Explanipedia

Vision-related convergent gene losses reveal SERPINE3’s unknown role in the eye Open

Henrike Indrischek, Juliane Hammer, Anja Machate, Nikolai Hecker, Bogdan Kirilenko , et al. · 2022

Despite decades of research, knowledge about the genes that are important for development and function of the mammalian eye and are involved in human eye disorders remains incomplete. During mammalian evolution, mammals that naturally exhi…

Author response: Vision-related convergent gene losses reveal SERPINE3’s unknown role in the eye Open

Henrike Indrischek, Juliane Hammer, Anja Machate, Nikolai Hecker, Bogdan Kirilenko , et al. · 2022

Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Appendix 1 Data availability References Decision letter Author response Article and author information Metrics Abstract Despite dec…

Vision-related convergent gene losses reveal SERPINE3 ’s unknown role in the eye Open

Henrike Indrischek, Juliane Hammer, Anja Machate, Nikolai Hecker, Bogdan Kirilenko , et al. · 2022

Despite decades of research, knowledge about the genes that are important for development and function of the mammalian eye and are involved in human eye disorders remains incomplete. During mammalian evolution, mammals that naturally exhi…

Positive Selection in Gene Regulatory Factors Suggests Adaptive Pleiotropic Changes During Human Evolution Open

Vladimir Jovanović, Melanie Sarfert, Carlos S. Reyna-Blanco, Henrike Indrischek, Dulce I. Valdivia , et al. · 2021

Gene regulatory factors (GRFs), such as transcription factors, co-factors and histone-modifying enzymes, play many important roles in modifying gene expression in biological processes. They have also been proposed to underlie speciation an…

Divergent evolution in the genomes of closely related lacertids, Lacerta viridis and L. bilineata, and implications for speciation Open

Sree Rohit Raj Kolora, Anne Weigert, Amin Saffari, Stephanie Kehr, Maria Beatriz Walter Costa , et al. · 2018

Background Lacerta viridis and Lacerta bilineata are sister species of European green lizards (eastern and western clades, respectively) that, until recently, were grouped together as the L. viridis complex. Genetic incompatibilities were …

Introducing evolutionary biologists to the analysis of big data: guidelines to organize extended bioinformatics training courses Open

Rui Faria, Deborah A. Triant, Álvaro Perdomo-Sabogal, Bert Overduin, Christoph Bleidorn , et al. · 2018

Research in evolutionary biology has been progressively influenced by big data such as massive genome and transcriptome sequencing data, scalar measurements of several phenotypes on tens to thousands of individuals, as well as from collect…

Tracing the evolution of the heterotrimeric G protein α subunit in Metazoa Open

Alyssa D. Lokits, Henrike Indrischek, Jens Meiler, Heidi E. Hamm, Peter F. Stadler · 2018

Additional file 5: of Tracing the evolution of the heterotrimeric G protein α subunit in Metazoa Open

Alyssa D. Lokits, Henrike Indrischek, Jens Meiler, Heidi E. Hamm, Peter F. Stadler · 2018

Supplemental file 6. ML trees of the non-Vertebrata Deuterostomia preGNAI and preGNAQ nucleotide sequences which corresponded to the mutually exclusive exons, exon6 or exon5, respectively. Bootstrapped replicates were summarized into Exten…

Additional file 3: of Tracing the evolution of the heterotrimeric G protein α subunit in Metazoa Open

Alyssa D. Lokits, Henrike Indrischek, Jens Meiler, Heidi E. Hamm, Peter F. Stadler · 2018

Supplemental file 4. Maximum Likelihood Tree built on the nucleotide level further supports the emergence of GNAI1–4, GNAT1–4, and GNAZ, in addition to GNAO paralogs from the 2R WGD in Vertebrata. It shows the pattern of GNAI0-GNAT0 duplic…

Additional file 4: of Tracing the evolution of the heterotrimeric G protein α subunit in Metazoa Open

Alyssa D. Lokits, Henrike Indrischek, Jens Meiler, Heidi E. Hamm, Peter F. Stadler · 2018

Supplemental file 5. Maximum Likelihood Tree of duplications of exon4 in GNAQ and GNA11 and the homologous sequence of preGNAI, encoded by exon5, duplicated in Urochordata. Bootstrapped replicates were summarized into Extended Majority Rul…

Additional file 1: of Tracing the evolution of the heterotrimeric G protein α subunit in Metazoa Open

Alyssa D. Lokits, Henrike Indrischek, Jens Meiler, Heidi E. Hamm, Peter F. Stadler · 2018

Table S1. Species Evaluated. All major branches of Deuterostomia were investigated using the EMS pipeline (where sequenced genomes exist). Nine species were also included from non-Deuterostomia Opisthokonta lineages to act as outgroups. Co…

Uncovering missing pieces: duplication and deletion history of arrestins in deuterostomes Open