Hester C. Timmerhuis
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View article: Identification of robust associations between admission microbiome profiles and complications of acute pancreatitis
Identification of robust associations between admission microbiome profiles and complications of acute pancreatitis Open
Objective Patients with acute pancreatitis show reduced gut microbiome diversity and high abundance of pathogenic bacteria compared with healthy subjects. Admission microbiome profiles are increasingly linked to severity, but methodology a…
View article: Cost-effectiveness of immediate <i>versus</i> postponed intervention for infected necrotizing pancreatitis: planned secondary analysis of the POINTER trial
Cost-effectiveness of immediate <i>versus</i> postponed intervention for infected necrotizing pancreatitis: planned secondary analysis of the POINTER trial Open
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View article: Gallstones as a cause in presumed acute alcoholic pancreatitis: observational multicentre study
Gallstones as a cause in presumed acute alcoholic pancreatitis: observational multicentre study Open
Background Data on the incidence and clinical relevance of gallstones in patients with suspected acute alcoholic pancreatitis are lacking and are essential to minimize the risk of recurrent acute pancreatitis. The aim of this study was to …
View article: Splanchnic vein thrombosis in necrotizing pancreatitis: a post-hoc analysis of a nationwide prospective cohort
Splanchnic vein thrombosis in necrotizing pancreatitis: a post-hoc analysis of a nationwide prospective cohort Open
SVT is a common and early complication of necrotizing pancreatitis, associated with parenchymal necrosis and younger age. SVT is associated with increased complications and a worse clinical course, whereas anticoagulant use does not appear…
View article: Long-term follow-up study of necrotising pancreatitis: interventions, complications and quality of life
Long-term follow-up study of necrotising pancreatitis: interventions, complications and quality of life Open
Objective To describe the long-term consequences of necrotising pancreatitis, including complications, the need for interventions and the quality of life. Design Long-term follow-up of a prospective multicentre cohort of 373 necrotising pa…
View article: Prospective multicentre study of indications for surgery in patients with idiopathic acute pancreatitis following endoscopic ultrasonography (PICUS)
Prospective multicentre study of indications for surgery in patients with idiopathic acute pancreatitis following endoscopic ultrasonography (PICUS) Open
Background Cholecystectomy in patients with idiopathic acute pancreatitis (IAP) is controversial. A randomized trial found cholecystectomy to reduce the recurrence rate of IAP but did not include preoperative endoscopic ultrasonography (EU…
View article: Management of Infected Necrosis
Management of Infected Necrosis Open
When infected necrosis is clinically or radiologically suspected in a patient with necrotizing pancreatitis, antibiotic therapy is indicated. An intervention is indicated in patients who fail to improve or who show clinical deterioration u…
View article: Therapeutic anticoagulation for splanchnic vein thrombosis in acute pancreatitis: A national survey and case-vignette study
Therapeutic anticoagulation for splanchnic vein thrombosis in acute pancreatitis: A national survey and case-vignette study Open
In this national survey, the pancreatologists seemed to agree on the use of therapeutic anticoagulation, using LMWH in the acute phase, for acute portal thrombosis and in the case of thrombus progression, irrespective of the presence of in…
View article: Overuse and Misuse of Antibiotics and the Clinical Consequence in Necrotizing Pancreatitis
Overuse and Misuse of Antibiotics and the Clinical Consequence in Necrotizing Pancreatitis Open
Objective: The use and impact of antibiotics and the impact of causative pathogens on clinical outcomes in a large real-world cohort covering the entire clinical spectrum of necrotizing pancreatitis remain unknown. Summary Background Data:…
View article: Central hepatectomy for large hepatocellular carcinoma
Central hepatectomy for large hepatocellular carcinoma Open
View article: Suspected common bile duct stones: reduction of unnecessary ERCP by pre-procedural imaging and timing of ERCP
Suspected common bile duct stones: reduction of unnecessary ERCP by pre-procedural imaging and timing of ERCP Open
View article: Perforation and Fistula of the Gastrointestinal Tract in Patients With Necrotizing Pancreatitis
Perforation and Fistula of the Gastrointestinal Tract in Patients With Necrotizing Pancreatitis Open
Objective: The aim of this study was to explore the incidence, risk factors, clinical course and treatment of perforation and fistula of the gastrointestinal (GI) tract in a large unselected cohort of patients with necrotizing pancreatitis…
View article: Comparison of lumen-apposing metal stents versus double-pigtail plastic stents for infected necrotising pancreatitis
Comparison of lumen-apposing metal stents versus double-pigtail plastic stents for infected necrotising pancreatitis Open
Objective Lumen-apposing metal stents (LAMS) are believed to clinically improve endoscopic transluminal drainage of infected necrosis when compared with double-pigtail plastic stents. However, comparative data from prospective studies are …
View article: Endoscopic Versus Surgical Step-Up Approach for Infected Necrotizing Pancreatitis (ExTENSION): Long-term Follow-up of a Randomized Trial
Endoscopic Versus Surgical Step-Up Approach for Infected Necrotizing Pancreatitis (ExTENSION): Long-term Follow-up of a Randomized Trial Open
View article: Optimal timing of rectal diclofenac in preventing post-endoscopic retrograde cholangiopancreatography pancreatitis
Optimal timing of rectal diclofenac in preventing post-endoscopic retrograde cholangiopancreatography pancreatitis Open
Background and study aims Rectal nonsteroidal anti-inflammatory drug (NSAID) prophylaxis reduces incidence of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis. Direct comparisons to the optimal timing of administrati…
View article: ExTENSION: Long-Term Follow-up Study of an Endoscopic versus a Surgical Step-up Approach for Infected Necrotizing Pancreatitis
ExTENSION: Long-Term Follow-up Study of an Endoscopic versus a Surgical Step-up Approach for Infected Necrotizing Pancreatitis Open
View article: Performance of diagnostic tools for acute cholangitis in patients with suspected biliary obstruction
Performance of diagnostic tools for acute cholangitis in patients with suspected biliary obstruction Open
Background Acute cholangitis is an infection requiring endoscopic retrograde cholangiopancreatography (ERCP) and antibiotics. Several diagnostic tools help to diagnose cholangitis. Because diagnostic performance of these tools has not been…
View article: Immediate versus Postponed Intervention for Infected Necrotizing Pancreatitis
Immediate versus Postponed Intervention for Infected Necrotizing Pancreatitis Open
BACKGROUNDInfected necrotizing pancreatitis is a potentially lethal disease that is treated with the use of a step-up approach, with catheter drainage often delayed until the infected necrosis is encapsulated. Whether outcomes could be imp…
View article: Optimal timing of cholecystectomy after necrotising biliary pancreatitis
Optimal timing of cholecystectomy after necrotising biliary pancreatitis Open
Objective Following an episode of acute biliary pancreatitis, cholecystectomy is advised to prevent recurrent biliary events. There is limited evidence regarding the optimal timing and safety of cholecystectomy in patients with necrotising…
View article: Aggressive fluid hydration plus non-steroidal anti-inflammatory drugs versus non-steroidal anti-inflammatory drugs alone for post-endoscopic retrograde cholangiopancreatography pancreatitis (FLUYT): a multicentre, open-label, randomised, controlled trial
Aggressive fluid hydration plus non-steroidal anti-inflammatory drugs versus non-steroidal anti-inflammatory drugs alone for post-endoscopic retrograde cholangiopancreatography pancreatitis (FLUYT): a multicentre, open-label, randomised, controlled trial Open
View article: Diagnosis and treatment of pancreatic duct disruption or disconnection: an international expert survey and case vignette study
Diagnosis and treatment of pancreatic duct disruption or disconnection: an international expert survey and case vignette study Open
View article: Optimal timing of cholecystectomy after necrotising biliary pancreatitis
Optimal timing of cholecystectomy after necrotising biliary pancreatitis Open
View article: Disruption or Disconnection of the Pancreatic Duct in Patients with Severe Acute Pancreatitis: A Large Prospective Multi-center Cohort
Disruption or Disconnection of the Pancreatic Duct in Patients with Severe Acute Pancreatitis: A Large Prospective Multi-center Cohort Open
View article: Postponed or Immediate Drainage of Infected Necrotizing Pancreatitis (POINTER): A Multicenter Randomized Trial
Postponed or Immediate Drainage of Infected Necrotizing Pancreatitis (POINTER): A Multicenter Randomized Trial Open
View article: Role of endoscopic ultrasonography in the diagnostic work-up of idiopathic acute pancreatitis (PICUS): study protocol for a nationwide prospective cohort study
Role of endoscopic ultrasonography in the diagnostic work-up of idiopathic acute pancreatitis (PICUS): study protocol for a nationwide prospective cohort study Open
Introduction Idiopathic acute pancreatitis (IAP) remains a dilemma for physicians as it is uncertain whether patients with IAP may actually have an occult aetiology. It is unclear to what extent additional diagnostic modalities such as end…
View article: Various Modalities Accurate in Diagnosing a Disrupted or Disconnected Pancreatic Duct in Acute Pancreatitis: A Systematic Review
Various Modalities Accurate in Diagnosing a Disrupted or Disconnected Pancreatic Duct in Acute Pancreatitis: A Systematic Review Open
View article: Endoscopic ultrasonography can detect a cause in the majority of patients with idiopathic acute pancreatitis: a systematic review and meta-analysis
Endoscopic ultrasonography can detect a cause in the majority of patients with idiopathic acute pancreatitis: a systematic review and meta-analysis Open
Background Idiopathic acute pancreatitis (IAP) has a 25 % pancreatitis recurrence rate. Endoscopic ultrasonography (EUS) may diagnose treatable causes of IAP and hence prevent recurrence. The goal of this systematic review with meta-analys…
View article: Diagnosis of disrupted and disconnected pancreatic duct in acute pancreatitis: a systematic review
Diagnosis of disrupted and disconnected pancreatic duct in acute pancreatitis: a systematic review Open