Hideki Yasui
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View article: Antifibrotic therapy in familial idiopathic pulmonary fibrosis: a comparative cohort study
Antifibrotic therapy in familial idiopathic pulmonary fibrosis: a comparative cohort study Open
Before the introduction of antifibrotic therapy, patients with familial pulmonary fibrosis (FPF) were reported to have a higher mortality risk than those with sporadic disease. Genetic predisposition plays an important role in the developm…
View article: Risk stratification of acute exacerbations by autoantibodies in patients with idiopathic interstitial pneumonia
Risk stratification of acute exacerbations by autoantibodies in patients with idiopathic interstitial pneumonia Open
Although acute exacerbation of idiopathic interstitial pneumonia (AE-IIP) is a critical event, the detailed features of connective tissue diseases (CTD) that affect the incidence of AE-IIP have not been fully elucidated. This study aimed t…
View article: Effectiveness of Statins for Oxaliplatin‐Induced Peripheral Neuropathy: A Multicenter Retrospective Observational Study
Effectiveness of Statins for Oxaliplatin‐Induced Peripheral Neuropathy: A Multicenter Retrospective Observational Study Open
Chemotherapy‐induced peripheral neuropathy, including oxaliplatin‐induced peripheral neuropathy (OIPN), can have a negative impact on patient quality of life for months or even years after discontinuation of chemotherapy. Statins are commo…
View article: PAI-1 Inhibitor TM5441 Attenuates Emphysema and Airway Inflammation in a Murine Model of Chronic Obstructive Pulmonary Disease
PAI-1 Inhibitor TM5441 Attenuates Emphysema and Airway Inflammation in a Murine Model of Chronic Obstructive Pulmonary Disease Open
Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality worldwide, primarily driven by chronic airway inflammation due to cigarette smoke exposure. Despite its burden, however, current anti-inflammatory the…
View article: Analysis of the relationship between bronchoalveolar lavage lymphocyte fraction and detailed autoimmune features in patients with idiopathic interstitial pneumonia
Analysis of the relationship between bronchoalveolar lavage lymphocyte fraction and detailed autoimmune features in patients with idiopathic interstitial pneumonia Open
Bronchoalveolar lavage (BAL) is crucial for the diagnosis of interstitial lung disease (ILD). Although BAL lymphocytosis is found in patients with connective tissue disease (CTD)-related ILD, the effects of CTD-associated features on BAL l…
View article: Alveolar Sarcoidosis Mimicking Idiopathic Interstitial Pneumonia Without Mediastinal Lymphadenopathy
Alveolar Sarcoidosis Mimicking Idiopathic Interstitial Pneumonia Without Mediastinal Lymphadenopathy Open
We present a case of alveolar sarcoidosis showing lower lobe‐predominant areas of airspace consolidation and ground‐glass attenuation on HRCT , mimicking idiopathic interstitial pneumonia ( IIP ) with spontaneous wandering. Mediastinal lym…
View article: Pulmonary Hyalinizing Granuloma With Favourable and Longitudinal Treatment Response
Pulmonary Hyalinizing Granuloma With Favourable and Longitudinal Treatment Response Open
We present a case of pulmonary hyalinising granuloma, a rare benign disease of unknown aetiology, diagnosed using lung nodule biopsy. Glucocorticoid treatment reduced the nodule size and was effective for 5 years. However, there was persis…
View article: Quantitative Assessment of Systemic Sclerosis–Related Interstitial Lung Disease via <scp>3D</scp>‐Imaging
Quantitative Assessment of Systemic Sclerosis–Related Interstitial Lung Disease via <span>3D</span>‐Imaging Open
Background and Objective Interstitial lung disease (ILD) is a leading cause of morbidity and mortality in patients with systemic sclerosis (SSc). The disease course of SSc‐related ILD (SSc‐ILD) is heterogeneous, and several risk‐based mode…
View article: Severe drug-induced interstitial lung disease after photoimmunotherapy with cetuximab–sarotalocan sodium in a patient with oropharyngeal cancer: A case report
Severe drug-induced interstitial lung disease after photoimmunotherapy with cetuximab–sarotalocan sodium in a patient with oropharyngeal cancer: A case report Open
We report the first case of DIILD caused by CS-PIT. Because cetuximab is a component of CS, CS-PIT has the potential to induce DIILD. Risk assessments and monitoring for DIILD are recommended for patients receiving CS-PIT.
View article: Prognostic value of computed tomography assessment of normal lung volume in upper lobe in idiopathic pleuroparenchymal fibroelastosis
Prognostic value of computed tomography assessment of normal lung volume in upper lobe in idiopathic pleuroparenchymal fibroelastosis Open
This novel method for quantitatively measuring the normal upper-lobe lung volume using three-dimensional computed tomography is useful for assessing disease severity and mortality risk in idiopathic pleuroparenchymal fibroelastosis https:/…
View article: Risk factors for relapse of immune-related pneumonitis after 6-week oral prednisolone therapy: a follow-up analysis of a phase II study
Risk factors for relapse of immune-related pneumonitis after 6-week oral prednisolone therapy: a follow-up analysis of a phase II study Open
In irP patients treated with 6-week prednisolone tapering therapy, OP pattern and duration to irP onset ≥ 100 days were associated with relapse risk. Assessment of the risk factors for irP relapse will be helpful for irP management.
View article: Case of familial interstitial lung disease attributed to ATP-binding cassette transporter 3 gene mutation in identical twins.
Case of familial interstitial lung disease attributed to ATP-binding cassette transporter 3 gene mutation in identical twins. Open
Mutations in ABCA3 can result in surfactant deficiency, leading to respiratory distress syndrome in term neonates, and interstitial lung disease (ILD) in children. Here, we report an extremely rare case of ILD in an identical twin with nov…
View article: 3D-CT-derived lung volumes and mortality risk in patients with fibrotic hypersensitivity pneumonitis
3D-CT-derived lung volumes and mortality risk in patients with fibrotic hypersensitivity pneumonitis Open
Quantitatively measuring standardized LV can help determine disease severity, progression, and mortality risk in patients with fibrotic-HP.
View article: Antifibrotics and mortality in idiopathic pulmonary fibrosis: external validity and avoidance of immortal time bias
Antifibrotics and mortality in idiopathic pulmonary fibrosis: external validity and avoidance of immortal time bias Open
Background and objective Pooled analyses of previous randomized controlled trials reported that antifibrotics improved survival in patients with idiopathic pulmonary fibrosis (IPF), but the results were only based on short-term outcome dat…
View article: Olanzapine Plus Triple Antiemetic Therapy for the Prevention of Carboplatin-Induced Nausea and Vomiting: A Randomized, Double-Blind, Placebo-Controlled Phase III Trial
Olanzapine Plus Triple Antiemetic Therapy for the Prevention of Carboplatin-Induced Nausea and Vomiting: A Randomized, Double-Blind, Placebo-Controlled Phase III Trial Open
PURPOSE We evaluated the efficacy and safety of antiemetic therapy with olanzapine, a neurokinin-1 receptor antagonist (RA), a 5-hydroxytryptamine-3 (5-HT 3 ) RA, and dexamethasone for preventing chemotherapy-induced nausea and vomiting in…
View article: CT assessment of the normal upper-lobe lung volume in idiopathic pleuroparenchymal fibroelastosis
CT assessment of the normal upper-lobe lung volume in idiopathic pleuroparenchymal fibroelastosis Open
Idiopathic pleuroparenchymal fibroelastosis (iPPFE) is characterized by upper lobe-dominant fibrosis involving the pleura and subpleural lung parenchyma. Upper-lobe lung volume (UL-volume) loss is a hallmark of iPPFE. The UL volume include…
View article: Pan-cancer assessment of antineoplastic therapy-induced interstitial lung disease in patients receiving subsequent therapy immediately following immune checkpoint blockade therapy
Pan-cancer assessment of antineoplastic therapy-induced interstitial lung disease in patients receiving subsequent therapy immediately following immune checkpoint blockade therapy Open
Background Drug-induced interstitial lung disease (DIILD) is a serious adverse event potentially induced by any antineoplastic agent. Whether cancer patients are predisposed to a higher risk of DIILD after receiving immune checkpoint inhib…
View article: Investigation of the Actual Conditions of Non-compliance in Specified Clinical Trials Based on Analysis of Non-compliance Reports
Investigation of the Actual Conditions of Non-compliance in Specified Clinical Trials Based on Analysis of Non-compliance Reports Open
Serious non-compliance in specified clinical trials is defined as a deviation that affects the human rights and safety of research subjects, or the reliability of the results. This survey aimed to clarify processes that were likely to caus…
View article: Six-week oral prednisolone therapy for immune-related pneumonitis: a single-arm phase II study
Six-week oral prednisolone therapy for immune-related pneumonitis: a single-arm phase II study Open
Background There has been no prospective trial for treatment of immune-related pneumonitis (irP) occurred after immune checkpoint inhibitors (ICIs). Methods In this single-arm phase II study, patients with cancer with grade ≥2 irP received…