Hideyuki Ito
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View article: Ellagitannin Oligomers from Eucalyptus camaldulensis Leaves and Their Role in the Detoxification of Aluminum
Ellagitannin Oligomers from Eucalyptus camaldulensis Leaves and Their Role in the Detoxification of Aluminum Open
Eucalyptus camaldulensis of the Myrtaceae family shows high resistance to aluminum (Al) ions and contains various compounds such as steroids, terpenoids, saponins, flavonoids, glycosides, alkaloids, and tannins. Although the ellagitannin o…
View article: Antiallergic Activity of 3-O-Dodecyl-l-ascorbic Acid
Antiallergic Activity of 3-O-Dodecyl-l-ascorbic Acid Open
2-O-Alkyl-l-ascorbic acids and 3-O-alkyl-l-ascorbic acids were synthesized, and their degranulation inhibitory activities were evaluated. Among ascorbic acid derivatives with butyl, octyl, dodecyl, hexadecyl, and octadecyl groups introduce…
View article: Identification of Antioxidative Hydrolyzable Tannins in Water Chestnut
Identification of Antioxidative Hydrolyzable Tannins in Water Chestnut Open
Despite the various biological activities exhibited by water chestnut (the fruit of the Trapa genus), the phenolic compounds present in its extract require comprehensive characterization. Accordingly, we analyzed a 80% methanol extract of …
View article: Heterologous gene expression system for the production of hydrolyzable tannin intermediates in herbaceous model plants
Heterologous gene expression system for the production of hydrolyzable tannin intermediates in herbaceous model plants Open
Aluminum toxicity is the main factor limiting the elongation of plant roots in acidic soil. The tree species Eucalyptus camaldulensis is considerably more resistant to aluminum than herbaceous model plants and crops. Hydrolyzable tannins (…
View article: Heterologous gene expression system for the production of hydrolyzable tannin intermediates in herbaceous model plants
Heterologous gene expression system for the production of hydrolyzable tannin intermediates in herbaceous model plants Open
Aluminum toxicity is the main factor limiting the elongation of plant roots in acidic soil. The tree species Eucalyptus camaldulensis is considerably more resistant to aluminum than herbaceous model plants and crops. Hydrolyzable tannins (…
View article: Neurite Outgrowth-Promoting Compounds from the Petals of Paeonia lactiflora in PC12 Cells
Neurite Outgrowth-Promoting Compounds from the Petals of Paeonia lactiflora in PC12 Cells Open
Isorhamnetin-3-O-glucoside and astragalin, flavonol glucosides, were isolated from the petals of Paeonia lactiflora as neurite outgrowth-promoting compounds. Isoquercitrin, formed by demethylating the B ring of isorhamnetin-3-O-glucoside o…
View article: Degranulation Inhibitors from Petals of Coreopsis grandiflora
Degranulation Inhibitors from Petals of Coreopsis grandiflora Open
The extracts of petals of Coreopsis grandiflora, a member of the Asteraceae family, were found to inhibit degranulation in RBL-2H3 cells, and lanceoletin, leptosidin, okanin, and 4-methoxylanceoletin were isolated as degranulation inhibito…
View article: Synthesis of Ascorbic Acid Derivatives with Different Types of C<sub>8</sub> Straight Acyl Chain and Their Neurite Outgrowth-Enhancing Activities
Synthesis of Ascorbic Acid Derivatives with Different Types of C<sub>8</sub> Straight Acyl Chain and Their Neurite Outgrowth-Enhancing Activities Open
We previously reported that 2-O-α-D-glucopyranosyl-6-O-octanoyl-L-ascorbic acid, having a C8 straight acyl chain, at a concentration of 100 μM remarkably enhanced nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells after bein…
View article: AN ANALYSIS OF PUSH-MODE HUMANITARIAN LOGISTIC CHAIN FOR NANKAI TROUGH EARTHQUAKE
AN ANALYSIS OF PUSH-MODE HUMANITARIAN LOGISTIC CHAIN FOR NANKAI TROUGH EARTHQUAKE Open
南海トラフ地震の発生に際して国が実施を計画している避難者への「プッシュ型支援」について,名古屋市での実行可能性と効率性を検討した.物資の積み替え時間などを仮定した上で地域内輸送拠点(二次拠点)の利用の有無や組み合わせによる輸送時間の増減の検討を行った結果,広域物資輸送拠点(一次拠点)から二次拠点への輸送の集約によって輸送の所要時間を短縮でき,二次拠点を利用する場合でもその総所要時間を利用しない場合に近づけられることがわかった.さらに,地震災害による道路ネットワークのランダム…
View article: Examination of the acute efficacy and safety about aggressive use of tolvaptan for early rising after admission in super-elder patients with congestive heart failure
Examination of the acute efficacy and safety about aggressive use of tolvaptan for early rising after admission in super-elder patients with congestive heart failure Open
Background From August 2015, for shortening of hospitalization period through efficient medical care in acute phase, we had introduced a unique clinical pathway (PATH) for congestive heart failure (CHF) cases. In PATH, since immediate taki…
View article: Characterization and Identification of Bioactive Polyphenols in the Trapabispinosa Roxb. Pericarp Extract
Characterization and Identification of Bioactive Polyphenols in the Trapabispinosa Roxb. Pericarp Extract Open
In this study, we present the isolation and characterization of the structure of six gallotannins (1–6), three ellagitannins (7–9), a neolignan glucoside (10), and three related polyphenolic compounds (gallic acid, 11 and 12) from Trapa bi…
View article: Antiallergic Activity of 6-Deoxy-2-O-methyl-6-(N-hexadecanoyl)amino-l-ascorbic Acid
Antiallergic Activity of 6-Deoxy-2-O-methyl-6-(N-hexadecanoyl)amino-l-ascorbic Acid Open
Allergy is an excessive immune response to a specific antigen. Type I allergies, such as hay fever and food allergies, have increased significantly in recent years and have become a worldwide problem. We previously reported that an ascorbi…
View article: Functional Evaluation of the Ethanol Extracts from <i>Rosmarinus officinalis</i> L. (Rosemary)
Functional Evaluation of the Ethanol Extracts from <i>Rosmarinus officinalis</i> L. (Rosemary) Open
Rosemary is used as an herb in cooking and aromatic oils, and has long been used as a medicinal herb because of its functional components. According to folklore, monks recommended a remedy of rosemary in alcohol ("Hungarian water") to a Hu…
View article: Quality Evaluation and Characterization of Fractions with Biological Activity from Ephedra Herb Extract and Ephedrine Alkaloids-Free Ephedra Herb Extract
Quality Evaluation and Characterization of Fractions with Biological Activity from Ephedra Herb Extract and Ephedrine Alkaloids-Free Ephedra Herb Extract Open
Previously, we reported that the c-Met inhibitory effect of Ephedra Herb extract (EHE) is derived from ingredients besides ephedrine alkaloids. Moreover, analgesic and anti-influenza activities of EHE and ephedrine alkaloids-free Ephedra H…
View article: Ellagitannins from <i>Punica granatum</i> leaves suppress microsomal prostaglandin E synthase-1 expression and induce lung cancer cells to undergo apoptosis
Ellagitannins from <i>Punica granatum</i> leaves suppress microsomal prostaglandin E synthase-1 expression and induce lung cancer cells to undergo apoptosis Open
Prostaglandin E2 (PGE2), which is a potent pro-inflammatory lipid mediator, is biosynthesized from arachidonic acid by cyclooxygenase-2 (COX-2) and microsomal PGE synthase-1 (mPGES-1). Non-steroidal anti-inflammatory drugs (NSAIDs) are use…
View article: Identification of the characteristic components in walnut and anti-inflammatory effect of glansreginin A as an indicator for quality evaluation
Identification of the characteristic components in walnut and anti-inflammatory effect of glansreginin A as an indicator for quality evaluation Open
Walnut is a nutritious food material, but only a few studies have been conducted on the mechanisms of its functions and the technique for quality evaluation. Therefore, we analyzed the components in aqueous methanol extract of walnut, and …
View article: Special Issue Dedicated to Late Professor Takuo Okuda
Special Issue Dedicated to Late Professor Takuo Okuda Open
Antioxidative polyphenols represented by tannins and flavonoids are rich in numerous food sources and traditional natural medicines and currently attracting increased attention in health care and food industries because of their multiple b…
View article: Involvement of the Hydroperoxy Group in the Irreversible Inhibition of Leukocyte-Type 12-Lipoxygenase by Monoterpene Glycosides Contained in the Qing Shan Lu Shui Tea
Involvement of the Hydroperoxy Group in the Irreversible Inhibition of Leukocyte-Type 12-Lipoxygenase by Monoterpene Glycosides Contained in the Qing Shan Lu Shui Tea Open
We have previously found two novel monoterpene glycosides, liguroside A and liguroside B, with an inhibitory effect on the catalytic activity of the enzyme leukocyte-type 12-lipoxygenase in the Qing Shan Lu Shui tea. Here, two new monoterp…
View article: Proanthocyanidin and anthocyanins from the hulls and beards of red-kerneled rice and their antiglycation properties
Proanthocyanidin and anthocyanins from the hulls and beards of red-kerneled rice and their antiglycation properties Open
In the current study, we isolated a proanthocyanidin oligomer from the hulls of red-kerneled rice. The structure of the oligomer was characterized based on spectral data and chemical reaction. Furthermore, two anthocyanins were isolated fr…
View article: Antioxidant activity and Neurite outgrowth-enhancing activity of scorbamic acid and a red pigment derived from ascorbic acid
Antioxidant activity and Neurite outgrowth-enhancing activity of scorbamic acid and a red pigment derived from ascorbic acid Open
L-Ascorbic acid (AA), known as vitamin C, can form browning products by a non-enzymatic process during storage and the browning products cause deterioration of agricultural products. In the browning reaction, a red pigment, 2,2´-nitrilodi-…
View article: Diets containing pomegranate polyphenol and soy isoflavone attenuate contact hypersensitivity in mice
Diets containing pomegranate polyphenol and soy isoflavone attenuate contact hypersensitivity in mice Open
Contact hypersensitivity (CHS) is frequently used as an animal model for human allergic contact dermatitis (ACD). Diets of pomegranate polyphenols (PPs) or soy isoflavones (SIs) each alleviated CHS symptoms; however, the effect of diets co…
View article: Simultaneous Quantification of Ellagitannins and Related Polyphenols in Geranium thunbergii Using Quantitative NMR
Simultaneous Quantification of Ellagitannins and Related Polyphenols in Geranium thunbergii Using Quantitative NMR Open
Compared to commonly employed liquid chromatography-based methods, quantitative nuclear magnetic resonance (qNMR) is a recently developed method for accurate quantification of natural compounds in extracts. The simultaneous quantification …
View article: Potential Antitumor Activity of 2-O-α-d-Glucopyranosyl-6-O-(2-Pentylheptanoyl)-l-Ascorbic Acid
Potential Antitumor Activity of 2-O-α-d-Glucopyranosyl-6-O-(2-Pentylheptanoyl)-l-Ascorbic Acid Open
Intravenous administration of high-dose ascorbic acid (AA) has been reported as a treatment for cancer patients. However, cancer patients with renal failure cannot receive this therapy because high-dose AA infusion can have side effects. T…
View article: The Inhibitory Effect of a Polyphenol Concentrate from Pomegranate Juice on 2,4-dinitrofluorobenzene-induced Contact Hypersensitivity in Mice
The Inhibitory Effect of a Polyphenol Concentrate from Pomegranate Juice on 2,4-dinitrofluorobenzene-induced Contact Hypersensitivity in Mice Open
Pomegranate juice (PJ) has higher polyphenol content and antioxidative activity than any other fruit juice. We used a pomegranate polyphenol concentrate (PPC) from pomegranate juice and investigated its inhibitory effects and mechanism of …