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View article: Eupalinolide A inhibits cancer progression and induces ferroptosis and apoptosis by targeting the AMPK/mTOR/SCD1 signalling in non-small cell lung cancer
Eupalinolide A inhibits cancer progression and induces ferroptosis and apoptosis by targeting the AMPK/mTOR/SCD1 signalling in non-small cell lung cancer Open
Background Non-small cell lung cancer (NSCLC) is a common malignancy with limited efficacy of established therapies and a poor prognosis that often entails a high financial burden. Eupatorium lindleyanum DC. and its main component Eupalino…
View article: Regulatory roles of LncRNAs in colorectal cancer immune evasion: current concepts and future perspectives
Regulatory roles of LncRNAs in colorectal cancer immune evasion: current concepts and future perspectives Open
Colorectal cancer (CRC) remains a major global health challenge, ranking as the second leading cause of cancer-related mortality due to late-stage diagnosis and limited effective treatments. Long non-coding RNAs (lncRNAs) have emerged as c…
View article: PLGA-based nanoparticles in colorectal cancer immunotherapy: current concepts and future perspectives
PLGA-based nanoparticles in colorectal cancer immunotherapy: current concepts and future perspectives Open
Colorectal cancer (CRC) remains a leading cause of cancer mortality, and the benefits of immune checkpoint inhibitors are largely confined to the dMMR/MSI-H minority, underscoring the need to remodel the immunosuppressive tumor microenviro…
View article: Therapeutic cancer vaccines in pancreatic cancer
Therapeutic cancer vaccines in pancreatic cancer Open
Pancreatic cancer is a leading cause of cancer-related mortality, and unfortunately, the prognosis for this stubborn tumor type has remained bleak for an extended period. Current treatment options are limited and often ineffective, highlig…
View article: Characteristic of the power decay length of small ELMs measured by infrared camera on EAST
Characteristic of the power decay length of small ELMs measured by infrared camera on EAST Open
Small edge-localized-mode (ELM) regimes are being studied as promising solution to reduce the heat flux to the first-wall within tolerable levels in future machines. This study represents the first utilization of a high-resolution infrared…
View article: Genome-Wide Identification and Expression Analysis of TCP Transcription Factors Responding to Multiple Stresses in Arachis hypogaea L.
Genome-Wide Identification and Expression Analysis of TCP Transcription Factors Responding to Multiple Stresses in Arachis hypogaea L. Open
The TEOSINTE-BRANCHED1/CYCLOIDEA/PROLIFERATING-CELL-FACTOR (TCP) gene family, a plant-specific transcription factor family, plays pivotal roles in various processes such as plant growth and development regulation, hormone crosstalk, and st…
View article: A Cross-Calibration Approach for Coastline Extraction With Time Series Satellite Images
A Cross-Calibration Approach for Coastline Extraction With Time Series Satellite Images Open
In tidal flat regions, the spectral differences between water and land are often weak, making it challenging to extract the coastline from remote sensing imagery. Due to tidal influences, the satellite images captured at different times ha…
View article: A comparison of muscle activation and concomitant intermuscular coupling of antagonist muscles among bench presses with different instability degrees in untrained men
A comparison of muscle activation and concomitant intermuscular coupling of antagonist muscles among bench presses with different instability degrees in untrained men Open
The aim of this study was to analyze and compare the muscle activation and concomitant intermuscular coupling of antagonist muscles among bench presses with different instability degrees. Twenty-nine untrained male college students perform…
View article: Salt gradient and ion-pair mediated anion exchange of intact messenger ribonucleic acids
Salt gradient and ion-pair mediated anion exchange of intact messenger ribonucleic acids Open
Small molecule drugs and protein-based therapeutics are widely used to treat various diseases, yet even more aspects of human health can be addressed through new modalities, like messenger RNA (mRNA). The complex nature and chemical struct…
View article: The association of serum vascular endothelial growth factor levels and psoriasis vulgaris
The association of serum vascular endothelial growth factor levels and psoriasis vulgaris Open
Background: In recent years, more and more attention has been paid to the role of skin microcirculation in the pathogenesis of psoriasis. The vascular network of the skin is mainly distributed in the dermis and the subcutaneous fat layer j…
View article: Genetic polymorphisms of the drug-metabolizing enzyme CYP2J2 in a Tibetan population
Genetic polymorphisms of the drug-metabolizing enzyme CYP2J2 in a Tibetan population Open
As an important metabolic enzyme, it is necessary to investigate the genetic polymorphisms of CYP2J2 among healthy Tibetan individuals. Genetic polymorphisms of CYP2J2 could affect enzyme activity and lead to differences among individual r…
View article: Increased Concentrations of Extracellular Histones in Patients with Tuberculous Pleural Effusion
Increased Concentrations of Extracellular Histones in Patients with Tuberculous Pleural Effusion Open
BACKGROUND Extracellular histones have recently been suggested as critical mediators in many inflammatory diseases. However, the role of extracellular histones in tuberculous pleural effusion (TPE) is unclear. The goal of this study was to…
View article: Functional proteomic analysis revels that the ethanol extract of Annona muricata L. induces liver cancer cell apoptosis through endoplasmic reticulum stress pathway
Functional proteomic analysis revels that the ethanol extract of Annona muricata L. induces liver cancer cell apoptosis through endoplasmic reticulum stress pathway Open
Our results indicate that the ethanol extract of leaves of Annona muricata L. causes apoptosis of liver cancer cells through ER stress pathway, which supports the ethnomedicinal use of this herb as an alternative or complementary therapy f…