Hidehiko Kawai
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View article: Fibrosis in Asymptomatic Steatotic Liver Disease With Normal Alanine Aminotransferase: Analysis of 2448 Health Check‐Up Cohort by Ultrasound Attenuation Imaging and Shear Wave Elastography
Fibrosis in Asymptomatic Steatotic Liver Disease With Normal Alanine Aminotransferase: Analysis of 2448 Health Check‐Up Cohort by Ultrasound Attenuation Imaging and Shear Wave Elastography Open
Background and Aim Steatotic liver disease (SLD) is now the most common chronic liver disease, with the potential to progress to cirrhosis and hepatocellular carcinoma (HCC). Although alanine aminotransferase (ALT) is commonly used for scr…
View article: Visualization of oxidized guanine nucleotides accumulation in living cells with split MutT
Visualization of oxidized guanine nucleotides accumulation in living cells with split MutT Open
Cancer cells produce vast quantities of reactive oxygen species, leading to the accumulation of toxic nucleotides as 8-oxo-7,8-dihydro-2′-deoxyguanosine 5′-triphosphate (8-oxo-dGTP). The human MTH1 protein catalyzes the hydrolysis of 8-oxo…
View article: Systematic mutagenesis assay promotes comprehension of the strand-bias laws for mutations induced by oxidative DNA damage
Systematic mutagenesis assay promotes comprehension of the strand-bias laws for mutations induced by oxidative DNA damage Open
We have recently developed an efficient and sensitive method for analyzing mutations caused by various environmental and endogenous factors which utilizes nucleotide-barcoded supF shuttle vector libraries with a multiplexed NGS assay, refe…
View article: Correction of substitution, deletion, and insertion mutations by 5′-tailed duplexes
Correction of substitution, deletion, and insertion mutations by 5′-tailed duplexes Open
View article: Data from Radiation-Induced Myofibroblasts Promote Tumor Growth via Mitochondrial ROS–Activated TGFβ Signaling
Data from Radiation-Induced Myofibroblasts Promote Tumor Growth via Mitochondrial ROS–Activated TGFβ Signaling Open
Fibroblasts are a key stromal cell in the tumor microenvironment (TME) and promote tumor growth via release of various growth factors. Stromal fibroblasts in cancer, called cancer-associated fibroblasts (CAF), are related to myofibroblasts…
View article: Supplemental Figure Legends from Radiation-Induced Myofibroblasts Promote Tumor Growth via Mitochondrial ROS–Activated TGFβ Signaling
Supplemental Figure Legends from Radiation-Induced Myofibroblasts Promote Tumor Growth via Mitochondrial ROS–Activated TGFβ Signaling Open
S1. The percentage of TIG-3 and MRC-5 cells with alpha-SMA staining exposed to indicated doses is shown in the graph. S2. Tumor volumes of HeLa, HeLa+MRC-5 0FR tumors, HeLa+MRC-5 0.05FR tumors, HeLa+MRC-5 NAC 0FR tumors, and HeLa+MRC-5 0.0…
View article: Figure S1 from Radiation-Induced Myofibroblasts Promote Tumor Growth via Mitochondrial ROS–Activated TGFβ Signaling
Figure S1 from Radiation-Induced Myofibroblasts Promote Tumor Growth via Mitochondrial ROS–Activated TGFβ Signaling Open
Induction of alpha-SMA after acute single radiation
View article: Data from Radiation-Induced Myofibroblasts Promote Tumor Growth via Mitochondrial ROS–Activated TGFβ Signaling
Data from Radiation-Induced Myofibroblasts Promote Tumor Growth via Mitochondrial ROS–Activated TGFβ Signaling Open
Fibroblasts are a key stromal cell in the tumor microenvironment (TME) and promote tumor growth via release of various growth factors. Stromal fibroblasts in cancer, called cancer-associated fibroblasts (CAF), are related to myofibroblasts…
View article: FIgure S2 from Radiation-Induced Myofibroblasts Promote Tumor Growth via Mitochondrial ROS–Activated TGFβ Signaling
FIgure S2 from Radiation-Induced Myofibroblasts Promote Tumor Growth via Mitochondrial ROS–Activated TGFβ Signaling Open
Individual tumor measurements data
View article: FIgure S2 from Radiation-Induced Myofibroblasts Promote Tumor Growth via Mitochondrial ROS–Activated TGFβ Signaling
FIgure S2 from Radiation-Induced Myofibroblasts Promote Tumor Growth via Mitochondrial ROS–Activated TGFβ Signaling Open
Individual tumor measurements data
View article: Supplemental Figure Legends from Radiation-Induced Myofibroblasts Promote Tumor Growth via Mitochondrial ROS–Activated TGFβ Signaling
Supplemental Figure Legends from Radiation-Induced Myofibroblasts Promote Tumor Growth via Mitochondrial ROS–Activated TGFβ Signaling Open
S1. The percentage of TIG-3 and MRC-5 cells with alpha-SMA staining exposed to indicated doses is shown in the graph. S2. Tumor volumes of HeLa, HeLa+MRC-5 0FR tumors, HeLa+MRC-5 0.05FR tumors, HeLa+MRC-5 NAC 0FR tumors, and HeLa+MRC-5 0.0…
View article: Figure S1 from Radiation-Induced Myofibroblasts Promote Tumor Growth via Mitochondrial ROS–Activated TGFβ Signaling
Figure S1 from Radiation-Induced Myofibroblasts Promote Tumor Growth via Mitochondrial ROS–Activated TGFβ Signaling Open
Induction of alpha-SMA after acute single radiation
View article: Supplementary Data 2 from Periostin Promotes Invasion and Anchorage-Independent Growth in the Metastatic Process of Head and Neck Cancer
Supplementary Data 2 from Periostin Promotes Invasion and Anchorage-Independent Growth in the Metastatic Process of Head and Neck Cancer Open
Supplementary Data 2 from Periostin Promotes Invasion and Anchorage-Independent Growth in the Metastatic Process of Head and Neck Cancer
View article: Supplementary Data 2 from Periostin Promotes Invasion and Anchorage-Independent Growth in the Metastatic Process of Head and Neck Cancer
Supplementary Data 2 from Periostin Promotes Invasion and Anchorage-Independent Growth in the Metastatic Process of Head and Neck Cancer Open
Supplementary Data 2 from Periostin Promotes Invasion and Anchorage-Independent Growth in the Metastatic Process of Head and Neck Cancer
View article: Supplementary Data 1 from Periostin Promotes Invasion and Anchorage-Independent Growth in the Metastatic Process of Head and Neck Cancer
Supplementary Data 1 from Periostin Promotes Invasion and Anchorage-Independent Growth in the Metastatic Process of Head and Neck Cancer Open
Supplementary Data 1 from Periostin Promotes Invasion and Anchorage-Independent Growth in the Metastatic Process of Head and Neck Cancer
View article: Supplementary Figure 1 from RING Domain–Mediated Interaction Is a Requirement for MDM2's E3 Ligase Activity
Supplementary Figure 1 from RING Domain–Mediated Interaction Is a Requirement for MDM2's E3 Ligase Activity Open
Supplementary Figure 1 from RING Domain–Mediated Interaction Is a Requirement for MDM2's E3 Ligase Activity
View article: Data from Periostin Promotes Invasion and Anchorage-Independent Growth in the Metastatic Process of Head and Neck Cancer
Data from Periostin Promotes Invasion and Anchorage-Independent Growth in the Metastatic Process of Head and Neck Cancer Open
Head and neck squamous cell carcinoma (HNSCC) is one of the most common types of human cancer. Typically, HNSCC cells show persistent invasion that frequently leads to local recurrence and distant lymphatic metastasis. However, molecular m…
View article: Supplementary Figure 1 from RING Domain–Mediated Interaction Is a Requirement for MDM2's E3 Ligase Activity
Supplementary Figure 1 from RING Domain–Mediated Interaction Is a Requirement for MDM2's E3 Ligase Activity Open
Supplementary Figure 1 from RING Domain–Mediated Interaction Is a Requirement for MDM2's E3 Ligase Activity
View article: Data from RING Domain–Mediated Interaction Is a Requirement for MDM2's E3 Ligase Activity
Data from RING Domain–Mediated Interaction Is a Requirement for MDM2's E3 Ligase Activity Open
The RING domain of MDM2 that is essential for its E3 ligase activity mediates binding to itself and its structural homologue MDMX. Whereas it has been reported that RING domain interactions are critical, it is not well understood how they …
View article: Data from RING Domain–Mediated Interaction Is a Requirement for MDM2's E3 Ligase Activity
Data from RING Domain–Mediated Interaction Is a Requirement for MDM2's E3 Ligase Activity Open
The RING domain of MDM2 that is essential for its E3 ligase activity mediates binding to itself and its structural homologue MDMX. Whereas it has been reported that RING domain interactions are critical, it is not well understood how they …
View article: Data from Periostin Promotes Invasion and Anchorage-Independent Growth in the Metastatic Process of Head and Neck Cancer
Data from Periostin Promotes Invasion and Anchorage-Independent Growth in the Metastatic Process of Head and Neck Cancer Open
Head and neck squamous cell carcinoma (HNSCC) is one of the most common types of human cancer. Typically, HNSCC cells show persistent invasion that frequently leads to local recurrence and distant lymphatic metastasis. However, molecular m…
View article: Supplementary Data 1 from Periostin Promotes Invasion and Anchorage-Independent Growth in the Metastatic Process of Head and Neck Cancer
Supplementary Data 1 from Periostin Promotes Invasion and Anchorage-Independent Growth in the Metastatic Process of Head and Neck Cancer Open
Supplementary Data 1 from Periostin Promotes Invasion and Anchorage-Independent Growth in the Metastatic Process of Head and Neck Cancer
View article: Methylmercury Decreases AMPA Receptor Subunit GluA2 Levels in Cultured Rat Cortical Neurons
Methylmercury Decreases AMPA Receptor Subunit GluA2 Levels in Cultured Rat Cortical Neurons Open
Methylmercury (MeHg) is a well-known environmental pollutant that has harmful effects on the central nervous systems of humans and animals. The molecular mechanisms of MeHg-induced neurotoxicity at low concentrations are not fully understo…
View article: Hypertension and diabetes mellitus are associated with high FIB-4 index in a health checkup examination cohort without known liver disease
Hypertension and diabetes mellitus are associated with high FIB-4 index in a health checkup examination cohort without known liver disease Open
View article: DDX41 coordinates RNA splicing and transcriptional elongation to prevent DNA replication stress in hematopoietic cells
DDX41 coordinates RNA splicing and transcriptional elongation to prevent DNA replication stress in hematopoietic cells Open
View article: Development of a versatile high-throughput mutagenesis assay with multiplexed short-read NGS using DNA-barcoded supF shuttle vector library amplified in E. coli
Development of a versatile high-throughput mutagenesis assay with multiplexed short-read NGS using DNA-barcoded supF shuttle vector library amplified in E. coli Open
A forward mutagenesis assay using the supF gene has been widely employed for the last several decades in studies addressing mutation frequencies and mutation spectra associated with various intrinsic and environmental mutagens. In this stu…
View article: Author response: Development of a versatile high-throughput mutagenesis assay with multiplexed short-read NGS using DNA-barcoded supF shuttle vector library amplified in E. coli
Author response: Development of a versatile high-throughput mutagenesis assay with multiplexed short-read NGS using DNA-barcoded supF shuttle vector library amplified in E. coli Open
View article: DDX41 coordinates RNA splicing and transcriptional elongation to prevent DNA replication stress in hematopoietic cells
DDX41 coordinates RNA splicing and transcriptional elongation to prevent DNA replication stress in hematopoietic cells Open
Myeloid malignancies with DDX41 mutations are often associated with bone marrow failure and cytopenia before overt disease manifestation. However, the mechanisms underlying these specific conditions remain elusive. Here, we demonstrate tha…
View article: RFWD3 and translesion DNA polymerases contribute to PCNA modification–dependent DNA damage tolerance
RFWD3 and translesion DNA polymerases contribute to PCNA modification–dependent DNA damage tolerance Open
DNA damage tolerance pathways are regulated by proliferating cell nuclear antigen (PCNA) modifications at lysine 164. Translesion DNA synthesis by DNA polymerase η (Polη) is well studied, but less is known about Polη-independent mechanisms…
View article: Development of a versatile high-throughput mutagenesis assay with multiplexed short read NGS using DNA-barcoded <i>supF</i> shuttle vector library amplified in non-SOS <i>E. coli</i>
Development of a versatile high-throughput mutagenesis assay with multiplexed short read NGS using DNA-barcoded <i>supF</i> shuttle vector library amplified in non-SOS <i>E. coli</i> Open
A forward mutagenesis assay using the supF gene has been widely employed for the last several decades in studies addressing mutation frequencies and mutation spectra associated with various intrinsic and environmental mutagens. In this stu…