Hidenori Takahashi
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View article: Routine use of intravenous acetaminophen safely enhances pain control after minimally invasive hepatectomies: a retrospective cohort study
Routine use of intravenous acetaminophen safely enhances pain control after minimally invasive hepatectomies: a retrospective cohort study Open
Multimodal analgesia comprising routine intravenous acetaminophen administration could be safe and effective after minimally invasive hepatectomy, without adverse effects regarding hepatic function.
View article: Tumor Endothelial Cells Induce <scp>M2</scp> Macrophage Polarization via <scp>IL</scp> ‐4, Enhancing Tumor Growth in Hepatocellular Carcinoma
Tumor Endothelial Cells Induce <span>M2</span> Macrophage Polarization via <span>IL</span> ‐4, Enhancing Tumor Growth in Hepatocellular Carcinoma Open
Tumor‐associated macrophages (TAMs) and tumor endothelial cells (TECs) are important components in tumor microenvironments. This study examined the interaction between TECs and TAMs in hepatocellular carcinoma (HCC). The aim of this study …
View article: The effect of neoadjuvant chemoradiation therapy in resectable pancreatic cancer was independent of intratumoral vascularization
The effect of neoadjuvant chemoradiation therapy in resectable pancreatic cancer was independent of intratumoral vascularization Open
The histopathological efficacy of NACRT for resectable PC did not differ significantly on the basis of enhancement pattern observed on CH-EUS. NACRT may provide additional therapeutic benefit independent of blood flow considerations.
View article: Immune-mediated adverse events in the randomized phase 3 TOPAZ-1 study of durvalumab plus gemcitabine and cisplatin in advanced biliary tract cancer
Immune-mediated adverse events in the randomized phase 3 TOPAZ-1 study of durvalumab plus gemcitabine and cisplatin in advanced biliary tract cancer Open
Introduction We assessed immune-mediated adverse events (imAEs) in the TOPAZ-1 (NCT03875235) study of durvalumab plus gemcitabine and cisplatin (GemCis) in advanced biliary tract cancer (aBTC). Methods Participants were randomized 1:1 to d…
View article: Discrepancy Between Radiographic and Pathological Response Assessment in Neoadjuvant Treatment for Pancreatic Cancer: A Comparison Between Neoadjuvant Chemotherapy and Neoadjuvant Chemoradiotherapy
Discrepancy Between Radiographic and Pathological Response Assessment in Neoadjuvant Treatment for Pancreatic Cancer: A Comparison Between Neoadjuvant Chemotherapy and Neoadjuvant Chemoradiotherapy Open
Aim Appropriate reassessment of treatment response plays a crucial role in identifying optimal candidates for resection in neoadjuvant treatment (NAT) strategy for pancreatic cancer (PC); however, radiological evaluations are associated wi…
View article: Slow‐Release Prostacyclin Agonist‐Immersed Sheet Implantation Suppresses Liver Fibrosis via Hippo Signaling Pathway Activation
Slow‐Release Prostacyclin Agonist‐Immersed Sheet Implantation Suppresses Liver Fibrosis via Hippo Signaling Pathway Activation Open
Aim Liver cirrhosis is characterized by fibrosis of the liver. No effective treatments are currently available other than liver transplantation. The slow‐release version of prostacyclin agonist ONO1301, ONO1301SR, has prolonged effects and…
View article: Routine Use of Intravenous Acetaminophen Safely Enhances Pain Control After Minimally Invasive Hepatectomies: a retrospective cohort study
Routine Use of Intravenous Acetaminophen Safely Enhances Pain Control After Minimally Invasive Hepatectomies: a retrospective cohort study Open
Background Effective postoperative pain management is crucial after minimally invasive hepatectomy (MIH) to promote recovery, and multimodal analgesia strategies are used to reduce opioid requirements and improve outcomes. Multimodal thera…
View article: Author Correction: Adipose-derived stem cells using fibrin gel as a scaffold enhances post-hepatectomy liver regeneration
Author Correction: Adipose-derived stem cells using fibrin gel as a scaffold enhances post-hepatectomy liver regeneration Open
View article: The <i>C11orf24</i> Gene as a Useful Biomarker for Predicting Severe Neutropenia in Modified <scp>FOLFIRINOX</scp> for Pancreatic Cancer
The <i>C11orf24</i> Gene as a Useful Biomarker for Predicting Severe Neutropenia in Modified <span>FOLFIRINOX</span> for Pancreatic Cancer Open
Pancreatic cancer (PC) is an aggressive and lethal tumor with a poor prognosis. FOLFIRINOX improves the prognosis of patients with PC; however, despite UGT1A1 screening, adverse events, such as severe neutropenia, occur frequently. This st…
View article: The Charlson Comorbidity Index Predicts Clinically Relevant Postoperative Pancreatic Fistula in Patients Undergoing Distal Pancreatectomy Not Pancreaticoduodenectomy
The Charlson Comorbidity Index Predicts Clinically Relevant Postoperative Pancreatic Fistula in Patients Undergoing Distal Pancreatectomy Not Pancreaticoduodenectomy Open
Background Postoperative pancreatic fistula (POPF) is a severe complication after pancreatectomy. The preoperative prediction of POPF would benefit patients by providing postoperative management tailored to each patient based on the risk f…
View article: Novel immune drug combination induces tumour microenvironment remodelling and reduces the dosage of anti-PD-1 antibody
Novel immune drug combination induces tumour microenvironment remodelling and reduces the dosage of anti-PD-1 antibody Open
View article: Impact of a robotic approach on hypoattenuated area formation leading to postoperative pancreatic fistula in patients after pancreatoduodenectomy
Impact of a robotic approach on hypoattenuated area formation leading to postoperative pancreatic fistula in patients after pancreatoduodenectomy Open
Background Hypoattenuated area (HA) formation at the pancreatojejunostomy (PJ) site on contrast-enhanced computed tomography (CE-CT) is significantly associated with clinically relevant postoperative pancreatic fistula (CR-POPF) after open…
View article: Adipose-derived stem cells using fibrin gel as a scaffold enhances post-hepatectomy liver regeneration
Adipose-derived stem cells using fibrin gel as a scaffold enhances post-hepatectomy liver regeneration Open
We investigated the potential of adipose-derived stem cells (ADSCs) in preventing post-hepatectomy liver failure, emphasizing the necessity of direct administration using a scaffold. A fibrin gel scaffold was employed for ADSCs (gelADSC) t…
View article: Possibility of incorrect evaluation of intraoperative blood loss during open and laparoscopic distal pancreatectomy
Possibility of incorrect evaluation of intraoperative blood loss during open and laparoscopic distal pancreatectomy Open
Aim Decreasing intraoperative blood loss is one reported advantage of laparoscopic surgery compared with open surgery. However, several reports indicate that blood loss during laparoscopic surgery may be underestimated. No studies have eva…
View article: Minimally invasive approach of hepatectomy and thrombectomy for hepatocellular carcinoma with right atrial tumor thrombus without sternotomy using percutaneous cardiopulmonary bypass
Minimally invasive approach of hepatectomy and thrombectomy for hepatocellular carcinoma with right atrial tumor thrombus without sternotomy using percutaneous cardiopulmonary bypass Open
This report by Maki and colleagues with accompanying surgical video introduces a less invasive surgical option for managing right atrial tumor thrombus in hepatocellular carcinoma, avoiding sternotomy. This approach might reduce operative …
View article: Lymphocyte Antigen 6 Family Member D (LY6D) Affects Stem Cell Phenotype and Progression of Pancreatic Adenocarcinoma
Lymphocyte Antigen 6 Family Member D (LY6D) Affects Stem Cell Phenotype and Progression of Pancreatic Adenocarcinoma Open
Our study showed that LY6D is a novel prognostic indicator and plays a key role in regulation of cancer stemness in PDAC.
View article: Novel Immune Drug Combination Induces Tumour Microenvironment Remodelling and Reduces the Dosage of Anti-PD-1 Antibody
Novel Immune Drug Combination Induces Tumour Microenvironment Remodelling and Reduces the Dosage of Anti-PD-1 Antibody Open
Immune checkpoint inhibitors (ICIs) are effective in clinical settings; however, they present immune-related adverse effects and financial burden. Although dose reduction of ICIs may mitigate these limitations, it could compromise therapeu…
View article: Impact of infectious complications after gastrectomy on non‑gastric cancer‑related deaths
Impact of infectious complications after gastrectomy on non‑gastric cancer‑related deaths Open
Infectious complications (ICs) have been reported as major causes of postoperative mortality in patients with cancer. However, to the best of our knowledge, the impact of ICs after gastrectomy on non-gastric cancer-related deaths (NGCDs) r…
View article: Effect of Adipose-Derived Stem Cells Embedded in Fibrin Gel on Post-Hepatectomy Liver Regeneration: A Therapeutic Model Inducing a Paracrine Effect
Effect of Adipose-Derived Stem Cells Embedded in Fibrin Gel on Post-Hepatectomy Liver Regeneration: A Therapeutic Model Inducing a Paracrine Effect Open
We investigated the potential of adipose-derived stem cells (ADSCs) in preventing post-hepatectomy liver failure, emphasizing the necessity of direct administration using a scaffold to harness their paracrine effects. A fibrin gel scaffold…
View article: Outcomes of patients with initially unresectable pancreatic cancer who underwent conversion surgery after <scp>FOLFIRINOX</scp> or gemcitabine plus nab‐paclitaxel chemotherapy: A multicenter retrospective cohort study (<scp>PC</scp>‐<scp>CURE</scp>‐1)
Outcomes of patients with initially unresectable pancreatic cancer who underwent conversion surgery after <span>FOLFIRINOX</span> or gemcitabine plus nab‐paclitaxel chemotherapy: A multicenter retrospective cohort study (<span>PC</span>‐<span>CURE</span>‐1) Open
Background The efficacy and safety of conversion surgery (CS) after FOLFIRINOX or gemcitabine plus nab‐paclitaxel (GnP) chemotherapy in patients with initially unresectable pancreatic cancer (PC) remains unclear. Methods This multicenter r…
View article: Safety and Feasibility of Neoadjuvant-Modified FOLFIRINOX in Elderly Patients with Pancreatic Cancer
Safety and Feasibility of Neoadjuvant-Modified FOLFIRINOX in Elderly Patients with Pancreatic Cancer Open
The optimal treatment strategy for neoadjuvant chemotherapy in elderly patients with pancreatic cancer (PC) remains unclear. Hence, this study was aimed at evaluating the safety and feasibility of neoadjuvant-modified FOLFIRINOX (mFOLFIRIN…
View article: Clinical significance of ribosomal protein <scp>S15</scp> expression in patients with colorectal cancer liver metastases
Clinical significance of ribosomal protein <span>S15</span> expression in patients with colorectal cancer liver metastases Open
Background Liver metastasis is the most frequently observed distant metastasis of colorectal cancer, and the residual liver recurrence rate after hepatic resection is still high. To explore the mechanism of liver metastasis to discover pot…
View article: Serum levels of the N-terminal fragment of connective tissue growth factor is a novel biomarker for chronic pancreatitis
Serum levels of the N-terminal fragment of connective tissue growth factor is a novel biomarker for chronic pancreatitis Open
View article: Lymphocyte Antigen 6 Family Member D (LY6D) affects stem cell phenotype and progression of pancreatic adenocarcinoma
Lymphocyte Antigen 6 Family Member D (LY6D) affects stem cell phenotype and progression of pancreatic adenocarcinoma Open
The membrane-bound protein Lymphocyte Antigen 6 Family Member D (LY6D) has been implicated in stemness and is associated with various tumors. LY6D is specifically expressed in cancer cells, with little expression in normal cells, but its p…
View article: High <scp>N6</scp>‐methyladenosine‐activated <scp>TCEAL8 mRNA</scp> is a novel pancreatic cancer marker
High <span>N6</span>‐methyladenosine‐activated <span>TCEAL8 mRNA</span> is a novel pancreatic cancer marker Open
N6‐methyladenosine (m6A) is an RNA modification involved in RNA processing and widely found in transcripts. In cancer cells, m6A is upregulated, contributing to their malignant transformation. In this study, we analyzed gene expression and…
View article: The preliminary analysis of lymphatic flow around the connective tissues surrounding SMA and SpA elucidates patients’ oncological condition in borderline-resectable pancreatic cancer
The preliminary analysis of lymphatic flow around the connective tissues surrounding SMA and SpA elucidates patients’ oncological condition in borderline-resectable pancreatic cancer Open
Background In pancreatic ductal adenocarcinoma (PDAC), invasion of connective tissues surrounding major arteries is a crucial prognostic factor after radical resection. However, why the connective tissues invasion is associated with poor p…
View article: High standard uptake value of the primary lesion of hepatocellular carcinoma correlates with early recurrence after curative resection
High standard uptake value of the primary lesion of hepatocellular carcinoma correlates with early recurrence after curative resection Open
Background Fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) is useful for detecting the presence of distant metastases in many types of cancer, including hepatocellular carcinoma (HCC). However, …
View article: High standard uptake value on FDG-PET/CT of the primary lesion of hepatocellular carcinoma correlates with early recurrence after curative resection
High standard uptake value on FDG-PET/CT of the primary lesion of hepatocellular carcinoma correlates with early recurrence after curative resection Open
Purpose Fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) is useful for detecting the presence of distant metastases in many types of cancer, including hepatocellular carcinoma (HCC). However, the…
View article: Results of a Randomized Clinical Study of Gemcitabine Plus Nab-Paclitaxel Versus Gemcitabine Plus S-1 as Neoadjuvant Chemotherapy for Resectable and Borderline Resectable Pancreatic Ductal Adenocarcinoma (RCT, CSGO-HBP-015)
Results of a Randomized Clinical Study of Gemcitabine Plus Nab-Paclitaxel Versus Gemcitabine Plus S-1 as Neoadjuvant Chemotherapy for Resectable and Borderline Resectable Pancreatic Ductal Adenocarcinoma (RCT, CSGO-HBP-015) Open
View article: Is multidisciplinary treatment effective for invasive intraductal papillary mucinous carcinoma?
Is multidisciplinary treatment effective for invasive intraductal papillary mucinous carcinoma? Open
Background Surgical resection is standard treatment for invasive intraductal papillary mucinous carcinoma (IPMC); however, impact of multidisciplinary treatment on survival including postoperative adjuvant therapy (AT), neoadjuvant therapy…