Hiroyuki Ueda
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View article: Gross hematuria after COVID-19 mRNA vaccination and kidney function trajectory in IgA nephropathy
Gross hematuria after COVID-19 mRNA vaccination and kidney function trajectory in IgA nephropathy Open
Gross hematuria (GH) following COVID-19 mRNA vaccination has been increasingly reported in patients with IgA nephropathy (IgAN). This study assessed the effect of post-vaccination GH on kidney function. A total of 441 Japanese outpatients …
View article: Supportive Evidence of Surrogate End Points Based on Treatment Effect of Corticosteroid in IgA Nephropathy
Supportive Evidence of Surrogate End Points Based on Treatment Effect of Corticosteroid in IgA Nephropathy Open
Both the eGFR slope and proteinuria reduction demonstrated strong and consistent associations with kidney outcomes in the context of corticosteroid therapy. These findings support their effectiveness as surrogate end points for clinical tr…
View article: The association between low-grade proteinuria and adverse kidney outcomes in IgA nephropathy: A systematic review and meta-analysis
The association between low-grade proteinuria and adverse kidney outcomes in IgA nephropathy: A systematic review and meta-analysis Open
Background Overt proteinuria (>1.0 g/day) is a well-established risk factor for kidney disease progression in IgA nephropathy (IgAN). However, recent evidence suggests that even low-grade proteinuria, typically defined as 0.5–1.0 g/day, ma…
View article: Initial change in fractional excretion of total protein after SGLT2 inhibitors predicts renal prognosis in patients with chronic kidney disease
Initial change in fractional excretion of total protein after SGLT2 inhibitors predicts renal prognosis in patients with chronic kidney disease Open
Background Sodium–glucose co-transporter 2 inhibitors (SGLT2i) reduce glomerular hyperfiltration, resulting in an initial estimated glomerular filtration rate (eGFR) dip in chronic kidney disease (CKD). The association between the initial …
View article: Initial proteinuria reduction and adverse kidney outcomes in IgA nephropathy: An analysis from the J-IGACS
Initial proteinuria reduction and adverse kidney outcomes in IgA nephropathy: An analysis from the J-IGACS Open
Background Proteinuria reduction is considered a potential surrogate endpoint predictive of reflecting long-term kidney prognosis in IgA nephropathy (IgAN). However, its association with adverse kidney outcomes and IgAN-related decline in …
View article: Validation of Estimated Glomerular Filtration Slope and Proteinuria Reduction as Surrogate Endpoints in IgA Nephropathy: A post-hoc Analysis from the J-IGACS
Validation of Estimated Glomerular Filtration Slope and Proteinuria Reduction as Surrogate Endpoints in IgA Nephropathy: A post-hoc Analysis from the J-IGACS Open
Background Estimated glomerular filtration rate (eGFR) slope and proteinuria reduction have been proposed as surrogate endpoints for kidney outcomes in IgA nephropathy (IgAN), but their validity remains under debate. We aimed to evaluate t…
View article: Annual eGFR slope and Adverse kidney outcome in IgA nephropathy: A post-hoc analysis of the Japan IgA Nephropathy Cohort Study (J-IGACS)
Annual eGFR slope and Adverse kidney outcome in IgA nephropathy: A post-hoc analysis of the Japan IgA Nephropathy Cohort Study (J-IGACS) Open
Background In IgA nephropathy (IgAN), early surrogate markers that reflect disease progression are critical for understanding long-term outcomes. While prior studies have suggested a potential role for eGFR slope, its validity as a surroga…
View article: Microscopic Distribution of Bentonite in Pore Spaces of Sand after Infiltration of Stabilizing Solution with Different Concentrations
Microscopic Distribution of Bentonite in Pore Spaces of Sand after Infiltration of Stabilizing Solution with Different Concentrations Open
In the earth drilling method, ground excavation is performed using stabilizing solution made of bentonite. The solution infiltrates into the excavated ground and forms a mud film on the trench wall, contributing to the stability of the tre…
View article: A Case of Successful Transcatheter Coil Embolization of Multiple Systemic Arteries-to-Pulmonary Artery Fistulas
A Case of Successful Transcatheter Coil Embolization of Multiple Systemic Arteries-to-Pulmonary Artery Fistulas Open
Pulmonary vascular malformations include pulmonary arteriovenous fistula, systemic artery-to-pulmonary artery fistula (SAPAF), and systemic artery-to-pulmonary vein fistula. In particular, systemic artery-to-pulmonary artery fistulas with …
View article: The Future Pioneered by Intestinal Organoid Culture Technology
The Future Pioneered by Intestinal Organoid Culture Technology Open
Intestinal organoids are three-dimensional cell culture models that replicate the structure and function of the intestine, and have drawn significant attention in recent years for their potential in research and medical applications. Organ…
View article: A Man with Primary Hyperchylomicronemia with Triglyceride Levels Exceeding 11,000 mg/dL Was Well Controlled by Pemafibrate Combined with Dietary Therapy
A Man with Primary Hyperchylomicronemia with Triglyceride Levels Exceeding 11,000 mg/dL Was Well Controlled by Pemafibrate Combined with Dietary Therapy Open
A 50-year-old man with a triglyceride (TG) level of 11,397 mg/dL was admitted to our hospital. He consumed a high-fat and high-carbohydrate diet as well as more than 100 g of alcohol per day. He had type 2 diabetes and obesity and had prev…
View article: Cerebrovascular Disease Detected on Preprocedural Computed Tomography in Patients With Severe Aortic Stenosis Undergoing Aortic Valve Replacement
Cerebrovascular Disease Detected on Preprocedural Computed Tomography in Patients With Severe Aortic Stenosis Undergoing Aortic Valve Replacement Open
Background There is a scarcity of data on the prevalence and clinical impact of cerebrovascular disease detected on preprocedural computed tomography (CT) before aortic valve replacement (AVR) in patients with severe aortic stenosis. Metho…
View article: Acute kidney tubular injury after ingestion of red yeast rice supplement
Acute kidney tubular injury after ingestion of red yeast rice supplement Open
A 47-year-old woman developed severe kidney dysfunction after taking a lipid-lowering supplement, Red Yeast Rice Cholestehelp, for approximately 7 months. The patient developed sudden nausea and had an elevated serum creatinine level of 4.…
View article: Histological Correlation between Tonsillar and Glomerular Lesions in Patients with IgA Nephropathy Justifying Tonsillectomy: A Retrospective Cohort Study
Histological Correlation between Tonsillar and Glomerular Lesions in Patients with IgA Nephropathy Justifying Tonsillectomy: A Retrospective Cohort Study Open
Tonsillectomy with steroid pulse therapy (SPT) has been established as an effective treatment for immunoglobulin A nephropathy (IgAN) in Japan. However, the underlying mechanisms supporting tonsillectomy remain unclear. This study assessed…
View article: Foreign Body Granuloma After Embolization of Internal Iliac Artery Aneurysm Using N-Butyl-2-Cyanoacrylate: A Case Report
Foreign Body Granuloma After Embolization of Internal Iliac Artery Aneurysm Using N-Butyl-2-Cyanoacrylate: A Case Report Open
Foreign body granulomas following endovascular treatment are rare complications and are mostly reported in the brain or cutaneous vascular tissues. To the best of our knowledge, no study to date has reported on foreign body granulomas in t…
View article: Accelerated involution of germinal center in palatine tonsils in IgA nephropathy
Accelerated involution of germinal center in palatine tonsils in IgA nephropathy Open
Background Altered immunological responses in the palatine tonsils may be involved in the pathogenesis of IgA nephropathy (IgAN). The germinal center serves as the site for antigen-specific humoral immune responses in the palatine tonsils.…
View article: Glomerular Hypertrophy and Initial Dip in Estimated Glomerular Filtration Rate Following Dapagliflozin Administration
Glomerular Hypertrophy and Initial Dip in Estimated Glomerular Filtration Rate Following Dapagliflozin Administration Open
The renoprotective effects of sodium–glucose cotransporter 2 (SGLT-2) inhibitors, independent of their hypoglycemic actions, have attracted considerable attention in recent years.1–4 Treatment with SGLT-2 inhibitors is accompanied by an ac…
View article: Foreign body granuloma after embolization of internal iliac artery using N-butyl-2-cyanoacrylate: a case report
Foreign body granuloma after embolization of internal iliac artery using N-butyl-2-cyanoacrylate: a case report Open
Background Foreign body granulomas following endovascular treatment rarely occur in the brain or cutaneous vascular tissues. To the best of our knowledge, no study to date has reported on foreign body granulomas in the abdomen after inject…
View article: A 20-year follow-up study of identical twin sisters with immunoglobulin A nephropathy
A 20-year follow-up study of identical twin sisters with immunoglobulin A nephropathy Open
Immunoglobulin A nephropathy (IgAN) is characterized by diverse clinicopathological phenotypes. Herein we present a follow-up study of previously reported identical twin sisters with IgAN. The older sister exhibited more severe kidney hist…
View article: Fractional excretion of total protein predicts renal prognosis in Japanese patients with primary membranous nephropathy
Fractional excretion of total protein predicts renal prognosis in Japanese patients with primary membranous nephropathy Open
Background Primary membranous nephropathy (pMN) is one of the most common types of glomerulonephritis, with a third of patients progressing to renal insufficiency. Various prognostic factors have been reported, of which urinary protein and…
View article: Simplified Shielded MEG-MRI Multimodal System with Scalar-mode Optically Pumped Magnetometers as MEG Sensors
Simplified Shielded MEG-MRI Multimodal System with Scalar-mode Optically Pumped Magnetometers as MEG Sensors Open
Magnetoencephalography (MEG) conventionally operates within high-performance magnetic shields due to the extremely weak magnetic field signals from the measured objects and the narrow dynamic range of the magnetic sensors employed for dete…