Hisataka Sabe
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View article: MitoNEET reduces the mitochondrial oxidative phosphorylation during epithelial-mesenchymal transition
MitoNEET reduces the mitochondrial oxidative phosphorylation during epithelial-mesenchymal transition Open
Mitochondrial functions range from catabolic to anabolic, which are tightly coordinated to meet cellular demands for proliferation and motility. MitoNEET is a mitochondrial outer membrane protein with a CDGSH domain and is involved in mito…
View article: p53 ensures the normal behavior and modification of G1/S-specific histone H3.1 in the nucleus
p53 ensures the normal behavior and modification of G1/S-specific histone H3.1 in the nucleus Open
H3.1 histone is predominantly synthesized and enters the nucleus during the G1/S phase of the cell cycle, as a new component of duplicating nucleosomes. Here, we found that p53 is necessary to secure the normal behavior and modification of…
View article: p53 secures the normal behavior of H3.1 histone in the nucleus by regulating nuclear phosphatidic acid and EZH2 during the G1/S phase
p53 secures the normal behavior of H3.1 histone in the nucleus by regulating nuclear phosphatidic acid and EZH2 during the G1/S phase Open
Histones are key molecules of epigenetic regulation and inheritance, and are thought to be chaperoned and transported into the nucleus appropriately prior to being integrated into nucleosomes. H3.1 histone is predominantly synthesized and …
View article: Data from Arid5a Promotes Immune Evasion by Augmenting Tryptophan Metabolism and Chemokine Expression
Data from Arid5a Promotes Immune Evasion by Augmenting Tryptophan Metabolism and Chemokine Expression Open
The acquisition of mesenchymal traits leads to immune evasion in various cancers, but the underlying molecular mechanisms remain unclear. In this study, we found that the expression levels of AT-rich interaction domain-containing protein 5…
View article: Supplementary Figures and Tables from Arid5a Promotes Immune Evasion by Augmenting Tryptophan Metabolism and Chemokine Expression
Supplementary Figures and Tables from Arid5a Promotes Immune Evasion by Augmenting Tryptophan Metabolism and Chemokine Expression Open
Supplementary Figures 1-8 and Tables 1-3
View article: Data from Arid5a Promotes Immune Evasion by Augmenting Tryptophan Metabolism and Chemokine Expression
Data from Arid5a Promotes Immune Evasion by Augmenting Tryptophan Metabolism and Chemokine Expression Open
The acquisition of mesenchymal traits leads to immune evasion in various cancers, but the underlying molecular mechanisms remain unclear. In this study, we found that the expression levels of AT-rich interaction domain-containing protein 5…
View article: Supplementary Figures and Tables from Arid5a Promotes Immune Evasion by Augmenting Tryptophan Metabolism and Chemokine Expression
Supplementary Figures and Tables from Arid5a Promotes Immune Evasion by Augmenting Tryptophan Metabolism and Chemokine Expression Open
Supplementary Figures 1-8 and Tables 1-3
View article: Enhanced mitochondrial oxidative metabolism in peripheral blood mononuclear cells is associated with fatty liver in obese young adults
Enhanced mitochondrial oxidative metabolism in peripheral blood mononuclear cells is associated with fatty liver in obese young adults Open
Systemic inflammation underlies the association between obesity and nonalcoholic fatty liver disease (NAFLD). Here, we investigated functional changes in leukocytes’ mitochondria in obese individuals and their associations with NAFLD. We a…
View article: Cross-disease communication between cancer and heart failure provides a rational approach to prevention and treatment of both diseases
Cross-disease communication between cancer and heart failure provides a rational approach to prevention and treatment of both diseases Open
Accumulating clinical data have demonstrated a clear positive association between cancer and cardiac disorders, particularly chronic heart failure (CHF). These two diseases can be mutual drivers of each other, and hence frequently co-occur…
View article: Succinyl-CoA-based energy metabolism dysfunction in chronic heart failure
Succinyl-CoA-based energy metabolism dysfunction in chronic heart failure Open
Heart failure (HF) is a leading cause of death and repeated hospitalizations and often involves cardiac mitochondrial dysfunction. However, the underlying mechanisms largely remain elusive. Here, using a mouse model in which myocardial inf…
View article: ARF6-AMAP1 pathway induces pancreatic cancer cells to express immunosuppressive chemokines
ARF6-AMAP1 pathway induces pancreatic cancer cells to express immunosuppressive chemokines Open
Aim: The tumor microenvironment (TME) of pancreatic ductal adenocarcinoma (PDAC) is highly immune suppressive with modest T-cell infiltration, and only rarely responds to immune checkpoint inhibition (ICI) therapy. Our aim was to clarify t…
View article: Succinyl-CoA-based energy metabolism dysfunctions in chronic heart failure
Succinyl-CoA-based energy metabolism dysfunctions in chronic heart failure Open
Heart failure (HF) is a leading cause of death and repeated hospitalizations1. HF progression generally involves mitochondrial dysfunction2-4. However, how mitochondria react to chronic HF remains unclear. Here, we show the molecular basis…
View article: Arid5a Promotes Immune Evasion by Augmenting Tryptophan Metabolism and Chemokine Expression
Arid5a Promotes Immune Evasion by Augmenting Tryptophan Metabolism and Chemokine Expression Open
The acquisition of mesenchymal traits leads to immune evasion in various cancers, but the underlying molecular mechanisms remain unclear. In this study, we found that the expression levels of AT-rich interaction domain-containing protein 5…
View article: Brain-Derived Neurotrophic Factor Improves Impaired Fatty Acid Oxidation Via the Activation of Adenosine Monophosphate-Activated Protein Kinase-ɑ – Proliferator-Activated Receptor-r Coactivator-1ɑ Signaling in Skeletal Muscle of Mice With Heart Failure
Brain-Derived Neurotrophic Factor Improves Impaired Fatty Acid Oxidation Via the Activation of Adenosine Monophosphate-Activated Protein Kinase-ɑ – Proliferator-Activated Receptor-r Coactivator-1ɑ Signaling in Skeletal Muscle of Mice With Heart Failure Open
Background: We recently reported that treatment with rhBDNF (recombinant human brain-derived neurotrophic factor) improved the reduced exercise capacity of mice with heart failure (HF) after myocardial infarction (MI). Since BDNF is report…
View article: High expression of AMAP1, an ARF6 effector, is associated with elevated levels of PD-L1 and fibrosis of pancreatic cancer
High expression of AMAP1, an ARF6 effector, is associated with elevated levels of PD-L1 and fibrosis of pancreatic cancer Open
Background Not merely the onset of immune evasion, but other factors, such as acidosis and fibrosis, are also major barriers in cancer therapeutics. Dense fibrosis is a hallmark of pancreatic ductal carcinoma (PDAC), in which hyperactivati…
View article: Abnormalities of Skeletal Muscle, Adipocyte Tissue, and Lipid Metabolism in Heart Failure: Practical Therapeutic Targets
Abnormalities of Skeletal Muscle, Adipocyte Tissue, and Lipid Metabolism in Heart Failure: Practical Therapeutic Targets Open
Chronic diseases, including heart failure (HF), are often accompanied with skeletal muscle abnormalities in both quality and quantity, which are the major cause of impairment of the activities of daily living and quality of life. We have s…
View article: ARF6 and AMAP1 are major targets of <i>KRAS</i> and <i>TP53</i> mutations to promote invasion, PD-L1 dynamics, and immune evasion of pancreatic cancer
ARF6 and AMAP1 are major targets of <i>KRAS</i> and <i>TP53</i> mutations to promote invasion, PD-L1 dynamics, and immune evasion of pancreatic cancer Open
Significance Pancreatic ductal carcinomas (PDACs) have been extensively studied regarding their genomic alterations, microenvironmental intercommunication, and metabolic reprogramming. However, identification of the protein machinery of tu…
View article: Statins may have double-edged effects in patients with lung adenocarcinoma after lung resection
Statins may have double-edged effects in patients with lung adenocarcinoma after lung resection Open
Shigeto Nishikawa,1 Toshi Menju,1 Koji Takahashi,1 Ryo Miyata,1 Toyofumi Fengshi Chen-Yoshikawa,1 Makoto Sonobe,1 Akihiko Yoshizawa,2 Hisataka Sabe,3 Tosiya Sato,4 Hiroshi Date11Department of Thoracic Surgery, Graduate School of Medicine, …
View article: <p>Statins may have double-edged effects in patients with lung adenocarcinoma after lung resection</p>
Statins may have double-edged effects in patients with lung adenocarcinoma after lung resection Open
Purpose: The epithelial to mesenchymal transition (EMT) is pivotal for driving metastasis and recurrence in lung cancer. Some in vitro reports have shown that statins suppress EMT by inactivating mutant p53 functions. Several clinical tria…