Lukas Kunz
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View article: Behavioral investigation of allocentric and egocentric cognitive maps in human spatial memory
Behavioral investigation of allocentric and egocentric cognitive maps in human spatial memory Open
Spatial memory is a fundamental cognitive function that enables humans and other species to encode and recall the locations of items in their environments. Humans employ diverse strategies to support spatial memory, including the use of co…
View article: Behavioral investigation of allocentric and egocentric cognitive maps in human spatial memory
Behavioral investigation of allocentric and egocentric cognitive maps in human spatial memory Open
Spatial memory is a fundamental cognitive function that enables humans and other species to encode and recall the locations of items in their environments. Humans employ diverse strategies to support spatial memory, including the use of co…
View article: Path integration deficits are related to Alzheimer’s disease pathology
Path integration deficits are related to Alzheimer’s disease pathology Open
Background The medial temporal lobe (MTL) is the first cortical region affected by tauopathy in Alzheimer’s disease (AD) and is implicated in spatial orientation. In early AD stages, navigation deficits, including path integration deficits…
View article: Rotation errors in path integration indicate Alzheimer’s disease tau pathology: a cross-sectional study
Rotation errors in path integration indicate Alzheimer’s disease tau pathology: a cross-sectional study Open
Background Early Alzheimer’s disease diagnosis is crucial for preventive therapy development. Standard neuropsychological evaluation does not identify clinically normal individuals with brain amyloidosis, the first stage of the pathology, …
View article: A preserved neural code for temporal order between memory formation and recall in the human medial temporal lobe
A preserved neural code for temporal order between memory formation and recall in the human medial temporal lobe Open
Temporal memory enables us to remember the temporal order of events happening in our life. The human medial temporal lobe (MTL) appears to contain neural representations supporting temporal memory formation, but the cellular mechanisms tha…
View article: Quantitative modeling of the emergence of macroscopic grid-like representations
Quantitative modeling of the emergence of macroscopic grid-like representations Open
When subjects navigate through spatial environments, grid cells exhibit firing fields that are arranged in a triangular grid pattern. Direct recordings of grid cells from the human brain are rare. Hence, functional magnetic resonance imagi…
View article: Theta-phase locking of single neurons during human spatial memory
Theta-phase locking of single neurons during human spatial memory Open
The precise timing of single-neuron activity in relation to local field potentials may support various cognitive functions. Extensive research in rodents, along with some evidence in humans, suggests that single-neuron activity at specific…
View article: Path integration deficits related to Alzheimer’s disease pathology in clinically normal older adults
Path integration deficits related to Alzheimer’s disease pathology in clinically normal older adults Open
Background The entorhinal cortex (EC) is the first cortical region affected by tauopathy in Alzheimer’s disease (AD) and is implicated in path integration. In early stages of AD, path integration deficits could be present, even before over…
View article: Deep-brain stimulation of the human nucleus accumbens-medial septum enhances memory formation
Deep-brain stimulation of the human nucleus accumbens-medial septum enhances memory formation Open
Deep-brain stimulation (DBS) is a potential novel treatment for memory dysfunction. Current attempts to enhance memory focus on stimulating human hippocampus or entorhinal cortex. However, an alternative strategy is to stimulate brain area…
View article: Neurons in the human entorhinal cortex map abstract emotion space
Neurons in the human entorhinal cortex map abstract emotion space Open
When animals move through space, neurons in their entorhinal cortex activate periodically at multiple locations to form a map of the spatial environment. These grid cells may also map non-physical, conceptual spaces to support various othe…
View article: Using multi‐task experiments to test principles of hippocampal function
Using multi‐task experiments to test principles of hippocampal function Open
Investigations of hippocampal functions have revealed a dizzying array of findings, from lesion‐based behavioral deficits, to a diverse range of characterized neural activations, to computational models of putative functionality. Across th…
View article: Using multi-task experiments to test principles of hippocampal function
Using multi-task experiments to test principles of hippocampal function Open
Investigations of hippocampal functions have revealed a dizzying array of findings, from lesion-based behavioral deficits, to a diverse range of characterized neural activations, to computational models of putative functionality. Across th…
View article: A Learned Map for Places and Concepts in the Human Medial Temporal Lobe
A Learned Map for Places and Concepts in the Human Medial Temporal Lobe Open
Distinct lines of research in both humans and animals point to a specific role of the hippocampus in both spatial and episodic memory function. The discovery of concept cells in the hippocampus and surrounding medial temporal lobe (MTL) re…
View article: Maintenance and transformation of representational formats during working memory prioritization
Maintenance and transformation of representational formats during working memory prioritization Open
Visual working memory depends on both material-specific brain areas in the ventral visual stream (VVS) that support the maintenance of stimulus representations and on regions in prefrontal cortex (PFC) that control these representations. R…
View article: Quantitative modeling of the emergence of macroscopic grid-like representations
Quantitative modeling of the emergence of macroscopic grid-like representations Open
Grid cells are neurons in the entorhinal cortex that are thought to perform neural computations in support of spatial navigation. When subjects navigate through spatial environments, grid cells exhibit firing fields that are arranged in a …
View article: Aversive memory formation in humans involves an amygdala-hippocampus phase code
Aversive memory formation in humans involves an amygdala-hippocampus phase code Open
Memory for aversive events is central to survival but can become maladaptive in psychiatric disorders. Memory enhancement for emotional events is thought to depend on amygdala modulation of hippocampal activity. However, the neural dynamic…
View article: Ripple-locked coactivity of stimulus-specific neurons supports human associative memory
Ripple-locked coactivity of stimulus-specific neurons supports human associative memory Open
Associative memory is the ability to encode and retrieve relations between different stimuli. To better understand its neural basis, we investigated whether associative memory involves precisely timed spiking of neurons in the medial tempo…
View article: How is single-neuron activity related to LFP oscillations?
How is single-neuron activity related to LFP oscillations? Open
Local field potentials (LFPs) can provide biomarkers of cognitive function at the meso-scale level of brain organization. LFPs represent the aggregation of thousands of transmembrane currents from local and non-local brain regions and it i…
View article: A gradient of electrophysiological novelty responses along the human hippocampal long axis
A gradient of electrophysiological novelty responses along the human hippocampal long axis Open
The hippocampus is implicated in novelty detection, thought to be important for regulating entry of information into long-term memory. Whether electrophysiological responses to novelty differ along the human hippocampal long axis is curren…
View article: Theta oscillations coordinate grid-like representations between ventromedial prefrontal and entorhinal cortex
Theta oscillations coordinate grid-like representations between ventromedial prefrontal and entorhinal cortex Open
Human iEEG reveals synchronous theta oscillations and coordinated grid-like representations between vmPFC and entorhinal cortex.
View article: Aversive memory formation in humans is determined by an amygdala-hippocampus phase code
Aversive memory formation in humans is determined by an amygdala-hippocampus phase code Open
Memory for aversive events is central to survival, but can also become maladaptive in psychiatric disorders. Emotional memory relies on the amygdala and hippocampus, but the neural dynamics of their communication during emotional memory en…