Hideaki Ijichi
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View article: ARID1A mutation drives gastric tumorigenesis via activating type 2 immune dominant microenvironment
ARID1A mutation drives gastric tumorigenesis via activating type 2 immune dominant microenvironment Open
View article: Development of a novel PIK3CA-mutated pancreatic tumor mouse model and evaluation of the therapeutic effects of a PI3K inhibitor
Development of a novel PIK3CA-mutated pancreatic tumor mouse model and evaluation of the therapeutic effects of a PI3K inhibitor Open
Pancreatic ductal adenocarcinoma (PDAC) is a fatal malignancy. Personalized medicine based on genetic mutations is required to improve its prognosis. The PI3K/AKT pathway plays a crucial role in cancer progression. While PI3K inhibitors ha…
View article: Predicting the risk of developing diabetes in steatotic liver disease using controlled attenuation parameter in a health checkup population
Predicting the risk of developing diabetes in steatotic liver disease using controlled attenuation parameter in a health checkup population Open
Introduction Excessive hepatic steatosis is linked to systemic metabolic disorders. We investigated the association between hepatic steatosis quantified by controlled attenuation parameter (CAP) and the development of type 2 diabetes melli…
View article: Duloxetine improves hyperosmia in mice with pancreatic cancer by increasing dopamine levels in the olfactory bulb
Duloxetine improves hyperosmia in mice with pancreatic cancer by increasing dopamine levels in the olfactory bulb Open
The mechanism and therapeutic insights regarding hyperosmia to food odors in patients with cancer are poorly understood. We therefore evaluated the mechanism and effect of duloxetine in KPPC (LSL-KrasG12D/+; Trp53flox/flox<…
View article: <i>Muc6</i> -expressing gastric isthmus progenitors contribute to regeneration and metaplasia supported by myeloid-mesenchymal interactions
<i>Muc6</i> -expressing gastric isthmus progenitors contribute to regeneration and metaplasia supported by myeloid-mesenchymal interactions Open
Summary Gastric mucosal homeostasis is maintained by tissue-resident stem and progenitor cells residing in the isthmus region. Following mucosal injury, surviving cells contribute to regeneration, coinciding with characteristic pathologica…
View article: P358: Impact of tumor histology on the number of positive axillary lymph nodes in sentinel lymph node-positive breast cancer
P358: Impact of tumor histology on the number of positive axillary lymph nodes in sentinel lymph node-positive breast cancer Open
View article: Relationship between oral hypofunction and medical expenditure in older adults in Japan
Relationship between oral hypofunction and medical expenditure in older adults in Japan Open
This study aimed to analyze the impact of poor oral function on medical expenditures among older adults. We diagnosed oral hypofunction based on dental data obtained from oral health examinations and examined its association with several a…
View article: WWP1 inhibition suppresses the proliferation of pancreatic cancer cells by regulating the PI3K-AKT pathway
WWP1 inhibition suppresses the proliferation of pancreatic cancer cells by regulating the PI3K-AKT pathway Open
View article: Factors correlated to oral frailty and number of remaining teeth among 80-year-old population in Japan
Factors correlated to oral frailty and number of remaining teeth among 80-year-old population in Japan Open
The main clinical implication of this study is that improving behaviors regarding oral healthcare among community-dwelling individuals may be an effective way to reduce oral frailty. Moreover, ≥ 20 remaining teeth in the 80-year-old popula…
View article: CC chemokine receptor 2 mediated regulation of macrophages is involved in pancreatic cancer progression in the tumor microenvironment
CC chemokine receptor 2 mediated regulation of macrophages is involved in pancreatic cancer progression in the tumor microenvironment Open
Objective: The interaction between pancreatic ductal adenocarcinoma (PDAC) cells and non-tumor cells is important in PDAC. In this study, we investigated the effects of CC chemokines in PDAC. Design: According to microarray data of cancer-…
View article: The role of <scp>DPYD</scp> and the effects of <scp>DPYD</scp> suppressor luteolin combined with 5‐<scp>FU</scp> in pancreatic cancer
The role of <span>DPYD</span> and the effects of <span>DPYD</span> suppressor luteolin combined with 5‐<span>FU</span> in pancreatic cancer Open
Background Despite advances in the treatment of cancer, pancreatic ductal adenocarcinoma (PDAC) remains highly lethal due to the lack of effective therapies. Our previous study showed that Luteolin (Lut), a flavonoid, suppressed pancreatoc…
View article: Targeting mutated KRAS in the first‐line therapy
Targeting mutated KRAS in the first‐line therapy Open
KRAS is one of the most frequently mutated oncogenes in cancer. 1 Codon 12, 13 and 61 mutations are frequently observed as the hot spot mutations in various cancers.Normally, KRAS protein functions as a molecular switch downstream of cell …
View article: Significance of Tumor Microenvironment for Regulating Pancreatic Cancer
Significance of Tumor Microenvironment for Regulating Pancreatic Cancer Open
Pancreatic cancer is the most lethal common cancer in the world [...]
View article: Supplementary Table 1 from Loss of Transforming Growth Factor Beta Type II Receptor Increases Aggressive Tumor Behavior and Reduces Survival in Lung Adenocarcinoma and Squamous Cell Carcinoma
Supplementary Table 1 from Loss of Transforming Growth Factor Beta Type II Receptor Increases Aggressive Tumor Behavior and Reduces Survival in Lung Adenocarcinoma and Squamous Cell Carcinoma Open
PDF file - 787K
View article: Supplementary Figure 1 from Loss of Transforming Growth Factor Beta Type II Receptor Increases Aggressive Tumor Behavior and Reduces Survival in Lung Adenocarcinoma and Squamous Cell Carcinoma
Supplementary Figure 1 from Loss of Transforming Growth Factor Beta Type II Receptor Increases Aggressive Tumor Behavior and Reduces Survival in Lung Adenocarcinoma and Squamous Cell Carcinoma Open
PDF file - 209K
View article: Supplementary Legends for Tables 1-2, Figures 1-6 from Loss of Transforming Growth Factor Beta Type II Receptor Increases Aggressive Tumor Behavior and Reduces Survival in Lung Adenocarcinoma and Squamous Cell Carcinoma
Supplementary Legends for Tables 1-2, Figures 1-6 from Loss of Transforming Growth Factor Beta Type II Receptor Increases Aggressive Tumor Behavior and Reduces Survival in Lung Adenocarcinoma and Squamous Cell Carcinoma Open
PDF file - 80K
View article: Supplementary Figure 2 from Loss of Transforming Growth Factor Beta Type II Receptor Increases Aggressive Tumor Behavior and Reduces Survival in Lung Adenocarcinoma and Squamous Cell Carcinoma
Supplementary Figure 2 from Loss of Transforming Growth Factor Beta Type II Receptor Increases Aggressive Tumor Behavior and Reduces Survival in Lung Adenocarcinoma and Squamous Cell Carcinoma Open
PDF file - 1.2MB
View article: Supplementary Figure 6 from Loss of Transforming Growth Factor Beta Type II Receptor Increases Aggressive Tumor Behavior and Reduces Survival in Lung Adenocarcinoma and Squamous Cell Carcinoma
Supplementary Figure 6 from Loss of Transforming Growth Factor Beta Type II Receptor Increases Aggressive Tumor Behavior and Reduces Survival in Lung Adenocarcinoma and Squamous Cell Carcinoma Open
PDF file - 8.6MB
View article: Supplementary Figure 5 from Loss of Transforming Growth Factor Beta Type II Receptor Increases Aggressive Tumor Behavior and Reduces Survival in Lung Adenocarcinoma and Squamous Cell Carcinoma
Supplementary Figure 5 from Loss of Transforming Growth Factor Beta Type II Receptor Increases Aggressive Tumor Behavior and Reduces Survival in Lung Adenocarcinoma and Squamous Cell Carcinoma Open
PDF file - 694K
View article: Supplementary Legends for Tables 1-2, Figures 1-6 from Loss of Transforming Growth Factor Beta Type II Receptor Increases Aggressive Tumor Behavior and Reduces Survival in Lung Adenocarcinoma and Squamous Cell Carcinoma
Supplementary Legends for Tables 1-2, Figures 1-6 from Loss of Transforming Growth Factor Beta Type II Receptor Increases Aggressive Tumor Behavior and Reduces Survival in Lung Adenocarcinoma and Squamous Cell Carcinoma Open
PDF file - 80K
View article: Supplementary Figure 2 from Loss of Transforming Growth Factor Beta Type II Receptor Increases Aggressive Tumor Behavior and Reduces Survival in Lung Adenocarcinoma and Squamous Cell Carcinoma
Supplementary Figure 2 from Loss of Transforming Growth Factor Beta Type II Receptor Increases Aggressive Tumor Behavior and Reduces Survival in Lung Adenocarcinoma and Squamous Cell Carcinoma Open
PDF file - 1.2MB
View article: Supplementary Figure 4 from Loss of Transforming Growth Factor Beta Type II Receptor Increases Aggressive Tumor Behavior and Reduces Survival in Lung Adenocarcinoma and Squamous Cell Carcinoma
Supplementary Figure 4 from Loss of Transforming Growth Factor Beta Type II Receptor Increases Aggressive Tumor Behavior and Reduces Survival in Lung Adenocarcinoma and Squamous Cell Carcinoma Open
PDF file - 7.4MB
View article: Supplementary Figure 3 from Loss of Transforming Growth Factor Beta Type II Receptor Increases Aggressive Tumor Behavior and Reduces Survival in Lung Adenocarcinoma and Squamous Cell Carcinoma
Supplementary Figure 3 from Loss of Transforming Growth Factor Beta Type II Receptor Increases Aggressive Tumor Behavior and Reduces Survival in Lung Adenocarcinoma and Squamous Cell Carcinoma Open
PDF file - 8.7MB
View article: Supplementary Figure 5 from Loss of Transforming Growth Factor Beta Type II Receptor Increases Aggressive Tumor Behavior and Reduces Survival in Lung Adenocarcinoma and Squamous Cell Carcinoma
Supplementary Figure 5 from Loss of Transforming Growth Factor Beta Type II Receptor Increases Aggressive Tumor Behavior and Reduces Survival in Lung Adenocarcinoma and Squamous Cell Carcinoma Open
PDF file - 694K
View article: Supplementary Figure 6 from Loss of Transforming Growth Factor Beta Type II Receptor Increases Aggressive Tumor Behavior and Reduces Survival in Lung Adenocarcinoma and Squamous Cell Carcinoma
Supplementary Figure 6 from Loss of Transforming Growth Factor Beta Type II Receptor Increases Aggressive Tumor Behavior and Reduces Survival in Lung Adenocarcinoma and Squamous Cell Carcinoma Open
PDF file - 8.6MB
View article: Supplementary Figure 3 from Loss of Transforming Growth Factor Beta Type II Receptor Increases Aggressive Tumor Behavior and Reduces Survival in Lung Adenocarcinoma and Squamous Cell Carcinoma
Supplementary Figure 3 from Loss of Transforming Growth Factor Beta Type II Receptor Increases Aggressive Tumor Behavior and Reduces Survival in Lung Adenocarcinoma and Squamous Cell Carcinoma Open
PDF file - 8.7MB
View article: Supplementary Table 2 from Loss of Transforming Growth Factor Beta Type II Receptor Increases Aggressive Tumor Behavior and Reduces Survival in Lung Adenocarcinoma and Squamous Cell Carcinoma
Supplementary Table 2 from Loss of Transforming Growth Factor Beta Type II Receptor Increases Aggressive Tumor Behavior and Reduces Survival in Lung Adenocarcinoma and Squamous Cell Carcinoma Open
PDF file - 449K
View article: Supplementary Figure 1 from Loss of Transforming Growth Factor Beta Type II Receptor Increases Aggressive Tumor Behavior and Reduces Survival in Lung Adenocarcinoma and Squamous Cell Carcinoma
Supplementary Figure 1 from Loss of Transforming Growth Factor Beta Type II Receptor Increases Aggressive Tumor Behavior and Reduces Survival in Lung Adenocarcinoma and Squamous Cell Carcinoma Open
PDF file - 209K
View article: Data from Loss of Transforming Growth Factor Beta Type II Receptor Increases Aggressive Tumor Behavior and Reduces Survival in Lung Adenocarcinoma and Squamous Cell Carcinoma
Data from Loss of Transforming Growth Factor Beta Type II Receptor Increases Aggressive Tumor Behavior and Reduces Survival in Lung Adenocarcinoma and Squamous Cell Carcinoma Open
Purpose: Lung adenocarcinoma and lung squamous cell carcinoma (SCC) are the most common non–small cell lung cancer (NSCLC) subtypes. This study was designed to determine whether reduced expression of TGFβ type II receptor (TGFβRI…
View article: Supplementary Figure 4 from Loss of Transforming Growth Factor Beta Type II Receptor Increases Aggressive Tumor Behavior and Reduces Survival in Lung Adenocarcinoma and Squamous Cell Carcinoma
Supplementary Figure 4 from Loss of Transforming Growth Factor Beta Type II Receptor Increases Aggressive Tumor Behavior and Reduces Survival in Lung Adenocarcinoma and Squamous Cell Carcinoma Open
PDF file - 7.4MB