John W.B. Hershey
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View article: Unsupervised Improved MVDR Beamforming for Sound Enhancement
Unsupervised Improved MVDR Beamforming for Sound Enhancement Open
Neural networks have recently become the dominant approach to sound separation. Their good performance relies on large datasets of isolated recordings. For speech and music, isolated single channel data are readily available; however the s…
View article: Engineered transient and stable overexpression of translation factors eIF3i and eIF3c in CHOK1 and HEK293 cells gives enhanced cell growth associated with increased c-Myc expression and increased recombinant protein synthesis
Engineered transient and stable overexpression of translation factors eIF3i and eIF3c in CHOK1 and HEK293 cells gives enhanced cell growth associated with increased c-Myc expression and increased recombinant protein synthesis Open
There is a desire to engineer mammalian host cell lines to improve cell growth/biomass accumulation and recombinant biopharmaceutical protein production in industrially relevant cell lines such as the CHOK1 and HEK293 cell lines. The over-…
View article: Protein Synthesis and Translational Control: A Historical Perspective
Protein Synthesis and Translational Control: A Historical Perspective Open
Protein synthesis and its regulation are central to all known forms of life and impinge on biological arenas as varied as agriculture, biotechnology, and medicine. Otherwise known as translation and translational control, these processes h…
View article: Principles of Translational Control
Principles of Translational Control Open
Protein synthesis involves a complex machinery comprising numerous proteins and RNAs joined by noncovalent interactions. Its function is to link long chains of amino acids into proteins with precise sequences as encoded by the genome. Regu…
View article: Evidence for a Negative Cooperativity between eIF5A and eEF2 on Binding to the Ribosome
Evidence for a Negative Cooperativity between eIF5A and eEF2 on Binding to the Ribosome Open
eIF5A is the only protein known to contain the essential and unique amino acid residue hypusine. eIF5A functions in both translation initiation due to its stimulation of methionyl-puromycin synthesis and translation elongation, being highl…