Henrietta Howells
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View article: MegaTrack: a framework for the anatomically accurate and time-efficient virtual dissection and analysis of large-scale tractography datasets
MegaTrack: a framework for the anatomically accurate and time-efficient virtual dissection and analysis of large-scale tractography datasets Open
The increasing prevalence of large-scale neuroimaging initiatives has created a need for efficient and anatomically accurate methods for analysing tractography data. Here, we present MegaTrack, a framework designed to combine the anatomica…
View article: Peaglet: A user-friendly probabilistic Kernel density estimation of intracranial cortical and subcortical stimulation sites
Peaglet: A user-friendly probabilistic Kernel density estimation of intracranial cortical and subcortical stimulation sites Open
Peaglet provides a robust probabilistic estimation of the cortical and subcortical distribution of DES sites going beyond a region of interest approach, respecting cortical and subcortical intrinsic geometrical features. Results can be eas…
View article: Atypical brain structural connectivity and social cognition in childhood maltreatment and peer victimisation
Atypical brain structural connectivity and social cognition in childhood maltreatment and peer victimisation Open
Background Childhood maltreatment (CM) is associated with neurobiological aberrations and atypical social cognition. Few studies have examined the neural effects of another common early-life interpersonal stressor, namely peer victimisatio…
View article: Connectivity defines the distinctive anatomy and function of the hand-knob area
Connectivity defines the distinctive anatomy and function of the hand-knob area Open
Control of the hand muscles during fine digit movements requires a high level of sensorimotor integration, which relies on a complex network of cortical and subcortical hubs. The components of this network have been extensively studied in …
View article: Examining Brain Structural Connectivity in Early-life Interpersonal Stress
Examining Brain Structural Connectivity in Early-life Interpersonal Stress Open
Introduction Early-life interpersonal stress, particularly childhood maltreatment (CM), is associated with social cognition deficits as well as neurobiological abnormalities including alterations in brain structure and function and heighte…
View article: Motor impairment evoked by direct electrical stimulation of human parietal cortex during object manipulation
Motor impairment evoked by direct electrical stimulation of human parietal cortex during object manipulation Open
View article: White matter variability, cognition, and disorders: a systematic review
White matter variability, cognition, and disorders: a systematic review Open
Inter-individual differences can inform treatment procedures and—if accounted for—have the potential to significantly improve patient outcomes. However, when studying brain anatomy, these inter-individual variations are commonly unaccounte…
View article: Stimulation of frontal pathways disrupts hand muscle control during object manipulation
Stimulation of frontal pathways disrupts hand muscle control during object manipulation Open
The activity of frontal motor areas during hand-object interaction is coordinated by dense communication along specific white matter pathways. This architecture allows the continuous shaping of voluntary motor output but, despite extensive…
View article: White Matter Variability, Cognition, and Disorders
White Matter Variability, Cognition, and Disorders Open
View article: Factors Influencing Mood Disorders and Health Related Quality of Life in Adults With Glioma: A Longitudinal Study
Factors Influencing Mood Disorders and Health Related Quality of Life in Adults With Glioma: A Longitudinal Study Open
Objective At present, it is not clear whether Mood Disorders (MD) and poor Health Related Quality of Life (HRQoL) in the glioma population correlate with features of the tumor, or rather with secondary symptoms associated with treatment. T…
View article: Distinct Functional and Structural Connectivity of the Human Hand-Knob Supported by Intraoperative Findings
Distinct Functional and Structural Connectivity of the Human Hand-Knob Supported by Intraoperative Findings Open
Fine motor skills rely on the control of hand muscles exerted by a region of primary motor cortex (M1) that has been extensively investigated in monkeys. Although neuroimaging enables the exploration of this system also in humans, indirect…
View article: White matter variability, cognition, and disorders: a systematic review.
White matter variability, cognition, and disorders: a systematic review. Open
Inter-individual differences can inform treatment procedures and - if accounted for - have the potential to significantly improve patient outcomes. However, when studying brain anatomy, these inter-individual variations are commonly unacco…
View article: Challenging Giant Insular Gliomas With Brain Mapping: Evaluation of Neurosurgical, Neurological, Neuropsychological, and Quality of Life Results in a Large Mono-Institutional Series
Challenging Giant Insular Gliomas With Brain Mapping: Evaluation of Neurosurgical, Neurological, Neuropsychological, and Quality of Life Results in a Large Mono-Institutional Series Open
Objective Giant insular tumors are commonly not amenable to complete resection and are associated with a high postoperative morbidity rate. Transcortical approach and brain mapping techniques allow to identify peri-insular functional netwo…
View article: Reproducing macaque lateral grasping and oculomotor networks using resting state functional connectivity and diffusion tractography
Reproducing macaque lateral grasping and oculomotor networks using resting state functional connectivity and diffusion tractography Open
View article: Preserving Visual Functions During Gliomas Resection: Feasibility and Efficacy of a Novel Intraoperative Task for Awake Brain Surgery
Preserving Visual Functions During Gliomas Resection: Feasibility and Efficacy of a Novel Intraoperative Task for Awake Brain Surgery Open
Objective: The intraoperative identification and preservation of optic radiations (OR) during tumor resection requires the patient to be awake. Different tasks are used. However, they do not grant the maintenance of foveal vision du…
View article: Same, same but different? A multi-method review of the processes underlying executive control.
Same, same but different? A multi-method review of the processes underlying executive control. Open
Attention, working memory, and executive control are commonly considered distinct cognitive functions with important reciprocal interactions. Yet, longstanding evidence from lesion studies demonstrated both overlap and dissociation in thei…
View article: Clinical Pearls and Methods for Intraoperative Motor Mapping
Clinical Pearls and Methods for Intraoperative Motor Mapping Open
Resection of brain tumors involving motor areas and pathways requires the identification and preservation of various cortical and subcortical structures involved in motor control at the time of the procedure, in order to maintain the patie…
View article: White matter variability, cognition, and disorders: a systematic review
White matter variability, cognition, and disorders: a systematic review Open
Inter-individual differences can inform treatment procedures and - if accounted for - have the potential to significantly improve patient outcomes. However, when studying brain anatomy, these inter-individual variations are commonly unacco…
View article: The role of left fronto-parietal tracts in hand selection: Evidence from neurosurgery
The role of left fronto-parietal tracts in hand selection: Evidence from neurosurgery Open
Strong right-hand preference on the population level is a uniquely human feature, although its neural basis is still not clearly defined. Recent behavioural and neuroimaging literature suggests that hand preference may be related to the or…
View article: Accelerating the Evolution of Nonhuman Primate Neuroimaging
Accelerating the Evolution of Nonhuman Primate Neuroimaging Open
View article: An ancestral anatomical and spatial bias for visually guided behavior
An ancestral anatomical and spatial bias for visually guided behavior Open
International audience
View article: Differences in Frontal Network Anatomy Across Primate Species
Differences in Frontal Network Anatomy Across Primate Species Open
The frontal lobe is central to distinctive aspects of human cognition and behavior. Some comparative studies link this to a larger frontal cortex and even larger frontal white matter in humans compared with other primates, yet others dispu…
View article: Preoperative transcranial magnetic stimulation for picture naming is reliable in mapping segments of the arcuate fasciculus
Preoperative transcranial magnetic stimulation for picture naming is reliable in mapping segments of the arcuate fasciculus Open
In preoperative planning for neurosurgery, both anatomical (diffusion imaging tractography) and functional tools (MR-navigated transcranial magnetic stimulation) are increasingly used to identify and preserve eloquent language structures s…
View article: The effect of left fronto-parietal resections on hand selection: a lesion-tractography study
The effect of left fronto-parietal resections on hand selection: a lesion-tractography study Open
Strong right-hand preference on the population level is a uniquely human feature, although the neural basis for this is still not clearly defined. Recent behavioural and neuroimaging literature suggests that hand preference may be related …
View article: Large scale networks for human hand-object interaction: Functionally distinct roles for two premotor regions identified intraoperatively
Large scale networks for human hand-object interaction: Functionally distinct roles for two premotor regions identified intraoperatively Open
View article: Resection of tumors within the primary motor cortex using high-frequency stimulation: oncological and functional efficiency of this versatile approach based on clinical conditions
Resection of tumors within the primary motor cortex using high-frequency stimulation: oncological and functional efficiency of this versatile approach based on clinical conditions Open
OBJECTIVE Brain mapping techniques allow one to effectively approach tumors involving the primary motor cortex (M1). Tumor resectability and maintenance of patient integrity depend on the ability to successfully identify motor tracts durin…
View article: Altered white matter connectivity in young people exposed to childhood abuse: a tract-based spatial statistics (TBSS) and tractography study
Altered white matter connectivity in young people exposed to childhood abuse: a tract-based spatial statistics (TBSS) and tractography study Open
Background: Childhood abuse is associated with structural brain abnormalities. Few studies have investigated white matter tract abnormalities in medication-naive, drug-free individuals who experienced childhood abuse. We examined the assoc…
View article: Direct Electrical Stimulation of Premotor Areas: Different Effects on Hand Muscle Activity during Object Manipulation
Direct Electrical Stimulation of Premotor Areas: Different Effects on Hand Muscle Activity during Object Manipulation Open
Dorsal and ventral premotor (dPM and vPM) areas are crucial in control of hand muscles during object manipulation, although their respective role in humans is still debated. In patients undergoing awake surgery for brain tumors, we studied…
View article: Is supratotal resection achievable in low-grade gliomas? Feasibility, putative factors, safety, and functional outcome
Is supratotal resection achievable in low-grade gliomas? Feasibility, putative factors, safety, and functional outcome Open
OBJECTIVE Surgery for low-grade gliomas (LGGs) aims to achieve maximal tumor removal and maintenance of patients’ functional integrity. Because extent of resection is one of the factors affecting the natural history of LGGs, surgery could …
View article: OUP accepted manuscript
OUP accepted manuscript Open
A key aspect of cognitive control is the management of conflicting incoming information to achieve a goal, termed ‘interference control’. Although the role of the right frontal lobe in interference control is evident, the white matter trac…