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View article: Characterization of the mutational status of glioblastoma and high-grade astrocytomas in a Latin American cohort
Characterization of the mutational status of glioblastoma and high-grade astrocytomas in a Latin American cohort Open
View article: Evaluating the link between periodontitis and oral squamous cell carcinoma through Wnt/β-catenin pathway: a critical review
Evaluating the link between periodontitis and oral squamous cell carcinoma through Wnt/β-catenin pathway: a critical review Open
Oral Squamous Cell Carcinoma (OSCC), the main form of oral cancer, is a major health problem globally that affects 400,000 people every year. It has been postulated that periodontitis, a chronic inflammatory disease characterized by alveol…
View article: IRE1α Mediates the Hypertrophic Growth of Cardiomyocytes Through Facilitating the Formation of Initiation Complex to Promote the Translation of TOP-Motif Transcripts
IRE1α Mediates the Hypertrophic Growth of Cardiomyocytes Through Facilitating the Formation of Initiation Complex to Promote the Translation of TOP-Motif Transcripts Open
BACKGROUND: Cardiomyocyte growth is coupled with active protein synthesis, which is one of the basic biological processes in living cells. However, it is unclear whether the unfolded protein response transducers and effectors directly take…
View article: Characterization of the mutational landscape of high-grade gliomas in a Latin American cohort
Characterization of the mutational landscape of high-grade gliomas in a Latin American cohort Open
Background Glioblastoma, an aggressive form of high-grade glioma, exhibits variations in the incidence and mortality patterns between populations of different ancestry. However, Hispanic and Latino populations remain largely underrepresent…
View article: LOX rises as a potential survival biomarker: A commentary on “Identification of LOX as a candidate prognostic biomarker in Glioblastoma multiforme” by Liu et al.
LOX rises as a potential survival biomarker: A commentary on “Identification of LOX as a candidate prognostic biomarker in Glioblastoma multiforme” by Liu et al. Open
View article: The endoplasmic reticulum stress sensor IRE1 regulates collagen secretion through the enforcement of the proteostasis factor P4HB/PDIA1 contributing to liver damage and fibrosis
The endoplasmic reticulum stress sensor IRE1 regulates collagen secretion through the enforcement of the proteostasis factor P4HB/PDIA1 contributing to liver damage and fibrosis Open
Collagen is one the most abundant proteins and the main cargo of the secretory pathway, contributing to hepatic fibrosis and cirrhosis due to excessive deposition of extracellular matrix. Here we investigated the possible contribution of t…
View article: Mutation in protein disulfide isomerase A3 causes neurodevelopmental defects by disturbing endoplasmic reticulum proteostasis
Mutation in protein disulfide isomerase A3 causes neurodevelopmental defects by disturbing endoplasmic reticulum proteostasis Open
View article: Control of lysosomal-mediated cell death by the pH-dependent calcium channel RECS1
Control of lysosomal-mediated cell death by the pH-dependent calcium channel RECS1 Open
RECS1, a member of the TMBIM family, triggers lysosomal membrane permeabilization in cells undergoing lysosomal stress.
View article: BH3‐only proteins are part of a regulatory network that control the sustained signalling of the unfolded protein response sensor IRE1α
BH3‐only proteins are part of a regulatory network that control the sustained signalling of the unfolded protein response sensor IRE1α Open
View article: Author Correction: IRE1α governs cytoskeleton remodeling and cell migration through a direct interaction with filamin A
Author Correction: IRE1α governs cytoskeleton remodeling and cell migration through a direct interaction with filamin A Open
View article: Caveolin-1 suppresses tumor formation through the inhibition of the unfolded protein response
Caveolin-1 suppresses tumor formation through the inhibition of the unfolded protein response Open
View article: The UPRosome – decoding novel biological outputs of IRE1α function
The UPRosome – decoding novel biological outputs of IRE1α function Open
Different perturbations alter the function of the endoplasmic reticulum (ER), resulting in the accumulation of misfolded proteins in its lumen, a condition termed ER stress. To restore ER proteostasis, a highly conserved pathway is engaged…
View article: Genotoxic stress triggers the activation of IRE1α-dependent RNA decay to modulate the DNA damage response
Genotoxic stress triggers the activation of IRE1α-dependent RNA decay to modulate the DNA damage response Open
The molecular connections between homeostatic systems that maintain both genome integrity and proteostasis are poorly understood. Here we identify the selective activation of the unfolded protein response transducer IRE1α under genotoxic s…
View article: Publisher Correction: Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics
Publisher Correction: Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics Open
View article: Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics
Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics Open
View article: Emerging Roles of the Endoplasmic Reticulum Associated Unfolded Protein Response in Cancer Cell Migration and Invasion
Emerging Roles of the Endoplasmic Reticulum Associated Unfolded Protein Response in Cancer Cell Migration and Invasion Open
Endoplasmic reticulum (ER) proteostasis is often altered in tumor cells due to intrinsic (oncogene expression, aneuploidy) and extrinsic (environmental) challenges. ER stress triggers the activation of an adaptive response named the Unfold…
View article: Cyclosporine A binding to COX-2 reveals a novel signaling pathway that activates the IRE1α unfolded protein response sensor
Cyclosporine A binding to COX-2 reveals a novel signaling pathway that activates the IRE1α unfolded protein response sensor Open
Cyclosporine, a widely used immunosuppressant in organ transplantation and in treatment of various autoimmune diseases, activates the unfolded protein response (UPR), an ER stress coping response. In this study we discovered a new and unan…
View article: Synaptotagmin-1 overexpression under inflammatory conditions affects secretion in salivary glands from Sjögren's syndrome patients
Synaptotagmin-1 overexpression under inflammatory conditions affects secretion in salivary glands from Sjögren's syndrome patients Open
View article: Publisher Correction: IRE1α governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A
Publisher Correction: IRE1α governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A Open
View article: IRE1α governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A
IRE1α governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A Open
View article: Homeostatic interplay between FoxO proteins and ER proteostasis in cancer and other diseases
Homeostatic interplay between FoxO proteins and ER proteostasis in cancer and other diseases Open
View article: Interactome Screening Identifies the ER Luminal Chaperone Hsp47 as a Regulator of the Unfolded Protein Response Transducer IRE1α
Interactome Screening Identifies the ER Luminal Chaperone Hsp47 as a Regulator of the Unfolded Protein Response Transducer IRE1α Open
View article: Fine-tuning PERK signaling to control cell fate under stress
Fine-tuning PERK signaling to control cell fate under stress Open
PERK is a major sensor of the unfolded protein response controlling cell fate under endoplasmic reticulum (ER) stress. A new study reveals an additional step for optimal PERK signaling, involving the binding of CNPY2 to PERK's luminal doma…
View article: Endoplasmic reticulum proteostasis in glioblastoma—From molecular mechanisms to therapeutic perspectives
Endoplasmic reticulum proteostasis in glioblastoma—From molecular mechanisms to therapeutic perspectives Open
Combined therapies targeting the unfolded protein stress response might be a way to treat glioblastomas.
View article: Endoplasmic Reticulum Stress and the Hallmarks of Cancer
Endoplasmic Reticulum Stress and the Hallmarks of Cancer Open
View article: ER proteostasis addiction in cancer biology: Novel concepts
ER proteostasis addiction in cancer biology: Novel concepts Open