Explanipedia

Evaluation of an artificial intelligence model based on multiparametric transrectal ultrasound for localizing clinically significant prostate cancer by simulation of targeted biopsies Open

Daniël L. van den Kroonenberg, Florian Delberghe, Auke Jager, Arnoud W. Postema, K.C.C. de Bie , et al. · 2025

Introduction and objectives An AI model that performs well during training does not guarantee similar performance in clinical practice and should be carefully evaluated before implementation. We aimed to evaluate a voxel-level trained AI m…

Three-Dimensional Shear-Wave Viscoelastographic Estimation by System Identification for Prostate Cancer Localization Open

X. Li, Florian Delberghe, Simona Turco, David Mills, Kirk Wallace , et al. · 2025

We are the first to report in-vivo voxel-based viscosity of the prostate using SWE. Combining viscosity with elasticity did not significantly improve PCa detection, likely due to system limitations, acquisition noise, and modeling simplifi…

Contrast-ultrasound dispersion imaging for renal cell carcinoma diagnostics Open

Peiran Chen, Simona Turco, Zhonggui Liu, Christiaan Widdershoven, Jorg R. Oddens , et al. · 2025

Cost-effective screening methods for Renal Cell Carcinoma (RCC) are still lacking. Angiogenesis is a recognized hallmark of cancer growth, leading to distinguishable perfusion patterns in tumors from those in normal tissue. This establishe…

The impact of monodisperse microbubble size on contrast-enhanced ultrasound super-localization imaging Open

Peiran Chen, Andreas Pollet, Simona Turco, Mike Vargas, Lisa Te Winkel , et al. · 2025

Contrast-enhanced ultrasound (CEUS) super-localization imaging has shown promise for the assessment of microvascular networks by localizing and tracking microbubbles. The size of the available microbubbles for clinical use is polydisperse,…

Mapping of prostate cancer microvascular patterns using super-resolution ultrasound imaging Open

Mairead Butler, Γεώργιος Παπαγεωργίου, Evangelos Kanoulas, Vasiliki Voulgaridou, Hessel Wijkstra , et al. · 2025

The unique second wave phenomenon in contrast enhanced ultrasound imaging with nanobubbles Open

Chuan Chen, Reshani Perera, Michael C. Kolios, Hessel Wijkstra, Agata A. Exner , et al. · 2024

Investigation of nanobubble (NB) pharmacokinetics in contrast-enhanced ultrasound (CEUS) at the pixel level shows a unique phenomenon where the first pass of the contrast agent bolus is accompanied by a second wave. This effect has not bee…

Pharmacokinetic Modeling of the Second-Wave Phenomenon in Nanobubble-Based Contrast-Enhanced Ultrasound Open

Chuan Chen, Reshani Perera, Michael C. Kolios, Hessel Wijkstra, Agata A. Exner , et al. · 2024

With a typical 100-500 nm diameter, nanobubbles are a promising new-generation ultrasound contrast agent that paves ways for several applications, such as efficient drug delivery, molecular imaging, and assessment of vascular permeability.…

Pharmacokinetic modeling of PSMA-targeted nanobubbles for quantification of extravasation and binding in mice models of prostate cancer Open

Chuan Chen, Reshani Perera, Michael C. Kolios, Hessel Wijkstra, Massimo Mischi , et al. · 2024

Purpose Contrast-enhanced ultrasound (CEUS) by injection of microbubbles (MBs) has shown promise as a cost-effective imaging modality for prostate cancer (PCa) detection. More recently, nanobubbles (NBs) have been proposed…

The unique second wave phenomenon in contrast enhanced ultrasound imaging with nanobubbles Open

Chuan Chen, Reshani Perera, Michael C. Kolios, Hessel Wijkstra, Agata A. Exner , et al. · 2024

Investigation of nanobubble (NB) pharmacokinetics in contrast-enhanced ultrasound (CEUS) at the pixel level shows a unique phenomenon where the first pass of the contrast agent bolus is accompanied by a second wave. This effect has not bee…

Is There an Added Value of Quantitative DCE-MRI by Magnetic Resonance Dispersion Imaging for Prostate Cancer Diagnosis? Open

Auke Jager, Jorg R. Oddens, Arnoud W. Postema, Razvan L. Miclea, Ivo G. Schoots , et al. · 2024

In this multicenter, retrospective study, we evaluated the added value of magnetic resonance dispersion imaging (MRDI) to standard multiparametric MRI (mpMRI) for PCa detection. The study included 76 patients, including 51 with clinically …

Local Density Random Walk Model Preprocessing for Local Shear Wave Viscoelastographic Estimation Open

X. Li, Simona Turco, Hessel Wijkstra, Massimo Mischi · 2024

Shear wave (SW) elastography is an ultrasound technique that provides quantitative tissue elasticity and viscosity measurements by imaging the tissue response to an applied excitation. In particular, the phase difference method allows for …

Is There an Added Value of Quantitative DCE-MRI by Magnetic Resonance Dispersion Imaging for Prostate Cancer Diagnosis? Open

Auke Jager, Jorg R. Oddens, Arnoud W. Postema, Razvan L. Miclea, Ivo G. Schoots , et al. · 2024

In this multicenter, retrospective study we evaluated the added value of magnetic resonance dispersion imaging (MRDI) to standard multiparametric MRI (mpMRI) for PCa detection. The study included 76 patients - 51 with clinically significan…

Can 3D Multiparametric Ultrasound Imaging Predict Prostate Biopsy Outcome? Open

Peiran Chen, Simona Turco, Yao Wang, Auke Jager, Gautier Daures , et al. · 2024

Our results suggest 3D multiparametric ultrasound imaging combining hemodynamic and tissue-stiffness features to represent a promising diagnostic tool for biopsy outcome prediction, aiding in csPCa localization.

Delayed matrix pencil method for local shear wave viscoelastographic estimation Open

X. Li, Simona Turco, Ronald M. Aarts, Hessel Wijkstra, Massimo Mischi · 2024

Shear wave (SW) elastography is an ultrasound imaging modality that provides quantitative viscoelastic measurements of tissue. The phase difference method allows for local estimation of viscoelasticity by computing the dispersion curve usi…

Spatiotemporal analysis of contrast-enhanced ultrasound for differentiating between malignant and benign breast lesions Open

Chuan Chen, Simona Turco, Panagiotis Kapetas, Ritse M. Mann, Hessel Wijkstra , et al. · 2023

Contains fulltext : 307721.pdf (Publisher’s version ) (Open Access)

Corrigendum to “Clinical Trial Protocol: Developing an Image Classification Algorithm for Prostate Cancer Diagnosis on Three-dimensional Multiparametric Transrectal Ultrasound” [Eur. Urol. Open Sci. 49 (2023) 32–43] Open

Auke Jager, Arnoud W. Postema, Massimo Mischi, Hessel Wijkstra, Harrie P. Beerlage , et al. · 2023

[This corrects the article DOI: 10.1016/j.euros.2022.12.018.].

Prostate cancer risk assessment using a radiogenomic analysis Open

Catarina Dinis Fernandes, Annekoos Schaap, J A Kant, Petra J. van Houdt, Hessel Wijkstra , et al. · 2023

Prostate cancer (PCa) is a very prevalent cancer type with a heterogeneous prognosis. An accurate assessment of tumor aggressiveness can pave the way for tailored treatment strategies, potentially leading to a better prognosis. Tumor aggre…

Radiogenomics Analysis Linking Multiparametric MRI and Transcriptomics in Prostate Cancer Open

Catarina Dinis Fernandes, Annekoos Schaap, J A Kant, Petra J. van Houdt, Hessel Wijkstra , et al. · 2023

Prostate cancer (PCa) is a highly prevalent cancer type with a heterogeneous prognosis. An accurate assessment of tumor aggressiveness can pave the way for tailored treatment strategies, potentially leading to better outcomes. While tumor …

Clinical Trial Protocol: Developing an Image Classification Algorithm for Prostate Cancer Diagnosis on Three-dimensional Multiparametric Transrectal Ultrasound Open

Auke Jager, Arnoud W. Postema, Massimo Mischi, Hessel Wijkstra, Harrie P. Beerlage , et al. · 2023

Delayed Matrix Pencil Method for Local Shear Wave Viscoelastographic Estimation Open

X. Li, Simona Turco, Ronald M. Aarts, Hessel Wijkstra, Massimo Mischi · 2023

Pharmacokinetic modeling of PSMA‐targeted nanobubbles for quantification of extravasation and binding in mice models of prostate cancer Open

Chuan Chen, Reshani Perera, Michael C. Kolios, Hessel Wijkstra, Massimo Mischi , et al. · 2022

Purpose Contrast‐enhanced ultrasound (CEUS) by injection of microbubbles (MBs) has shown promise as a cost‐effective imaging modality for prostate cancer (PCa) detection. More recently, nanobubbles (NBs) have been proposed as novel ultraso…

The unique second wave phenomenon in contrast enhanced ultrasound imaging with nanobubbles Open

Chuan Chen, Reshani Perera, Michael C. Kolios, Hessel Wijkstra, Agata A. Exner , et al. · 2022

Pharmacokinetic Modeling of the Second-Wave Phenomenon in Nanobubble-Based Contrast-Enhanced Ultrasound Open

Chuan Chen, Reshani Perera, Michael C. Kolios, Hessel Wijkstra, Agata A. Exner , et al. · 2022

With a typical 100-500 nm diameter, nanobubbles are a promising new-generation ultrasound contrast agent that paves ways for several applications, such as efficient drug delivery, molecular imaging, and assessment of vascular permeability.…

How Reliable Is Endoscopic Stone Recognition? A Comparison Between Visual Stone Identification and Formal Stone Analysis Open

Michaël M. E. L. Henderickx, Simone Joanna-Maria Stoots, Daniël M. de Bruin, Hessel Wijkstra, Jan Erik Freund , et al. · 2022

Objective: To assess the diagnostic accuracy and intra-observer agreement of endoscopic stone recognition (ESR) compared with formal stone analysis. Introduction: Stone analysis is a corner stone in the preventi…

B/A Measurement of Clear Cell Renal Cell Carcinoma versus Healthy Kidney Tissue Open

Anastasiia Panfilova, Xufei Chen, Christiaan Widdershoven, Jan Erik Freund, Dilara Savci Heijink , et al. · 2022

The acoustic parameter of non-linearity B/A has been found capable of discriminating some types of pathological tissue from healthy tissue. The literature on the utility of B/A for cancer diagnostics is very limited, with measurements on t…

Contrast Enhanced Ultrasound Imaging with Nanobubbles: Unique Second-Wave Phenomenon Open

Chuan Chen, Reshani Perera, Michael C. Kolios, Hessel Wijkstra, Agata A. Exner , et al. · 2022

Investigation of nanobubble (NB) pharmacokinetics in contrast-enhanced ultrasound (CEUS) at the pixel level shows a unique phenomenon where the first pass of the contrast agent bolus is accompanied by a second wave. This effect has not bee…

Deep learning for prostate and zonal segmentation on a multicenter MRI dataset Open

Catarina Dinis Fernandes, Hubert Blach, Jelle O. Barentsz, Stijn W. T. P. J. Heijmink, Hessel Wijkstra , et al. · 2021

Is a quantitative analysis of dynamic contrast-enhanced MRI of added value for prostate cancer diagnosis? Open

Simona Turco, Catarina Dinis Fernandes, Razvan L. Miclea, I.G. Schoot, P. Noojien , et al. · 2021

Prostate cancer localization by 3D multiparametric contrast-ultrasound dispersion imaging and shear-wave elastography Open

P. Chen, Simona Turco, Hessel Wijkstra, Arta Dilo, Pao Huang , et al. · 2021

Experimental acoustic characterization of an endoskeletal antibubble contrast agent: First results Open

Anastasiia Panfilova, Peiran Chen, Ruud J. G. van Sloun, Hessel Wijkstra, Michiel Postema , et al. · 2021

Purpose An antibubble is an encapsulated gas bubble with an incompressible inclusion inside the gas phase. Current‐generation ultrasound contrast agents are bubble‐based: they contain encapsulated gas bubbles with no inclusions. The object…

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