococcus pyogenes (StrepA) non-invasive isolates during the 2022–2023 UK upsurge
Molecular characterization of Streptococcus pyogenes (StrepA) non-invasive isolates during the 2022–2023 UK upsurge Open
At the end of 2022 into early 2023, the UK Health Security Agency reported unusually high levels of scarlet fever and invasive disease caused by Streptococcus pyogenes (StrepA or group A Streptococcus ). During this time, we collected and …
View article: Pathological Pulmonary Manifestations in Chronic Kidney Disease Patients Undergoing Hemodialysis
Pathological Pulmonary Manifestations in Chronic Kidney Disease Patients Undergoing Hemodialysis Open
Provenance of chronic kidney diseases is much more common in these days especially in patients suffering from secondary causes like diabetes mellitus and hypertension. Objective: To study the prevalence of pathological pulmonary manifestat…
View article: Molecular characterisation of<i>Streptococcus pyogenes</i>(StrepA) non-invasive isolates during the 2022-23 UK upsurge
Molecular characterisation of<i>Streptococcus pyogenes</i>(StrepA) non-invasive isolates during the 2022-23 UK upsurge Open
At the end of 2022 into early 2023 the UK Health Security Agency reported unusually high levels of scarlet fever and invasive disease caused by Streptococcus pyogenes (StrepA or group A Streptococcus ). During this time, we collected and g…
View article: CD9 co-operation with syndecan-1 is required for a major staphylococcal adhesion pathway
CD9 co-operation with syndecan-1 is required for a major staphylococcal adhesion pathway Open
Epithelial colonization is a critical first step in bacterial pathogenesis. Staphylococcus aureus can utilize several host factors to associate with cells, including α5β1 integrin and heparan sulfate proteoglycans, such as the syndecans. H…
View article: CD9 co-operation with syndecan-1 is required for a major staphylococcal adhesion pathway
CD9 co-operation with syndecan-1 is required for a major staphylococcal adhesion pathway Open
Objectives Epithelial colonisation is a critical first step in bacterial pathogenesis. Staphylococcus aureus can utilise several host factors to associate with cells, including α5βl integrin and heparan sulphate proteoglycans, such as the …
View article: The Frequency of Abnormally High Liver Enzymes and their Connection to Type 2 Diabetes Mellitus
The Frequency of Abnormally High Liver Enzymes and their Connection to Type 2 Diabetes Mellitus Open
Objective: The purpose of this research is to measure liver enzyme activity in Pakistani people with type 2 diabetes. Study Design: Cross sectional Place and Duration: The study was conducted in department of Pathology Women Medical& Denta…
View article: Genomic Characterization of Skin and Soft Tissue Streptococcus pyogenes Isolates from a Low-Income and a High-Income Setting
Genomic Characterization of Skin and Soft Tissue Streptococcus pyogenes Isolates from a Low-Income and a High-Income Setting Open
The global burden of rheumatic heart disease (RHD) has triggered a World Health Organization response to drive forward development of a vaccine against the causative human pathogen Streptococcus pyogenes . This burden stems primarily from …
View article: Glycosylated Hemoglobin (HbA1c) as a Marker for Dyslipidemia in Type 2 Diabetes Mellitus
Glycosylated Hemoglobin (HbA1c) as a Marker for Dyslipidemia in Type 2 Diabetes Mellitus Open
Objective: The purpose of this research was to examine the effectiveness of HbA1c as a predictor of dyslipidemia in patients with Type-2 Diabetes Mellitus. Study Design: Cross-sectional Place and Duration: Department of Pathology; Women Me…
View article: Prevalence of Hepatitis B and C Viral Infections in Chronic Liver Disorder
Prevalence of Hepatitis B and C Viral Infections in Chronic Liver Disorder Open
Background and aim: Hepatitis is a liver infection caused by a variety of viruses and is a major public health issue worldwide. Hepatitis B and C are common liver infections caused by HBV and HCV that spread through sexual contact, contami…
View article: Incidence of Metallo Beta-Lactamase Producing Pseudomonas Aeruginosa in Diabetes and Cancer Patients
Incidence of Metallo Beta-Lactamase Producing Pseudomonas Aeruginosa in Diabetes and Cancer Patients Open
Objective: Estimate to the prevalence of hemorrhoids Signs and Symptoms among pregnancies in maternity teaching hospitals in Mosul city. Material: Descriptive study was conducted in maternity teaching hospital 20to30 September 2022 . A pur…
View article: Pattern of Uterine and Cervical Lesions Marked on Histopathological Examination of Hysterectomy Specimens
Pattern of Uterine and Cervical Lesions Marked on Histopathological Examination of Hysterectomy Specimens Open
Background: In Gynecology, most of the knowledge circles around the female reproductive tract and uterus has been a vital organ playing central role in female reproductive life cycle both in terms of menstrual and ostereous cycles. Uterus …
View article: Role of Helicobacter Bacteria in Colitis and Colorectal Neoplasms: A Histopathological and Immunohistochemically Study
Role of Helicobacter Bacteria in Colitis and Colorectal Neoplasms: A Histopathological and Immunohistochemically Study Open
Background and Aim: Adenocarcinomas have progressed from hyper proliferative epithelium through adenomatous lesions to adenocarcinomas and adenomas. In this case, the adenomatous foci are typically neoplastic intraluminal protrusions and o…
View article: Comparative genomic analysis of skin and soft tissue <i>Streptococcus pyogenes</i> isolates from low- and high-income settings
Comparative genomic analysis of skin and soft tissue <i>Streptococcus pyogenes</i> isolates from low- and high-income settings Open
Streptococcus pyogenes is a leading cause of human morbidity and mortality, especially in resource limited settings. The World Health Organisation has recently made a vaccine for S. pyogenes a global health priority to reduce the burden of…
View article: Chikungunya virus requires cellular chloride channels for efficient genome replication
Chikungunya virus requires cellular chloride channels for efficient genome replication Open
Chikungunya virus (CHIKV) is a re-emerging, pathogenic alphavirus that is transmitted to humans by Aedes spp. mosquitoes-causing fever and debilitating joint pain, with frequent long-term health implications and high morbidity. The CHIKV l…
View article: Structural and phenotypic analysis of Chikungunya virus RNA replication elements
Structural and phenotypic analysis of Chikungunya virus RNA replication elements Open
Chikungunya virus (CHIKV) is a re-emerging, pathogenic Alphavirus transmitted to humans by Aedes spp. mosquitoes. We have mapped the RNA structure of the 5′ region of the CHIKV genome using selective 2′-hydroxyl acylation analysed by prime…
View article: Pan-viral protection against arboviruses by targeting inoculation site-based skin macrophages
Pan-viral protection against arboviruses by targeting inoculation site-based skin macrophages Open
Arthropod-borne viruses (arboviruses) are important human pathogens for which there are no specific antiviral medicines. The large number of genetically-distinct arbovirus species, coupled with the unpredictable nature of their outbreaks, …
View article: Replication of the Chikungunya virus genome requires cellular chloride channels
Replication of the Chikungunya virus genome requires cellular chloride channels Open
Chikungunya virus (CHIKV) causes fever and debilitating joint pain, with frequent long-term health implications and cumulating fatalities worldwide. There are no specific antivirals and vaccines, therefore understanding CHIKV replication i…
View article: Structural and phenotypic analysis of Chikungunya Virus RNA structures during viral genome replication and translation
Structural and phenotypic analysis of Chikungunya Virus RNA structures during viral genome replication and translation Open
Chikungunya virus (CHIKV) is a pathogenic, positive-sense RNA virus of the Alphavirus genus, which causes fever and debilitating joint pain in humans. CHIKV is transmitted by Aedes mosquitoes and is currently re-emerging in the absence of …
View article: PAD4 inhibitors: potential sensitizers of tumour cells to TRAIL-induced apoptosis
PAD4 inhibitors: potential sensitizers of tumour cells to TRAIL-induced apoptosis Open
Targeting tumour necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), a mediator of apoptosis (cell death) and death ligand belonging to the TNF superfamily, represents a promising approach in anti-cancer therapy due to its sel…