Explanipedia

<i>ADCY3</i> Ser107Pro links difficulty awakening in the morning to adiposity through circadian regulation of adipose thermogenesis Open

Cynthia Tchio, Matthew Maher, Christopher W. Moth, Jens Meiler, Jacqueline M. Lane , et al. · 2025

SUMMARY Modern lifestyles often disturb circadian rhythms, yet the genetic circuits that convert this stress into metabolic dysfunction remain poorly defined. Here, we identify a missense variant in ADCY3 (rs11676272; Ser107Pro) as a pleio…

Contributors to caregiver burden, depression, and anxiety in the partners of professional American-style football players: a cross-sectional study Open

Niki A. Konstantinides, Paula S. Atkeson, Heather DiGregorio, Inana Dairi, Cheyenne Brown , et al. · 2025

Introduction American-style football (ASF) has been linked to chronic adverse health outcomes. The extent to which ASF players' careers impact their spouses' caregiver burden, depression, and anxiety remains unknown. In addition to convent…

Biological Age as a Predictor of Arterial Stiffness in Young and Early Midlife Black and White Women Open

Telisa Spikes, Álvaro Alonso, Roland J. Thorpe, Jordan Pelkmans, Melinda Higgins , et al. · 2025

BACKGROUND Chronological age (CA) is independently associated with arterial stiffness, but it is not a sufficient measure of aging or the disparities related to disease risk. While biological age (BA) is considered a more accurate indicato…

Effect of Early Life Trauma Exposure on Vascular Dysfunction in Black Men and Women Open

Telisa Spikes, Roland J. Thorpe, Vasiliki Michopoulos, Whitney Wharton, Jordan Pelkmans , et al. · 2025

Background Psychosocial stressors such as childhood trauma have been associated with an increased risk of hypertension. The impact of childhood trauma on vascular dysfunction in Black adults remains less clear. We examined the association …

Biological Age as a Predictor of Arterial Stiffness in Young and Early Midlife Black and White Women Open

Telisa Spikes, Álvaro Alonso, Roland J. Thorpe, Jordan Pelkmans, Melinda Higgins , et al. · 2024

Background: Arterial stiffness is a precursor of hypertension and hallmark of vascular aging. Chronological age (CA), a robust determinant of arterial stiffness, is considered an insufficient indicator of aging and disparities associated w…

Advancing Equity in Rare Disease Research: Insights From the Undiagnosed Disease Network Open

Nicholas A. Borja, Rory J. Tinker, Stephanie Bivona, Carson Smith, Theodore Krijnse Locker , et al. · 2024

Rare diseases affect 6%–8% of the population and present diagnostic challenges, particularly for historically marginalized ethnic and racial groups. The Undiagnosed Diseases Network (UDN) aims to enhance diagnosis rates and research partic…

Racial and Ethnic Disparities in Age-Specific All-Cause Mortality During the COVID-19 Pandemic Open

Jeremy Samuel Faust, Benjamin Renton, Tasce Bongiovanni, Alexander Chen, Karen Dorsey Sheares , et al. · 2024

Importance The end of the COVID-19 public health emergency (PHE) provides an opportunity to fully describe pandemic-associated racial and ethnic mortality disparities. Age-specific excess mortality differences have important downstream imp…

Perceived Chronic Traumatic Encephalopathy and Suicidality in Former Professional Football Players Open

Rachel Grashow, Douglas P. Terry, Grant L. Iverson, Heather DiGregorio, Inana Dairi , et al. · 2024

Importance Participation in American-style football (ASF) has been linked to chronic traumatic encephalopathy neuropathological change (CTE-NC), a specific neuropathologic finding that can only be established at autopsy. Despite being a po…

Data release and baseline analysis of the largest collection of 6-minute walk tests: the My Heart Counts Cardiovascular Health Study, a fully digital smartphone platform Open

Daniel S. Kim, Narayan Schuetz, Anders Johnson, Alexander Tolas, Sriya Mantena , et al. · 2024

The six-minute walk test (6MWT) is a sub-maximal exercise test used clinically as a measure of functional capacity. With the emergence of advanced sensors, 6MWTs were commonly performed remotely via smartphones and other devices. The My He…

Concussion burden and later‐life cardiovascular risk factors in former professional American‐style football players Open

Can Ozan Tan, Rachel Grashow, Roland J. Thorpe, Karen K. Miller, David M. Nathan , et al. · 2024

Objective Mid‐life cardiovascular risk factors are associated with later cognitive decline. Whether repetitive head injury among professional athletes impacts cardiovascular risk is unknown. We investigated associations between concussion …

Risk of Long-Term Ischemic Stroke in Patients With Traumatic Brain Injury and Incident Hypertension Open

Farid Radmanesh, Saef Izzy, Ran S. Rotem, Zabreen Tahir, Quinn Rademaker , et al. · 2024

Traumatic brain injury (TBI) is independently associated with hypertension and ischemic stroke. The goal of this study was to determine the interplay between TBI and incident hypertension in the occurrence of post-TBI stroke. This prospect…

Age-Specific All-Cause Mortality Disparities by Race and Ethnicity During the COVID-19 Pandemic Open

Jeremy Samuel Faust, Benjamin Renton, Tasce Bongiovanni, Alexander Chen, Karen Dorsey Sheares , et al. · 2024

BACKGROUND The end of the public health emergency provides an opportunity to fully describe disparities during the Covid-19 pandemic. METHODS In this retrospective cohort analysis of US deaths during the Covid-19 public health emergency (M…

Metabolomic signatures of ideal cardiovascular health in black adults Open

Shabatun Islam, Chang Liu, Appesh Mohandas, Kimberly Rooney, Aditi Nayak , et al. · 2024

A multitrait genetic study of hemostatic factors and hemorrhagic transformation after stroke treatment Open

Cristina Gallego-Fábrega, Gerard Temprano‐Sagrera, Jara Cárcel‐Márquez, Elena Muiño, Natàlia Cullell , et al. · 2023

Long-term risk of cardiovascular disease after traumatic brain injury: screening and prevention Open

Saef Izzy, Rachel Grashow, Farid Radmanesh, Patrick Chen, Herman A. Taylor , et al. · 2023

Combining crowd-sourcing, census data, and public review forums for real-time, high-resolution food desert estimation Open

Mohsen Salari, Michael R. Kramer, Matthew A. Reyna, Herman A. Taylor, Gari D. Clifford · 2023

Race differences in pain and pain-related risk factors among former professional American-style football players Open

Robert R. Edwards, Can Ozan Tan, Inana Dairi, Alicia J. Whittington, Julius Dewayne Thomas , et al. · 2023

The burden of pain is unequal across demographic groups, with broad and persisting race differences in pain-related outcomes in the United States. Members of racial and ethnic minorities frequently report more pervasive and severe pain com…

Tau Positron Emission Tomography and Neurocognitive Function Among Former Professional American-Style Football Players Open

Maëva Dhaynaut, Rachel Grashow, Marc D. Normandin, Ona Wu, Dean A. Marengi , et al. · 2023

American-style football (ASF) players experience repetitive head impacts that may result in chronic traumatic encephalopathy neuropathological change (CTE-NC). At present, a definitive diagnosis of CTE-NC requires the identification of loc…

Excess Mortality and Years of Potential Life Lost Among the Black Population in the US, 1999-2020 Open

César Caraballo, Daisy Massey, Chima D. Ndumele, Trent Haywood, Shayaan Kaleem , et al. · 2023

Importance Amid efforts in the US to promote health equity, there is a need to assess recent progress in reducing excess deaths and years of potential life lost among the Black population compared with the White population. Objective To ev…

Association Between Life's Simple 7 and Biomarkers of Cardiovascular Disease: Aldosterone, Interleukin‐6, C‐Reactive Protein Open

Yan Emily Yuan, Andrea Haas, Gordon H. Williams, Herman A. Taylor, Ellen W. Seely , et al. · 2023

Background To promote ideal cardiovascular health, the American Heart Association recommends adhering to Life's Simple 7 (LS7)—achieving healthy targets for body mass index, physical activity, dietary intake, blood pressure, fasting plasma…

The role of aldosterone and ideal cardiovascular health in incident cardiovascular disease: The Jackson heart study Open

Bjorn Kluwe, Neal Pohlman, Veena Kesireddy, Songzhu Zhao, Yubo Tan , et al. · 2023

Aldosterone partially mediates the association of ICH with incident CVD and both blood pressure and glucose partially mediate the association of aldosterone with incident CVD, emphasizing the potential importance of aldosterone and ICH in …

The role of aldosterone and ideal cardiovascular health in incident diabetes: The Jackson Heart Study Open

Veena Kesireddy, Bjorn Kluwe, Neal Pohlman, Songzhu Zhao, Yubo Tan , et al. · 2023

Neighborhood characteristics and arterial stiffness among Black adults – Results from the Jackson Heart Study and Morehouse-Emory Cardiovascular Center for Health Equity Open

Shabatun Islam, Jeong Hwan Kim, Xiaona Li, Yi‐An Ko, Peter Baltrus , et al. · 2023

Introduction: Poor quality neighborhood environments are independent risk factors for cardiovascular disease (CVD) but are understudied in Black adults, who face large CVD health disparities. Arterial stiffness, a marker of early vascular …

Healthspan and chronic disease burden among young adult and middle-aged male former American-style professional football players Open

Rachel Grashow, Taylor Valencia Shaffer-Pancyzk, Inana Dairi, Hang Lee, Dean A. Marengi , et al. · 2022

Objective To examine the relationships between age, healthspan and chronic illness among former professional American-style football (ASF) players. Methods We compared age-specific race-standardised and body mass index-standardised prevale…

Excess Mortality and Years of Potential Life Lost Among Black People in the US from 1999 to 2020 Open

César Caraballo, Daisy Massey, Chima D. Ndumele, Trent Haywood, Shayaan Kaleem , et al. · 2022

Importance Amid efforts in the United States to promote health equity, there is a need to assess progress in reducing excess deaths and years of potential life lost (YPLL) among Black people compared with White people. Objective To evaluat…

National Projections for Clinical Implications of Race-Free Creatinine-Based GFR Estimating Equations Open

James A. Diao, Gloria J. Wu, Jason K. Wang, Isaac S. Kohane, Herman A. Taylor , et al. · 2022

Significance Statement A national task force convened by the NKF-ASN recently recommended a new race-free creatinine equation for calculating eGFR. Although this equation is expected to be widely adopted, its broad effect on recommended cl…

Scientific opportunities in resilience research for cardiovascular health and wellness. Report from a National Heart, Lung, and Blood Institute workshop Open

Herman A. Taylor, Toren Finkel, Yunling Gao, Scott W. Ballinger, Rebecca Campo , et al. · 2022

Exposure of biological systems to acute or chronic insults triggers a host of molecular and physiological responses to either tolerate, adapt, or fully restore homeostasis; these responses constitute the hallmarks of resilience. Given the …

Cardiac Troponin Testing as a Component of Return to Play Cardiac Screening in Young Competitive Athletes Following SARS‐CoV‐2 Infection Open

Nathaniel Moulson, Bradley J. Petek, Timothy W. Churchill, Jonathan A. Drezner, Kimberly G. Harmon , et al. · 2022

Background Initial protocols for return to play cardiac testing in young competitive athletes following SARS‐CoV‐2 infection recommended cardiac troponin (cTn) to screen for cardiac involvement. This study aimed to define the diagnostic yi…

Modifiable Resources and Resilience in Racially and Ethnically Diverse Older Women: Implications for Health Outcomes and Interventions Open

Sparkle Springfield, Feifei Qin, Haley Hedlin, Charles B. Eaton, Milagros C. Rosal , et al. · 2022

Introduction: Resilience—which we define as the “ability to bounce back from stress”—can foster successful aging among older, racially and ethnically diverse women. This study investigated the association between psychological resilience i…

Association of Traumatic Brain Injury With the Risk of Developing Chronic Cardiovascular, Endocrine, Neurological, and Psychiatric Disorders Open

Saef Izzy, Patrick Chen, Zabreen Tahir, Rachel Grashow, Farid Radmanesh , et al. · 2022

These findings suggest that TBI of any severity was associated with a higher risk of chronic cardiovascular, endocrine, and neurological comorbidities in patients without baseline diagnoses. Medical comorbidities were observed in relativel…

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