Explanipedia

Rapid Bolus Inflow into the Esophagus in a Patient with a Tracheostomy after Surgical Treatment for Dysphagia Open

Kenjiro Kunieda, Takashi Shigematsu, Hideaki Kanazawa, Akiko Nomoto · 2025

This report describes a case in which a patient with an open tracheostomy, following surgery for severe dysphagia, acquired vacuum swallowing and exhibited rapid bolus inflow into the esophagus. A 39-year-old man with bulbar palsy caused b…

Real-World Patent Foramen Ovale Closure in Japan　― Results From 1-Year Follow-up of the Amplatzer<sup>TM</sup> PFO Occluder Japan Post-Marketing Surveillance Study ― Open

Teiji Akagi, Hidehiko Hara, Hideaki Kanazawa, Shigefumi Fukui, Yoichiro Hashimoto , et al. · 2025

Through 1 year of follow-up in this real-world Japanese study with 30% of patients aged >60 years, a high degree of closure was achieved with the Amplatzer^TMPFO Occluder, along with low rates of atrial fibrillation, ischemic str…

The Advancement in Coronary Physiology Open

Kazumasa Ikeda, Jun Yamashita, Kazuhiro Satomi, Hideaki Kanazawa · 2025

Ischemic heart disease (IHD) remains the leading global cause of mortality, underscoring the need for precise physiological assessments for accurate diagnosis and effective management. Both the epicardial coronary arteries and the coronary…

Metabolic changes of human induced pluripotent stem cell-derived cardiomyocytes and teratomas after transplantation Open

Y Soma, Shugo Tohyama, Akiko Kubo, Tomoteru Yamasaki, Noriko Kabasawa , et al. · 2024

Cardiac regenerative therapy using human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) has been applied in clinical settings. Herein, we aimed to investigate the in vivo metabolic profiles of hiPSC-CM grafts. RNA …

Real-World Patent Foramen Ovale (PFO) Closure in Japan　― 30-Day Clinical Outcomes From the Amplatzer<sup>TM</sup> PFO Occluder Japan Post-Marketing Surveillance Study ― Open

Teiji Akagi, Hidehiko Hara, Hideaki Kanazawa, Shigefumi Fukui, Yoichiro Hashimoto , et al. · 2024

In this real-world Japanese study with almost one-third of patients aged >60 years, PFO closure with the Amplatzer^TM PFO Occluder was performed successfully and safely, with a low incidence of procedure-related atrial arrhythmia…

Coronary Artery Bypass Grafting for a Young Female Patient With Chronic Active Epstein-Barr Virus Infection Open

Juri Iwata, Masaki Kodaira, Yoshikazu Kishino, Atsushi Anzai, Hideaki Kanazawa , et al. · 2024

Assessment of Ebstein Severity in a 28-year-old Male with Multiple Large Ostium Secundum Atrial Septal Defects Open

Masaki Kodaira, Shigeo Okuda, Naritaka Kimura, Hideaki Kanazawa, Hiroyuki Yamagishi , et al. · 2024

Scalable production of homogeneous cardiac organoids derived from human pluripotent stem cells Open

Taijun Moriwaki, Hidenori Tani, Kotaro Haga, Yuika Morita-Umei, Y Soma , et al. · 2023

Seamless and non-destructive monitoring of extracellular microRNAs during cardiac differentiation from human pluripotent stem cells Open

Otoya Sekine, Sayaka Kanaami, Kanako Masumoto, Yuki Aihara, Yuika Morita-Umei , et al. · 2023

Deep learning-based model detects atrial septal defects from electrocardiography: a cross-sectional multicenter hospital-based study Open

Kotaro Miura, Ryuichiro Yagi, Hiroshi Miyama, Mai Kimura, Hideaki Kanazawa , et al. · 2023

Intracardiac Echocardiography Guidance for Percutaneous Transcatheter Closure of Atrial Septal Defects　― Nationwide Registry Data Analysis ― Open

Yasuhiro Tanabe, Mitsuyoshi Takahara, Shun Kohsaka, Toshiro Shinke, Itaru Takamisawa , et al. · 2023

Percutaneous transcatheter ASD closure was as feasible under ICE as under TEE guidance. ICE guidance is used for less challenging cases in high-volume centers in Japan.

Deep Learning-Based Model Detects Atrial Septal Defectsfrom Electrocardiography: A Multicenter Study Open

Kotaro Miura, Shinichi Goto, Hiroshi Miyama, Mai Kimura, Hideaki Kanazawa , et al. · 2023

Upregulation of neuropeptide Y in cardiac sympathetic nerves induces stress (Takotsubo) cardiomyopathy Open

Takahide Arai, Hideaki Kanazawa, Kensuke Kimura, Masahito Munakata, Hiroyuki Yamakawa , et al. · 2022

Substantial emotional or physical stress may lead to an imbalance in the brain, resulting in stress cardiomyopathy (SC) and transient left ventricular (LV) apical ballooning. Even though these conditions are severe, their precise underlyin…

Impaired Left Atrial Function in Patients with Atrial Septal Defect and History of Atrial Fibrillation Open

Manabu Nitta, Makoto Kaneko, Sayuri Shimizu, Hideaki Kanazawa, Yuji Itabashi , et al. · 2022

In patients with atrial septal defect (ASD), atrial left-to-right shunting causes left atrial (LA) remodeling and dysfunction, leading to atrial fibrillation (AF). In adults with ASD and concomitant AF, LA function should be evaluated afte…

The plasticity of cardiac sympathetic nerves and its clinical implication in cardiovascular disease Open

Hideaki Kanazawa, Keiichi Fukuda · 2022

The heart is electrically and mechanically controlled by the autonomic nervous system, which consists of both the sympathetic and parasympathetic systems. It has been considered that the sympathetic and parasympathetic nerves regulate the …

Reduction of Atrial Septal Defect Size After Catheter Ablation for Atrial Tachyarrhythmia and Its Predictive Factors Open

Mai Kimura, Keitaro Shinada, Kotaro Miura, Jin Endo, Hikaru Tsuruta , et al. · 2022

The prevalence of atrial tachyarrhythmia is high in patients with atrial septal defect (ASD), and catheter ablation (CA) is often performed before percutaneous ASD closure. We aimed to clarify the effect of CA on the ASD size. We analysed …

Assessment of cardiac function in rat endovascular perforation model of subarachnoid hemorrhage; A model of subarachnoid hemorrhage-induced cardiac dysfunction Open

Masahito Munakata, Hideaki Kanazawa, Kensuke Kimura, Takahide Arai, Hiroaki Sukegawa , et al. · 2022

Although the association between cardiac dysfunction and subarachnoid hemorrhage (SAH) has been recognized, its precise underlying mechanism remains unknown. Furthermore, no suitable animal models are available to study this association. H…

Intracardiac echocardiography guidance for percutaneous transcatheter closure of atrial septal defects: A nationwide registry data analysis Open

Yasuhiro Tanabe, Mitsuyoshi Takahara, Shun Kohsaka, Toshiro Shinke, Itaru Takamisawa , et al. · 2022

The authors have withdrawn their manuscript because they decided to modify their analysis because of how the imaging devices are employed in the real-world practice in Japan. Instead of simply comparing ICE vs. TEE patients, they decided t…

Percutaneous Patent Foramen Ovale Closure in a Patient With Anomalous Aortic Origin of the Left Coronary Artery Open

Shiro Miura, Takehiro Yamashita, Hideaki Kanazawa, Hidehiko Hara, Jonathan M. Tobis · 2022

The anomalous aortic origin of the coronary artery is a rare congenital disease that occurs in approximately 0.7% of the general population, often causing sudden death with a high risk of anatomic features, such as a slit-like ostium or an…

Iatrogenic Atrial Septal Defect Requiring Transcatheter Closure Following Transcatheter Mitral Valve Repair Open

Yoichi Takaya, Teiji Akagi, Hidehiko Hara, Hideaki Kanazawa, Yuji Ikari , et al. · 2022

Transcatheter iASD closure was required in 1% of patients who underwent the MitraClip procedure. Many of these patients immediately underwent transcatheter iASD closure because of hypoxemia with right-to-left shunt or right-sided heart fai…

The Present State and Future Perspectives of Cardiac Regenerative Therapy Using Human Pluripotent Stem Cells Open

Y Soma, Yuika Morita, Yoshikazu Kishino, Hideaki Kanazawa, Keiichi Fukuda , et al. · 2021

The number of patients with heart failure (HF) is increasing with aging in our society worldwide. Patients with HF who are resistant to medication and device therapy are candidates for heart transplantation (HT). However, the shortage of d…

Efficacy of treat-and-repair strategy for atrial septal defect with pulmonary arterial hypertension Open

Yoichi Takaya, Teiji Akagi, Ichiro Sakamoto, Hideaki Kanazawa, Gaku Nakazawa , et al. · 2021

Objective Therapeutic strategies for atrial septal defect (ASD) with severe pulmonary arterial hypertension (PAH) are controversial. This study aimed to evaluate the efficacy of PAH-specific medications and subsequent transcatheter closure…

Cough-Inducing Method Using a Tartaric Acid Nebulizer for Patients with Silent Aspiration Open

Tomohisa Ohno, Naomi Tanaka, Mariko Fujimori, Keishi Okamoto, Satoe Hagiwara , et al. · 2021

Intramyocardial Transplantation of Human iPS Cell–Derived Cardiac Spheroids Improves Cardiac Function in Heart Failure Animals Open

Shinji Kawaguchi, Y Soma, Kazuaki Nakajima, Hideaki Kanazawa, Shugo Tohyama , et al. · 2021

The severe shortage of donor hearts hampered the cardiac transplantation to patients with advanced heart failure. Therefore, cardiac regenerative therapies are eagerly awaited as a substitution. Human induced pluripotent stem cells (hiPSCs…

Incoordination during the pharyngeal phase in severe dysphagia due to lateral medullary syndrome Open

Kenjiro Kunieda, Takafumi Sugi, Tomohisa Ohno, Akiko Nomoto, Takashi Shigematsu , et al. · 2021

One of the mechanisms of severe dysphagia due to lateral medullary syndrome may be a reversed pressure gradient caused by incoordination of pharyngeal contractility and UES opening during swallowing.

Tryptophan metabolism regulates proliferative capacity of human pluripotent stem cells Open

Shota Someya, Shugo Tohyama, K Kameda, Sho Tanosaki, Yuika Morita , et al. · 2021

Evaluation of a palatal lift prosthesis with a flexible lift in a lower cranial nerve palsy patient with dysphagia using high-resolution manometry: A case report Open

Akiko Nomoto, Tomohisa Ohno, Kenjiro Kunieda, Hideaki Kanazawa, Takashi Shigematsu , et al. · 2021

Patient Palatal lift prostheses (PLPs) are used for dysarthria caused by velopharyngeal incompetence (VPI) and improving hypernasal speech. In this case, we used a PLP with a flexible lift (f-PLP) in a patient with dysphagia associated wit…

Allogeneic Cardiospheres Delivered via Percutaneous Transendocardial Injection Increase Viable Myocardium, Decrease Scar Size, and Attenuate Cardiac Dilatation in Porcine Ischemic Cardiomyopathy Open

Kristine Yee, Konstantinos Malliaras, Hideaki Kanazawa, Eleni Tseliou, Ke Cheng , et al. · 2020

BackgroundEpicardial injection of heart-derived cell products is safe and effective post-myocardial infarction (MI), but clinically-translatable transendocardial injection has never been evaluated. We sought to assess the feasibility, safe…

Cellular Postconditioning: Allogeneic Cardiosphere-Derived Cells Reduce Infarct Size and Attenuate Microvascular Obstruction When Administered After Reperfusion in Pigs With Acute Myocardial Infarction Open

Hideaki Kanazawa, Eleni Tseliou, Konstantinos Malliaras, Kristine Yee, James Dawkins , et al. · 2020

Intracoronary (IC) delivery of cardiosphere-derived cells (CDCs) has been demonstrated to be safe and effective in porcine and human chronic myocardial infarction (MI). However, IC delivery of CDCs after reperfusion in acute MI has never b…

Incoordination during the pharyngeal phase in severe dysphagia due to lateral medullary syndrome Open

Kenjiro Kunieda, Takafumi Sugi, Tomohisa Ohno, Akiko Nomoto, Takashi Shigematsu , et al. · 2020

Incoordination during the pharyngeal phase in severe dysphagia due to lateral medullary syndromeRunning title: Severe dysphagia due to LMS

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