Explanipedia

LAPTM5 exacerbates STING-mediated inflammation induced by LL-37 through stabilizing STING in rosacea Open

Wenyue Huang, Hailun He, Haien Wu, Yichong Wang, Jingyu Wang , et al. · 2025

Chronic interferon-stimulated gene transcription promotes oncogene-induced breast cancer Open

Hexiao Wang, Claudia Canasto‐Chibuque, Jun Hyun Kim, Marcel Hohl, Christina S. Leslie , et al. · 2024

The MRE11 complex (comprising MRE11, RAD50, and NBS1) is integral to the maintenance of genome stability. We previously showed that a hypomorphic Mre11 mutant mouse strain ( Mre11 ATLD1/ATLD1 ) was highly susceptible to oncogene-induced br…

Chronic Interferon Stimulated Gene Transcription Promotes Oncogene Induced Breast Cancer Open

Hexiao Wang, Claudia Canasto‐Chibuque, Jun Hyun Kim, Marcel Hohl, Christina S. Leslie , et al. · 2023

The Mre11 complex (comprising Mre11, Rad50, Nbs1) is integral to the maintenance of genome stability. We previously showed that a hypomorphic Mre11 mutant mouse strain ( Mre11 ATLD1/ATLD1 ) was highly susceptible to oncogene induced breast…

Modification of the Early Gene Enhancer-promoter Improves the Oncolytic Potency of Adenovirus 11 Open

Han Hsi Wong, Guozhong Jiang, Rathi Gangeswaran, Pengju Wang, Jiwei Wang , et al. · 2022

RTEL1 influences the abundance and localization of TERRA RNA Open

Fiorella Ghisays, Aitor Garzia, Hexiao Wang, Claudia Canasto‐Chibuque, Marcel Hohl , et al. · 2021

Telomere repeat containing RNAs (TERRAs) are a family of long non-coding RNAs transcribed from the subtelomeric regions of eukaryotic chromosomes. TERRA transcripts can form R-loops at chromosome ends; however the importance of these struc…

RTEL1 Influences the Abundance and Localization of TERRA RNA Open

Fiorella Ghisays, Aitor Garzia, Hexiao Wang, Claudia Canasto‐Chibuque, Marcel Hohl , et al. · 2020

Summary Telomere repeat containing RNAs (TERRAs) are a family of long non-coding RNAs transcribed from the sub-telomeric regions of eukaryotic chromosomes. TERRA transcripts can form R-loops at chromosome ends; however the importance of th…

Inhibition of Heme Oxygenase-1 enhances hyperthermia-induced autophagy and antiviral effect Open

Yang� Yang, Hexiao Wang, Lan Zhang, Wei Huo, Xiaodong Li , et al. · 2019

Hyperthermia has been clinically utilized as an adjuvant therapy in the treatment of cervical carcinoma. However, thermotolerance induced by heme oxygenase-1 (HO-1), a stress-inducible cytoprotective protein, limits the efficacy of hyperth…

Dose modification and therapy interruption due to adverse events in treatment with anlotinib for refractory advanced NSCLC: Data from ALTER0303 Open

L. Zhang, Xiaoyan Si, Hexiao Wang, Xi Zhang, M. Wang , et al. · 2018

Background: Anlotinib is an oral tyrosine kinase inhibitor targeting VEGFR, FGFR, PDGFR and c-kit. Anlotinib showed significantly improvement in overall survival in ALTER0303 trial for refractory NSCLC, a randomized, double-blind, placebo-…

P1.01-108 Management of Anlotinib-Related Adverse Events: Data From ALTER 0303 Open

Xiaoyan Si, L. Zhang, Hexiao Wang, Xi Zhang, M. Wang , et al. · 2018

P1.01-107 The Impact of Anlotinib on Quality of Life in Patients with Advance NSCLC: Post-Hoc Analysis of a Phase III Randomized Control Trial (ALTER0303) Open

Xiaoyan Si, L. Zhang, Hexiao Wang, Xi Zhang, M. Wang , et al. · 2018

G9A promotes gastric cancer metastasis by upregulating ITGB3 in a SET domain-independent manner Open

Lei Hu, Mingde Zang, Hexiao Wang, Zhang Bao-gui, Zhenqiang Wang , et al. · 2018

Tumor metastasis is the leading cause of death in patients with advanced gastric cancer (GC). Limited therapeutic regimens are available for this condition, which is associated with a poor prognosis, and the mechanisms underlying tumor met…

Immunotherapy Bridge 2017 and Melanoma Bridge 2017: meeting abstracts Open

David Carbone, Michael F. Sharpnack, Kai He, Lisa H. Butterfield, Alexander Eggermont , et al. · 2018

P2.03-041 The Concentration of Avitinib in Cerebrospinal Fluid and Its Efficacy and Safety in NSCLC Patients with T790M Mutation Open

Hexiao Wang, L. Zhang, Xinxin Zheng, Xiaoyan Si, Xinge Cui , et al. · 2017

P2.03-050 The Efficacy of EGFR Tyrosine Kinase Inhibitors in Advanced Non-Small Cell Lung Cancer Harboring G719X Mutation Open

Hexiao Wang, L. Zhang, Tao Lu, Xi Zhang, Xiaoyan Si , et al. · 2017

Luteolin suppresses gastric cancer progression by reversing epithelial-mesenchymal transition via suppression of the Notch signaling pathway Open

Mingde Zang, Lei Hu, Zhiyuan Fan, Hexiao Wang, Zhenglun Zhu , et al. · 2017

In this study, GC progression was inhibited by luteolin through suppressing Notch1 signaling and reversing EMT, suggesting that luteolin may serve as an effective anti-tumor drug in GC treatment.

Biglycan stimulates VEGF expression in endothelial cells by activating the TLR signaling pathway Open

Lei Hu, Mingde Zang, Hexiao Wang, Jianfang Li, Liping Su , et al. · 2016

Biglycan (BGN) is an important component of the extracellular matrix (ECM) that is implicated in a variety of human cancers. In our previous study, we reported that BGN was overexpressed in gastric cancer (GC) tissues and promoted cancer m…

REG4 promotes peritoneal metastasis of gastric cancer through GPR37 Open

Hexiao Wang, Lei Hu, Mingde Zang, Zhang Bao-gui, Yantao Duan , et al. · 2016

Being the major reason of recurrence and death after surgery, peritoneal metastasis of gastric cancer dooms the prognosis of advanced gastric cancer patients. Regenerating islet-derived family, member 4 (REG4) is believed to promote perito…

miR-31 is distinctively overexpressed in primary male extramammary Paget's disease Open

Hao Guo, Ruiqun Qi, Yani Lv, Hexiao Wang, Yuxiao Hong , et al. · 2016

MicroRNAs (miRNAs) are small noncoding RNAs involved in cancer development. Extramammary Paget's disease (EMPD) is a rare cutaneous malignancy and the role of miRNAs in EMPD remains unknown. Here, we used TaqMan miRNA arrays to characteriz…

<i>Helicobacter pylori</i> CagA induces tumor suppressor gene hypermethylation by upregulating DNMT1 via AKT-NFκB pathway in gastric cancer development Open

Baogui Zhang, Lei Hu, Mingde Zang, Hexiao Wang, Wei Zhao , et al. · 2016

Methylation of CpG islands in tumor suppressor gene prompter is one of the most characteristic abnormalities in Helicobacter pylori (HP)-associated gastric carcinoma (GC). Here, we investigated the pathogenic and molecular mechanisms under…

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