Heok Cheow
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View article: SUN-243 Micronodular Asymmetrical Disease and Lack of Rigorous Biochemical Success following Adrenalectomy for Primary Aldosteronism detected by PET-CT Imaging and Post-Operative Confirmatory Testing
SUN-243 Micronodular Asymmetrical Disease and Lack of Rigorous Biochemical Success following Adrenalectomy for Primary Aldosteronism detected by PET-CT Imaging and Post-Operative Confirmatory Testing Open
Disclosure: J. Kearney: None. D. Gillett: None. E. Goodchild: None. H. Cheow: None. M. Krishnamurthy: None. K. Laycock: None. X. Wu: None. M. Gurnell: None. W. Drake: None. M.J. Brown: None. Background: Complete clinical success, defined b…
View article: Mediastinal NUT Carcinoma With Raised Serum Alpha-Fetoprotein Mimicking a Malignant Germ Cell Tumor: Suspicion Raised Due to Negative Serum miR-371a-3p Levels
Mediastinal NUT Carcinoma With Raised Serum Alpha-Fetoprotein Mimicking a Malignant Germ Cell Tumor: Suspicion Raised Due to Negative Serum miR-371a-3p Levels Open
NUT carcinoma is challenging to diagnose and may mimic a germ cell tumor (GCT) due to raised serum alpha-fetoprotein (AFP). A 15-year-old patient presented with back pain and cough. Investigation revealed a mediastinal mass and multiple bo…
View article: The DIRECT study: A roadmap for ctDNA-based risk prediction, molecular profiling and MRD detection in Diffuse Large B Cell Lymphoma
The DIRECT study: A roadmap for ctDNA-based risk prediction, molecular profiling and MRD detection in Diffuse Large B Cell Lymphoma Open
DIRECT was a prospective, multisite study assessing the feasibility and utility of circulating tumor DNA (ctDNA) in 188 patients with aggressive B-cell non-Hodgkin lymphoma using a lymphoma-customized assay and open-source pipeline. CtDNA …
View article: Endoscopic, ultrasound-guided, radiofrequency ablation of aldosterone-producing adenomas (FABULAS): a UK, multicentre, prospective, proof-of-concept trial
Endoscopic, ultrasound-guided, radiofrequency ablation of aldosterone-producing adenomas (FABULAS): a UK, multicentre, prospective, proof-of-concept trial Open
National Institute for Health and Care Research Biomedical Research Centres at Barts, University College Hospitals, and Cambridge University Hospitals, Barts Charity, and British Heart Foundation.
View article: A Phase I/IIa Clinical Trial to Evaluate Safety and Adrenal Uptake of Para-Chloro-2-[<sup>18</sup>F]Fluoroethyletomidate in Healthy Volunteers and Patients with Primary Aldosteronism
A Phase I/IIa Clinical Trial to Evaluate Safety and Adrenal Uptake of Para-Chloro-2-[<sup>18</sup>F]Fluoroethyletomidate in Healthy Volunteers and Patients with Primary Aldosteronism Open
Primary aldosteronism (PA) is a common, potentially reversible, cause of hypertension. Distinguishing unilateral from bilateral PA is critical when deciding who should be offered surgery (unilateral adrenalectomy). Recent studies have show…
View article: Bilateral and recurrent adrenocortical carcinoma in MEN1: a case report and review of the literature
Bilateral and recurrent adrenocortical carcinoma in MEN1: a case report and review of the literature Open
The autosomal dominant hereditary cancer syndrome multiple endocrine neoplasia type 1 (MEN1) is associated with an increased prevalence of both benign and malignant adrenal lesions. Although MEN1 mutations are implicated in around 7% of al…
View article: Endoscopic, ultrasound guided, radiofrequency ablation of aldosterone producing adenomas: A prospective, proof-of-concept trial
Endoscopic, ultrasound guided, radiofrequency ablation of aldosterone producing adenomas: A prospective, proof-of-concept trial Open
Unilateral aldosterone-producing adrenal adenomas (APAs) are the potentially curable cause of 5% of all cases of hypertension. At present surgical removal of a whole gland is the only approved option for achieving cure, with uncertain long…
View article: Real-world experience with 11C-methionine positron emission tomography in the management of acromegaly
Real-world experience with 11C-methionine positron emission tomography in the management of acromegaly Open
Background L-[methyl-11C]-methionine-positron emission tomography (Met-PET) is a potentially important imaging adjunct in the diagnostic workup of pituitary adenomas, including somatotroph tumors. Met-PET can identify residual or occult di…
View article: THU594 Outcome Data From Fabulas: A Feasibility Study Of Radiofrequency Endoscopic Ablation, With Ultrasound Guidance, As A Non-surgical, Adrenal Sparing Treatment For Aldosterone Producing Adenomas
THU594 Outcome Data From Fabulas: A Feasibility Study Of Radiofrequency Endoscopic Ablation, With Ultrasound Guidance, As A Non-surgical, Adrenal Sparing Treatment For Aldosterone Producing Adenomas Open
Disclosure: G. Argentesi: None. X. Wu: None. A. Ney: None. E. Goodchild: None. K. Laycock: None. Y. Lee: None. R. Senanayake: None. J. MacFarlane: None. E. Ng: None. J. Kearney: None. A. Palma: None. I. Munteanu: None. J. Salsbury: None. E…
View article: FRI152 Outcome Data From FABULAS: A Feasibility Study Of Radiofrequency Endoscopic Ablation, With Ultrasound Guidance, As A Non-surgical, Adrenal Sparing Treatment For Aldosterone Producing Adenomas
FRI152 Outcome Data From FABULAS: A Feasibility Study Of Radiofrequency Endoscopic Ablation, With Ultrasound Guidance, As A Non-surgical, Adrenal Sparing Treatment For Aldosterone Producing Adenomas Open
Disclosure: G. Argentesi: None. X. Wu: None. E. Goodchild: None. Y. Lee: None. K. Laycock: None. N. Alexander: None. R. Senanayake: None. J. MacFarlane: None. E.D. Benu: None. G. Goodchild: None. P. Wilson: None. E.M. Godfrey: None. M. Gur…
View article: FRI156 Novel Radiolabeled Ligand, Para-chloro-2-[18F]fluoroethyletomidate (CETO) Is Equivalent To [11C]metomidate-PET (MTO) For The Lateralisation Of Primary Aldosteronism (PA)
FRI156 Novel Radiolabeled Ligand, Para-chloro-2-[18F]fluoroethyletomidate (CETO) Is Equivalent To [11C]metomidate-PET (MTO) For The Lateralisation Of Primary Aldosteronism (PA) Open
Disclosure: E. Goodchild: None. R. Senanayake: None. X. Wu: None. W. Bashari: None. J. Salsbury: None. G. Argentesi: None. S.M. O'Toole: None. J. McFarlane: None. K. Laycock: None. D. Gillett: None. I. Boros: None. A. Sahdev: None. N. Bird…
View article: OR02-02 Pre-operative Blood Pressure Response To Aldosterone Antagonists And Urinary Hybrid Steroid Ratios Predict Clinical Outcomes In Unilateral Primary Aldosteronism For At Least 2 Years Post-adrenalectomy
OR02-02 Pre-operative Blood Pressure Response To Aldosterone Antagonists And Urinary Hybrid Steroid Ratios Predict Clinical Outcomes In Unilateral Primary Aldosteronism For At Least 2 Years Post-adrenalectomy Open
Disclosure: X. Wu: None. E. Goodchild: None. R. Senanayake: None. W. Bashari: None. J. Salsbury: None. C.P. Cabrera: None. G. Argentesi: None. S.M. O’Toole: None. J. McFarlane: None. M. Matson: None. L. Parvanta: None. N. Hilliard: None. V…
View article: Dual Role for l-[Methyl-<sup>11</sup>C]-Methionine PET in Acromegaly: Confirming Remission and Detecting Recurrence
Dual Role for l-[Methyl-<sup>11</sup>C]-Methionine PET in Acromegaly: Confirming Remission and Detecting Recurrence Open
Molecular imaging using the amino acid PET tracer l-[methyl-11C]-methionine (11C-Met PET) is emerging as an important addition to the armamentarium of clinicians treating pituitary disease. In acromegaly cases, 11C-Met PET can accurately l…
View article: Clinical Utility of 18Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (18F-FDG PET/CT) in Multivisceral Transplant Patients
Clinical Utility of 18Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (18F-FDG PET/CT) in Multivisceral Transplant Patients Open
Multivisceral transplant (MVTx) refers to a composite graft from a cadaveric donor, which often includes the liver, the pancreaticoduodenal complex, and small intestine transplanted en bloc. It remains rare and is performed in specialist c…
View article: Diagnostic utility of <sup>11</sup>C‐methionine PET/CT in primary hyperparathyroidism in a UK cohort: A single‐centre experience and literature review
Diagnostic utility of <sup>11</sup>C‐methionine PET/CT in primary hyperparathyroidism in a UK cohort: A single‐centre experience and literature review Open
Objective Primary hyperparathyroidism is a common endocrine disorder, with 80% of all cases usually caused by one single hyperfunctioning parathyroid adenoma. Conventional imaging modalities for the diagnostic work‐up of primary hyperparat…
View article: Development of a bespoke phantom to optimize molecular PET imaging of pituitary tumors
Development of a bespoke phantom to optimize molecular PET imaging of pituitary tumors Open
Background Image optimization is a key step in clinical nuclear medicine, and phantoms play an essential role in this process. However, most phantoms do not accurately reflect the complexity of human anatomy, and this presents a particular…
View article: [11C]metomidate PET-CT versus adrenal vein sampling for diagnosing surgically curable primary aldosteronism: a prospective, within-patient trial
[11C]metomidate PET-CT versus adrenal vein sampling for diagnosing surgically curable primary aldosteronism: a prospective, within-patient trial Open
Primary aldosteronism (PA) due to a unilateral aldosterone-producing adenoma is a common cause of hypertension. This can be cured, or greatly improved, by adrenal surgery. However, the invasive nature of the standard pre-surgical investiga…
View article: Low-dose <i>i</i> nterleukin 2 for the reduction of <i>v</i> ascular inflammati <i>o</i> n in acute corona <i>ry</i> syndromes (IVORY): protocol and study rationale for a randomised, double-blind, placebo-controlled, phase II clinical trial
Low-dose <i>i</i> nterleukin 2 for the reduction of <i>v</i> ascular inflammati <i>o</i> n in acute corona <i>ry</i> syndromes (IVORY): protocol and study rationale for a randomised, double-blind, placebo-controlled, phase II clinical trial Open
Introduction Inflammation plays a critical role in the pathogenesis of atherosclerosis, the leading cause of ischaemic heart disease (IHD). Studies in preclinical models have demonstrated that an increase in regulatory T cells (Tregs), whi…
View article: An Approach to a Patient With Primary Hyperparathyroidism and a Suspected Ectopic Parathyroid Adenoma
An Approach to a Patient With Primary Hyperparathyroidism and a Suspected Ectopic Parathyroid Adenoma Open
Primary hyperparathyroidism (PHPT) is characterized by hypercalcemia driven by excess parathyroid hormone (PTH) secretion. PHPT is a common endocrine condition with a prevalence of 1 to 7 cases per 1000 adults. PHPT typically presents in t…
View article: 11C-metomidate PET CT versus Adrenal Vein Sampling for diagnosing surgically curable primary aldosteronism: prospective test validation, and impact of somatic genotype and ethnicity on outcomes
11C-metomidate PET CT versus Adrenal Vein Sampling for diagnosing surgically curable primary aldosteronism: prospective test validation, and impact of somatic genotype and ethnicity on outcomes Open
Primary aldosteronism (PA) due to a unilateral aldosterone-producing adenoma (APA) is a common, curable cause of hypertension, but invasive methods of diagnosis and treatment contribute to <1% of patients being offered the chance of cure. …
View article: Primary Results From MATCH: A Randomised Controlled Trial in Primary Aldosteronism
Primary Results From MATCH: A Randomised Controlled Trial in Primary Aldosteronism Open
Primary aldosteronism (PA) is now considered the sole, often curable, cause of hypertension in 5-10% of patients. Yet there has been only one RCT, and practice has changed little since the advent of CT scanning. Adrenal vein sampling (AVS)…
View article: PET-guided repeat transsphenoidal surgery for previously deemed unresectable lateral disease in acromegaly
PET-guided repeat transsphenoidal surgery for previously deemed unresectable lateral disease in acromegaly Open
OBJECTIVE The object of this study was to determine if revision transsphenoidal surgery (TSS), guided by 11 C-methionine PET/CT coregistered with volumetric MRI (Met-PET/MR CR ), can lead to remission in patients with persistent acromegaly…
View article: SAT-546 Endoscopic Ultrasound-Guided Radiofrequency Ablation (EUS-RFA) as an Alternative to Adrenalectomy for the Treatment of Aldosterone-Producing Adenomas (APAs)
SAT-546 Endoscopic Ultrasound-Guided Radiofrequency Ablation (EUS-RFA) as an Alternative to Adrenalectomy for the Treatment of Aldosterone-Producing Adenomas (APAs) Open
Primary Aldosteronism (PA) carries significant cardiometabolic risk, over and above those attributable to hypertension alone. The Endocrine Society guidelines recommend adrenalectomy in those with unilateral disease. However surgery is lik…
View article: OR34-07 Prospective Multicentre Study Comparing 11C-metomidate PET CT with Adrenal Vein Sampling (AVS) in the Detection of Unilateral Aldosterone-Producing Adenomas (APAs)
OR34-07 Prospective Multicentre Study Comparing 11C-metomidate PET CT with Adrenal Vein Sampling (AVS) in the Detection of Unilateral Aldosterone-Producing Adenomas (APAs) Open
Approximately 50% of Primary Aldosteronism (PA) cases are unilateral, potentially curable by adrenalectomy. However far fewer patients progress to surgery, partly due to difficulties in identifying unilateral disease. AVS is the current cr…