Hermann Nabi
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View article: Structural equation modeling of factors influencing women’s attitudes, comfort and willingness toward risk-stratified breast cancer screening
Structural equation modeling of factors influencing women’s attitudes, comfort and willingness toward risk-stratified breast cancer screening Open
View article: Using Machine Learning to Improve Control for Confounding in the Dynamic Weighted Ordinary Least Squares Estimator of Optimal Adaptive Treatment Strategies
Using Machine Learning to Improve Control for Confounding in the Dynamic Weighted Ordinary Least Squares Estimator of Optimal Adaptive Treatment Strategies Open
Estimating optimal adaptive treatment strategies (ATSs) can be done in several ways, including dynamic weighted ordinary least squares (dWOLS). This approach is doubly robust as it requires modeling both the treatment and the response, but…
View article: A community pharmacy-based program to enhance adherence to adjuvant endocrine therapy among breast cancer survivors (PACHA): protocol for a pilot cluster-randomized controlled trial
A community pharmacy-based program to enhance adherence to adjuvant endocrine therapy among breast cancer survivors (PACHA): protocol for a pilot cluster-randomized controlled trial Open
Background Adjuvant endocrine therapy (AET) is an oral treatment prescribed for 5 to 10 years to women with hormone-sensitive breast cancer. Despite the benefits of AET for reducing breast cancer recurrence, suboptimal adherence is common.…
View article: Primary care providers’ experience and satisfaction with personalised breast cancer screening risk communication: a descriptive cross-sectional study
Primary care providers’ experience and satisfaction with personalised breast cancer screening risk communication: a descriptive cross-sectional study Open
Objective To describe primary care providers’ (PCPs) experience and satisfaction with receiving risk communication documents on their patient’s breast cancer (BC) risk assessment and proposed screening action plan. Design Descriptive cross…
View article: Underrepresented populations in genomic research: a qualitative study of researchers’ perspectives
Underrepresented populations in genomic research: a qualitative study of researchers’ perspectives Open
Background The lack of diversity in genomic data limits researchers’ ability to investigate the relationships between genetic profiles, disease manifestations, and responses to new therapies. As a result, innovations in treatment could hav…
View article: Barriers and Facilitators to Delivering Multifactorial Risk Assessment and Communication for Personalized Breast Cancer Screening: A Qualitative Study Exploring Implementation in Canada
Barriers and Facilitators to Delivering Multifactorial Risk Assessment and Communication for Personalized Breast Cancer Screening: A Qualitative Study Exploring Implementation in Canada Open
Many jurisdictions are considering a shift to risk-stratified breast cancer screening; however, evidence on the feasibility of implementing it on a population scale is needed. We conducted a prospective cohort study in the PERSPECTIVE I&I …
View article: Genetic discrimination in insurance and employment based on personalized risk stratification for breast cancer screening
Genetic discrimination in insurance and employment based on personalized risk stratification for breast cancer screening Open
Background The Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm (BOADICEA) incorporates the effects of common genetic variants, from polygenic risk scores, pathogenic variants in major breast cancer (BC) su…
View article: Feasibility and acceptability of a personalised primary prevention strategy for women and men at high risk of breast and prostate cancer: the 3PC study protocol for a pilot randomised controlled trial
Feasibility and acceptability of a personalised primary prevention strategy for women and men at high risk of breast and prostate cancer: the 3PC study protocol for a pilot randomised controlled trial Open
Introduction Several primary prevention strategies, including chemoprevention, prophylactic surgery and lifestyle modifications, have been shown to reduce the risk of breast cancer (BC) and prostate cancer (Pca). However, the uptake of the…
View article: Cross‐cultural adaptation and validation of a French version of the perceived personal control questionnaire as an outcome measure instrument for genetic counseling
Cross‐cultural adaptation and validation of a French version of the perceived personal control questionnaire as an outcome measure instrument for genetic counseling Open
The perceived personal control (PPC) questionnaire serves as an instrument to assess the concept of PPC, which refers to a person's perception of their ability to achieve positive outcomes while avoiding the negative effects of a given sit…
View article: PSA, an outdated biomarker for prostate cancer: In search of a more specific biomarker, citrate takes the spotlight
PSA, an outdated biomarker for prostate cancer: In search of a more specific biomarker, citrate takes the spotlight Open
The prevailing biomarker employed for prostate cancer (PCa) screening and diagnosis is the prostate-specific antigen (PSA). Despite excellent sensitivity, PSA lacks specificity, leading to false positives, unnecessary biopsies and overdiag…
View article: Implementing Multifactorial Risk Assessment with Polygenic Risk Scores for Personalized Breast Cancer Screening in the Population Setting: Challenges and Opportunities
Implementing Multifactorial Risk Assessment with Polygenic Risk Scores for Personalized Breast Cancer Screening in the Population Setting: Challenges and Opportunities Open
Risk-stratified breast screening has been proposed as a strategy to overcome the limitations of age-based screening. A prospective cohort study was undertaken within the PERSPECTIVE I&I project, which will generate the first Canadian evide…
View article: Mapping inter-professional collaboration in oncogenetics: Results from a scoping review
Mapping inter-professional collaboration in oncogenetics: Results from a scoping review Open
Inter-professional collaboration could improve timely access and quality of oncogenetic services. Here, we present the results of a scoping review conducted to systematically identify collaborative models available, unpack the nature and e…
View article: Disruptions in Cancer Care Due to the COVID-19 Pandemic and Fear of Cancer Recurrence in Women with Breast Cancer: A Mixed-Methods Study
Disruptions in Cancer Care Due to the COVID-19 Pandemic and Fear of Cancer Recurrence in Women with Breast Cancer: A Mixed-Methods Study Open
Objective. This study investigated if fear of cancer recurrence (FCR) levels and the proportion of women having a clinical level of FCR differed by whether women had or had not experienced disruptions in their cancer tests and treatments d…
View article: General Medical Practitioners Acting as Geneticists, a Risky Business?
General Medical Practitioners Acting as Geneticists, a Risky Business? Open
The availability of precision medicine tools and approaches has increased considerably over the past decades, propelled by rapid scientific advances in genomics and the popularity of direct-to-consumer genetic testing. Genetic specialists …
View article: A Systematic Review and Critical Assessment of Breast Cancer Risk Prediction Tools Incorporating a Polygenic Risk Score for the General Population
A Systematic Review and Critical Assessment of Breast Cancer Risk Prediction Tools Incorporating a Polygenic Risk Score for the General Population Open
Single nucleotide polymorphisms (SNPs) in the form of a polygenic risk score (PRS) have emerged as a promising factor that could improve the predictive performance of breast cancer (BC) risk prediction tools. This study aims to appraise an…
View article: Risk-stratified breast cancer screening incorporating a polygenic risk score: a survey of UK GPs’ knowledge and attitudes
Risk-stratified breast cancer screening incorporating a polygenic risk score: a survey of UK GPs’ knowledge and attitudes Open
Background A polygenic risk score (PRS) quantifies the aggregated effects of common genetic variants in an individual. A ‘personalised breast cancer risk assessment’ combines PRS with other genetic and non-genetic risk factors to offer ris…
View article: Regulating cancer risk prediction: legal considerations and stakeholder perspectives on the Canadian context
Regulating cancer risk prediction: legal considerations and stakeholder perspectives on the Canadian context Open
View article: Canadian Healthcare Professionals’ Views and Attitudes toward Risk-Stratified Breast Cancer Screening
Canadian Healthcare Professionals’ Views and Attitudes toward Risk-Stratified Breast Cancer Screening Open
Given the controversy over the effectiveness of age-based breast cancer (BC) screening, offering risk-stratified screening to women may be a way to improve patient outcomes with detection of earlier-stage disease. While this approach seems…
View article: Risk-Stratified Breast Cancer Screening Incorporating a Polygenic Risk Score: A Survey of UK General Practitioners’ Knowledge and Attitudes
Risk-Stratified Breast Cancer Screening Incorporating a Polygenic Risk Score: A Survey of UK General Practitioners’ Knowledge and Attitudes Open
A polygenic risk score (PRS) quantifies the aggregated effects of common genetic variants in an individual. A ‘personalised breast cancer risk assessment’ combines PRS with other genetic and nongenetic risk factors to offer risk-stratified…
View article: Cancer Risk Prediction Regulation Models: Canada Contrasted with the U.S. and the E.U.
Cancer Risk Prediction Regulation Models: Canada Contrasted with the U.S. and the E.U. Open
Risk prediction models hold great promise to reduce the impact of cancer in society through advanced warning of risk and improved preventative modalities. These models are evolving and becoming more complex, increasingly integrating geneti…
View article: Adherence to CONSORT Guidelines and Reporting of the Determinants of External Validity in Clinical Oncology Randomized Controlled Trials: A Review of Trials Published in Four Major Journals between 2013 and 2015
Adherence to CONSORT Guidelines and Reporting of the Determinants of External Validity in Clinical Oncology Randomized Controlled Trials: A Review of Trials Published in Four Major Journals between 2013 and 2015 Open
Our primary objective was to determine the proportion of trials that report the number of patients assessed for eligibility before randomization. We performed the systematic retrieval and analysis of all phase II, III, and IV RCTs publishe…
View article: Examining interprofessional collaboration in oncogenetic service delivery models for hereditary cancers: a scoping review protocol
Examining interprofessional collaboration in oncogenetic service delivery models for hereditary cancers: a scoping review protocol Open
Introduction In a context of limited genetic specialists, collaborative models have been proposed to ensure timely access to high quality oncogenetic services for individuals with inherited cancer susceptibility. Yet, extensive variability…
View article: Personalized Approaches for the Prevention and Treatment of Breast Cancer
Personalized Approaches for the Prevention and Treatment of Breast Cancer Open
Breast cancer (BC) remains a major public health issue worldwide [...]
View article: Enjeux associés au risque héréditaire de cancer : connaissances, attitudes et pratiques infirmières en oncologie
Enjeux associés au risque héréditaire de cancer : connaissances, attitudes et pratiques infirmières en oncologie Open
La collecte des antécédents familiaux de cancer permet d’évaluer la prédisposition à certains types de cancers héréditaires. Une enquête par questionnaire a été menée auprès d’infirmières travaillant auprès de personnes atteintes de cancer…
View article: Issues associated with a hereditary risk of cancer: Knowledge, attitudes and practices of nurses in oncology settings
Issues associated with a hereditary risk of cancer: Knowledge, attitudes and practices of nurses in oncology settings Open
Documenting a patient’s family history of cancer is useful in assessing their predisposition to some types of hereditary cancers. A group of nurses working with cancer patients were surveyed, by way of a questionnaire, to determine their l…
View article: Should Age-Dependent Absolute Risk Thresholds Be Used for Risk Stratification in Risk-Stratified Breast Cancer Screening?
Should Age-Dependent Absolute Risk Thresholds Be Used for Risk Stratification in Risk-Stratified Breast Cancer Screening? Open
In risk-stratified cancer screening, multiple risk factors are incorporated into the risk assessment. An individual’s estimated absolute cancer risk is linked to risk categories with tailored screening recommendations for each risk categor…
View article: Cross-Cultural Adaptation and Validation of a French Version of the Genetic Counseling Satisfaction Scale (GCSS) as an Outcome Measure of Genetic Counseling for Hereditary Breast and Ovarian Cancer
Cross-Cultural Adaptation and Validation of a French Version of the Genetic Counseling Satisfaction Scale (GCSS) as an Outcome Measure of Genetic Counseling for Hereditary Breast and Ovarian Cancer Open
(1) Background: The Genetic Counseling Satisfaction Scale (GCSS) is a widely used tool to evaluate patient satisfaction. To our knowledge, a validated French-language version of this tool is not yet available. This article reports on the c…
View article: Identifying Clinicopathological Factors Associated with Oncotype DX® 21-Gene Recurrence Score: A Real-World Retrospective Cohort Study of Breast Cancer Patients in Quebec City, Canada
Identifying Clinicopathological Factors Associated with Oncotype DX® 21-Gene Recurrence Score: A Real-World Retrospective Cohort Study of Breast Cancer Patients in Quebec City, Canada Open
Gene expression profiling tests such as the Oncotype DX (ODX) 21-gene recurrence score (RS) assay is increasingly used in clinical practice to predict the risk of recurrence and support treatment planning for early-stage breast cancer (BC)…
View article: Risk-Stratified Approach to Breast Cancer Screening in Canada: Women’s Knowledge of the Legislative Context and Concerns about Discrimination from Genetic and Other Predictive Health Data
Risk-Stratified Approach to Breast Cancer Screening in Canada: Women’s Knowledge of the Legislative Context and Concerns about Discrimination from Genetic and Other Predictive Health Data Open
The success of risk-stratified approaches in improving population-based breast cancer screening programs depends in no small part on women’s buy-in. Fear of genetic discrimination (GD) could be a potential barrier to genetic testing uptake…
View article: Whether, when, how, and how much? General public’s and cancer patients’ views about the disclosure of genomic secondary findings
Whether, when, how, and how much? General public’s and cancer patients’ views about the disclosure of genomic secondary findings Open