Henry T. Hsueh
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View article: Engineered peptide-drug conjugate provides sustained protection of retinal ganglion cells with topical administration in rats
Engineered peptide-drug conjugate provides sustained protection of retinal ganglion cells with topical administration in rats Open
View article: Machine learning-driven multifunctional peptide engineering for sustained ocular drug delivery
Machine learning-driven multifunctional peptide engineering for sustained ocular drug delivery Open
Sustained drug delivery strategies have many potential benefits for treating a range of diseases, particularly chronic diseases that require treatment for years. For many chronic ocular diseases, patient adherence to eye drop dosing regime…
View article: Reduced inspired oxygen decreases retinal superoxide radicals and promotes cone function and survival in a model of retinitis pigmentosa
Reduced inspired oxygen decreases retinal superoxide radicals and promotes cone function and survival in a model of retinitis pigmentosa Open
View article: Injectable, Drug-Eluting Nanocrystals Prevent Fibrosis and Stricture Formation In Vivo
Injectable, Drug-Eluting Nanocrystals Prevent Fibrosis and Stricture Formation In Vivo Open
View article: Ion-Complex Microcrystal Formulation Provides Sustained Delivery of a Multimodal Kinase Inhibitor from the Subconjunctival Space for Protection of Retinal Ganglion Cells
Ion-Complex Microcrystal Formulation Provides Sustained Delivery of a Multimodal Kinase Inhibitor from the Subconjunctival Space for Protection of Retinal Ganglion Cells Open
Glaucoma is the leading cause of irreversible blindness worldwide. Elevated intraocular pressure (IOP) is one of the major risk factors for glaucoma onset and progression, and available pharmaceutical interventions are exclusively targeted…
View article: A hypotonic gel-forming eye drop provides enhanced intraocular delivery of a kinase inhibitor with melanin-binding properties for sustained protection of retinal ganglion cells
A hypotonic gel-forming eye drop provides enhanced intraocular delivery of a kinase inhibitor with melanin-binding properties for sustained protection of retinal ganglion cells Open
View article: Strategy to Enhance Dendritic Cell‐Mediated DNA Vaccination in the Lung
Strategy to Enhance Dendritic Cell‐Mediated DNA Vaccination in the Lung Open
We here introduce a new paradigm to promote pulmonary DNA vaccination. Specifically, we demonstrate that nanoparticles designed to rapidly penetrate airway mucus (mucus-penetrating particle or MPP) enhance the delivery of inhaled model DNA…
View article: Avoiding a Sticky Situation: Bypassing the Mucus Barrier for Improved Local Drug Delivery
Avoiding a Sticky Situation: Bypassing the Mucus Barrier for Improved Local Drug Delivery Open
View article: Gelling hypotonic polymer solution for extended topical drug delivery to the eye
Gelling hypotonic polymer solution for extended topical drug delivery to the eye Open