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View article: Dual role of Lyz2-positive myeloid cells in traumatic brain injury: acute anti-inflammatory effects vs. chronic neurological deterioration
Dual role of Lyz2-positive myeloid cells in traumatic brain injury: acute anti-inflammatory effects vs. chronic neurological deterioration Open
Introduction Neuroinflammation is a critical factor contributing to secondary brain injury following traumatic brain injury (TBI). This process engages diverse cell types within the central nervous system (CNS), including significant infil…
View article: Correction: Neuroprotective effects of the pannexin-1 channel inhibitor: probenecid on spinal cord injury in rats
Correction: Neuroprotective effects of the pannexin-1 channel inhibitor: probenecid on spinal cord injury in rats Open
[This corrects the article DOI: 10.3389/fnmol.2022.848185.].
View article: Farrerol confers neuroprotection in spinal cord injury by regulating macrophages/microglia polarization through the JAK2/STAT3 pathway
Farrerol confers neuroprotection in spinal cord injury by regulating macrophages/microglia polarization through the JAK2/STAT3 pathway Open
FAR promotes functional recovery after spinal cord injury by modulating macrophages/microglia M1/M2 polarization through JAK2/STAT3 pathway inhibition, thereby attenuating neuroinflammation and neuronal death. These findings provide novel …
View article: [Corrigendum] Morroniside protects SK‑N‑SH human neuroblastoma cells against H<sub>2</sub>O<sub>2</sub>‑induced damage
[Corrigendum] Morroniside protects SK‑N‑SH human neuroblastoma cells against H<sub>2</sub>O<sub>2</sub>‑induced damage Open
Following the publication of the above article, an interested reader drew to the authors' attention that, in Fig. 2D on p. 606, which showed the results of cellular morphological experiments, two pairs of data panels were overlapping, such…
View article: Ezrin, a novel marker of ependymal cells, can be used to demonstrate their proliferation regulation after spinal cord injury in mice
Ezrin, a novel marker of ependymal cells, can be used to demonstrate their proliferation regulation after spinal cord injury in mice Open
Ependymal cells (EpCs), as a potential stem cell niche, have gained interest for their potential in vivo stem cell therapy for spinal cord injury (SCI). Heterogeneity of spinal EpCs may contribute to differences in the ability of spinal Ep…
View article: [Role of Abelson interactor 2 in progression and prognosis of gastric cancer and its regulatory mechanisms].
[Role of Abelson interactor 2 in progression and prognosis of gastric cancer and its regulatory mechanisms]. Open
ABI2 is highly expressed in gastric cancer, which affects long-term prognosis of the patients, possible due to its regulatory effect on Wnt signaling to promote proliferation, migration and invasion of gastric cancer cells.
View article: The beneficial effect of α-lipoic acid on spinal cord injury repair in rats is mediated through inhibition of oxidative stress: A transcriptomic analysis
The beneficial effect of α-lipoic acid on spinal cord injury repair in rats is mediated through inhibition of oxidative stress: A transcriptomic analysis Open
Overall, the findings of this study confirmed the beneficial effects of ALA on recovery in SCI rats through transcriptome sequencing, behavioral, as well histology analyses.
View article: Mitophagy protects against silver nanoparticle–induced hepatotoxicity by inhibiting mitochondrial ROS and the NLRP3 inflammasome
Mitophagy protects against silver nanoparticle–induced hepatotoxicity by inhibiting mitochondrial ROS and the NLRP3 inflammasome Open
Silver nanoparticles (AgNPs) have wide clinical applications because of their excellent antibacterial properties; however, they can cause liver inflammation in animals. Macrophages are among the main cells mediating inflammation and are al…
View article: IL-11 ameliorates oxidative stress damage in neurons after spinal cord injury by activating the JAK/STAT signaling pathway
IL-11 ameliorates oxidative stress damage in neurons after spinal cord injury by activating the JAK/STAT signaling pathway Open
IL-11 inhibited oxidative stress-induced neuronal apoptosis at least in part by activating the JAK/STAT signaling pathway and further promoted the recovery of motor function. These findings suggest that IL-11 may be an effective target for…
View article: A Microsoft-Excel Template for Identifying Mouse Myeloid Cell Types in the Central Nervous System Based on Single-cell RNA Sequencing Data
A Microsoft-Excel Template for Identifying Mouse Myeloid Cell Types in the Central Nervous System Based on Single-cell RNA Sequencing Data Open
ficult problem.5][6] Morphology mainly relies on conventional staining to identify cells through characteristic morphology under the microscope, which is very subjective.Moreover, their morphologies are very similar under pathological cond…
View article: Peer Review #1 of "The polarization of microglia and infiltrated macrophages in the injured mice spinal cords: a dynamic analysis (v0.1)"
Peer Review #1 of "The polarization of microglia and infiltrated macrophages in the injured mice spinal cords: a dynamic analysis (v0.1)" Open
Background.Following spinal cord injury (SCI), a large number of peripheral monocytes infiltrate into the lesion area and differentiate into macrophages (Mø).These monocyte-derived Mø are very difficult to distinguish from the local activa…
View article: Peer Review #1 of "The polarization of microglia and infiltrated macrophages in the injured mice spinal cords: a dynamic analysis (v0.2)"
Peer Review #1 of "The polarization of microglia and infiltrated macrophages in the injured mice spinal cords: a dynamic analysis (v0.2)" Open
Background.Following spinal cord injury (SCI), a large number of peripheral monocytes infiltrate into the lesion area and differentiate into macrophages (Mø).These monocyte-derived Mø are very difficult to distinguish from the local activa…
View article: The polarization of microglia and infiltrated macrophages in the injured mice spinal cords: a dynamic analysis
The polarization of microglia and infiltrated macrophages in the injured mice spinal cords: a dynamic analysis Open
Background Following spinal cord injury (SCI), a large number of peripheral monocytes infiltrate into the lesion area and differentiate into macrophages (Mø). These monocyte-derived Mø are very difficult to distinguish from the local activ…
View article: Peer Review #2 of "The polarization of microglia and infiltrated macrophages in the injured mice spinal cords: a dynamic analysis (v0.1)"
Peer Review #2 of "The polarization of microglia and infiltrated macrophages in the injured mice spinal cords: a dynamic analysis (v0.1)" Open
Background.Following spinal cord injury (SCI), a large number of peripheral monocytes infiltrate into the lesion area and differentiate into macrophages (Mø).These monocyte-derived Mø are very difficult to distinguish from the local activa…
View article: Neuroprotective Effects of the Pannexin-1 Channel Inhibitor: Probenecid on Spinal Cord Injury in Rats
Neuroprotective Effects of the Pannexin-1 Channel Inhibitor: Probenecid on Spinal Cord Injury in Rats Open
Proinflammatory immune cell subsets constitute the majority in the local microenvironment after spinal cord injury (SCI), leading to secondary pathological injury. Previous studies have demonstrated that inflammasomes act as an important p…
View article: Atractylenolide III ameliorates spinal cord injury in rats by modulating microglial/macrophage polarization
Atractylenolide III ameliorates spinal cord injury in rats by modulating microglial/macrophage polarization Open
Background Inflammatory reactions induced by spinal cord injury (SCI) are essential for recovery after SCI. Atractylenolide III (ATL‐III) is a natural monomeric herbal bioactive compound that is mainly derived in Atractylodes macrocephala …
View article: Excel Template for Identifying Mouse Myeloid Cell-Types in the Central Nervous System Based on Single-Cell RNA Sequencing Data
Excel Template for Identifying Mouse Myeloid Cell-Types in the Central Nervous System Based on Single-Cell RNA Sequencing Data Open
Background The myeloid cells play a vital role in health and disease of central nervous system (CNS). However, how to clearly distinguish them is still a knotty problem. At present, single-cell RNA Sequencing (scRNA-Seq) technology can seq…
View article: Morroniside protects OLN-93 cells against H<sub>2</sub>O<sub>2</sub>-induced injury through the PI3K/Akt pathway-mediated antioxidative stress and antiapoptotic activities
Morroniside protects OLN-93 cells against H<sub>2</sub>O<sub>2</sub>-induced injury through the PI3K/Akt pathway-mediated antioxidative stress and antiapoptotic activities Open
Neurodegenerative disorders, including spinal cord injury (SCI), result in oxidative stress-induced cell damage. Morroniside (MR), a major active ingredient of the Chinese herb Shan Zhu Yu, has been shown to ameliorate oxidative stress and…
View article: VX-765 reduces neuroinflammation after spinal cord injury in mice
VX-765 reduces neuroinflammation after spinal cord injury in mice Open
Inflammation is a major cause of neuronal injury after spinal cord injury. We hypothesized that inhibiting caspase-1 activation may reduce neuroinflammation after spinal cord injury, thus producing a protective effect in the injured spinal…
View article: CRID3, a blocker of apoptosis associated speck like protein containing a card, ameliorates murine spinal cord injury by improving local immune microenvironment
CRID3, a blocker of apoptosis associated speck like protein containing a card, ameliorates murine spinal cord injury by improving local immune microenvironment Open
Background After spinal cord injury (SCI), destructive immune cell subsets are dominant in the local microenvironment, which are the important mechanism of injury. Studies have shown that inflammasomes play an important role in the inflamm…
View article: Effect of VX‑765 on the transcriptome profile of mice spinal cords with acute injury
Effect of VX‑765 on the transcriptome profile of mice spinal cords with acute injury Open
Previous studies have shown that caspase-1 plays an important role in the acute inflammatory response of spinal cord injury (SCI). VX‑765, a novel and irreversible caspase‑1 inhibitor, has been reported to effectively intervene in inflamma…
View article: CRID3 , a blocker of apoptosis associated speck like protein containing a card, ameliorates murine spinal cord injury by improving local immune microenvironment
CRID3 , a blocker of apoptosis associated speck like protein containing a card, ameliorates murine spinal cord injury by improving local immune microenvironment Open
Background: After spinal cord injury (SCI), destructive immune cell subsets are dominant in the local microenvironment, which are the important mechanism of injury. Studies have shown that inflammasomes play an important role in the inflam…
View article: Peer Review #2 of "A transcriptomic study of probenecid on injured spinal cords in mice (v0.2)"
Peer Review #2 of "A transcriptomic study of probenecid on injured spinal cords in mice (v0.2)" Open
Background.Recent studies have found that probenecid has neuroprotective and reparative effects on central nervous system (CNS) injuries.However, its effect on genome-wide transcription in acute spinal cord injury (SCI) remains unknown.In …
View article: Peer Review #3 of "A transcriptomic study of probenecid on injured spinal cords in mice (v0.1)"
Peer Review #3 of "A transcriptomic study of probenecid on injured spinal cords in mice (v0.1)" Open
Background.Recent studies have found that probenecid has neuroprotective and reparative effects on central nervous system (CNS) injuries.However, its effect on genome-wide transcription in acute spinal cord injury (SCI) remains unknown.In …
View article: Peer Review #1 of "A transcriptomic study of probenecid on injured spinal cords in mice (v0.2)"
Peer Review #1 of "A transcriptomic study of probenecid on injured spinal cords in mice (v0.2)" Open
Background.Recent studies have found that probenecid has neuroprotective and reparative effects on central nervous system (CNS) injuries.However, its effect on genome-wide transcription in acute spinal cord injury (SCI) remains unknown.In …
View article: Peer Review #2 of "A transcriptomic study of probenecid on injured spinal cords in mice (v0.1)"
Peer Review #2 of "A transcriptomic study of probenecid on injured spinal cords in mice (v0.1)" Open
Background.Recent studies have found that probenecid has neuroprotective and reparative effects on central nervous system (CNS) injuries.However, its effect on genome-wide transcription in acute spinal cord injury (SCI) remains unknown.In …
View article: Peer Review #1 of "A transcriptomic study of probenecid on injured spinal cords in mice (v0.1)"
Peer Review #1 of "A transcriptomic study of probenecid on injured spinal cords in mice (v0.1)" Open
Background.Recent studies have found that probenecid has neuroprotective and reparative effects on central nervous system (CNS) injuries.However, its effect on genome-wide transcription in acute spinal cord injury (SCI) remains unknown.In …
View article: A transcriptomic study of probenecid on injured spinal cords in mice
A transcriptomic study of probenecid on injured spinal cords in mice Open
Background Recent studies have found that probenecid has neuroprotective and reparative effects on central nervous system injuries. However, its effect on genome-wide transcription in acute spinal cord injury (SCI) remains unknown. In the …