Heyjun Park
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View article: High-resolution lifestyle profiling and metabolic subphenotypes of type 2 diabetes
High-resolution lifestyle profiling and metabolic subphenotypes of type 2 diabetes Open
Distinct metabolic susceptibilities (beta-cell dysfunction, insulin resistance (IR), and impaired incretin response) underlie type 2 diabetes (T2D). However, their relationships with habitual lifestyle behaviors are underexplored. This stu…
View article: Individual variations in glycemic responses to carbohydrates and underlying metabolic physiology
Individual variations in glycemic responses to carbohydrates and underlying metabolic physiology Open
Elevated postprandial glycemic responses (PPGRs) are associated with type 2 diabetes and cardiovascular disease. PPGRs to the same foods have been shown to vary between individuals, but systematic characterization of the underlying physiol…
View article: Lifestyle Profiling Using Wearables and Prediction of Glucose Metabolism in Individuals with Normoglycemia or Prediabetes
Lifestyle Profiling Using Wearables and Prediction of Glucose Metabolism in Individuals with Normoglycemia or Prediabetes Open
This study examined the relationship between lifestyles (diet, sleep, and physical activity) and glucose responses at a personal level. 36 healthy adults in the Bay Area were monitored for their lifestyles and glucose levels using wearable…
View article: Gut microbiome shifts in chronic systolic heart failure are associated with disease severity and clinical improvement
Gut microbiome shifts in chronic systolic heart failure are associated with disease severity and clinical improvement Open
Chronic systolic heart failure (HF) is a prevalent and morbid disease with marked variability in its progression and response to therapies. The gut microbiome may play a role in pathophysiology and progression of chronic HF, but clinical s…
View article: Predicting Type 2 Diabetes Metabolic Phenotypes Using Continuous Glucose Monitoring and a Machine Learning Framework
Predicting Type 2 Diabetes Metabolic Phenotypes Using Continuous Glucose Monitoring and a Machine Learning Framework Open
Type 2 diabetes (T2D) and prediabetes are classically defined by the level of fasting glucose or surrogates such as hemoglobin HbA1c. This classification does not take into account the heterogeneity in the pathophysiology of glucose dysreg…
View article: Global, distinctive, and personal changes in molecular and microbial profiles by specific fibers in humans
Global, distinctive, and personal changes in molecular and microbial profiles by specific fibers in humans Open
Dietary fibers act through the microbiome to improve cardiovascular health and prevent metabolic disorders and cancer. To understand the health benefits of dietary fiber supplementation, we investigated two popular purified fibers, arabino…
View article: Meal Timing-Based Dietary Patterns Are Associated With Glucose Regulation, Insulin Resistance, and Incretin Effect in Individuals at Risk for Type 2 Diabetes
Meal Timing-Based Dietary Patterns Are Associated With Glucose Regulation, Insulin Resistance, and Incretin Effect in Individuals at Risk for Type 2 Diabetes Open
Food is an external cue to entrain the circadian rhythm, and when and how to eat may be a crucial factor for glucose homeostasis. This study sought to quantify the impact of meal timing-based dietary habits on glucose homeostasis in predia…
View article: Effects of Habitual Sleep on Glucose Regulation in Individuals at Risk for Type 2 Diabetes
Effects of Habitual Sleep on Glucose Regulation in Individuals at Risk for Type 2 Diabetes Open
OBJECTIVES: This study sought to advance understanding of the impact of habitual sleep patterns on glucose regulation in individuals at risk for type 2 diabetes (T2D). METHODS: To achieve this aim, we examined associations between a compre…
View article: Vitamin D binding protein rs7041 genotype alters vitamin D metabolism in pregnant women
Vitamin D binding protein rs7041 genotype alters vitamin D metabolism in pregnant women Open
Research has identified reduced circulating 25–hydroxyvitamin D [25(OH)D] in individuals with the rs7041 (c.1296T>G) T allele in the vitamin D binding protein gene (GC); however, the effects of the T allele on vitamin D biomarkers during p…