Hernán García
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View article: Insulin resistance parameters in children born very preterm and adequate for gestational age
Insulin resistance parameters in children born very preterm and adequate for gestational age Open
Background Preterm neonates are at risk for metabolic syndrome later in life. Whether prematurity constitutes an independent risk factor for the development of cardiovascular disease and metabolic syndrome remains controversial. Objective …
View article: Variación estacional de 25-hidroxi-vitamina D3, hormona paratiroidea y fosfatasa alcalina en niños escolares
Variación estacional de 25-hidroxi-vitamina D3, hormona paratiroidea y fosfatasa alcalina en niños escolares Open
El principal rol de la vitamina D es la regulación del metabolismo del calcio, cuya principal fuente es la vitamina D3 que se obtiene principalmente por la acción de la luz ultravioleta (UV) en la piel.Objetivo: Evaluar las diferencias est…
View article: Variación estacional de 25-hidroxi-vitamina D3, hormona paratiroidea y fosfatasa alcalina en niños escolares
Variación estacional de 25-hidroxi-vitamina D3, hormona paratiroidea y fosfatasa alcalina en niños escolares Open
El principal rol de la vitamina D es la regulación del metabolismo del calcio, cuya principal fuente es la vitamina D3 que se obtiene principalmente por la acción de la luz ultravioleta (UV) en la piel.Objetivo: Evaluar las diferencias est…
View article: OC07.11: Metabolomic profiling of pathophysiological pathways in early onset severe pre‐eclampsia
OC07.11: Metabolomic profiling of pathophysiological pathways in early onset severe pre‐eclampsia Open
To investigate the pathophysiological pathways involved in early-onset severe pre-eclampsia by maternal blood metabolomic analysis. A prospective observational study including 20 singleton pregnancies with a diagnosis of early-onset (deliv…
View article: P15.04: Maternal proteomics reveals the involvement of complement and coagulation cascades in early onset pre‐eclampsia
P15.04: Maternal proteomics reveals the involvement of complement and coagulation cascades in early onset pre‐eclampsia Open
To investigate the pathophysiological pathways involved in early onset pre-eclampsia (PE) by maternal blood proteomic analysis. A prospective case control study including 20 singleton pregnancies with a diagnosis of early onset (delivering…
View article: Biodiesel a partir de aceite usado de locales gastronómicos: efecto de la temperatura de reacción
Biodiesel a partir de aceite usado de locales gastronómicos: efecto de la temperatura de reacción Open
El objetivo del trabajo fue evaluar la producción de biodiesel mediante transes- terificación alcalina de aceites usados (AU) recolectados en tres locales gastronómicos, a diferentes temperaturas de reacción. Los AU utilizados como materia…
View article: Clinical, Biochemical, and Genetic Characteristics of “Nonclassic” Apparent Mineralocorticoid Excess Syndrome
Clinical, Biochemical, and Genetic Characteristics of “Nonclassic” Apparent Mineralocorticoid Excess Syndrome Open
These findings suggest a spectrum of partial 11β-HSD2 insufficiency in a primary care cohort without the classic phenotype and genotype of AME. NC-AME may represent a phenotype of MR activation and cardiovascular risk, suggesting that thes…
View article: Sodium Intake Is associated With Endothelial Damage Biomarkers and Metabolic Dysregulation
Sodium Intake Is associated With Endothelial Damage Biomarkers and Metabolic Dysregulation Open
BACKGROUND Mounting evidence has associated high sodium (HS) intake with hypertension, cardiovascular disease, and stroke. We investigated whether HS intake modulates the parameters of endothelial damage, inflammation, and oxidative stress…
View article: Talla baja e hipotiroidismo en un niño con Síndrome de Nail-Patella. Reporte de un caso clínico
Talla baja e hipotiroidismo en un niño con Síndrome de Nail-Patella. Reporte de un caso clínico Open
We present a child with proven NPS with short stature and hypothyroi dism. We did not find publications that described this triple association. It can't be ruled out that there could be a relationship between NPS and the thyroid alteration…
View article: Perfil clínico de niños con cetoacidosis diabética en una Unidad de Paciente Crítico
Perfil clínico de niños con cetoacidosis diabética en una Unidad de Paciente Crítico Open
Most of the DKA admissions were due to T1DM onset. In the group of patients already diagnosed with diabetes, the poor adherence to treatment was the main cause of decompensation. There were no serious complications or deaths associated wit…
View article: Cortisol/cortisone ratio and matrix metalloproteinase-9 activity are associated with pediatric primary hypertension
Cortisol/cortisone ratio and matrix metalloproteinase-9 activity are associated with pediatric primary hypertension Open
We report that MMP-9 activity and the cortisol/cortisone ratio were higher in pediatric primary hypertensive patients, and these associations were independent of the effect of obesity. The potential role of these novel biomarkers in predic…
View article: Usefulness and Pitfalls in Sodium Intake Estimation: Comparison of Dietary Assessment and Urinary Excretion in Chilean Children and Adults
Usefulness and Pitfalls in Sodium Intake Estimation: Comparison of Dietary Assessment and Urinary Excretion in Chilean Children and Adults Open
Our results showed that average sodium intake was higher than recommended in both children and adults (WHO ≤2,000mg/d). The sodium intake estimated by dietary assessment correlated with urinary excretion in all subjects, but in obese adult…
View article: II Consenso de la Sociedad Chilena de Endocrinología y Diabetes sobre resistencia a la insulina
II Consenso de la Sociedad Chilena de Endocrinología y Diabetes sobre resistencia a la insulina Open
Insulin resistance is a prevalent condition commonly associated with unhealthy lifestyles. It affects several metabolic pathways, increasing risk of abnormalities at different organ levels. Thus, diverse medical specialties should be invol…
View article: Citosine-Adenine-Repeat Microsatellite of 11β-hydroxysteroid dehydrogenase 2 Gene in Hypertensive Children
Citosine-Adenine-Repeat Microsatellite of 11β-hydroxysteroid dehydrogenase 2 Gene in Hypertensive Children Open
The CA-repeat length did not influence BP levels or serum F/E ratios in pediatric subjects. However, the serum F/E ratio was associated with BP, suggesting a role of 11βHSD2 in mineralocorticoid hypertension.
View article: An<i>XRCC4</i>Splice Mutation Associated With Severe Short Stature, Gonadal Failure, and Early-Onset Metabolic Syndrome
An<i>XRCC4</i>Splice Mutation Associated With Severe Short Stature, Gonadal Failure, and Early-Onset Metabolic Syndrome Open
In this study we have identified a novel pathogenic variant in XRCC4, a gene that plays a critical role in non-homologous end-joining DNA repair. This finding expands the spectrum of DNA damage repair syndromes to include XRCC4 deficiency …
View article: Supplementary Material for: A Deletion of More than 800 kb Is the Most Recurrent Mutation in Chilean Patients with <b><i>SHOX</i></b> Gene Defects
Supplementary Material for: A Deletion of More than 800 kb Is the Most Recurrent Mutation in Chilean Patients with <b><i>SHOX</i></b> Gene Defects Open
Background: Deletions in the SHOX gene are the most frequent genetic cause of Leri-Weill syndrome and Langer mesomelic dysplasia, which are also present in idiopathic short stature. Aim: To describe the m…
View article: A Deletion of More than 800 kb Is the Most Recurrent Mutation in Chilean Patients with <b><i>SHOX</i></b> Gene Defects
A Deletion of More than 800 kb Is the Most Recurrent Mutation in Chilean Patients with <b><i>SHOX</i></b> Gene Defects Open
Background: Deletions in the SHOX gene are the most frequent genetic cause of Leri-Weill syndrome and Langer mesomelic dysplasia, which are also present in idiopathic short stature. Aim: To describe the m…