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View article: Mucus concentration–dependent biophysical abnormalities unify submucosal gland and superficial airway dysfunction in cystic fibrosis
Mucus concentration–dependent biophysical abnormalities unify submucosal gland and superficial airway dysfunction in cystic fibrosis Open
Cystic fibrosis (CF) is characterized by abnormal transepithelial ion transport. However, a description of CF lung disease pathophysiology unifying superficial epithelial and submucosal gland (SMG) dysfunctions has remained elusive. We hyp…
View article: Mucus concentration–dependent biophysical abnormalities unify submucosal gland and superficial airway dysfunction in cystic fibrosis
Mucus concentration–dependent biophysical abnormalities unify submucosal gland and superficial airway dysfunction in cystic fibrosis Open
Cystic fibrosis (CF) is characterized by abnormal transepithelial ion transport. However, a description of CF lung disease pathophysiology unifying superficial epithelial and submucosal gland (SMG) dysfunctions has remained elusive. We hyp…
View article: Hyperconcentrated Mucus Unifies Submucosal Gland and Superficial Airway Dysfunction in Cystic Fibrosis
Hyperconcentrated Mucus Unifies Submucosal Gland and Superficial Airway Dysfunction in Cystic Fibrosis Open
Cystic fibrosis (CF) is characterized by abnormal transepithelial ion transport. However, a description of CF lung disease pathophysiology unifying superficial epithelial and submucosal gland (SMG) dysfunctions has remained elusive. We hyp…
View article: Roles of mucus adhesion and cohesion in cough clearance
Roles of mucus adhesion and cohesion in cough clearance Open
Clearance of intrapulmonary mucus by the high-velocity airflow generated by cough is the major rescue clearance mechanism in subjects with mucoobstructive diseases and failed cilial-dependent mucus clearance, e.g., subjects with cystic fib…
View article: E-Liquid Autofluorescence can be used as a Marker of Vaping Deposition and Third-Hand Vape Exposure
E-Liquid Autofluorescence can be used as a Marker of Vaping Deposition and Third-Hand Vape Exposure Open
In the past 5 years, e-cigarette use has been increasing rapidly, particularly in youth and young adults. Due to the novelty of e-cigarettes (e-cigs) and e-cigarette liquids (e-liquids), research on their chemo-physical properties is still…
View article: Adhesive and Cohesive Peel Force Measurement of Human Airway Mucus
Adhesive and Cohesive Peel Force Measurement of Human Airway Mucus Open
In health, the high-speed airflow associated with cough represents a vital backup mechanism for clearing accumulated mucus from our airways. However, alterations in the mucus layer in cystic fibrosis (CF) and chronic obstructive pulmonary …
View article: Roles of mucus adhesion and cohesion in cough clearance
Roles of mucus adhesion and cohesion in cough clearance Open
Significance Mucoobstructive lung diseases, including chronic obstructive pulmonary disease, asthma, and cystic fibrosis, are characterized by intrapulmonary accumulations of hyperconcentrated mucus. Ultimately, mucus accumulation in disea…
View article: Low-Power Wearable Systems for Continuous Monitoring of Environment and Health for Chronic Respiratory Disease
Low-Power Wearable Systems for Continuous Monitoring of Environment and Health for Chronic Respiratory Disease Open
We present our efforts toward enabling a wearable sensor system that allows for the correlation of individual environmental exposures with physiologic and subsequent adverse health responses. This system will permit a better understanding …