Hideya Onishi
YOU?
Author Swipe
View article: Dendritic cell-derived exosomes induce monocyte antigen-presentation and immune amplification in neoantigen vaccine therapy
Dendritic cell-derived exosomes induce monocyte antigen-presentation and immune amplification in neoantigen vaccine therapy Open
Mature dendritic cells release exosomes; however, the immunological role of exosomes in dendritic cell vaccine therapy remains unclear. We examined the immunogenicity of neoantigen peptide-pulsed dendritic cell-derived exosomes (Neo-P DEX)…
View article: Neoantigen peptide-pulsed dendritic cell vaccine therapy after surgical treatment of pancreatic cancer: a retrospective study
Neoantigen peptide-pulsed dendritic cell vaccine therapy after surgical treatment of pancreatic cancer: a retrospective study Open
Introduction Pancreatic cancer shows very poor prognosis and high resistance to conventional standard chemotherapy and immunotherapy; therefore, the development of new breakthrough therapies is highly desirable. Method We retrospectively e…
View article: A Novel Oncolytic Viral Therapy Using Coxsackievirus B3 (CVB3) for Human Pancreatic Cancer Including Cancer-associated Fibroblasts
A Novel Oncolytic Viral Therapy Using Coxsackievirus B3 (CVB3) for Human Pancreatic Cancer Including Cancer-associated Fibroblasts Open
CVB3 shows promise as an oncolytic virus effective against pancreatic cancer cells and CAFs, suggesting its potential as a novel virotherapy for pancreatic cancer. These findings highlight CVB3 as a candidate for further development as a t…
View article: Modulation of allograft immune responses by Porphyromonas gingivalis lipopolysaccharide administration in a rat model of kidney transplantation
Modulation of allograft immune responses by Porphyromonas gingivalis lipopolysaccharide administration in a rat model of kidney transplantation Open
Periodontitis is a chronic inflammatory disease that affects the periodontal tissues. Although it is associated with various systemic diseases, the impact of periodontitis on kidney transplantation (KT) outcomes, particularly allograft rej…
View article: Modulation of allograft immune responses by Porphyromonas gingivalis lipopolysaccharide administration in a rat model of kidney transplantation
Modulation of allograft immune responses by Porphyromonas gingivalis lipopolysaccharide administration in a rat model of kidney transplantation Open
Periodontitis is a chronic inflammatory disease that affects the periodontal tissues. Although it is associated with various systemic diseases, the impact of periodontitis on kidney transplantation (KT) outcomes, particularly allograft rej…
View article: Biological and genetic characterization of a newly established human external auditory canal carcinoma cell line, SCEACono2
Biological and genetic characterization of a newly established human external auditory canal carcinoma cell line, SCEACono2 Open
Squamous cell carcinoma of the external auditory canal (EACSCC) is an extraordinarily rare and aggressive malignant disease. Establishment of EACSCC cell line with robust molecular characteristics is essential for the basic and translation…
View article: Autophagy inhibition in pancreatic cancer cells synergizes with immunotherapy via DC activation due to increased antigenicity and adjuvanticity
Autophagy inhibition in pancreatic cancer cells synergizes with immunotherapy via DC activation due to increased antigenicity and adjuvanticity Open
The effect of immune checkpoint inhibitors is extremely limited in patients with pancreatic ductal adenocarcinoma (PDAC), due to the immunosuppressive tumor microenvironment (TME). Dendritic cell (DC) paucity and dysfunction are major elem…
View article: Immunological analysis of hybrid neoantigen peptide encompassing class I/II neoepitope-pulsed dendritic cell vaccine
Immunological analysis of hybrid neoantigen peptide encompassing class I/II neoepitope-pulsed dendritic cell vaccine Open
Neoantigens/ are tumor-specific antigens that evade central immune tolerance mechanisms in the thymus. Long-term tumor-specific cytotoxic T lymphocyte activity maintenance requires class II antigen-reactive CD4 + T cells. We had previously…
View article: PTPN3 inhibition contributes to the activation of the dendritic cell function to be a promising new immunotherapy target
PTPN3 inhibition contributes to the activation of the dendritic cell function to be a promising new immunotherapy target Open
View article: MAML3 Contributes to Induction of Malignant Phenotype of Gallbladder Cancer Through Morphogenesis Signalling Under Hypoxia
MAML3 Contributes to Induction of Malignant Phenotype of Gallbladder Cancer Through Morphogenesis Signalling Under Hypoxia Open
MAML3 contributes to the induction of the malignant phenotype of GBC under hypoxia through the HH and NOTCH signalling pathways and may be a comprehensive therapeutic target of morphogenesis signalling in GBC.
View article: PTPN3 inhibition contributes to the activation of the dendritic cell function to augment the effect of cancer immunotherapy
PTPN3 inhibition contributes to the activation of the dendritic cell function to augment the effect of cancer immunotherapy Open
In a previous study, protein tyrosine phosphatase non-receptor type (PTPN) 3 was identified as an immune checkpoint molecule in lymphocytes, and its potential as a novel therapeutic target for cancer immunotherapy was anticipated. However,…
View article: Effects of periodontal pathogen-induced intestinal dysbiosis on transplant immunity in an allogenic skin graft model
Effects of periodontal pathogen-induced intestinal dysbiosis on transplant immunity in an allogenic skin graft model Open
View article: C4orf47 contributes to the dormancy of pancreatic cancer under hypoxic conditions
C4orf47 contributes to the dormancy of pancreatic cancer under hypoxic conditions Open
In our comprehensive analysis of pancreatic cancer pathology, we found that the C4orf47 molecule was upregulated in hypoxic environments. C4orf47 is reported to be a centrosome-associated protein, but its biological significance in cancer …
View article: Effects of periodontal pathogen–induced intestinal dysbiosis on transplant immunity in an allogenic skin graft model
Effects of periodontal pathogen–induced intestinal dysbiosis on transplant immunity in an allogenic skin graft model Open
Periodontal disease can alter the intestinal microbiota. Harmful changes to the microbiota are called “dysbiosis” and can induce systemic inflammation and affect transplant immunity. Here we examined the effects of periodontal disease–rela…
View article: Tropomyosin-related Kinase B Is Potentially a Biomarker of Prognosis and Therapeutic Target for Malignant Thymic Epithelial Tumors
Tropomyosin-related Kinase B Is Potentially a Biomarker of Prognosis and Therapeutic Target for Malignant Thymic Epithelial Tumors Open
TrkB expression is a biomarker of the prognosis for TETs and the BDNF/TrkB signaling pathway is potentially a new therapeutic target for mTETs.
View article: Lymph Nodes as Anti-Tumor Immunotherapeutic Tools: Intranodal-Tumor-Specific Antigen-Pulsed Dendritic Cell Vaccine Immunotherapy
Lymph Nodes as Anti-Tumor Immunotherapeutic Tools: Intranodal-Tumor-Specific Antigen-Pulsed Dendritic Cell Vaccine Immunotherapy Open
Hundreds of lymph nodes (LNs) are scattered throughout the body. Although each LN is small, it represents a complete immune organ that contains almost all types of immunocompetent and stromal cells functioning as scaffolds. In this review,…
View article: Cancer therapy that targets the Hedgehog signaling pathway considering the cancer microenvironment (Review)
Cancer therapy that targets the Hedgehog signaling pathway considering the cancer microenvironment (Review) Open
Recently, the cancer microenvironment (CME) has received significant attention. At the local site of the tumor, cancer progression is affected by secreted cytokines and conditions derived from the CME and stimulation by cancer‑induced cyto…
View article: Corrigendum to “PTPN3 is a potential target for a new cancer immunotherapy that has a dual effect of T cell activation and direct cancer inhibition in lung neuroendocrine tumor” [Volume 14, Issue 9, September 2021, 101152]
Corrigendum to “PTPN3 is a potential target for a new cancer immunotherapy that has a dual effect of T cell activation and direct cancer inhibition in lung neuroendocrine tumor” [Volume 14, Issue 9, September 2021, 101152] Open
View article: Maml3 Contributes to the Induction of Malignant Phenotype for Gallbladder Cancer Via the Morphogenesis Signaling Under Hypoxia
Maml3 Contributes to the Induction of Malignant Phenotype for Gallbladder Cancer Via the Morphogenesis Signaling Under Hypoxia Open
View article: ERAP2 is a novel target involved in autophagy and activation of pancreatic stellate cells via UPR signaling pathway
ERAP2 is a novel target involved in autophagy and activation of pancreatic stellate cells via UPR signaling pathway Open
View article: Efficacy of Intranodal Neoantigen Peptide-pulsed Dendritic Cell Vaccine Monotherapy in Patients With Advanced Solid Tumors: A Retrospective Analysis
Efficacy of Intranodal Neoantigen Peptide-pulsed Dendritic Cell Vaccine Monotherapy in Patients With Advanced Solid Tumors: A Retrospective Analysis Open
Intranodal neoantigen peptide-pulsed DC vaccine administration therapy has clinical and immunological efficacy and safety.
View article: TrkB/BDNF Signaling Could Be a New Therapeutic Target for Pancreatic Cancer
TrkB/BDNF Signaling Could Be a New Therapeutic Target for Pancreatic Cancer Open
TrkB/BDNF signaling may be a new therapeutic target for PDAC. Therapies targeting TrkB/BDNF signaling may be a conclusive cancer therapy for refractory solid cancer.
View article: PTPN3 is a potential target for a new cancer immunotherapy that has a dual effect of T cell activation and direct cancer inhibition in lung neuroendocrine tumor
PTPN3 is a potential target for a new cancer immunotherapy that has a dual effect of T cell activation and direct cancer inhibition in lung neuroendocrine tumor Open
In our previous study, we found that inhibition of protein tyrosine phosphatase non-receptor type 3 (PTPN3), which is expressed in lymphocytes, enhances lymphocyte activation, suggesting PTPN3 may act as an immune checkpoint molecule. Howe…
View article: Establishment and characterization of a primary cell culture derived from external auditory canal squamous cell carcinoma
Establishment and characterization of a primary cell culture derived from external auditory canal squamous cell carcinoma Open
There are no human cancer cell lines of external auditory canal origin available for research use. This report describes the establishment of a culture condition for external auditory canal squamous cell carcinoma, derived from human tumor…
View article: GLI2 but not GLI1/GLI3 plays a central role in the induction of malignant phenotype of gallbladder cancer
GLI2 but not GLI1/GLI3 plays a central role in the induction of malignant phenotype of gallbladder cancer Open
We previously reported that Hedgehog (Hh) signal was enhanced in gallbladder cancer (GBC) and was involved in the induction of malignant phenotype of GBC. In recent years, therapeutics that target Hh signaling have focused on molecules dow…
View article: NFκB and TGFβ contribute to the expression of PTPN3 in activated human lymphocytes
NFκB and TGFβ contribute to the expression of PTPN3 in activated human lymphocytes Open
View article: Intranodal Administration of Neoantigen Peptide-loaded Dendritic Cell Vaccine Elicits Epitope-specific T Cell Responses and Clinical Effects in a Patient with Chemorefractory Ovarian Cancer with Malignant Ascites
Intranodal Administration of Neoantigen Peptide-loaded Dendritic Cell Vaccine Elicits Epitope-specific T Cell Responses and Clinical Effects in a Patient with Chemorefractory Ovarian Cancer with Malignant Ascites Open
Chemorefractory ovarian cancer has limited therapeutic options. Hence, new types of treatment including neoantigen-specific immunotherapy need to be investigated. Neoantigens represent promising targets for personalized cancer immunotherap…
View article: FAM115C could be a novel tumor suppressor associated with prolonged survival in pancreatic cancer patients
FAM115C could be a novel tumor suppressor associated with prolonged survival in pancreatic cancer patients Open
Hypoxia is a characteristic feature of the tumor microenvironment in pancreatic ductal adenocarcinoma (PDAC). We have recently explored new targeting molecules and pathways in PDAC cells under hypoxic conditions. In this study, we performe…
View article: Patched 1-interacting Peptide Represses Fibrosis in Pancreatic Cancer to Augment the Effectiveness of Immunotherapy
Patched 1-interacting Peptide Represses Fibrosis in Pancreatic Cancer to Augment the Effectiveness of Immunotherapy Open
Pancreatic ductal adenocarcinoma (PDAC) is resistant to immunotherapy. As a factor of resistance, the dense fibrosis of this cancer acts as a barrier to inhibit immune cell infiltration into a tumor. We examined the influence of a Hedgehog…
View article: Protein tyrosine phosphatase non-receptor type 3 (PTPN3) could be a new therapeutic target for pancreatic cancer
Protein tyrosine phosphatase non-receptor type 3 (PTPN3) could be a new therapeutic target for pancreatic cancer Open