Explanipedia

Circulating Fibroblast Growth Factor 21 (FGF21) as a Prognostic and Diagnostic Biomarker in Hepatocellular Carcinoma Open

Joe Eid, Merih Yalçıner, Lianchun Xiao, Ryan Sun, Mahesh Kumar Kannan , et al. · 2025

Draft genome sequence of <i>Dolosicoccus paucivorans</i> DSM 15742 <sup>T</sup> isolated from a patient’s blood in Cleveland, Ohio Open

Ana María Guzmán, Andrea Orozco, Hesham M. Amin, Rüdiger Pukall, Markus Goeker , et al. · 2025

This study describes the whole genome sequence of Dolosicoccus paucivorans 2991-95 (DSM 15742) isolated from human blood in Cleveland, Ohio. The genome length is approximately 1.8 Mbp with 107 contigs and a G + C content of 37.91%. Annotat…

280P Key performance indicators (KPIs) of screening via clinical breast examination (CBE): A pooled analysis of 9.3 million screened women Open

J. Atherton, S.G. Gopalakrishnan, Yasmen Wahba, Ramez Kirollos, Emad Shash , et al. · 2025

Tissue and Imaging Biomarkers of Response to Neoadjuvant Nivolumab or Nivolumab plus Ipilimumab in Patients with Resectable Hepatocellular Carcinoma Open

Michael LaPelusa, Shadi Chamseddine, Hop S. Tran Cao, Lianchun Xiao, Elshad Hasanov , et al. · 2024

Introduction: Perioperative immunotherapy has shown promise in some patients with early-stage hepatocellular carcinoma (HCC). This study examined tissue and imaging biomarkers associated with pathologic response in a phase II clinical tria…

Circulating Galectin-3: A Prognostic Biomarker in Hepatocellular Carcinoma Open

Shadi Chamseddine, Betül Gök Yavuz, Yehia I. Mohamed, Sunyoung S. Lee, James C. Yao , et al. · 2024

Introduction Galectin-3 plays critical roles in the adhesion, proliferation, and differentiation of tumor cells. Recent data have suggested that galectin-3 plays a role in the development of hepatocellular carcinoma (HCC); however, its pro…

Circulating tumor DNA (ctDNA) as a biomarker of response to therapy in advanced Hepatocellular carcinoma treated with Nivolumab Open

Yehia I. Mohamed, Sunyoung S. Lee, Tarık Demir, Shadi Chamseddine, Zishuo Ian Hu , et al. · 2024

BACKGROUND: Circulating tumor DNA (ctDNA) is a promising non-invasive marker for detection, diagnosis, treatment selection, and prognosis of hepatocellular carcinoma (HCC). OBJECTIVE: This study aimed to examine the utility of ctDNA as a p…

From mitochondria to tumor suppression: ACAT1's crucial role in gastric cancer Open

Wei He, Yanfang Li, Songbai Liu, Ying Chang, S.H. Han , et al. · 2024

Acetyl CoA acetyltransferase 1 (ACAT1), a mitochondrial enzyme, is mainly involved in the formation and decomposition of ketones, isoleucine, and fatty acids. Previous clinical studies showed that mutations in the ACAT1 gene lead to ketoac…

Severe febrile neutropenia and pancytopenia in a patient with advanced hepatocellular carcinoma treated with atezolizumab and bevacizumab: a case report Open

Shadi Chamseddine, Michael LaPelusa, Kristen Carter, Van Du Nguyen, Yehia I. Mohamed , et al. · 2024

In conclusion, we observed temporary severe febrile neutropenia and pancytopenia during systemic immunotherapy in a patient with unresectable HCC. Healthcare providers should consider hematological irAEs (hem-irAEs) in patients after the a…

Plasma Growth Hormone as a Prognostic Biomarker to Durvalumab and Tremelimumab in Patients with Advanced Hepatocellular Carcinoma Open

Shadi Chamseddine, Michael LaPelusa, Lianchun Xiao, Yehia I. Mohamed, Sunyoung Lee , et al. · 2024

Plasma GH is a prognostic biomarker in patients with advanced HCC treated with D+T. Given the relatively small patient cohort size, this finding should be further validated in larger randomized clinical trials in advanced HCC patients.

Genome-wide association study identifies high-impact susceptibility loci for HCC in North America Open

Manal M. Hassan, Donghui Li, Younghun Han, Jinyoung Byun, Rikita Hatia , et al. · 2024

Background and Aims: Despite the substantial impact of environmental factors, individuals with a family history of liver cancer have an increased risk for HCC. However, genetic factors have not been studied systematically by genome-wide ap…

The Gut Microbiome as a Biomarker and Therapeutic Target in Hepatocellular Carcinoma Open

Betül Gök Yavuz, Saumil Datar, Shadi Chamseddine, Yehia I. Mohamed, Michael LaPelusa , et al. · 2023

The microbiome is pivotal in maintaining health and influencing disease by modulating essential inflammatory and immune responses. Hepatocellular carcinoma (HCC), ranking as the third most common cause of cancer-related fatalities globally…

The Gut Microbiome as a Biomarker and Therapeutic Target in Hepatocellular Carcinoma Open

Betül Gök Yavuz, Saumil Datar, Shadi Chamseddine, Yehia I. Mohamed, Michael LaPelusa , et al. · 2023

The microbiome is pivotal in maintaining health and influencing disease by modulating essential inflammatory and immune responses. Hepatocellular carcinoma (HCC), ranking as the third most common cause of cancer-related fatalities globally…

Zyxin inhibits the epithelial–mesenchymal transition process in gastric cancer by upregulating SIRT1 Open

Jing Lou, Sha Geng, Wei He, Songbai Liu, Xinghong Shi , et al. · 2023

Tumor development relies on the stemness of cancer stem cells, which is regulated by environmental cues. Previous studies have shown that zyxin can inhibit the expression of genes for embryonic stem cell status. In the present study, the e…

Therapeutic effects of combining curcumin and swimming in osteoarthritis using a rat model Open

Mona M. Saber, Manal M. A. Mahmoud, Hesham M. Amin, Reham M. Essam · 2023

Correction: Dual inhibition of IGF-IR and ALK as an effective strategy to eradicate NPM-ALK+ T-cell lymphoma Open

Bhawana George, Suraj K. George, Wenyu Shi, Abedul Haque, Ping Shi , et al. · 2023

Data from Molecular Profiling of Hepatocellular Carcinoma Using Circulating Cell-Free DNA Open