Hershel Raff
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View article: SUN-067 The Reflex Dexamethasone Suppression Test: Development and Assessment of Reflexed Serum Dexamethasone Measurement for the Diagnosis of Cushing Syndrome
SUN-067 The Reflex Dexamethasone Suppression Test: Development and Assessment of Reflexed Serum Dexamethasone Measurement for the Diagnosis of Cushing Syndrome Open
Disclosure: J. Klahr: None. T.B. Carroll: Corcept Therapeutics. R. Nerenz: None. H. Raff: None. The overnight 1 mg dexamethasone suppression test (oDST) is used to screen for Cushing Syndrome (CS). Serum dexamethasone (SerDex) measurement …
View article: Soluble urokinase plasminogen activator receptor and acute kidney injury in hematopoietic cell transplantation
Soluble urokinase plasminogen activator receptor and acute kidney injury in hematopoietic cell transplantation Open
Acute kidney injury (AKI) frequently follows hematopoietic cell transplantation (HCT). Soluble urokinase-type plasminogen activator receptor (suPAR) is a biomarker of AKI in the general population. We evaluated suPAR and its association wi…
View article: Effect of High-Fat Diet and Lactiplantibacillus plantarum 299v on the Gut Microbiome of Adolescent and Adult Rats
Effect of High-Fat Diet and Lactiplantibacillus plantarum 299v on the Gut Microbiome of Adolescent and Adult Rats Open
Childhood and adolescent obesity and its associated morbidities are increasing in part due to the ingestion of diets high in fat (HFD). Changes in the gastrointestinal microbiome have been associated with these morbidities, including insul…
View article: Use of the Buffalo Concussion Treadmill Test in community adult patients with mild traumatic brain injury
Use of the Buffalo Concussion Treadmill Test in community adult patients with mild traumatic brain injury Open
Background The Buffalo Concussion Treadmill Test (BCTT) is used to establish exercise tolerance for rehabilitation and identify injury subtypes for youth athletes after mild traumatic brain injury (mTBI). Its utility in adult community mem…
View article: Salivary Cortisol and Cortisone Measurement Improves ACTH Stimulation Testing in Women Taking Oral Contraceptives
Salivary Cortisol and Cortisone Measurement Improves ACTH Stimulation Testing in Women Taking Oral Contraceptives Open
Journal Article Accepted manuscript Salivary cortisol and cortisone measurement improves ACTH stimulation testing in women taking oral contraceptives Get access Hershel Raff Hershel Raff Division of Endocrinology and Molecular Medicine, De…
View article: Differences in Fluid, Electrolyte, and Energy Balance in C57BL/6J Mice (Mus musculus) in Metabolic Caging at Thermoneutral or Standard Room Temperatures
Differences in Fluid, Electrolyte, and Energy Balance in C57BL/6J Mice (Mus musculus) in Metabolic Caging at Thermoneutral or Standard Room Temperatures Open
The Guide for the Care and Use of Laboratory Animals recommends mice be pair or group housed and provided with nesting materials. These provisions support social interactions and are also critical for thermoregulatory behaviors such as hud…
View article: The Power of the Heterogeneous Stock Rat Founder Strains in Modeling Metabolic Disease
The Power of the Heterogeneous Stock Rat Founder Strains in Modeling Metabolic Disease Open
Metabolic diseases are a host of complex conditions, including obesity, diabetes mellitus, and metabolic syndrome. Endocrine control systems (eg, adrenals, thyroid, gonads) are causally linked to metabolic health outcomes. N/NIH Heterogene…
View article: FRI189 Alcohol-induced Non-neoplastic Hypercortisolism: Report Of Eight Cases And Review Of The Literature
FRI189 Alcohol-induced Non-neoplastic Hypercortisolism: Report Of Eight Cases And Review Of The Literature Open
Disclosure: A. Surani: None. T.B. Carroll: Consulting Fee; Self; Corcept Therapeutics. Research Investigator; Self; Corcept Therapeutics, Recordati. B.R. Javorsky: Consulting Fee; Self; Clarus. Research Investigator; Self; Recordati, Amryt…
View article: Recognition of Nonneoplastic Hypercortisolism in the Evaluation of Patients With Cushing Syndrome
Recognition of Nonneoplastic Hypercortisolism in the Evaluation of Patients With Cushing Syndrome Open
The evaluation of suspected hypercortisolism is one of the most challenging problems in medicine. The signs and symptoms described by Dr Harvey Cushing are common and often create diagnostic confusion to even experienced endocrinologists. …
View article: Alcohol-induced Cushing syndrome: report of eight cases and review of the literature
Alcohol-induced Cushing syndrome: report of eight cases and review of the literature Open
Introduction Alcohol-induced hypercortisolism (AIH) is underrecognized and may masquerade as neoplastic hypercortisolism [Cushing syndrome (CS)] obscuring its diagnosis. Objective and methods In order to characterize AIH, we performed a ch…
View article: Issue Information
Issue Information Open
Cover image caption: The US healthcare system is primarily focused on care, and often only when disease is manifest.To make progress on health for all, a reconceptualization of health and the progression to disease is needed.Scientific adv…
View article: Genetic background in the rat affects endocrine and metabolic outcomes of bisphenol F exposure
Genetic background in the rat affects endocrine and metabolic outcomes of bisphenol F exposure Open
Environmental bisphenol compounds like bisphenol F (BPF) are endocrine-disrupting chemicals (EDCs) affecting adipose and classical endocrine systems. Genetic factors that influence EDC exposure outcomes are poorly understood and are unacco…
View article: Issue Information
Issue Information Open
Cover image caption: Mapping of serine phosphorylation sites in the 3D-modelled structure of FtsZ of Deinococcus radiodurans.The FtsZ of D. radiodurans (drFtsZ) undergoes phosphorylation by a DNA damage responsive Ser/Thr quinoprotein kina…
View article: Salivary Cortisol Dynamics After Mild Traumatic Brain Injury
Salivary Cortisol Dynamics After Mild Traumatic Brain Injury Open
Objective: To assess mild traumatic brain injury (mTBI)-related alterations in baseline (resting) salivary cortisol and cortisol reactivity to cognitive and exercise stressors, which are frequently encountered during mTBI rehabilitation an…
View article: Sleep restriction during opioid abstinence affects the hypothalamic-pituitary-adrenal (HPA) axis in male and female rats
Sleep restriction during opioid abstinence affects the hypothalamic-pituitary-adrenal (HPA) axis in male and female rats Open
Hypothalamic-pituitary-adrenal (HPA) axis dynamics are disrupted by opioids and may be involved in substance abuse; this persists during withdrawal and abstinence and is associated with co-morbid sleep disruption leading to vulnerability t…
View article: Sleep restriction during opioid abstinence affects the hypothalamic-pituitary-adrenal (HPA) axis in male and female rats
Sleep restriction during opioid abstinence affects the hypothalamic-pituitary-adrenal (HPA) axis in male and female rats Open
Hypothalamic-pituitary-adrenal (HPA) axis dynamics are disrupted by opioids and may be involved in substance abuse; this persists during withdrawal and abstinence and is associated with co-morbid sleep disruption leading to vulnerability t…
View article: Lipid signatures of chronic pain in female adolescents with and without obesity
Lipid signatures of chronic pain in female adolescents with and without obesity Open
Background Chronic pain in adolescence is associated with diminished outcomes, lower socioeconomic status in later life, and decreased family well-being. Approximately one third of adolescents with chronic pain have obesity compared to the…
View article: Interaction of chronic pain, obesity and time of day on cortisol in female human adolescents
Interaction of chronic pain, obesity and time of day on cortisol in female human adolescents Open
Adolescent obesity augments and impedes the treatment of chronic pain. This is associated with increased systemic inflammation and is more prominent in females. In addition, pain and obesity each independently affect the hypothalamic-pitui…
View article: Glucocorticoid Receptor Antagonist Alters Corticosterone and Receptor-sensitive mRNAs in the Hypoxic Neonatal Rat
Glucocorticoid Receptor Antagonist Alters Corticosterone and Receptor-sensitive mRNAs in the Hypoxic Neonatal Rat Open
Hypoxia, a common stressor with preterm birth, increases morbidity and mortality associated with prematurity. Glucocorticoids (GCs) are administered to the preterm infant to improve oxygenation; prolonged use of GCs remains controversial. …
View article: The Effect of a Novel Glucocorticoid Receptor Antagonist (CORT113176) on Glucocorticoid and Insulin Receptor Sensitive Hepatic Gene (mRNA) Expression in a Neonatal Rat Model of Human Prematurity
The Effect of a Novel Glucocorticoid Receptor Antagonist (CORT113176) on Glucocorticoid and Insulin Receptor Sensitive Hepatic Gene (mRNA) Expression in a Neonatal Rat Model of Human Prematurity Open
Preterm birth is a global health problem the sequelae of which are not well understood. Hypoxia, a common stressor with prematurity, can affect blood glucose via stress-induced increases in glucocorticoids (GC). GCs are also administered t…
View article: New Cutoffs for the Biochemical Diagnosis of Adrenal Insufficiency after ACTH Stimulation using Specific Cortisol Assays
New Cutoffs for the Biochemical Diagnosis of Adrenal Insufficiency after ACTH Stimulation using Specific Cortisol Assays Open
Context The normal cortisol response 30 or 60 minutes after cosyntropin (ACTH[1–24]) is considered to be ≥18 μg/dL (500 nmol/L). This threshold is based on older serum cortisol assays. Specific monoclonal antibody immunoassays or LC-MS/MS …
View article: Insulin and glucose responses to hypoxia in male and female neonatal rats: Effects of the androgen receptor antagonist flutamide
Insulin and glucose responses to hypoxia in male and female neonatal rats: Effects of the androgen receptor antagonist flutamide Open
Hypoxia is common with preterm birth and may lead to long-term effects on adult pancreatic endocrine function and insulin sensitivity. This phenomenon may be sexually dimorphic due to the hypoxia-induced augmentation of the neonatal androg…
View article: Circulating inflammatory biomarkers in adolescents: evidence of interactions between chronic pain and obesity
Circulating inflammatory biomarkers in adolescents: evidence of interactions between chronic pain and obesity Open
Introduction: The negative effects of chronic pain and obesity are compounded in those with both conditions. Despite this, little research has focused on the pathophysiology in pediatric samples. Objective: To examine the effects of comorb…
View article: Prospective Evaluation of Late-Night Salivary Cortisol and Cortisone by EIA and LC-MS/MS in Suspected Cushing Syndrome
Prospective Evaluation of Late-Night Salivary Cortisol and Cortisone by EIA and LC-MS/MS in Suspected Cushing Syndrome Open
Context Late-night salivary cortisol (LNSC) measured by enzyme immunoassay (EIA-F) is a first-line screening test for Cushing syndrome (CS) with a reported sensitivity and specificity of >90%. However, liquid chromatography-tandem mass …