Hicham Harnafi
YOU?
Author Swipe
View article: Argan Fruit Polyphenols Regulate Lipid Homeostasis, Prevent Liver Fat Accumulation, and Improve Antioxidant Defense in High-Calorie Diet Fed Mice: In Vivo Study and In Silico Prediction of Possible Underlying Mechanisms
Argan Fruit Polyphenols Regulate Lipid Homeostasis, Prevent Liver Fat Accumulation, and Improve Antioxidant Defense in High-Calorie Diet Fed Mice: In Vivo Study and In Silico Prediction of Possible Underlying Mechanisms Open
Background/Objectives: Argania spinosa L. Skeels is a Moroccan endemic plant widely used by the local population as folk medicine. This study aimed to investigate the effects of Argan fruit pulp on lipid metabolism disorders and liver stea…
View article: Combining In Vitro, In Vivo, and In Silico Approaches to Explore the Effect of Ceratonia siliqua and Ocimum basilicum Rich Phenolic Formula on Lipid Metabolism and Plasma Lipoprotein Oxidation in Mice Fed a High-Fat Diet: A Follow-Up Study
Combining In Vitro, In Vivo, and In Silico Approaches to Explore the Effect of Ceratonia siliqua and Ocimum basilicum Rich Phenolic Formula on Lipid Metabolism and Plasma Lipoprotein Oxidation in Mice Fed a High-Fat Diet: A Follow-Up Study Open
Background/Objectives: Hyperlipidemia is a serious risk factor for cardiovascular diseases and liver steatosis. In this work, we explored the effect of an herbal formula (CBF) containing immature Ceratonia siliqua pods and Ocimum basilicum…
View article: Effects of Cynara scolymus L. Bract Extract on Lipid Metabolism Disorders Through Modulation of HMG-CoA Reductase, Apo A-1, PCSK-9, p-AMPK, SREBP-2, and CYP2E1 Expression
Effects of Cynara scolymus L. Bract Extract on Lipid Metabolism Disorders Through Modulation of HMG-CoA Reductase, Apo A-1, PCSK-9, p-AMPK, SREBP-2, and CYP2E1 Expression Open
Background/Objectives: Hyperlipidemia is a major contributor to metabolic complications and tissue damage, leading to conditions such as liver steatosis, atherosclerosis, and obesity. This study aimed to investigate the effects of aqueous …
View article: Effect of Eriobotrya japonica L. (Chinese medicinal plant) on the regulation of lipid metabolism in atherosclerosis-induced mice and in HepG-2 cells
Effect of Eriobotrya japonica L. (Chinese medicinal plant) on the regulation of lipid metabolism in atherosclerosis-induced mice and in HepG-2 cells Open
Background: Hyperlipidemia and related metabolic disorders are the main cause of nonalcoholic fatty liver diseases, atherosclerosis and cardiovascular complications. Loquat (Eriobotrya japonica) leaf infusion is an innovative formula deriv…
View article: Metabolic Effects of Loquat Juice (Eriobotrya japonica Lindl Mkarkeb Variety) on Lipid Homeostasis, Liver Steatosis, and Oxidative Stress in Hyperlipidemic Mice Fed a High-Fat–High-Fructose Diet
Metabolic Effects of Loquat Juice (Eriobotrya japonica Lindl Mkarkeb Variety) on Lipid Homeostasis, Liver Steatosis, and Oxidative Stress in Hyperlipidemic Mice Fed a High-Fat–High-Fructose Diet Open
Background: Loquat fruit is consumed for its flavorful taste and a rich array of health-promoting compounds like phenolics, flavonoids, and carotenoids. This study aimed at the biochemical characterization of fresh juice from the Moroccan …
View article: Nutritional Composition and Effect of Loquat Fruit (<i>Eriobotrya japonica</i> L. var. <i>Navela</i>) on Lipid Metabolism and Liver Steatosis in High-Fat High-Sucrose Diet-Fed Mice
Nutritional Composition and Effect of Loquat Fruit (<i>Eriobotrya japonica</i> L. var. <i>Navela</i>) on Lipid Metabolism and Liver Steatosis in High-Fat High-Sucrose Diet-Fed Mice Open
Loquat (Eriobotrya japonica L.) is a popular fruit known for its sweet and slightly tangy flavor, which is widely consumed both fresh and in various processed forms. This study aimed to analyze the biochemical composition of loquat …
View article: The synergistic effect of the combination of <i>Ocimum basilicum</i> and <i>Ceratonia siliqua</i> on inflammation and oxidative stress
The synergistic effect of the combination of <i>Ocimum basilicum</i> and <i>Ceratonia siliqua</i> on inflammation and oxidative stress Open
The use of basil and carob in traditional medicine to address inflammation and oxidative stress reflects a long-standing practice rooted in folk medicine. This study was conducted to demonstrate the anti-inflammatory and antioxidant proper…
View article: Anti-Inflammatory Study and Phytochemical Characterization of <i>Zingiber officinale</i> Roscoe and <i>Citrus limon</i> L. Juices and Their Formulation
Anti-Inflammatory Study and Phytochemical Characterization of <i>Zingiber officinale</i> Roscoe and <i>Citrus limon</i> L. Juices and Their Formulation Open
Zingiber officinale and Citrus limon, well known as ginger and lemon, are two vegetals widely used in traditional medicine and the culinary field. The juices of the two vegetals were evaluated based on their inflammation, bot…
View article: Hypolipidemic Effect of Hemp Seed Oil from the Northern Morocco Endemic Beldiya Ecotype in a Mice Model: Comparison with Fenofibrate Hypolipidemic Drugs
Hypolipidemic Effect of Hemp Seed Oil from the Northern Morocco Endemic Beldiya Ecotype in a Mice Model: Comparison with Fenofibrate Hypolipidemic Drugs Open
Introduction. Cannabis sativa is a source of oil seeds for pharmaceutical, cosmetic, and food uses. Objective. The aim of this study is to evaluate the hypolipidemic effect of hemp seed oil (HSO) obtained from a local ecotype called “Beldi…
View article: Ginger (Zingiber officinale Roscoe), Lemon (Citrus limon L.) Juices as Preventive Agents from Chronic Liver Damage Induced by CCl4: A Biochemical and Histological Study
Ginger (Zingiber officinale Roscoe), Lemon (Citrus limon L.) Juices as Preventive Agents from Chronic Liver Damage Induced by CCl4: A Biochemical and Histological Study Open
Zingiber officinale Roscoe and Citrus limon L. are well known for their multi-use and for their pharmacological effect in the treatment of many illnesses. This study aims to investigate the chemical composition of the ginger and lemon juic…
View article: Toxicological Evaluation and Hepatoprotective Efficacy of Rosmarinic Acid-Rich Extract from Ocimum basilicum L.
Toxicological Evaluation and Hepatoprotective Efficacy of Rosmarinic Acid-Rich Extract from Ocimum basilicum L. Open
Exposure to carbon tetrachloride (CCl4) induces acute and chronic liver injuries as well as oxidative stress in rats. The present study was designed to evaluate the in vivo toxicity of rosmarinic acid-rich extract from Ocimum basilicum (RA…
View article: HPLC–DAD profiling of a phenolic extract from Moroccan sweet Basil and its application as oxidative stabilizer of sunflower oil
HPLC–DAD profiling of a phenolic extract from Moroccan sweet Basil and its application as oxidative stabilizer of sunflower oil Open
View article: Effect of polyphenol, flavonoid, and saponin fractions from Thymus atlanticus on acute and chronic hyperlipidemia in mice
Effect of polyphenol, flavonoid, and saponin fractions from Thymus atlanticus on acute and chronic hyperlipidemia in mice Open
View article: Phenolic-Rich Extract from Almond (Prunus dulcis ) Hulls Improves Lipid Metabolism in Triton WR-1339 and High-Fat Diet-Induced Hyperlipidemic Mice and Prevents Lipoprotein Oxidation: A Comparison with Fenofibrate and Butylated Hydroxyanisole
Phenolic-Rich Extract from Almond (Prunus dulcis ) Hulls Improves Lipid Metabolism in Triton WR-1339 and High-Fat Diet-Induced Hyperlipidemic Mice and Prevents Lipoprotein Oxidation: A Comparison with Fenofibrate and Butylated Hydroxyanisole Open
Hyperlipidemia and oxidative stress are risk factors for atherosclerosis. In this study, we investigated the hypolipidemic and anti-lipoprotein oxidation activities of polyphenol-rich extracts from almond hulls using Triton WR-1339 and hig…
View article: Effect of Aqueous Extract and Polyphenol Fraction Derived from <i>Thymus atlanticus</i> Leaves on Acute Hyperlipidemia in the Syrian Golden Hamsters
Effect of Aqueous Extract and Polyphenol Fraction Derived from <i>Thymus atlanticus</i> Leaves on Acute Hyperlipidemia in the Syrian Golden Hamsters Open
Thymus atlanticus , an endemic plant of Morocco, is traditionally used as a liniment or a drink to treat various diseases. However, there are few available scientific data regarding its biological effects. In this connection, the present s…
View article: <i>In Vitro</i>Antioxidant and<i>In Vivo</i>Lipid-Lowering Properties of<i>Zingiber officinale</i>Crude Aqueous Extract and Methanolic Fraction: A Follow-Up Study
<i>In Vitro</i>Antioxidant and<i>In Vivo</i>Lipid-Lowering Properties of<i>Zingiber officinale</i>Crude Aqueous Extract and Methanolic Fraction: A Follow-Up Study Open
Over the past decades, cardiovascular diseases have become the leading cause of death all over the world, and among these diseases there is atherosclerosis caused mainly by an increase in plasmatic cholesterol levels and by strong oxidatio…
View article: Acute toxicity and antiproliferative and procoagulant activities of fractions derived from Thymus satureioides of the Moroccan High Atlas
Acute toxicity and antiproliferative and procoagulant activities of fractions derived from Thymus satureioides of the Moroccan High Atlas Open
International audience
View article: Phenolic extract from Ocimum basilicum restores lipid metabolism in Triton WR-1339-induced hyperlipidemic mice and prevents lipoprotein-rich plasma oxidation
Phenolic extract from Ocimum basilicum restores lipid metabolism in Triton WR-1339-induced hyperlipidemic mice and prevents lipoprotein-rich plasma oxidation Open
In this study we investigated the hypolipidemic and anti-lipoprotein-oxidation activities of phenolic extract from sweet basil a popular culinary herb. The hypolipidemic activity was studied in mice model injected intraperitoneally with Tr…
View article: Anti-inflammatory, anticoagulant and antioxidant effects of aqueous extracts from Moroccan thyme varieties
Anti-inflammatory, anticoagulant and antioxidant effects of aqueous extracts from Moroccan thyme varieties Open
Objective: To evaluate the anti-inflammatory, anticoagulant and antioxidant effects of aqueous extracts of thyme varieties from Moroccan. Methods: The aqueous extracts of tree medicinal plants [Thymus atlanticus (T. atlanticus), Thymus sat…
View article: Investigation of antioxidant and antihemolytic properties of Thymus satureioides collected from Tafilalet Region, south-east of Morocco
Investigation of antioxidant and antihemolytic properties of Thymus satureioides collected from Tafilalet Region, south-east of Morocco Open
Objective:: To examine the antioxidant and antihemolytic activities of the aqueous extract, total polyphenols and total flavonoids of Thymus satureioides (T. satureioides). Methods:: This plant was collected from Tafilalet Region of Morocc…
View article: Olive Mill Waste Extracts: Polyphenols Content, Antioxidant, and Antimicrobial Activities
Olive Mill Waste Extracts: Polyphenols Content, Antioxidant, and Antimicrobial Activities Open
Natural polyphenols extracts have been usually associated with great bioactive properties. In this work, we investigated in vitro antioxidant and antimicrobial potential of the phenolic olive mill wastewater extracts (OWWE) and the olive c…