Hidenori Fukuoka
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View article: Generative image compression by prediction of optimal realism levels
Generative image compression by prediction of optimal realism levels Open
View article: Editorial: Recent advances in secondary diabetes and glucose intolerance
Editorial: Recent advances in secondary diabetes and glucose intolerance Open
View article: SAT-067 Evaluating Drug-Induced Effects on Cell Viability in Acromegaly Using a Patient-Derived 3D Culture Model
SAT-067 Evaluating Drug-Induced Effects on Cell Viability in Acromegaly Using a Patient-Derived 3D Culture Model Open
Disclosure: Y. Tsujimoto: None. A. Ishida: None. H. Shichi: None. N. Yamamoto: None. Y. Motomura: None. Y. Oi-Yo: None. Y. Sasaki: None. M. Suzuki: None. S. Urai: None. H. Bando: None. M. Yamamoto: None. M. Takahashi: None. G. Iguchi: None…
View article: SUN-069 The role of FTO-mediated m6A modification in ACTH regulation
SUN-069 The role of FTO-mediated m6A modification in ACTH regulation Open
Disclosure: N. Yamamoto: None. Y. Tsujimoto: None. H. Shichi: None. S. Urai: None. M. Suzuki: None. H. Bando: None. M. Yamamoto: None. Y. Motomura: None. Y. Sasaki: None. Y. Oi-Yo: None. M. Takahashi: None. G. Iguchi: None. D. Motooka: Non…
View article: SAT-067 Evaluating Drug-Induced Effects on Cell Viability in Acromegaly Using a Patient-Derived 3D Culture Model
SAT-067 Evaluating Drug-Induced Effects on Cell Viability in Acromegaly Using a Patient-Derived 3D Culture Model Open
Disclosure: Y. Tsujimoto: None. A. Ishida: None. H. Shichi: None. N. Yamamoto: None. Y. Motomura: None. Y. Oi-Yo: None. Y. Sasaki: None. M. Suzuki: None. S. Urai: None. H. Bando: None. M. Yamamoto: None. M. Takahashi: None. G. Iguchi: None…
View article: Long-acting GH Use in Patients With Adult GH Deficiency Coexisting With Type 1 Diabetes Mellitus
Long-acting GH Use in Patients With Adult GH Deficiency Coexisting With Type 1 Diabetes Mellitus Open
Somapacitan, a once-weekly GH preparation used to treat GH deficiency, has effects on glucose tolerance similar to those of daily GH (somatropin) treatment. However, its effects on glycemic control in patients with type 1 diabetes mellitus…
View article: Modeling of T cell-mediated autoimmune pituitary disease using human induced pluripotent stem cell-originated organoid
Modeling of T cell-mediated autoimmune pituitary disease using human induced pluripotent stem cell-originated organoid Open
View article: Pituitary incidentaloma: a Pituitary Society international consensus guideline statement
Pituitary incidentaloma: a Pituitary Society international consensus guideline statement Open
View article: A Rare Case of Pseudohypercalcemia Associated with Multiple Myeloma.
A Rare Case of Pseudohypercalcemia Associated with Multiple Myeloma. Open
We report a rare case of pseudohypercalcemia associated with multiple myeloma in a 77-year-old woman. Despite elevated albumin-corrected calcium levels (12.6 mg/dL), ionized calcium levels remained normal (1.25 mmol/L). Differential diagno…
View article: A Pregnant Woman with Primary Hyperparathyroidism Who Underwent Parathyroidectomy in the Second Trimester of Her Third Pregnancy: A Case Report.
A Pregnant Woman with Primary Hyperparathyroidism Who Underwent Parathyroidectomy in the Second Trimester of Her Third Pregnancy: A Case Report. Open
Primary hyperparathyroidism (PHPT) during pregnancy is rare, causing severe pregnancy complications. We report a pregnant woman with PHPT and a pregnancy complication history who underwent a single-gland parathyroidectomy during the second…
View article: Glucocorticoid Resistance Syndrome as a Hidden Cause of Nonneoplastic Hypercortisolism
Glucocorticoid Resistance Syndrome as a Hidden Cause of Nonneoplastic Hypercortisolism Open
Cases of hypercortisolemia without physical signs of Cushing's syndrome (CS), suggestive of nonneoplastic hypercortisolism (NNH), often remain partially unexplained. We present a unique case that was initially misdiagnosed as ACTH-dependen…
View article: Diagnosis of skeletal fragility due to Loeys-Dietz syndrome and treatment with romosozumab followed by denosumab
Diagnosis of skeletal fragility due to Loeys-Dietz syndrome and treatment with romosozumab followed by denosumab Open
View article: Prevalence and risk of complications in untreated patients with adult growth hormone deficiency
Prevalence and risk of complications in untreated patients with adult growth hormone deficiency Open
Purpose Adult growth hormone deficiency (AGHD) increases the prevalence of complications, including metabolic disorder, leading to increased cardiovascular mortality from cardiovascular diseases. However, no large database studies have eva…
View article: Management of Cushing’s disease in the initial phase~From detection to surgery~
Management of Cushing’s disease in the initial phase~From detection to surgery~ Open
Cushing's disease is a rare endocrine disorder that presents many systemic complications, and its initial phase management can be difficult in atypical and severe cases or at institutes with limited experience. It is a disease in which sev…
View article: Body mass index and metabolic complications in individuals with treatment-naïve acromegaly
Body mass index and metabolic complications in individuals with treatment-naïve acromegaly Open
Body mass index (BMI) can be used to define obesity-a global health concern and a risk factor for various complications. However, it does not accurately represent body composition. Furthermore, a correlation between BMI and the frequency o…
View article: Utility of gel filtration chromatography in evaluating successful resection of ectopic adrenocorticotropic hormone-producing tumor: a case report and literature review
Utility of gel filtration chromatography in evaluating successful resection of ectopic adrenocorticotropic hormone-producing tumor: a case report and literature review Open
Ectopic adrenocorticotropic hormone (ACTH) syndrome resulting from ectopically secreting tumors poses a significant clinical challenge. Accurately identifying the tumor source and achieving curative resection are pivotal for patient progno…
View article: A case of mineralocorticoid intermediate-producing sarcomatoid adrenal cortical carcinoma: case report and review of literature
A case of mineralocorticoid intermediate-producing sarcomatoid adrenal cortical carcinoma: case report and review of literature Open
Sarcomatoid adrenal cortical carcinoma (SACC) is an extremely rare histological subtype accounting for only 0.2% of all adrenal cortical carcinomas. Most reported cases of SACC are nonfunctional, showing a biphasic histological pattern wit…
View article: Efficacy of asfotase alfa in a patient with adult-onset hypophosphatasia without obvious bone lesions: a case report with review of literature
Efficacy of asfotase alfa in a patient with adult-onset hypophosphatasia without obvious bone lesions: a case report with review of literature Open
The use of asfotase alfa, a bone-targeted recombinant alkaline phosphatase (ALP) enzyme, for the treatment of adult-onset hypophosphatasia (HPP) remains controversial, particularly in patients without evident bone abnormalities. We report …
View article: Generative Image Compression by Prediction of Optimal Realism Levels
Generative Image Compression by Prediction of Optimal Realism Levels Open
View article: Metyrapone single administration, as a possible predictive tool of its dosage and timing in Cushing’s syndrome
Metyrapone single administration, as a possible predictive tool of its dosage and timing in Cushing’s syndrome Open
Metyrapone is commonly used in the initial management of Cushing’s syndrome to reduce hypercortisolemia, but its optimal dosage and timing can vary significantly between patients. Currently, there are limited guidelines on adjustment metho…
View article: 6776 A case of non-neoplastic hypercortisolism leading to the diagnosis of glucocorticoid resistance syndrome due to a novel NR3C1 variant
6776 A case of non-neoplastic hypercortisolism leading to the diagnosis of glucocorticoid resistance syndrome due to a novel NR3C1 variant Open
Disclosure: N. Yamamoto: None. N. Kido: None. H. Bando: None. M. Yamamoto: None. S. Urai: None. Y. Tsujimoto: None. Y. Ohmachi: None. Y. Motomoura: None. Y. Oi-Yo: None. Y. Sasaki: None. M. Suzuki: None. M. Takahashi: None. G. Iguchi: None…
View article: 6965 Discrepancy As A Diagnostic Dilemma Between Patient-Reported And Physician-Reported Symptoms Of Cushing's Syndrome
6965 Discrepancy As A Diagnostic Dilemma Between Patient-Reported And Physician-Reported Symptoms Of Cushing's Syndrome Open
Disclosure: Y. Motomura: None. S. Urai: None. H. Bando: None. M. Yamamoto: None. M. Suzuki: None. N. Yamamoto: None. G. Iguchi: None. W. Ogawa: None. H. Fukuoka: None. Background: The early diagnosis and immediate treatment of Cushing’s sy…
View article: 6374 Prevalence and risk factor of complications in patients with adult growth hormone deficiency: A retrospective database study
6374 Prevalence and risk factor of complications in patients with adult growth hormone deficiency: A retrospective database study Open
Disclosure: H. Fukuoka: None. S. Fujio: None. T. Endo: Employee; Self; Novo Nordisk. Stock Owner; Self; Novo Nordisk. S. Tsuboi: Employee; Self; Novo Nordisk. Stock Owner; Self; Novo Nordisk. Though adult growth hormone deficiency (AGHD) i…
View article: Acquired isolated ACTH deficiency co-occurrence with breast cancer irrespective of paraneoplastic syndrome: coincidence or inevitability
Acquired isolated ACTH deficiency co-occurrence with breast cancer irrespective of paraneoplastic syndrome: coincidence or inevitability Open
Summary A 52-year-old female patient with breast cancer presented with a history of fatigue and malaise 1 year prior. She was diagnosed with isolated adrenocorticotropic hormone (ACTH) deficiency (IAD) on endocrinological examination. Her …
View article: Diagnostic dilemma in Cushing’s syndrome: discrepancy between patient-reported and physician-assessed manifestations
Diagnostic dilemma in Cushing’s syndrome: discrepancy between patient-reported and physician-assessed manifestations Open
View article: Two Cases of Adrenal Cysts Lined by Thyroid Follicular Epithelium: Addressing Cellular Origin and Malignancy Concerns
Two Cases of Adrenal Cysts Lined by Thyroid Follicular Epithelium: Addressing Cellular Origin and Malignancy Concerns Open
Adrenal cysts lined by thyroid follicular epithelium are rare, with only 14 reported cases of “ectopic thyroid tissue” to date. While the primary consideration for differential diagnosis is thyroid carcinoma metastasis, exclusion of metast…
View article: Fluctuations in plasma adrenocorticotropic hormone concentration may predict the onset of immune checkpoint inhibitor-related hypophysitis
Fluctuations in plasma adrenocorticotropic hormone concentration may predict the onset of immune checkpoint inhibitor-related hypophysitis Open
Immune checkpoint inhibitor (ICI)-related hypophysitis (RH) is a common immune-related adverse event. The early detection of ICI-RH prevents life-threatening adrenal insufficiency. However, good predictors of secondary adrenal insufficienc…
View article: Prolonged Hypokalemia Following Metyrapone Treatment for Primary Bilateral Macronodular Adrenal Cortical Disease
Prolonged Hypokalemia Following Metyrapone Treatment for Primary Bilateral Macronodular Adrenal Cortical Disease Open
Surgical treatment is generally the standard therapeutic regimen used for primary bilateral macronodular adrenal cortical disease (PBMACD). However, in cases for which surgery is difficult or in which there is mild cortisol hypersecretion,…
View article: Fluctuations in serum adrenocorticotropic hormone concentration may predict the onset of immune checkpoint inhibitor-related hypophysitis
Fluctuations in serum adrenocorticotropic hormone concentration may predict the onset of immune checkpoint inhibitor-related hypophysitis Open
Background Immune checkpoint inhibitor (ICI)-related hypophysitis (RH) is a common immune-related adverse event. The early detection of ICI-RH prevents life-threatening adrenal insufficiency. However, good predictors of secondary adrenal i…
View article: Paraneoplastic isolated adrenocorticotropic hormone deficiency revealed after immune checkpoint inhibitors therapy: new insights into anti-corticotroph antibody
Paraneoplastic isolated adrenocorticotropic hormone deficiency revealed after immune checkpoint inhibitors therapy: new insights into anti-corticotroph antibody Open
Introduction A recently discovered facet of paraneoplastic adrenocorticotropic hormone (ACTH) deficiency exists in two forms: a paraneoplastic spontaneous isolated ACTH deficiency (IAD) and an immune checkpoint inhibitor (ICI)-related hypo…