Brian Schofield
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View article: Effect of ageing on pulmonary inflammation, airway hyperresponsiveness and T and B cell responses in antigen‐sensitized and ‐challenged mice
Effect of ageing on pulmonary inflammation, airway hyperresponsiveness and T and B cell responses in antigen‐sensitized and ‐challenged mice Open
Summary Background The effect of ageing on several pathologic features of allergic asthma (pulmonary inflammation, eosinophilia, mucus hypersecretion), and their relationship with airway hyperresponsiveness (AHR) is not well characterized.…
View article: C5 Modulates Airway Hyperreactivity and Pulmonary Eosinophilia during Enhanced Respiratory Syncytial Virus Disease by Decreasing C3a Receptor Expression
C5 Modulates Airway Hyperreactivity and Pulmonary Eosinophilia during Enhanced Respiratory Syncytial Virus Disease by Decreasing C3a Receptor Expression Open
Enhanced respiratory syncytial virus disease, a serious pulmonary disorder that affected recipients of an inactivated vaccine against respiratory syncytial virus in the 1960s, has delayed the development of vaccines against the virus. The …
View article: Immune responses in tuberculosis: antibodies and CD4‐CD8 lymphocytes with vascular adhesion molecules and cytokines (chemokines) cause a rapid antigen‐specific cell infiltration at sites of bacillus Calmette–Guérin reinfection
Immune responses in tuberculosis: antibodies and CD4‐CD8 lymphocytes with vascular adhesion molecules and cytokines (chemokines) cause a rapid antigen‐specific cell infiltration at sites of bacillus Calmette–Guérin reinfection Open
Summary Rabbit primary dermal bacillus Calmette–Guérin (BCG) lesions were compared with reinfection BCG lesions in order to gain insight into how immune responses protect against clinical tuberculosis. As early as 3 hr, a marked infiltrati…
View article: CpG Oligodeoxynucleotides Can Reverse Th2-Associated Allergic Airway Responses and Alter the B7.1/B7.2 Expression in a Murine Model of Asthma
CpG Oligodeoxynucleotides Can Reverse Th2-Associated Allergic Airway Responses and Alter the B7.1/B7.2 Expression in a Murine Model of Asthma Open
CpG oligodeoxynucleotides (CpG-ODN) administered during Ag sensitization or before Ag challenge can inhibit allergic pulmonary inflammation and airway hyperreactivity in murine models of asthma. In this study, we investigated whether CpG-O…
View article: Activation of Divergent Neuronal Cell Death Pathways in Different Target Cell Populations during Neuroadapted Sindbis Virus Infection of Mice
Activation of Divergent Neuronal Cell Death Pathways in Different Target Cell Populations during Neuroadapted Sindbis Virus Infection of Mice Open
Infection of adult mice with neuroadapted Sindbis virus (NSV) results in a severe encephalomyelitis accompanied by prominent hindlimb paralysis. We find that the onset of paralysis parallels morphologic changes in motor neuron cell bodies …
View article: Inhibition of TGF-β-induced apoptosis by ethinyl estradiol in cultured, precision cut rat liver slices and hepatocytes
Inhibition of TGF-β-induced apoptosis by ethinyl estradiol in cultured, precision cut rat liver slices and hepatocytes Open
Ethinyl estradiol (EE) is a strong promoter of hepatocarcinogenesis in the rat. Treatment with EE and other hepatic promoters induces transient growth stimulation followed by growth inhibition (mitosuppression) in hepatocytes. Previously, …
View article: Strain-Dependent Induction of Allergic Sensitization Caused by Peanut Allergen DNA Immunization in Mice
Strain-Dependent Induction of Allergic Sensitization Caused by Peanut Allergen DNA Immunization in Mice Open
To investigate the potential application of allergen gene immunization in the modulation of food allergy, C3H/HeSn (C3H) mice received i.m. injections of pAra h2 plasmid DNA encoding one of the major peanut allergens, Ara h2. Three weeks f…
View article: Presence of nicotinic acetylcholine receptors in cat carotid body afferent system
Presence of nicotinic acetylcholine receptors in cat carotid body afferent system Open
With immunocytochemical techniques using a monoclonal antibody for alpha7 subunits of neuronal nicotinic acetylcholine receptors, we have found these subunits to be exclusively expressed in nerve fibers in the carotid body. Double-immunost…
View article: Signal Transducer and Activator of Transcription Factor 6 (Stat6)-deficient Mice Are Protected from Antigen-induced Airway Hyperresponsiveness and Mucus Production
Signal Transducer and Activator of Transcription Factor 6 (Stat6)-deficient Mice Are Protected from Antigen-induced Airway Hyperresponsiveness and Mucus Production Open
The pleiotropic cytokine interleukin 4 (IL-4) has been shown to regulate many processes thought to be important in the allergic diathesis. To determine the mechanism(s) by which IL-4 mediates allergic airway responses to inhaled allergens,…
View article: Cavitary tuberculosis produced in rabbits by aerosolized virulent tubercle bacilli
Cavitary tuberculosis produced in rabbits by aerosolized virulent tubercle bacilli Open
Liquefaction of solid caseous tuberculous lesions and the subsequent cavity formation are probably the most dangerous processes in the pathogenesis of human pulmonary tuberculosis. In liquefied caseum, the tubercle bacilli grow extracellul…
View article: The effect of bronchial blood flow on hyperpnea-induced airway obstruction and injury.
The effect of bronchial blood flow on hyperpnea-induced airway obstruction and injury. Open
We examined the effect of bronchial blood flow (BBF) on hyperpnea-induced airway obstruction (HIAO) in dogs. HIAO in in situ isolated pulmonary lobes with or without BBF was monitored via a bronchoscope. An intravascular tracer in conjunct…
View article: Culture of arterial chemoreceptor cells from adult cats in defined medium
Culture of arterial chemoreceptor cells from adult cats in defined medium Open
Recently patch clamp techniques and optical fluorometric techniques have been applied to freshly dissociated or cultured carotid body. However, very few studies have shown the effects of the dissociation and/or culture conditions on the he…