Hezhao Zhang
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View article: Low-Dose Celastrol Modulates IL-6 Secretion to Overcome Resistance to Sorafenib in Hepatocellular Carcinoma Cells
Low-Dose Celastrol Modulates IL-6 Secretion to Overcome Resistance to Sorafenib in Hepatocellular Carcinoma Cells Open
Background: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality, with sorafenib being a key treatment option. However, resistance to sorafenib often develops, limiting its effectiveness. Celastrol, a phytochemical…
View article: Identification Of ANGPT2, FLT3, IGF1, and SPP1 associated with glycolysis and PI3K/Akt signaling pathway in hepatocellular carcinoma
Identification Of ANGPT2, FLT3, IGF1, and SPP1 associated with glycolysis and PI3K/Akt signaling pathway in hepatocellular carcinoma Open
This study identified four biomarkers linked to glycolysis and the PI3K/Akt signaling pathway in HCC, providing a theoretical foundation for HCC treatment.
View article: Beyond Hate Speech: NLP’s Challenges and Opportunities in Uncovering Dehumanizing Language
Beyond Hate Speech: NLP’s Challenges and Opportunities in Uncovering Dehumanizing Language Open
View article: Key genes and immune pathways in T-cell mediated rejection post-liver transplantation identified via integrated RNA-seq and machine learning
Key genes and immune pathways in T-cell mediated rejection post-liver transplantation identified via integrated RNA-seq and machine learning Open
View article: Identification of Key Genes and Exploration of Immune Activation Pathways in T-cell Mediated Rejection through Integrated Bulk and Single-Cell RNA-Seq Analysis with Machine Learning
Identification of Key Genes and Exploration of Immune Activation Pathways in T-cell Mediated Rejection through Integrated Bulk and Single-Cell RNA-Seq Analysis with Machine Learning Open
Liver transplantation is the definitive treatment for end-stage liver disease, yet T-cell mediated rejection (TCMR) remains a major challenge. This study aims to identify key genes associated with TCMR and their potential biological proces…
View article: EmoBox: Multilingual Multi-corpus Speech Emotion Recognition Toolkit and Benchmark
EmoBox: Multilingual Multi-corpus Speech Emotion Recognition Toolkit and Benchmark Open
Speech emotion recognition (SER) is an important part of human-computer interaction, receiving extensive attention from both industry and academia. However, the current research field of SER has long suffered from the following problems: 1…
View article: Analysis of endoscopic and pathological features of 6961 cases of gastric cancer
Analysis of endoscopic and pathological features of 6961 cases of gastric cancer Open
View article: RARRES1 inhibits hepatocellular carcinoma progression and increases its sensitivity to lenvatinib through interaction with SPINK2
RARRES1 inhibits hepatocellular carcinoma progression and increases its sensitivity to lenvatinib through interaction with SPINK2 Open
Background Lenvatinib is an oral small molecule inhibitor approved for treating patients with unresectable hepatocellular carcinoma (HCC) worldwide. Increasing cell sensitivity to lenvatinib would be an effective method of improving therap…
View article: Beyond Hate Speech: NLP's Challenges and Opportunities in Uncovering Dehumanizing Language
Beyond Hate Speech: NLP's Challenges and Opportunities in Uncovering Dehumanizing Language Open
Dehumanization, i.e., denying human qualities to individuals or groups, is a particularly harmful form of hate speech that can normalize violence against marginalized communities. Despite advances in NLP for detecting general hate speech, …
View article: Evaluation of the detection rate of high‑grade gastric intraepithelial neoplasia using linked color imaging and white light imaging
Evaluation of the detection rate of high‑grade gastric intraepithelial neoplasia using linked color imaging and white light imaging Open
As an endoscopic technology for the enhancement of images, linked color imaging (LCI) performs well when used for the early detection and diagnosis of gastrointestinal cancer. However, literature data are lacking for LCI in the detection o…
View article: Misinformation During the COVID-19 Outbreak in China: Cultural, Social and Political Entanglements
Misinformation During the COVID-19 Outbreak in China: Cultural, Social and Political Entanglements Open
Not only did COVID-19 give rise to a global pandemic, but also it resulted in an infodemic comprising misinformation, rumor, and propaganda. The consequences of this infodemic can erode public trust, impede the containment of the virus, an…