Henning F. Kramer
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View article: The mitochondrial fission protein Drp1 in liver is required to mitigate NASH and prevents the activation of the mitochondrial ISR
The mitochondrial fission protein Drp1 in liver is required to mitigate NASH and prevents the activation of the mitochondrial ISR Open
Objective: The mitochondrial fission protein Drp1 was proposed to promote NAFLD, as inhibition of hepatocyte Drp1 early in life prevents liver steatosis induced by high-fat diet in mice. However, whether Drp1-knockdown in older mice can re…
View article: A knowledge-based, structural-aided discovery of a novel class of 2-phenylimidazo[1,2-a]pyridine-6-carboxamide H-PGDS inhibitors
A knowledge-based, structural-aided discovery of a novel class of 2-phenylimidazo[1,2-a]pyridine-6-carboxamide H-PGDS inhibitors Open
View article: Complementary NAD+ replacement strategies fail to functionally protect dystrophin-deficient muscle
Complementary NAD+ replacement strategies fail to functionally protect dystrophin-deficient muscle Open
View article: The exploration of aza-quinolines as hematopoietic prostaglandin D synthase (H-PGDS) inhibitors with low brain exposure
The exploration of aza-quinolines as hematopoietic prostaglandin D synthase (H-PGDS) inhibitors with low brain exposure Open
View article: Complementary NAD+ Replacement Strategies Fail to Functionally Protect Dystrophin-Deficient Muscle
Complementary NAD+ Replacement Strategies Fail to Functionally Protect Dystrophin-Deficient Muscle Open
Background Duchenne muscular dystrophy (DMD) is a progressive muscle wasting disorder stemming from a loss of functional dystrophin. Current therapeutic options for DMD are limited, as small molecule modalities remain largely unable to dec…
View article: Complementary NAD+ Replacement Strategies Fail to Functionally Protect Dystrophin-Deficient Muscle
Complementary NAD+ Replacement Strategies Fail to Functionally Protect Dystrophin-Deficient Muscle Open
Background Duchenne muscular dystrophy (DMD) is a progressive muscle wasting disorder stemming from a loss of functional dystrophin. Current therapeutic options for DMD are limited, as small molecule modalities remain largely unable to les…
View article: Complementary NAD+ Replacement Strategies Fail to Functionally Protect Dystrophin-Deficient Muscle
Complementary NAD+ Replacement Strategies Fail to Functionally Protect Dystrophin-Deficient Muscle Open
Background Duchenne muscular dystrophy (DMD) is a progressive muscle wasting disorder stemming from a loss of functional dystrophin. Current therapeutic options for DMD are limited, as small molecule modalities remain largely unable to les…
View article: Additional file 1 of Complementary NAD+ replacement strategies fail to functionally protect dystrophin-deficient muscle
Additional file 1 of Complementary NAD+ replacement strategies fail to functionally protect dystrophin-deficient muscle Open
Additional file 1. Frederick et al Supplemental Table 1.
View article: Prostaglandin D<sub>2</sub>signaling is not involved in the recovery of rat hind limb tendons from injury
Prostaglandin D<sub>2</sub>signaling is not involved in the recovery of rat hind limb tendons from injury Open
Injured tendons heal through the formation of a fibrovascular scar that has inferior mechanical properties compared to native tendon tissue. Reducing inflammation that occurs as a result of the injury could limit scar formation and improve…
View article: Sustained elevation of MG53 in the bloodstream increases tissue regenerative capacity without compromising metabolic function
Sustained elevation of MG53 in the bloodstream increases tissue regenerative capacity without compromising metabolic function Open
View article: Prostaglandin D<sub>2</sub>Signaling is Not Involved in the Recovery of Rat Hindlimb Tendons from Injury
Prostaglandin D<sub>2</sub>Signaling is Not Involved in the Recovery of Rat Hindlimb Tendons from Injury Open
Injured tendons heal through the formation of a fibrovascular scar that has inferior mechanical properties compared to native tendon tissue. Reducing inflammation that occurs as a result of the injury could limit scar formation and improve…
View article: The discovery of quinoline-3-carboxamides as hematopoietic prostaglandin D synthase (H-PGDS) inhibitors
The discovery of quinoline-3-carboxamides as hematopoietic prostaglandin D synthase (H-PGDS) inhibitors Open
View article: Correction to: HIF prolyl hydroxylase inhibition protects skeletal muscle from eccentric contraction induced injury
Correction to: HIF prolyl hydroxylase inhibition protects skeletal muscle from eccentric contraction induced injury Open
View article: HIF prolyl hydroxylase inhibition protects skeletal muscle from eccentric contraction-induced injury
HIF prolyl hydroxylase inhibition protects skeletal muscle from eccentric contraction-induced injury Open
The results of these experiments highlight a novel skeletal muscle protective effect of prolyl hydroxylase inhibition via HIF-mediated expression of iNOS in macrophages. Partial recapitulation of these findings in healthy volunteers sugges…
View article: Additional file 7: of HIF prolyl hydroxylase inhibition protects skeletal muscle from eccentric contraction-induced injury
Additional file 7: of HIF prolyl hydroxylase inhibition protects skeletal muscle from eccentric contraction-induced injury Open
Table S4. Effect of daprodustat on serum protein changes pre- and 3 days post exercise. Excel file for SOMAscanÂŽ (SOMAlogic Inc.) aptamer-based proteome analysis of serum comparing baseline (pre-injury) and 72 h post-injury serum samples …
View article: Additional file 3: of HIF prolyl hydroxylase inhibition protects skeletal muscle from eccentric contraction-induced injury
Additional file 3: of HIF prolyl hydroxylase inhibition protects skeletal muscle from eccentric contraction-induced injury Open
Table S1. Excel file of Affymetrix Gene Chip mRNA levels from mouse gastrocnemius muscle 3, 6 and 9 hrs after injury with 10 mg/kg GSK360 vehicle. Table shows comparison of expression levels between vehicle and GSK360 treated muscle. (XLSX…
View article: Inhibition of prolyl 4-hydroxylase decreases muscle fibrosis following chronic rotator cuff tear
Inhibition of prolyl 4-hydroxylase decreases muscle fibrosis following chronic rotator cuff tear Open
Objectives Rotator cuff tears are among the most frequent upper extremity injuries. Current treatment strategies do not address the poor quality of the muscle and tendon following chronic rotator cuff tears. Hypoxia-inducible factor-1 alph…
View article: Genetic Ablation of CD38 Protects against Western Diet-Induced Exercise Intolerance and Metabolic Inflexibility
Genetic Ablation of CD38 Protects against Western Diet-Induced Exercise Intolerance and Metabolic Inflexibility Open
Nicotinamide adenine dinucleotide (NAD+) is a key cofactor required for essential metabolic oxidation-reduction reactions. It also regulates various cellular activities, including gene expression, signaling, DNA repair and calcium homeosta…