Explanipedia

Distant parenchymal recurrence during long-term use of TTFields treatment for glioblastoma Open

Yuhei Takido, Fumiharu Ohka, Shoichi Deguchi, Kazuya Motomura, Koichi Mitsuya , et al. · 2025

Re-examining the Optimal Extent of Lymph Node Dissection for Colon Cancer using the Lymphadenectomy Index Open

Yuta Marunaka, Jun Kiuchi, Yoshiaki Kuriu, Tomohiro Arita, Hiroki Shimizu , et al. · 2024

The optimal extent of lymph node dissection in colon cancer surgery is specified in guidelines based on the results of past analyses. However, with advances in surgical techniques and multidisciplinary treatments, the clinical significance…

Patients with T4N0 and T1‑3N1 colon cancer and a high preoperative carcinoembryonic antigen level benefit from adjuvant chemotherapy with oxaliplatin for 6 months Open

Hiroyuki Inoue, Hiroki Shimizu, Yoshiaki Kuriu, Tomohiro Arita, Kenji Nanishi , et al. · 2024

A shorter duration of oxaliplatin adjuvant chemotherapy has recently emerged as a potential option for patients with high-risk stage II and low-risk stage III (T1-3N1) colon cancer (CC). The present study aimed to elucidate the risk factor…

Deep pelvis and low visceral fat mass as risk factors for neurogenic bladder after rectal cancer surgery Open

Tomohiro Matsui, Jun Kiuchi, Yoshiaki Kuriu, Tomohiro Arita, Hiroki Shimizu , et al. · 2024

Lower VFA, older age, and prolonged surgery are independent risk factors for developing PONB. Additionally, a deep pelvis is an independent risk factor for severe PONB. Delicate surgical techniques should consider the risk of nerve injury …

CACNA2D1 regulates the progression and influences the microenvironment of colon cancer Open

Hiroyuki Inoue, Atsushi Shiozaki, Toshiyuki Kosuga, Hiroki Shimizu, Michihiro Kudou , et al. · 2024

CACNA2D1 plays an important role in the progression and the microenvironment of CC by regulating fibroblasts and may act as a biomarker for disease progression and a therapeutic target for CC.

Roles of miR-4442 in Colorectal Cancer: Predicting Early Recurrence and Regulating Epithelial-Mesenchymal Transition Open

Jun Shibamoto, Tomohiro Arita, Hirotaka Konishi, Satoshi Kataoka, Hirotaka Furuke , et al. · 2023

Early recurrence in patients with colorectal cancer (CRC) is associated with a poor prognosis. We aimed to identify circulating microRNAs that are biomarkers of early CRC recurrence and elucidate their functions. We identified miR-4442 as …

Clinical Impact of Preoperative to Long-term Postoperative PNI Trends in Elderly Patients Undergoing Adjuvant Chemotherapy for Colorectal Cancer Open

Jun Kiuchi, Yoshiaki Kuriu, Tomohiro Arita, Hiroki Shimizu, Eigo Otsuji · 2023

【目的】高齢の大腸癌術後補助化学療法施行例において，術前，補助化学療法導入時，再発時の栄養状態が予後に与える影響について検討した．

Anoctamin 5 regulates the cell cycle and affects prognosis in gastric cancer Open

Tomoyuki Fukami, Atsushi Shiozaki, Toshiyuki Kosuga, Michihiro Kudou, Hiroki Shimizu , et al. · 2022

ANO5 regulates the cell cycle progression by regulating the expression of cyclin-associated genes and affects the prognosis of patients with GC. These results may provide insights into the role of ANO5 as a key mediator in tumor progressio…

Removal of small extracellular vesicles inhibits the progression of peritoneal dissemination in gastric cancer Open

Jun Shibamoto, Tomohiro Arita, Hirotaka Konishi, Satoshi Kataoka, Hirotaka Furuke , et al. · 2022

Role of Extracellular High-Mobility Group Box-1 as a Therapeutic Target of Gastric Cancer Open

Wataru Takaki, Hirotaka Konishi, Daiki Matsubara, Katsutoshi Shoda, Tomohiro Arita , et al. · 2022

Background: High-mobility group box-1 (HMGB1) is involved in the tumorigenesis and metastasis of various cancers. The present study investigated the roles of extracellular HMGB1 in the progression of gastric cancer (GC) and the therapeutic…

Thyroidal Transcriptomic Profiles of Pathoadaptive Responses to Congenital Hypothyroidism in XB130 Knockout Mice Open

Junichi Sugihara, Aaron Wong, Hiroki Shimizu, Jinbo Zhao, Hae-Ra Cho , et al. · 2022

Congenital hypothyroidism is a genetic condition in which the thyroid gland fails to produce sufficient thyroid hormone (TH), resulting in metabolic dysfunction and growth retardation. Xb130−/− mice exhibit perturbations of thyrocyte cytos…

ASO Visual Abstract: TRPV2 Promotes Cell Migration and Invasion in Gastric Cancer via the TGF-β-Signaling Pathway Open

Shunji Kato, Atsushi Shiozaki, Michihiro Kudou, Hiroki Shimizu, Toshiyuki Kosuga , et al. · 2022

Colonic Metastasis from Breast Cancer: A Case Report and Review of the Literature Open

Hiroyuki Inoue, Tomohiro Arita, Yoshiaki Kuriu, Hiroki Shimizu, Jun Kiuchi , et al. · 2021

Although extremely rare, the possibility of CMBC should be considered in the case of colonic tumors in patients with a history of breast cancer.

Pathogenesis of Multinodular Goiter in Elderly XB130-Deficient Mice: Alteration of Thyroperoxidase Affinity with Iodide and Hydrogen Peroxide Open

Hae-Ra Cho, Junichi Sugihara, Hiroki Shimizu, Yun‐Yan Xiang, Xiaohui Bai , et al. · 2021

Background: Multinodular goiter (MNG) is the most common disorder of the thyroid gland. Aging and genetic mutations that impair thyroid hormone (TH) production have been implicated in the development of MNG. XB130 is an adapt…

Anterior gradient 2 regulates cancer progression in TP53‑wild‑type esophageal squamous cell carcinoma Open

Kazuya Takabatake, Hirotaka Konishi, Tomohiro Arita, Satoshi Kataoka, Jun Shibamoto , et al. · 2021

Anterior gradient 2 (AGR2) reportedly promotes tumor growth and has an unfavorable impact on survival in several cancers. However, no comprehensive functional analysis of AGR2 in esophageal squamous cell carcinoma (ESCC) has been performed…

XB130 Deficiency Causes Congenital Hypothyroidism in Mice due to Disorganized Apical Membrane Structure and Function of Thyrocytes Open

Yingchun Wang, Hiroki Shimizu, Yun‐Yan Xiang, Junichi Sugihara, Wei‐Yang Lu , et al. · 2021

Background: Congenital hypothyroidism is often caused by genetic mutations that impair thyroid hormone (TH) production, resulting in growth and development defects. XB130 (actin filament associated protein 1 like 2) is an ada…

NADPH oxidase 5 has a crucial role in cellular motility of colon cancer cells Open

Naoki Ashizawa, Hiroki Shimizu, Katsutoshi Shoda, Shinji Furuya, Hidenori Akaike , et al. · 2021

NADPH oxidases (NOXs) are a family of transmembrane proteins that generate reactive oxygen species. It was previously reported that patients with colon cancer who had high NOX5 expression had poor prognosis. However, no studies have invest…

Therapeutic Strategy of Colorectal Liver Metastasis Using Modified-JHBPS Nomogram Open

Hidemasa Kubo, Hisashi Ikoma, Yusuke Yamamoto, Ryo Morimura, Jun Kiuchi , et al. · 2021

The mJHBPS nomogram can stratify CRLM patients with sufficient differences in EFS and OS. SF was recommended for patients in the low-risk group.

Significance of Circular FAT1 as a Prognostic Factor and Tumor Suppressor for Esophageal Squamous Cell Carcinoma Open

Wataru Takaki, Hirotaka Konishi, Katsutoshi Shoda, Tomohiro Arita, Satoshi Kataoka , et al. · 2021

Background Circular RNA is a novel endogenous non-coding RNA with a stable loop structure, and theories for its biogenesis and usefulness as a biomarker in various cancers have been proposed. The present study investigated the significance…

Geriatric Nutritional Risk Index Predicts Poor Prognosis of Patients After Curative Surgery for Gastric Cancer Open

Hirotaka Furuke, Daiki Matsubara, Takeshi Kubota, Jun Kiuchi, Hidemasa Kubo , et al. · 2021

Background: The Geriatric Nutritional Risk Index (GNRI) is a nutritional measure for predicting the risk of morbidity and mortality in hospitalized patients. We evaluated the utility of the GNRI to predict the short-term and long-term outc…

LRRC8A influences the growth of gastric cancer cells via the p53 signaling pathway Open

Kento Kurashima, Atsushi Shiozaki, Michihiro Kudou, Hiroki Shimizu, Tomohiro Arita , et al. · 2021

Significance of Plasma <i>UCA1</i> for Predicting Colorectal Cancer and BRAF Mutation Status Open

Tomohito Maeda, Hirotaka Konishi, Wataru Takaki, Kazuya Takabatake, Daiki Matsubara , et al. · 2021

Plasma UCA1 is a useful biomarker for CRC detection and predicting clinicopathological features, particularly BRAF mutation.

ANO9 regulates PD‐L2 expression and binding ability to PD‐1 in gastric cancer Open

Keita Katsurahara, Atsushi Shiozaki, Toshiyuki Kosuga, Hiroki Shimizu, Michihiro Kudou , et al. · 2021

The function of ANO9 in gastrointestinal cancer remains unclear. We investigated the biological behaviors and clinical prognostic values of ANO9 in gastric cancer (GC). Knockdown experiments were performed on human GC cell lines using ANO9…

Early Drain Removal Regardless of Drain Fluid Amylase Level Might Reduce Risk of Postoperative Pancreatic Fistula Open

Hiromichi Kawaida, Hiroshi Kono, Hidetake Amemiya, Naohiro Hosomura, Yudai Higuchi , et al. · 2021

Early drain removal regardless of DFA level may reduce the risk of developing POPF. CRP measured on POD 3 and POD 5 appeared to be a useful predictor of clinically relevant POPF.

Clinical impact of postoperative interval until adjuvant chemotherapy following curative gastrectomy for advanced gastric cancer Open

Yusuke Takashima, Shuhei Komatsu, Keiji Nishibeppu, Jun Kiuchi, Takuma Ohashi , et al. · 2021

Background: Adjuvant chemotherapy (AC) following curative gastrectomy for stage II/III gastric cancer (GC) is recommended in Japan. However, for various reasons, patients cannot always start AC at the appropriate time. This study wa…

Emergency Management of Obstructive Colorectal Cancer – A Retrospective Study of Efficacy and Safety in Self-expanding Metallic Stents and Trans-anal Tubes Open

Hiroyuki Inoue, Tomohiro Arita, Yoshiaki Kuriu, Hiroki Shimizu, Jun Kiuchi , et al. · 2021

The long-term outcomes in the SEMS group were not significantly different than in the TAT group, and nutritional status was better in patients with SEMS, suggesting that SEMS is very effective and may be the first-line treatment of OCRC.

Clinical impact of postoperative prognostic nutritional index in colorectal cancer patients undergoing adjuvant chemotherapy. Open

Mizuki Tamai, Jun Kiuchi, Yoshiaki Kuriu, Tomohiro Arita, Hiroki Shimizu , et al. · 2021

Preoperative Prognostic Nutritional Index (PNI) could be a crucial factor for the prognosis of colorectal cancer (CRC). However, the clinical impact of postoperative PNI is still unclear, and there have been no reports on the significance …

Clinical safety and efficacy of neoadjuvant combination chemotherapy of tranilast in advanced esophageal squamous cell carcinoma Open

Atsushi Shiozaki, Michihiro Kudou, Hitoshi Fujiwara, Hirotaka Konishi, Hiroki Shimizu , et al. · 2020

Background: Transient receptor potential vanilloid 2 (TRPV2) was previously shown to play an important role in the maintenance of cancer stem cells, and its specific inhibitor, tranilast, also has potential as a targeted therapeutic agent …

Anastomosis technique for pancreatojejunostomy and early removal of drainage tubes may reduce postoperative pancreatic fistula Open

Hiromichi Kawaida, Hiroshi Kono, Hidetake Amemiya, Naohiro Hosomura, Mitsuaki Watanabe , et al. · 2020

Background Postoperative pancreatic fistula (POPF) is one of the most serious complications after pancreaticoduodenectomy (PD). Various factors have been reported as POPF risks, but the most serious of these is soft pancreas. To reduce POP…

Prognostic impact of the preoperative hemoglobin A1c levels in patients with gastric cancer surgery depends on postoperative complications Open

Jun Shibamoto, Katsutoshi Shoda, Takeshi Kubota, Toshiyuki Kosuga, Hidemasa Kubo , et al. · 2020

Purpose The long-term prognostic impact of the hemoglobin A1c levels has not yet been evaluated in patients with gastric cancer. The present study investigated the clinical significance of the hemoglobin A1c levels in patients with gastric…

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