Hidehiro Iida
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View article: Abnormal perinidal cerebral metabolism is associated with symptoms in brain arteriovenous malformation: New insights by a novel approach using oxygen-15 labelled tracers and PET
Abnormal perinidal cerebral metabolism is associated with symptoms in brain arteriovenous malformation: New insights by a novel approach using oxygen-15 labelled tracers and PET Open
The mechanisms underlying neurological symptoms, including epilepsy, in unruptured brain arteriovenous malformations (bAVM) remain to be elucidated. The dual-tracer basis function method (DBFM) with single-scan dual-tracer ( 15 O 2 and C 1…
View article: Automated Long Axial Field of View PET Image Processing and Kinetic Modelling with the TurBO Toolbox
Automated Long Axial Field of View PET Image Processing and Kinetic Modelling with the TurBO Toolbox Open
Long axial field of view (LAFOV) PET imaging requires a high level of automation and standardization, as the large number of target tissues increases the manual workload significantly. We introduce an automated analysis pipeline (TurBO, Tu…
View article: Cerebral Hemodynamic Impairment and Cognitive Dysfunction in <i>APOE4</i> Carriers With Asymptomatic Carotid Artery Stenosis/Occlusion
Cerebral Hemodynamic Impairment and Cognitive Dysfunction in <i>APOE4</i> Carriers With Asymptomatic Carotid Artery Stenosis/Occlusion Open
Background Our previous preclinical study demonstrated that APOE4 ‐targeted replacement mice exhibit more severe cerebral hypoperfusion and cognitive impairment than APOE3 ‐targeted replacement mice with carotid artery stenosis due to neur…
View article: Optimal Phosphate Concentration for Growth and Normal Functioning of Marine Anammox Bacteria, <i>Candidatus</i> Scalindua sp.
Optimal Phosphate Concentration for Growth and Normal Functioning of Marine Anammox Bacteria, <i>Candidatus</i> Scalindua sp. Open
The anammox process using marine anammox bacteria is a promising nitrogen removal process for recirculating aquaculture system wastewater. Marine anammox bacteria are typically found in oxygen-deficient zones and coastal areas under low ph…
View article: Spatial and temporal tracking of multi-layered cells sheet using reporter gene imaging with human sodium iodide symporter: a preclinical study using a rat model of myocardial infarction
Spatial and temporal tracking of multi-layered cells sheet using reporter gene imaging with human sodium iodide symporter: a preclinical study using a rat model of myocardial infarction Open
Purpose This study aimed to evaluate a novel technique for cell tracking by visualising the activity of the human sodium/iodide symporter (hNIS) after transplantation of hNIS-expressing multilayered cell sheets in a rat model of chronic my…
View article: Comparative analysis of peri-nidal cerebral blood flow and metabolism using a novel quantitative <sup>15</sup>O-PET method in patients with arteriovenous malformations
Comparative analysis of peri-nidal cerebral blood flow and metabolism using a novel quantitative <sup>15</sup>O-PET method in patients with arteriovenous malformations Open
To effectively treat cerebral arteriovenous malformations (AVMs), peri-nidal flow regulation and metabolic status must be understood. In this study, we used 15 O-oxygen positron emission tomography (PET) post-processing analysis to investi…
View article: REsveratrol for VAscular cognitive impairment investigating cerebral Metabolism and Perfusion (REVAMP trial): a study protocol for a randomized, double-blind, placebo-controlled trial
REsveratrol for VAscular cognitive impairment investigating cerebral Metabolism and Perfusion (REVAMP trial): a study protocol for a randomized, double-blind, placebo-controlled trial Open
Background Carotid artery stenosis or occlusion (CASO) is a major cause of vascular cognitive impairment (VCI). There is currently no effective treatment for VCI induced by CASO. Resveratrol, a type of polyphenol, improves cognitive perfor…
View article: Long-Term Resveratrol Intake for Cognitive and Cerebral Blood Flow Impairment in Carotid Artery Stenosis/Occlusion
Long-Term Resveratrol Intake for Cognitive and Cerebral Blood Flow Impairment in Carotid Artery Stenosis/Occlusion Open
Background and Purpose Carotid artery stenosis or occlusion (CASO) is a causative disease of vascular cognitive impairment (VCI) attributed to cerebral hypoperfusion, even without the development of symptomatic ischemic stroke. Preclinical…
View article: Small animal PET with spontaneous inhalation of <sup>15</sup>O-labelled oxygen gases: Longitudinal assessment of cerebral oxygen metabolism in a rat model of neonatal hypoxic-ischaemic encephalopathy
Small animal PET with spontaneous inhalation of <sup>15</sup>O-labelled oxygen gases: Longitudinal assessment of cerebral oxygen metabolism in a rat model of neonatal hypoxic-ischaemic encephalopathy Open
Perinatal hypoxic-ischaemic encephalopathy (HIE) is the leading cause of irreversible brain damage resulting in serious neurological dysfunction among neonates. We evaluated the feasibility of positron emission tomography (PET) methodology…
View article: Renal Cortical Glucose Uptake Is Decreased in Insulin Resistance and Correlates Inversely With Serum Free-fatty Acids
Renal Cortical Glucose Uptake Is Decreased in Insulin Resistance and Correlates Inversely With Serum Free-fatty Acids Open
Context Studies on human renal metabolism are scanty. Nowadays, functional imaging allows the characterization of renal metabolism in a noninvasive manner. We have recently demonstrated that fluorodeoxyglucose F18 (18F FDG) positron emissi…
View article: Quantitative Perfusion Imaging with Total-Body PET
Quantitative Perfusion Imaging with Total-Body PET Open
Recently, PET systems with a long axial field of view have become the current state of the art. Total-body PET scanners enable unique possibilities for scientific research and clinical diagnostics, but this new technology also raises numer…
View article: Evaluation of renal glucose uptake with [18F]FDG-PET: Methodological advancements and metabolic outcomes
Evaluation of renal glucose uptake with [18F]FDG-PET: Methodological advancements and metabolic outcomes Open
The data show for the first time that [18F]FDG-PET can still provide relevant physiological information on regional renal glucose uptake on the condition that [18F]FDG uptake is corrected for tubular radioactivity.
View article: Impaired neuronal integrity in traumatic brain injury detected by <sup>123</sup>I-iomazenil single photon emission computed tomography and MRI
Impaired neuronal integrity in traumatic brain injury detected by <sup>123</sup>I-iomazenil single photon emission computed tomography and MRI Open
This study was aiming at investigating the extent of neuronal damage in cases of traumatic brain injury (TBI) with diffuse axonal injury (DAI) using 123 I-iomazenil(IMZ) SPECT and MRI. We compared the findings in 31 patients with TBI witho…
View article: Evaluation of [18F]F-DPA PET for Detecting Microglial Activation in the Spinal Cord of a Rat Model of Neuropathic Pain
Evaluation of [18F]F-DPA PET for Detecting Microglial Activation in the Spinal Cord of a Rat Model of Neuropathic Pain Open
View article: Correction to: Brown adipose tissue fat‑fraction is associated with skeletal muscle adiposity
Correction to: Brown adipose tissue fat‑fraction is associated with skeletal muscle adiposity Open
View article: Assessment of a digital and an analog PET/CT system for accurate myocardial perfusion imaging with a flow phantom
Assessment of a digital and an analog PET/CT system for accurate myocardial perfusion imaging with a flow phantom Open
View article: A Noninvasive Method for Quantifying Cerebral Metabolic Rate of Oxygen by Hybrid PET/MRI: Validation in a Porcine Model
A Noninvasive Method for Quantifying Cerebral Metabolic Rate of Oxygen by Hybrid PET/MRI: Validation in a Porcine Model Open
The gold standard for imaging the cerebral metabolic rate of oxygen (CMRO2) is positron emission tomography (PET); however, it is an invasive and complex procedure that also requires correction for recirculating 15O-H…
View article: The relationship between postoperative muscle mass loss rate and nutritional status after pancreatectomy
The relationship between postoperative muscle mass loss rate and nutritional status after pancreatectomy Open
View article: Intravenously delivered multilineage-differentiating stress enduring cells dampen excessive glutamate metabolism and microglial activation in experimental perinatal hypoxic ischemic encephalopathy
Intravenously delivered multilineage-differentiating stress enduring cells dampen excessive glutamate metabolism and microglial activation in experimental perinatal hypoxic ischemic encephalopathy Open
Perinatal hypoxic ischemic encephalopathy (HIE) results in serious neurological dysfunction and mortality. Clinical trials of multilineage-differentiating stress enduring cells (Muse cells) have commenced in stroke using intravenous delive…
View article: Consensus Recommendations on the Use of<sup>18</sup>F-FDG PET/CT in Lung Disease
Consensus Recommendations on the Use of<sup>18</sup>F-FDG PET/CT in Lung Disease Open
PET with 18F-FDG has been increasingly applied, predominantly in the research setting, to study drug effects and pulmonary biology and to monitor disease progression and treatment outcomes in lung diseases that interfere with ga…
View article: Magnetic Resonance-Based Attenuation Correction and Scatter Correction in Neurological Positron Emission Tomography/Magnetic Resonance Imaging—Current Status With Emerging Applications
Magnetic Resonance-Based Attenuation Correction and Scatter Correction in Neurological Positron Emission Tomography/Magnetic Resonance Imaging—Current Status With Emerging Applications Open
In this review, we will summarize the past and current state-of-the-art developments in attenuation and scatter correction approaches for hybrid positron emission tomography (PET) and magnetic resonance (MR) imaging. The current status of …
View article: Renal vascular resistance is increased in patients with kidney transplant
Renal vascular resistance is increased in patients with kidney transplant Open
View article: Renal hemodynamics and fatty acid uptake: effects of obesity and weight loss
Renal hemodynamics and fatty acid uptake: effects of obesity and weight loss Open
Human studies of renal hemodynamics and metabolism in obesity are insufficient. We hypothesized that renal perfusion and renal free fatty acid (FFA) uptake are higher in subjects with morbid obesity compared with lean subjects and that the…
View article: Lee-Yang zeros in lattice QCD for searching phase transition points
Lee-Yang zeros in lattice QCD for searching phase transition points Open
View article: System evaluation of automated production and inhalation of 15O-labeled gaseous radiopharmaceuticals for the rapid 15O-oxygen PET examinations
System evaluation of automated production and inhalation of 15O-labeled gaseous radiopharmaceuticals for the rapid 15O-oxygen PET examinations Open
The present system allowed for automated production and inhalation of series of 15O-labeled radiopharmaceuticals as required in the rapid 15O-Oxygen PET protocol. The production and inhalation were reproducible and im…
View article: The renal blood flow reserve in healthy humans and patients with atherosclerotic renovascular disease measured by positron emission tomography using [15O]H2O
The renal blood flow reserve in healthy humans and patients with atherosclerotic renovascular disease measured by positron emission tomography using [15O]H2O Open
View article: Dysregulation of RNF213 promotes cerebral hypoperfusion
Dysregulation of RNF213 promotes cerebral hypoperfusion Open
RNF213 is a susceptibility gene for moyamoya disease, yet its exact functions remain unclear. To evaluate the role of RNF213 in adaptation of cerebral blood flow (CBF) under cerebral hypoperfusion, we performed bilateral common carotid art…
View article: Lee-Yang zeros in lattice QCD at finite baryon density from canonical approach
Lee-Yang zeros in lattice QCD at finite baryon density from canonical approach Open
We report Lee-Yang zeros behavior at finite temperature and density using the canonical approach in lattice QCD. The quark number densities are calculated at the pure imaginary chemical potential in lattice QCD. Canonical partition functio…
View article: Development of matrix metalloproteinase-targeted probes for lung inflammation detection with positron emission tomography
Development of matrix metalloproteinase-targeted probes for lung inflammation detection with positron emission tomography Open
View article: 123I–Labeled oxLDL Is Widely Distributed Throughout the Whole Body in Mice
123I–Labeled oxLDL Is Widely Distributed Throughout the Whole Body in Mice Open