Hermann Kneitz
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View article: Digital Papillary Adenocarcinoma Is HPV-42-Associated and BRAFV600E Negative: Perspectives for Diagnostic Practice
Digital Papillary Adenocarcinoma Is HPV-42-Associated and BRAFV600E Negative: Perspectives for Diagnostic Practice Open
Digital papillary adenocarcinoma (DPAC) is a rare, low-grade sweat gland carcinoma primarily found on the hands, fingers, or toes and predominantly affecting males. Distinguishing DPAC from benign sweat gland tumors can be challenging. We …
View article: VEXAS‐Syndrome, a newly described autoinflammatory systemic disease with dermatologic manifestations
VEXAS‐Syndrome, a newly described autoinflammatory systemic disease with dermatologic manifestations Open
Summary VEXAS syndrome is a recently identified autoinflammatory systemic disease caused by an acquired somatic mutation of the X‐linked UBA1 gene, the key enzyme of the first step of ubiquitylation. The acronym VEXAS stands for the charac…
View article: Neoadjuvant ipilimumab plus nivolumab in locally advanced melanoma: A real-world single-centre retrospective study
Neoadjuvant ipilimumab plus nivolumab in locally advanced melanoma: A real-world single-centre retrospective study Open
Background: Neoadjuvant immune-checkpoint inhibition (neoICI) with ipilimumab and nivolumab has shown high pathologic response rates as well as a long-lasting relapse-free survival in stage III melanoma patients. However, safety and effica…
View article: Recurrence of a Cellular Blue Nevus with Satellitosis—A Diagnostic Pitfall with Clinical Consequences
Recurrence of a Cellular Blue Nevus with Satellitosis—A Diagnostic Pitfall with Clinical Consequences Open
Blue nevus is a benign melanocytic lesion, typically asymptomatic and of unknown etiology. Several histologic and clinical variants have been distinguished, the most frequent being common blue nevus, cellular blue nevus, and combined blue …
View article: Ipilimumab plus nivolumab in avelumab-refractory Merkel cell carcinoma: a multicenter study of the prospective skin cancer registry ADOREG
Ipilimumab plus nivolumab in avelumab-refractory Merkel cell carcinoma: a multicenter study of the prospective skin cancer registry ADOREG Open
Merkel cell carcinoma is a rare, highly aggressive skin cancer with neuroendocrine differentiation. Immune checkpoint inhibition has significantly improved treatment outcomes in metastatic disease with response rates to programmed cell dea…
View article: Panel Sequencing of Primary Cutaneous B-Cell Lymphoma
Panel Sequencing of Primary Cutaneous B-Cell Lymphoma Open
Background: Primary cutaneous follicular B-cell lymphoma (PCFBCL) represents an indolent subtype of Non-Hodgkin’s lymphomas, being clinically characterized by slowly growing tumors of the skin and common cutaneous relapses, while only exhi…
View article: Diagnosis and therapy of <i>Mycobacterium marinum</i>: a single‐center 21‐year retrospective analysis
Diagnosis and therapy of <i>Mycobacterium marinum</i>: a single‐center 21‐year retrospective analysis Open
Summary Background and Objectives In Europe, infections with Mycobacterium (M.) marinum are rare. We conducted a retrospective single‐center study to assess the clinical spectrum of M. marinum infection and its diagnosis, treatment and out…
View article: Fatal maternal complication due to neurofibromatosis type 1-associated giant pigmented plexiform neurofibromas in pregnancy: a case report and literature review
Fatal maternal complication due to neurofibromatosis type 1-associated giant pigmented plexiform neurofibromas in pregnancy: a case report and literature review Open
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View article: Cutaneous epithelioid haemangiomas show somatic mutations in the mitogen‐activated protein kinase pathway
Cutaneous epithelioid haemangiomas show somatic mutations in the mitogen‐activated protein kinase pathway Open
Taken together, our data suggest that EH shows somatic mutations in genes of the MAPK pathway which might contribute to the formation of this benign tumour.
View article: Oncogenic Mutations and Gene Fusions in CD30-Positive Lymphoproliferations and Clonally Related Mycosis Fungoides Occurring in the Same Patients
Oncogenic Mutations and Gene Fusions in CD30-Positive Lymphoproliferations and Clonally Related Mycosis Fungoides Occurring in the Same Patients Open
The emergence of a common progenitor cell has been postulated for the association of CD30-positive lymphoproliferative disease (LPD) and mycosis fungoides (MF) within the same patient. Up to now, no comprehensive analysis has yet addressed…
View article: The transmembrane protein LRIG1 triggers melanocytic tumor development following chemically induced skin carcinogenesis
The transmembrane protein LRIG1 triggers melanocytic tumor development following chemically induced skin carcinogenesis Open
The incidence of melanoma and nonmelanoma skin cancer has increased tremendously in recent years. Although novel treatment options have significantly improved patient outcomes, the prognosis for most patients with an advanced disease remai…
View article: CD10-Positive Cutaneous PEComa: An Extremely Rare Skin Tumour
CD10-Positive Cutaneous PEComa: An Extremely Rare Skin Tumour Open
We here present the case of a 67-year-old woman with a history of a slowly progressive, polypous nodule on her left wrist. The lesion was excised, and the histological analysis revealed a clear cell tumour that was relatively sharply demar…
View article: Neonatal Acute Lymphoblastic Leukemia with t(9;11) Translocation Presenting as Blueberry Muffin Baby: Successful Treatment by ALL-BFM Induction Therapy, Allogeneic Stem Cell Transplantation from an Unrelated Donor, and PCR-MRD-Guided Post-Transplant Follow-Up
Neonatal Acute Lymphoblastic Leukemia with t(9;11) Translocation Presenting as Blueberry Muffin Baby: Successful Treatment by ALL-BFM Induction Therapy, Allogeneic Stem Cell Transplantation from an Unrelated Donor, and PCR-MRD-Guided Post-Transplant Follow-Up Open
BACKGROUND Neonatal acute leukemia is a rare condition. Little is known about its incidence and outcomes, and treatment options have not been standardized. CASE REPORT A 3-day old, apparently healthy male newborn was referred to the pediat…
View article: Long‐standing morphea and the risk of squamous cell carcinoma of the skin
Long‐standing morphea and the risk of squamous cell carcinoma of the skin Open
Summary Scleroderma is a heterogeneous group of fibrosing connective tissue disorders of unknown etiology. Morphea is a localized form of scleroderma that occasionally leads to chronic erosions and ulcerations of the skin. Fibrosis, inflam…
View article: Neoadjuvant immunotherapy with combined ipilimumab and nivolumab in patients with melanoma with primary or in transit disease
Neoadjuvant immunotherapy with combined ipilimumab and nivolumab in patients with melanoma with primary or in transit disease Open
The introduction of new therapeutic agents has revolutionized the treatment of metastatic melanoma. The approval of adjuvant anti-programmed death-1 monotherapy with nivolumab or pembrolizumab, and dabrafenib plus trametinib has recently s…
View article: The transmembrane protein LRIG2 increases tumor progression in skin carcinogenesis
The transmembrane protein LRIG2 increases tumor progression in skin carcinogenesis Open
Over the last few decades, the number of cases of non‐melanoma skin cancer (NMSC) has risen to over 3 million cases every year worldwide. Members of the ERBB receptor family are important regulators of skin development and homeostasis and,…
View article: Breaking avelumab resistance with combined ipilimumab and nivolumab in metastatic Merkel cell carcinoma?
Breaking avelumab resistance with combined ipilimumab and nivolumab in metastatic Merkel cell carcinoma? Open
Immune-checkpoint blockade (ICB) shows significant activity in metastatic Merkel cell carcinoma (MCC) but primary resistance remains a major clinical challenge [1.Nghiem P.T. Bhatia S. Lipson E.J. et al.PD-1 blockade with pembrolizumab in …
View article: Hemorrhagic Bullous Henoch-Schönlein Purpura: Case Report and Review of the Literature
Hemorrhagic Bullous Henoch-Schönlein Purpura: Case Report and Review of the Literature Open
Henoch-Schönlein Purpura (HSP) or IgA vasculitis is the most common systemic vasculitis of childhood and may affect skin, joints, gastrointestinal tract, and kidneys. Skin manifestations of HSP are characteristic and include a non-thromboc…
View article: Disease Manifestation and Inflammatory Activity as Modulators of Th17/Treg Balance and RORC/FoxP3 Methylation in Systemic Sclerosis
Disease Manifestation and Inflammatory Activity as Modulators of Th17/Treg Balance and RORC/FoxP3 Methylation in Systemic Sclerosis Open
Background: There is much evidence that T cells are strongly involved in the pathogenesis of localized and systemic forms of scleroderma (SSc). A dysbalance between FoxP3+ regulatory CD4+ T cells (Tregs) and inflammatory T-helper (Th) 17 c…
View article: Supplementary Material for: Disease Manifestation and Inflammatory Activity as Modulators of Th17/Treg Balance and RORC/FoxP3 Methylation in Systemic Sclerosis
Supplementary Material for: Disease Manifestation and Inflammatory Activity as Modulators of Th17/Treg Balance and RORC/FoxP3 Methylation in Systemic Sclerosis Open
Background: There is much evidence that T cells are strongly involved in the pathogenesis of localized and systemic forms of scleroderma (SSc). A dysbalance between FoxP3+ regulatory CD4+ T cells (Tregs) and inflammatory T-helper (Th) 17 c…
View article: Supplementary Material for: Disease Manifestation and Inflammatory Activity as Modulators of Th17/Treg Balance and RORC/FoxP3 Methylation in Systemic Sclerosis
Supplementary Material for: Disease Manifestation and Inflammatory Activity as Modulators of Th17/Treg Balance and RORC/FoxP3 Methylation in Systemic Sclerosis Open
Background: There is much evidence that T cells are strongly involved in the pathogenesis of localized and systemic forms of scleroderma (SSc). A dysbalance between FoxP3+ regulatory CD4+ T cells (Tregs) and inflammatory T-helper (Th) 17 c…
View article: Giant cutaneous horn associated with squamous cell carcinoma
Giant cutaneous horn associated with squamous cell carcinoma Open
A 90-year-old patient presented with a large cutaneous horn (cornu cutaneum) of nine-year duration arising at her right cheek. The lesion was removed by surgery. Histology was reported as cornu cutaneum with a well-differentiated squamous …