Henri Palacci
YOU?
Author Swipe
View article: Building Block-Based Binding Predictions for DNA-Encoded Libraries
Building Block-Based Binding Predictions for DNA-Encoded Libraries Open
DNA-encoded libraries (DELs) provide the means to make and screen millions of diverse compounds against a target of interest in a single experiment. However, despite producing large volumes of binding data at a relatively low cost, the DEL…
View article: Building Block-Based Binding Predictions for DNA-Encoded Libraries
Building Block-Based Binding Predictions for DNA-Encoded Libraries Open
DNA-encoded libraries (DELs) provide the means to make and screen millions of diverse compounds against a target of interest in a single experiment. However, despite producing large volumes of binding data at a relatively low cost, the DEL…
View article: Partial Product Aware Machine Learning on DNA-Encoded Libraries
Partial Product Aware Machine Learning on DNA-Encoded Libraries Open
DNA encoded libraries (DELs) are used for rapid large-scale screening of small molecules against a protein target. These combinatorial libraries are built through several cycles of chemistry and DNA ligation, producing large sets of DNA-ta…
View article: Applications of Modern Statistical Mechanics: Molecular Transport and Statistical Learning
Applications of Modern Statistical Mechanics: Molecular Transport and Statistical Learning Open
Statistical Mechanics describes the macroscopic behavior of a system through the analysis of its microscopic components. It is therefore a framework to move from a probabilistic, high-dimensional description of a system to its macroscopic …
View article: Scalable Natural Gradient Langevin Dynamics in Practice
Scalable Natural Gradient Langevin Dynamics in Practice Open
Stochastic Gradient Langevin Dynamics (SGLD) is a sampling scheme for Bayesian modeling adapted to large datasets and models. SGLD relies on the injection of Gaussian Noise at each step of a Stochastic Gradient Descent (SGD) update. In thi…
View article: Microtubule Motional Diffusion Coefficient in Motility Assays is Determined by Heterogeneity in Motor Stiffness
Microtubule Motional Diffusion Coefficient in Motility Assays is Determined by Heterogeneity in Motor Stiffness Open
In the past twenty years, our ability to manipulate and engineer devices at the nano-scale has grown exponentially. As the fabrication of autonomous systems at these scales becomes a reality, the observation of biological structures can he…