Hideyuki Abe
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View article: Comprehensive genetic profiling using tissue and blood in locally advanced tumors
Comprehensive genetic profiling using tissue and blood in locally advanced tumors Open
Comprehensive genomic profiling (CGP) aims to assist clinicians with the diagnosis, treatment decisions and early detection of recurrence in patients with cancer. CGP using tumor tissue is widely implemented, whereas circulating tumor DNA …
View article: Comparison of Comprehensive Genomic Profiling Testing “Ion Torrent Genexus Sequencer” With FoundationOne
Comparison of Comprehensive Genomic Profiling Testing “Ion Torrent Genexus Sequencer” With FoundationOne Open
The two cancer genome panels were equivalent but not perfect in terms of the detection of variants using tissue and blood, indicating that different assays and analytical methods may have influenced the results. When performing CGPs, it is…
View article: Comparison of Comprehensive Genomic Profiling Testing “Ion Torrent Genexus Sequencer” with FoundationOne
Comparison of Comprehensive Genomic Profiling Testing “Ion Torrent Genexus Sequencer” with FoundationOne Open
Background Molecular diagnostic tests are becoming increasingly routine, and the use of tissue- and blood-based next-generation sequencing (NGS) is integral to the delivery of personalized medicine for targeted cancer therapy. This study a…
View article: Elevated expression of N-myc downstream regulated gene 1 protein promotes neovascularization and tumor progression in glioblastomas
Elevated expression of N-myc downstream regulated gene 1 protein promotes neovascularization and tumor progression in glioblastomas Open
Aim The N-myc downstream regulated gene 1 ( NDRG1 ) is a member of the NDRG family, of which four members ( NDRG1, NDRG2, NDRG3, NDRG4 ) have been identified. NDRG1 is repressed by c-MYC and N-MYC proto-oncogenes. NDRG1 is translated into …
View article: Small Cell Neuroendocrine Carcinoma of the Parotid Gland: An Uncommon Example of Incompletely Encapsulated Tumor Including S100 Protein-Positive Clear Cells
Small Cell Neuroendocrine Carcinoma of the Parotid Gland: An Uncommon Example of Incompletely Encapsulated Tumor Including S100 Protein-Positive Clear Cells Open
Small cell carcinoma is rare in salivary glands and has recently been termed small cell neuroendocrine carcinoma. We herein describe an uncommon example arising in the parotid gland. The patient was a 75 yearold Japanese male who had swell…
View article: Circulating tumor cells and cell-free tumor DNA analyses in urothelial cancer using the LiquidBiopsy platform
Circulating tumor cells and cell-free tumor DNA analyses in urothelial cancer using the LiquidBiopsy platform Open
Background: Emerging data suggested that liquid biopsy such as detection of circulating tumor cells (CTCs) and cell-free tumor DNA analysis augments the management of patients with urothelial cancer (UC). We presented our pilot experience …
View article: Cytological features of epithelial-mesenchymal transition cells in effusion cytology in cases of pancreatic cancer
Cytological features of epithelial-mesenchymal transition cells in effusion cytology in cases of pancreatic cancer Open
目的：本検討の目的は，体腔液中にみられる上皮間葉転換（epithelial mesenchymal transition：EMT）細胞の細胞形態について検討することである．
View article: Influence of the storage temperature on the nucleic acid quality in liquid-based cytology samples prepared using fixed in CytoRich Red
Influence of the storage temperature on the nucleic acid quality in liquid-based cytology samples prepared using fixed in CytoRich Red Open
目的 : 核酸解析は疾患の特徴や治療選択のための重要な診断手段である. 本検討の目的はサイトリッチレッドを用いた細胞検体の保存状態における核酸品質に与える効果を調査することである.
View article: Liquid-based cytology of oral brushings in a case of adenoid cystic carcinoma arising from the palate
Liquid-based cytology of oral brushings in a case of adenoid cystic carcinoma arising from the palate Open
背景 : 腺様囊胞癌は, 悪性小唾液腺腫瘍の代表的な腫瘍である. 今回われわれは, 基底細胞様腫瘍との鑑別を要した腺様囊胞癌の口腔内擦過液状化検体細胞診 (LBC) を経験したので報告する.
View article: Nucleic acid quality in sodium alginate cell blocks prepared from liquid-based cytology specimens
Nucleic acid quality in sodium alginate cell blocks prepared from liquid-based cytology specimens Open
目的 : 液状化検体細胞診 (LBC) を用いたセルブロック (CB) 法における核酸品質を解析するとともに LBC-CB の保管における核酸品質の影響についても調査した.
View article: Nucleic acid quality and protein expression in sodium alginate FFPE cell blocks prepared under different formalin fixing conditions
Nucleic acid quality and protein expression in sodium alginate FFPE cell blocks prepared under different formalin fixing conditions Open
目的 : アルギン酸ナトリウムを用いたホルマリン固定パラフィン包埋セルブロック法が, 核酸品質と蛋白発現に及ぼす影響についてホルマリン固定条件の違いを通して検討した.
View article: NDRG1 activates VEGF-A-induced angiogenesis through PLCγ1/ERK signaling in mouse vascular endothelial cells
NDRG1 activates VEGF-A-induced angiogenesis through PLCγ1/ERK signaling in mouse vascular endothelial cells Open
Many diseases, including cancer, have been associated with impaired regulation of angiogenesis, of which vascular endothelial growth factor (VEGF)-A is a key regulator. Here, we test the contribution of N-myc downstream regulated gene 1 (N…
View article: A retrospective analysis of fine needle aspiration findings in the salivary gland region using the Milan System for Reporting Salivary Gland Cytopathology
A retrospective analysis of fine needle aspiration findings in the salivary gland region using the Milan System for Reporting Salivary Gland Cytopathology Open
目的 : 新たに提唱された唾液腺領域の穿刺吸引細胞診の報告様式であるミラノシステムを用いて後方視的な検討を行い, カテゴリー別の細胞学的所見を明らかにする.
View article: Insulinoma‐associated protein 1 is a novel diagnostic marker of small cell lung cancer in bronchial brushing and cell block cytology from pleural effusions: Validity and reliability with cutoff value
Insulinoma‐associated protein 1 is a novel diagnostic marker of small cell lung cancer in bronchial brushing and cell block cytology from pleural effusions: Validity and reliability with cutoff value Open
Background In recent years, insulinoma‐associated protein 1 (INSM1) has been shown to be a key regulator of neuroendocrine development, and it has been evaluated for diagnostic use in some organs. Methods To evaluate the relationship betwe…
View article: Abstract 183: N-myc downstream regulated gene 1 (NDRG1) is indispensable for VEGF-A-induced tumor angiogenesis through PLCγ/ERK signaling activation in vascular endothelial cells
Abstract 183: N-myc downstream regulated gene 1 (NDRG1) is indispensable for VEGF-A-induced tumor angiogenesis through PLCγ/ERK signaling activation in vascular endothelial cells Open
[Background] Vascular endothelial growth factor (VEGF)-A is a key regulator of tumor angiogenesis that is essential for tumor growth and progression. The unraveling of the precise mechanisms behind VEGF-A-induced tumor angiogenic process w…
View article: Significance of neoadjuvant chemoradiotherapy for borderline resectable pancreatic head cancer: Pathological local invasion and microvessel invasion analysis
Significance of neoadjuvant chemoradiotherapy for borderline resectable pancreatic head cancer: Pathological local invasion and microvessel invasion analysis Open
Borderline resectable pancreatic head cancer (BR-PHC) has low resectability due to vascular invasion. Although the clinical effects of neoadjuvant chemoradiotherapy (NAC-RT) for BR-PHC have been examined, few studies have reported its path…
View article: Expression of GLUT1 in Pseudopalisaded and Perivascular Tumor Cells Is an Independent Prognostic Factor for Patients With Glioblastomas
Expression of GLUT1 in Pseudopalisaded and Perivascular Tumor Cells Is an Independent Prognostic Factor for Patients With Glioblastomas Open
Glioblastomas are highly aggressive brain tumors with a particularly poor prognosis. Glucose transporter-1 (GLUT1/SLC2A1), a uniporter that is expressed by various carcinomas and may be involved in malignant neoplasm glycometabolism, may a…
View article: Issue Information
Issue Information Open
retrospective cytology case series of an uncommon high grade B-cell malignancy with C-MYC
View article: A Combined test using both cell sediment and supernatant cell‐free <scp>DNA</scp> in pleural effusion shows increased sensitivity in detecting activating <i><scp>EGFR</scp></i> mutation in lung cancer patients
A Combined test using both cell sediment and supernatant cell‐free <span>DNA</span> in pleural effusion shows increased sensitivity in detecting activating <i><span>EGFR</span></i> mutation in lung cancer patients Open
Introduction The aim of this study was to examine whether a combined test using both cell sediment and supernatant cytology cell‐free DNA (ccf DNA ) is more useful in detecting EGFR mutation than using cell sediment DNA or supernatant ccf …
View article: Thyroid sclerosing mucoepidermoid carcinoma with eosinophilia distinct from the salivary type
Thyroid sclerosing mucoepidermoid carcinoma with eosinophilia distinct from the salivary type Open
We report three cases of thyroid sclerosing mucoepidermoid carcinoma with eosinophilia (SMECE), which is an extremely rare variant of mucoepidermoid carcinoma (MEC). The aims of this report were to describe the clinicopathological findings…
View article: The activation of SRC family kinases and focal adhesion kinase with the loss of the amplified, mutated<i>EGFR</i>gene contributes to the resistance to afatinib, erlotinib and osimertinib in human lung cancer cells
The activation of SRC family kinases and focal adhesion kinase with the loss of the amplified, mutated<i>EGFR</i>gene contributes to the resistance to afatinib, erlotinib and osimertinib in human lung cancer cells Open
Second- and third-generation inhibitors of epidermal growth factor receptor (EGFR) tyrosine kinase activity (EGFR-TKIs) are improving the treatment of patients with non-small cell lung cancer. Here we established two sublines (BR1-8 and BR…
View article: Mucoepidermoid carcinoma of the sublingual gland harboring a translocation of the MAML2 gene: A case report
Mucoepidermoid carcinoma of the sublingual gland harboring a translocation of the MAML2 gene: A case report Open
Among tumors of the major salivary glands, tumors in the sublingual gland are rare. Although mucoepidermoid carcinoma (MEC) represents a histological type of salivary gland tumor, it is occasionally difficult to diagnose due to its histolo…
View article: Cytological findings of a pineal parenchymal tumor of intermediate differentiation
Cytological findings of a pineal parenchymal tumor of intermediate differentiation Open
背景 : 中間型松果体実質腫瘍の発生はまれで, 細胞学に関連した報告は少ない. 今回, われわれは中間型松果体実質腫瘍と診断された症例を経験したので, その細胞像と組織学的所見をあわせて報告する.症例 : 60 歳代, 女性. 頭痛を主訴に当院に精査加療を目的として入院した. MRI にて松果体部に 2 cm 大の腫瘍が認められ, 腫瘍摘出術が施行された. 圧挫細胞診標本において神経基質を背景に腫瘍細胞は結合性の緩やかな集塊で出現し, 異型性は乏しかった. 核クロマチンは,…
View article: Diagnostic utility of phosphorylated signal transducer and activator of transcription 5 immunostaining in the diagnosis of mammary analogue secretory carcinoma of the salivary gland: A comparative study of salivary gland cancers
Diagnostic utility of phosphorylated signal transducer and activator of transcription 5 immunostaining in the diagnosis of mammary analogue secretory carcinoma of the salivary gland: A comparative study of salivary gland cancers Open
BACKGROUND Mammary analogue secretory carcinoma (MASC) with an ETS variant gene 6 ( ETV6 )–neurotrophic tyrosine kinase receptor type 3 ( NTRK3 ) translocation is a newly described type of salivary gland cancer. It is known that overexpres…
View article: Epidermal growth factor receptor mutation status in cell‐free <scp>DNA</scp> supernatant of bronchial washings and brushings
Epidermal growth factor receptor mutation status in cell‐free <span>DNA</span> supernatant of bronchial washings and brushings Open
BACKGROUND The aim of the current study was to examine whether it would be possible to detect epidermal growth factor receptor ( EGFR ) mutations in cytology cell‐free DNA (ccfDNA) from the supernatant fluids of bronchial cytology samples.…
View article: A case of breast cancer coexisting with solid tubular carcinoma together with squamous cell differentiation and secretory carcinoma
A case of breast cancer coexisting with solid tubular carcinoma together with squamous cell differentiation and secretory carcinoma Open
背景 : 扁平上皮癌への分化を伴う充実腺管癌と分泌癌が併存した症例を経験したので報告する. 症例 : 80 歳代女性. 右乳房のしこりを主訴に来院. 超音波で “ひょうたん型” の腫瘤がみられ, 針生検が施行された. 針生検捺印標本ならびに LBC 標本を作製した. 捺印標本では粘液を背景に, 重積集塊で出現し, 細胞は境界不明瞭, 核は楕円形の異型細胞を多数認めた. 悪性と判定し, 組織型は粘液癌を疑った. 針生検では, 浸潤性乳管癌と診断した. 後日, 右乳房切除術が施…