Hideyuki Sakoda YOU? Author Swipe

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Liver-expressed antimicrobial peptide 2 is a hepatokine regulated by ghrelin, nutrients, and body weight Open

Md Nurul Islam, Hiroki Nabekura, Hiroaki Ueno, Takahiro Nishida, Atsushi Nanashima , et al. · 2024

Trk-fused gene plays a critical role in diet-induced adipose tissue expansion and is also involved in thyroid hormone action Open

Takeshi Yamamotoya, Yukino Ohata, Yasuyuki Akasaka, Shun Hasei, M. Inoue , et al. · 2024

Mutations in the Trk-fused gene (TFG) cause hereditary motor and sensory neuropathy with proximal dominant involvement, which reportedly has high co-incidences with diabetes and dyslipidemia, suggesting critical roles of the TFG in metabol…

The NERP-4–SNAT2 axis regulates pancreatic β-cell maintenance and function Open

Weidong Zhang, Ayako Miura, Md Moin Abu Saleh, Koichiro Shimizu, Yuichiro Mita , et al. · 2023

Insulin secretion from pancreatic β cells is regulated by multiple stimuli, including nutrients, hormones, neuronal inputs, and local signalling. Amino acids modulate insulin secretion via amino acid transporters expressed on β cells. The …

Auraptene Enhances AMP-Activated Protein Kinase Phosphorylation and Thereby Inhibits the Proliferation, Migration and Expression of Androgen Receptors and Prostate-Specific Antigens in Prostate Cancer Cells Open

Yasuyuki Akasaka, Shun Hasei, Yukino Ohata, Machi Kanna, Yusuke Nakatsu , et al. · 2023

Citrus hassaku extract reportedly activates AMPK. Because this extract contains an abundance of auraptene, we investigated whether pure auraptene activates AMPK and inhibits proliferation using prostate cancer cell lines. Indeed, auraptene…

Impact of the lipase inhibitor orlistat on the human gut microbiota Open

Yudai Uehira, Hiroaki Ueno, Junki Miyamoto, Ikuo Kimura, Yohei Ishizawa , et al. · 2023

Orlistat, an anti-obesity agent, inhibits the metabolism and absorption of dietary fat by inactivating pancreatic lipase in the gut. The effect of orlistat on the gut microbiota of Japanese individuals with obesity is unknown. This study a…

Hepatic Pin1 Expression, Particularly in Nuclei, Is Increased in NASH Patients in Accordance with Evidence of the Role of Pin1 in Lipid Accumulation Shown in Hepatoma Cell Lines Open

Machi Kanna, Yusuke Nakatsu, Takeshi Yamamotoya, Akifumi Kushiyama, Midori Fujishiro , et al. · 2023

Our previous studies using rodent models have suggested an essential role for Pin1 in the pathogenesis of non-alcoholic steatohepatitis (NASH). In addition, interestingly, serum Pin1 elevation has been reported in NASH patients. However, n…

Liver-Expressed Antimicrobial Peptide 2 Is a Hepatokine That Predicts Weight Loss and Complete Remission of Type 2 Diabetes Mellitus after Vertical Sleeve Gastrectomy in Japanese Individuals Open

Hiroki Nabekura, Md Nurul Islam, Hideyuki Sakoda, Takashi Yamaguchi, Atsuhito Saiki , et al. · 2023

Introduction: Vertical sleeve gastrectomy (VSG) is considered one of the most effective treatments for sustained weight loss and complete remission of type 2 diabetes mellitus (CR-T2DM). Liver-expressed antimicrobial peptide 2 (LEAP2), a g…

Supplementary Material for: Liver-Expressed Antimicrobial Peptide 2 is a Hepatokine that Predicts Weight Loss and Complete Remission of Type 2 Diabetes Mellitus After Vertical Sleeve Gastrectomy in Japanese Individuals Open

H. Nabekura, Islam M.N., Hideyuki Sakoda, Takashi Yamaguchi, Atsuhito Saiki , et al. · 2023

Introduction: Vertical sleeve gastrectomy (VSG) is considered one of the most effective treatments for sustained weight loss and complete remission of type 2 diabetes mellitus (CR-T2DM). Liver-expressed antimicrobial peptide 2 (LEAP2), a g…

Supplementary Material for: Liver-Expressed Antimicrobial Peptide 2 is a Hepatokine that Predicts Weight Loss and Complete Remission of Type 2 Diabetes Mellitus After Vertical Sleeve Gastrectomy in Japanese Individuals Open

H. Nabekura, Islam M.N., Hideyuki Sakoda, Takashi Yamaguchi, Atsuhito Saiki , et al. · 2023

Introduction: Vertical sleeve gastrectomy (VSG) is considered one of the most effective treatments for sustained weight loss and complete remission of type 2 diabetes mellitus (CR-T2DM). Liver-expressed antimicrobial peptide 2 (LEAP2), a g…

Supplementary Material for: Liver-Expressed Antimicrobial Peptide 2 is a Hepatokine that Predicts Weight Loss and Complete Remission of Type 2 Diabetes Mellitus After Vertical Sleeve Gastrectomy in Japanese Individuals Open

H. Nabekura, Islam M.N., Hideyuki Sakoda, Takashi Yamaguchi, Atsuhito Saiki , et al. · 2023

Introduction: Vertical sleeve gastrectomy (VSG) is considered one of the most effective treatments for sustained weight loss and complete remission of type 2 diabetes mellitus (CR-T2DM). Liver-expressed antimicrobial peptide 2 (LEAP2), a g…

Supplementary Material for: Liver-Expressed Antimicrobial Peptide 2 is a Hepatokine that Predicts Weight Loss and Complete Remission of Type 2 Diabetes Mellitus After Vertical Sleeve Gastrectomy in Japanese Individuals Open

H. Nabekura, Islam M.N., Hideyuki Sakoda, Takashi Yamaguchi, Atsuhito Saiki , et al. · 2023

Introduction: Vertical sleeve gastrectomy (VSG) is considered one of the most effective treatments for sustained weight loss and complete remission of type 2 diabetes mellitus (CR-T2DM). Liver-expressed antimicrobial peptide 2 (LEAP2), a g…

Practice and Safety of Static Balloon Atrial Septostomy Based on a Nationwide Registry Data Open

Ryo Inuzuka, Hisateru Tachimori, Sung‐Hae Kim, Hikoro Matsui, Tohru Kobayashi , et al. · 2022

This nationwide study revealed differences in patient background between static and pull-through BAS, as well as a higher incidence of adverse events related to static BAS. Patients weighing <3 kg are at high risk for adverse events after …

Investigation of Foreign Particles in Moderna COVID-19 Vaccine Open

Hiroko Shibata, Yusuke Nomura, Tsuyoshi Kawakami, Eiichi Yamamoto, Daisuke Ando , et al. · 2022

Particular batches of Moderna mRNA Coronavirus Disease 2019 (COVID-19) vaccine were recalled after foreign particles were found in some vaccine vials at the vaccination site in Japan in August 2021. We investigated the foreign particles at…

Liver-expressed antimicrobial peptide 2 functions independently of growth hormone secretagogue receptor in calorie-restricted mice Open

Md Nurul Islam, Weidong Zhang, Katsuya Sakai, Yuki Nakazato, Ryota Tanida , et al. · 2022

Ghrelin is a gastric-derived peptide that stimulates feeding, blood glucose elevation, body temperature reduction, and growth hormone (GH) secretion. Liver-expressed antimicrobial peptide 2 (LEAP2) is an endogenous antagonist of the ghreli…

Involvement of neuronal and muscular Trk-fused gene (TFG) defects in the development of neurodegenerative diseases Open

Takeshi Yamamotoya, Shun Hasei, Yasuyuki Akasaka, Yukino Ohata, Yusuke Nakatsu , et al. · 2022

Trk-fused gene (TFG) mutations have been identified in patients with several neurodegenerative diseases. In this study, we attempted to clarify the effects of TFG deletions in motor neurons and in muscle fibers, using tissue-specific TFG k…

Current status of diabetes treatment in Miyazaki Prefecture, Japan: Results of a questionnaire survey conducted in 2016 and 2020 Open

Yudai Uehira, Hiroaki Ueno, Emi Ebihara, Taisuke Uchida, Hiroki Nabekura , et al. · 2022

Aims/Introduction The Japanese diabetes treatment guidelines do not specify the first choice of hypoglycemic agents, unlike those of Western countries. Furthermore, the current situation in diabetes treatment is that the choice of hypoglyc…

Novel method to recover and quantify residual proteins for cleanliness evaluation of reusable and reprocessed medical devices Open

Miyuki Uematsu, Yuko Miyamoto, Yoshiaki Ito, Tomoko Naito, Shinji Fujii , et al. · 2022

There is no standard cleanliness evaluation procedure for reusable medical devices, only recommended guidelines. Our aim was to develop an efficient and reproducible method to recover proteins in greater amounts than conventional procedure…

Impact of Plasma Xanthine Oxidoreductase Activity on the Mechanisms of Distal Symmetric Polyneuropathy Development in Patients with Type 2 Diabetes Open

Midori Fujishiro, Hisamitsu Ishihara, Katsuhiko Ogawa, Takayo Murase, Takashi Nakamura , et al. · 2021

To unravel associations between plasma xanthine oxidoreductase (XOR) and diabetic vascular complications, especially distal symmetric polyneuropathy (DSP), we investigated plasma XOR activities using a novel assay. Patients with type 2 dia…

Pathological Role of Pin1 in the Development of DSS-Induced Colitis Open

Yasuka Matsunaga, Shun Hasei, Takeshi Yamamotoya, Hiroaki Honda, Akifumi Kushiyama , et al. · 2021

Inflammatory bowel diseases (IBDs) are serious disorders of which the etiologies are not, as yet, fully understood. In this study, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) protein was shown to be dramatically upregulat…

Neuromedin U uses Gαi2 and Gαo to suppress glucose-stimulated Ca2+ signaling and insulin secretion in pancreatic β cells Open

Weidong Zhang, Hideyuki Sakoda, Yuki Nakazato, Md Nurul Islam, François Pattou , et al. · 2021

Neuromedin U (NMU), a highly conserved peptide in mammals, is involved in a wide variety of physiological processes, including impairment of pancreatic β-cell function via induction of mitochondrial dysfunction and endoplasmic reticulum (E…

Carnosic Acid and Carnosol Activate AMPK, Suppress Expressions of Gluconeogenic and Lipogenic Genes, and Inhibit Proliferation of HepG2 Cells Open

Shun Hasei, Takeshi Yamamotoya, Yusuke Nakatsu, Yukino Ohata, Shota Itoga , et al. · 2021

Carnosic acid (CA), carnosol (CL) and rosmarinic acid (RA), components of the herb rosemary, reportedly exert favorable metabolic actions. This study showed that both CA and CL, but not RA, induce significant phosphorylation of AMP-depende…

Human liver‐expressed antimicrobial peptide 2 elevation in the cerebrospinal fluid in bacterial meningitis Open

Katsuya Sakai, Kazutaka Shiomi, Hitoshi Mochizuki, Md Nurul Islam, Hiroki Nabekura , et al. · 2021

Objective To study the presence of liver‐expressed antimicrobial peptide 2 (LEAP2) in human cerebrospinal fluid (CSF) and to measure its concentrations in neurological disorders. Materials & Methods We identified the presence of LEAP2 in h…

Author response for "Human liver‐expressed antimicrobial peptide 2 elevation in the cerebrospinal fluid in bacterial meningitis" Open

Katsuya Sakai, Kazutaka Shiomi, Hitoshi Mochizuki, Md. Nurul Islam, Hiroki Nabekura , et al. · 2021

Functional interaction between Ghrelin and GLP-1 regulates feeding through the vagal afferent system Open

Weidong Zhang, T.M. Zaved Waise, Koji Toshinai, Wakaba Tsuchimochi, Farhana Naznin , et al. · 2020

Pin1 Plays Essential Roles in NASH Development by Modulating Multiple Target Proteins Open

Masaki Inoue, Yusuke Nakatsu, Takeshi Yamamotoya, Shun Hasei, Mayu Kanamoto , et al. · 2019

Pin1 is one of the three known prolyl-isomerase types and its hepatic expression level is markedly enhanced in the obese state. Pin1 plays critical roles in favoring the exacerbation of both lipid accumulation and fibrotic change accompany…

Neuromedin U suppresses insulin secretion by triggering mitochondrial dysfunction and endoplasmic reticulum stress in pancreatic β‐cells Open

Weidong Zhang, Hideyuki Sakoda, Masamitsu Nakazato · 2019

Neuromedin U (NMU), a highly conserved peptide in mammals, is involved in a wide variety of physiological processes. NMU, which is synthesized in β‐cells and co‐localizes with insulin, directly acts on β‐cells via NMU receptor 1 (NMUR1) to…

Neuromedin U suppresses prolactin secretion via dopamine neurons of the arcuate nucleus Open

Keiko Nakahara, Keisuke Maruyama, Takuya Ensho, Kenji Mori, Mikiya Miyazato , et al. · 2019

Xanthine Oxidase Inhibitor Febuxostat Exerts an Anti-Inflammatory Action and Protects against Diabetic Nephropathy Development in KK-Ay Obese Diabetic Mice Open

Yu Mizuno, Takeshi Yamamotoya, Yusuke Nakatsu, Koji Ueda, Yasuka Matsunaga , et al. · 2019

Hyperuricemia has been recognized as a risk factor for insulin resistance as well as one of the factors leading to diabetic kidney disease (DKD). Since DKD is the most common cause of end-stage renal disease, we investigated whether febuxo…

Liver-expressed antimicrobial peptide 2 antagonizes the effect of ghrelin in rodents Open

Md Nurul Islam, Yuichiro Mita, Keisuke Maruyama, Ryota Tanida, Weidong Zhang , et al. · 2019

Ghrelin, a stomach-derived peptide, promotes feeding and growth hormone (GH) secretion. A recent study identified liver-expressed antimicrobial peptide 2 (LEAP2) as an endogenous inhibitor of ghrelin-induced GH secretion, but the effect of…

Detection of the KIAA1549-BRAF fusion gene in cells forming microvascular proliferations in pilocytic astrocytoma Open

Shinji Yamashita, Hideo Takeshima, Fumitaka Matsumoto, Kouji Yamasaki, Tsuyoshi Fukushima , et al. · 2019

Microvascular proliferation (MVP), an aberrant vascular structure containing multilayered mitotically active endothelial- and smooth-muscle cells/pericytes, is a histopathological hallmark of glioblastoma multiforme (GBM). Although MVP ten…

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