Hideyoshi Igata
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Creating a general-purpose generative model for healthcare data based on multiple clinical studies Open
Data for healthcare applications are typically customized for specific purposes but are often difficult to access due to high costs and privacy concerns. Rather than prepare separate datasets for individual applications, we propose a novel…
Creating a General-Purpose Generative Model for Healthcare Data based on Multiple Clinical Studies Open
Data for healthcare applications are typically customized for specific purposes but are often difficult to access due to high costs and privacy concerns. Rather than prepare separate datasets for individual applications, we propose a novel…
Awake hippocampal synchronous events are incorporated into offline neuronal reactivation Open
Learning novel experiences reorganizes hippocampal neuronal circuits, represented as coordinated reactivation patterns in post-experience offline states for memory consolidation. This study examines how awake synchronous events during a no…
Development of a Stereo-Vision Based High-Throughput Robotic System for Mouse Tail Vein Injection Open
In this paper, we present a robotic device for mouse tail vein injection. We propose a mouse holding mechanism to realize vein injection without anesthetizing the mouse, which consists of a tourniquet, vacuum port, and adaptive tail-end fi…
Multiple cancer type classification by small RNA expression profiles with plasma samples from multiple facilities Open
Liquid biopsy is expected to be a promising cancer screening method because of its low invasiveness and the possibility of detecting multiple types in a single test. In the last decade, many studies on cancer detection using small RNAs in …
Prioritized experience replays on a hippocampal predictive map for learning Open
Significance The hippocampus is crucial for spatial learning but their neuronal mechanisms remain unknown. Here, we found that hippocampal cell ensembles preferentially replayed salient reward-related locations as rats learned a new behavi…
Prioritized experience replay for learning in the rat hippocampus Open
Hippocampus is crucial for episodic-like memory formation. The dynamics of hippocampal neuronal ensembles during learning has not been well understood. To investigate the hippocampal circuit property during learning, we designed a new spat…
The Integration of Goal-Directed Signals onto Spatial Maps of Hippocampal Place Cells Open
Spatial firing of hippocampal place cells varies depending on the animal's behavior relative to its goals. Here, rats were trained to approach visually guided reward ports in a two-dimensional open field. Hippocampal place cells encoded tw…
The effects of GABA<sub>A</sub> receptor modulators on experimental febrile seizures. Open
Hyperthermia-induced febrile seizures (FSs) are the most common seizures during childhood, and prolonged complex FSs can result in the development of epilepsy. Currently, GABAA receptor modulators such as benzodiazepines and barbiturates a…
The Pharmacological Assessment of GABA<sub>A</sub>Receptor Activation in Experimental Febrile Seizures in Mice Open
Hyperthermia-induced febrile seizures (FSs) are the most common seizures during childhood, and prolonged complex FSs can result in the development of epilepsy. Currently, GABA A receptor modulators such as benzodiazepines and barbiturates …
Hippocampal neuron firing is variable across laps in a linear track task Open
Hippocampal cells increase their firing frequency when an animal is located in given restricted areas of an environment, termed place fields. In the majority of studies, firing patterns of 'place cell' have been characterized based on the …
Light-guided running behavior induces direction selective spikes of hippocampal neurons Open
The hippocampus consists of place cells that preferentially show spike activity when animals visit a limited area of the environment. A widely used behavioral task for characterizing place cells is a foraging task in which rats freely expl…
Spatial representation of hippocampal cells in response to aversive stimulus in a T-maze task Open
Hippocampal place cells are cells that specifically discharge when an animal enters a specific zone, so-called a place field. In addition, firing patterns of hippocampal cells are subject to non-spatial information, such as colors, objects…
Spatial Representation of Hippocampal Place Cells in a T-Maze with an Aversive Stimulation Open
The hippocampus contains place cells representing spaces in an environment, and these place cells have been suggested to play a fundamental role in the formation of a cognitive map for spatial processing. However, how alterations in the fi…
A new device for the simultaneous recording of cerebral, cardiac, and muscular electrical activity in freely moving rodents Open
We present a new technique for the simultaneous capture of bioelectrical time signals from the brain and peripheral organs of freely moving rodents. The recording system integrates all systemic signals into an electrical interface board th…