Henry R. Kranzler
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View article: An African ancestry-specific nonsense variant in CD36 is associated with a higher risk of dilated cardiomyopathy
An African ancestry-specific nonsense variant in CD36 is associated with a higher risk of dilated cardiomyopathy Open
View article: Mu-opioid receptor availability in patients with opioid use disorder treated with either methadone or buprenorphine
Mu-opioid receptor availability in patients with opioid use disorder treated with either methadone or buprenorphine Open
Methadone (MET) and buprenorphine (BUP)—mu-opioid receptor (MOR) agonists—are efficacious treatments for opioid use disorder (OUD). Using high-sensitivity, long axial field-of-view PET imaging with [ 11 C]carfentanil, we compared MOR avail…
View article: The cell-type-specific genetic architecture of chronic pain in brain and dorsal root ganglia
The cell-type-specific genetic architecture of chronic pain in brain and dorsal root ganglia Open
Chronic pain is a complex clinical problem comprising multiple conditions that may share a common genetic profile. Genome-wide association studies (GWAS) have identified many risk loci whose cell-type context remains unclear. Here, we inte…
View article: Whole-exome sequencing study of opioid dependence offers novel insights into the contributions of exome variants
Whole-exome sequencing study of opioid dependence offers novel insights into the contributions of exome variants Open
View article: The genetics of cannabis lifetime use
The genetics of cannabis lifetime use Open
Cannabis is one of the most commonly used drugs in the world, and use is trending alarmingly higher. We aimed to examine the genetic basis of cannabis lifetime use (CanLU) and its genetic relationships with a variety of psychiatric- and ph…
View article: T23. MULTIVARIATE, MULTIOMIC ANALYSIS IN 799,429 INDIVIDUALS IDENTIFIES 134 LOCI ASSOCIATED WITH SOMATOFORM TRAITS
T23. MULTIVARIATE, MULTIOMIC ANALYSIS IN 799,429 INDIVIDUALS IDENTIFIES 134 LOCI ASSOCIATED WITH SOMATOFORM TRAITS Open
View article: W90. MAJOR DEPRESSIVE DISORDER AMPLIFIES THE COMBINED EFFECT OF POLYGENIC RISK AND CHILDHOOD TRAUMA ON RISK OF LIFETIME SUICIDE ATTEMPT
W90. MAJOR DEPRESSIVE DISORDER AMPLIFIES THE COMBINED EFFECT OF POLYGENIC RISK AND CHILDHOOD TRAUMA ON RISK OF LIFETIME SUICIDE ATTEMPT Open
View article: Genotype‐by‐sex interaction analyses for alcohol use disorder across biobanks
Genotype‐by‐sex interaction analyses for alcohol use disorder across biobanks Open
Background Alcohol use and alcohol use disorder (AUD) are significant contributors to morbidity and mortality, with different prevalences between males and females. Despite the established genetic contribution to AUD, sex as a biological v…
View article: Defining suicidality phenotypes for genetic studies: perspectives of the Psychiatric Genomics Consortium Suicide Working Group
Defining suicidality phenotypes for genetic studies: perspectives of the Psychiatric Genomics Consortium Suicide Working Group Open
Suicidality phenotypes, consisting of suicidal ideation (SI), suicide attempt (SA), and suicide death (SD), are all heritable but present unique challenges in genome-wide association studies (GWAS) due to their individual complexity, overl…
View article: Multi-ancestry Genome-wide Association Study of Inpatient Opioid Dosing Following Knee or Hip Arthroplasty
Multi-ancestry Genome-wide Association Study of Inpatient Opioid Dosing Following Knee or Hip Arthroplasty Open
View article: SLC45A4 is a pain gene encoding a neuronal polyamine transporter
SLC45A4 is a pain gene encoding a neuronal polyamine transporter Open
View article: Effect of smartphone breathalyzer feedback on willingness to drive in moderately intoxicated individuals: A randomized trial.
Effect of smartphone breathalyzer feedback on willingness to drive in moderately intoxicated individuals: A randomized trial. Open
Being aware of their BAC may make drinkers more willing to drive up to the legal BAC limit of 0.08%, despite being in a range associated with increased crash risk. We recommend that breathalyzer apps provide salient feedback about the risk…
View article: Multi-ancestry Genome-wide Association Study of Inpatient Opioid Dosing Following Knee or Hip Arthroplasty
Multi-ancestry Genome-wide Association Study of Inpatient Opioid Dosing Following Knee or Hip Arthroplasty Open
Opioid analgesics are commonly prescribed to manage acute postoperative pain. However, individuals vary in their opioid dosing needs, with no validated biomarkers to guide prescribing. We used electronic health records data from the Millio…
View article: Etiological basis for chronic pain genetic variation in brain and dorsal root ganglia cell types
Etiological basis for chronic pain genetic variation in brain and dorsal root ganglia cell types Open
Chronic pain is a complex clinical problem comprising multiple conditions that may share a common genetic profile. Genome-wide association studies (GWAS) have identified many risk loci whose cell-type context remains unclear. Here, we inte…
View article: Pre-pandemic psychiatric disorders, disease specific polygenic scores, and alcohol consumption patterns during the COVID-19 pandemic
Pre-pandemic psychiatric disorders, disease specific polygenic scores, and alcohol consumption patterns during the COVID-19 pandemic Open
Genetic liability to AUD was associated with increased alcohol consumption during the COVID-19 pandemic but only among individuals without pre-pandemic AUD.
View article: 0538 A Randomized Controlled Trial of CBT-I in Veterans in Early Recovery from Alcohol Use Disorder
0538 A Randomized Controlled Trial of CBT-I in Veterans in Early Recovery from Alcohol Use Disorder Open
Introduction Although insomnia increases relapse risk in early recovery from Alcohol Use Disorder (AUD), no adequately powered clinical trial has evaluated the efficacy of Cognitive Behavioral Therapy for Insomnia (CBT-I) on either insomni…
View article: Methadone-involved overdose deaths in urban and rural communities before and after the public health emergency flexibilities for methadone take-home doses
Methadone-involved overdose deaths in urban and rural communities before and after the public health emergency flexibilities for methadone take-home doses Open
View article: Defining suicidality phenotypes for genetic studies: perspectives of the Psychiatric Genomics Consortium Suicide Working Group
Defining suicidality phenotypes for genetic studies: perspectives of the Psychiatric Genomics Consortium Suicide Working Group Open
Suicidality phenotypes, consisting of suicidal ideation (SI), suicide attempt (SA), and suicide death (SD), are all heritable but present unique challenges in genome-wide association studies (GWAS) due to their individual complexity, overl…
View article: Gene discovery and pleiotropic architecture of chronic pain in a genome-wide association study of >1.2 million individuals
Gene discovery and pleiotropic architecture of chronic pain in a genome-wide association study of >1.2 million individuals Open
Chronic pain is highly prevalent worldwide, and genome-wide association studies (GWAS) have identified a growing number of chronic pain loci. To further elucidate its genetic architecture, we leveraged data from 1,235,695 European ancestry…
View article: Neural cue reactivity and intrinsic functional connectivity in individuals with alcohol use disorder following treatment with topiramate or naltrexone
Neural cue reactivity and intrinsic functional connectivity in individuals with alcohol use disorder following treatment with topiramate or naltrexone Open
View article: Utility of Candidate Genes From an Algorithm Designed to Predict Genetic Risk for Opioid Use Disorder
Utility of Candidate Genes From an Algorithm Designed to Predict Genetic Risk for Opioid Use Disorder Open
Importance Recently, the US Food and Drug Administration gave premarketing approval to an algorithm based on its purported ability to identify individuals at genetic risk for opioid use disorder (OUD). However, the clinical utility of the …
View article: A Randomized Controlled Trial of Cognitive Behavioral Therapy for Insomnia During Early Recovery from Alcohol Use Disorder Among Veterans
A Randomized Controlled Trial of Cognitive Behavioral Therapy for Insomnia During Early Recovery from Alcohol Use Disorder Among Veterans Open
Study Objectives: 1) To determine the efficacy of Cognitive Behavioral Therapy for Insomnia (CBT-I) for improving insomnia, alcohol-related outcomes, and daytime functioning at post-treatment and at 3- and 6-month follow-up, in a largely A…
View article: [<sup>11</sup>C]Carfentanil PET Whole-Body Imaging of Mu-Opioid Receptors: A First In-Human Study
[<sup>11</sup>C]Carfentanil PET Whole-Body Imaging of Mu-Opioid Receptors: A First In-Human Study Open
Introduction Mu-opioid receptors (MORs) are G-coupled protein receptors with a high affinity for both endogenous and exogenous opioids. MORs are widely expressed in the central nervous system (CNS), peripheral organs, and the immune system…
View article: Multi-ancestral genome-wide association study of clinically defined nicotine dependence reveals strong genetic correlations with other substance use disorders and health-related traits
Multi-ancestral genome-wide association study of clinically defined nicotine dependence reveals strong genetic correlations with other substance use disorders and health-related traits Open
Background Genetic research on nicotine dependence has utilized multiple assessments that are in weak agreement. Methods We conducted a genome-wide association study (GWAS) of nicotine dependence defined using the Diagnostic and Statistica…
View article: Integrating HiTOP and RDoC frameworks Part I: Genetic architecture of externalizing and internalizing psychopathology
Integrating HiTOP and RDoC frameworks Part I: Genetic architecture of externalizing and internalizing psychopathology Open
Background There is considerable comorbidity between externalizing (EXT) and internalizing (INT) psychopathology. Understanding the shared genetic underpinnings of these spectra is crucial for advancing knowledge of their biological bases …
View article: Associations of Childhood Adversity and Polygenic Scores with Substance Use Initiation and Disorder Severity – ERRATUM
Associations of Childhood Adversity and Polygenic Scores with Substance Use Initiation and Disorder Severity – ERRATUM Open
View article: Author Correction: Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction
Author Correction: Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction Open
View article: Author Correction: Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction
Author Correction: Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction Open
Correction to "Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction"
View article: Multiomic Network Analysis Identifies Dysregulated Neurobiological Pathways in Opioid Addiction
Multiomic Network Analysis Identifies Dysregulated Neurobiological Pathways in Opioid Addiction Open
View article: <i>GLP1R</i> Gene Expression and Kidney Disease Progression
<i>GLP1R</i> Gene Expression and Kidney Disease Progression Open
Importance Glucagon-like peptide 1 receptor agonists (GLP-1RAs) may have nephroprotective properties beyond those related to weight loss and glycemic control. Objective To investigate the association of genetically proxied GLP-1RAs with ki…