Hideyuki Takeuchi
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View article: Letter Regarding ‘Combined Lyon and Milan Scores Predict Gerd Management Outcome Better Than Either Score Alone or Their Individual Components’
Letter Regarding ‘Combined Lyon and Milan Scores Predict Gerd Management Outcome Better Than Either Score Alone or Their Individual Components’ Open
View article: Facilitated α-synuclein oligomer sharing among glial cells by a centrally acting connexin inhibitor attenuates a rapidly progressive multiple system atrophy-cerebellar type model by reducing the neuronal α-synuclein burden
Facilitated α-synuclein oligomer sharing among glial cells by a centrally acting connexin inhibitor attenuates a rapidly progressive multiple system atrophy-cerebellar type model by reducing the neuronal α-synuclein burden Open
Glial connexins (Cxs) that make up astrocyte/oligodendrocyte gap junctions are extensively altered in multiple system atrophy-cerebellar type (MSA-C). Here, we investigated how Cx alterations affect the propagation of α-synuclein (α-syn) o…
View article: Prognostic factors for overall survival in advanced digestive neuroendocrine carcinoma treated with first-line cisplatin-based chemotherapy: a post hoc analysis of JCOG1213
Prognostic factors for overall survival in advanced digestive neuroendocrine carcinoma treated with first-line cisplatin-based chemotherapy: a post hoc analysis of JCOG1213 Open
Background: There is no consensus on prognostic factors for advanced digestive neuroendocrine carcinoma (ADNEC). JCOG1213 was a phase III randomized trial that demonstrated equivalent overall survival (OS) between cisplatin plus etoposide …
View article: Long‐Term Effects of Nusinersen Dosing Frequency on Adult Patients With Spinal Muscular Atrophy: Efficacy of a 6‐Month Dosing Interval
Long‐Term Effects of Nusinersen Dosing Frequency on Adult Patients With Spinal Muscular Atrophy: Efficacy of a 6‐Month Dosing Interval Open
Objective Spinal muscular atrophy (SMA) is a genetic disease caused by the degeneration of spinal motor neurons due to a deficiency in survival motor neuron protein (SMN) protein, leading to progressive muscle atrophy and weakness. nusiner…
View article: Symposium 4 “For Safe and Enjoyable Lifelong Eating : Addressing Dysphagia -The Japanese Medical Science Federation Transdisciplinary & Exploratory Activity Momentum （TEAM） Symposium” -Introduction
Symposium 4 “For Safe and Enjoyable Lifelong Eating : Addressing Dysphagia -The Japanese Medical Science Federation Transdisciplinary & Exploratory Activity Momentum （TEAM） Symposium” -Introduction Open
View article: Siponimod inhibits microglial inflammasome activation
Siponimod inhibits microglial inflammasome activation Open
Siponimod is the first oral drug approved for active secondary progressive multiple sclerosis. It acts as a functional antagonist of sphingosine-1-phosphate (S1P) receptor 1 (S1P1) through S1P1 internalization, and al…
View article: Transfer of Motor and Perceptual Learning in Parkinson’s Disease
Transfer of Motor and Perceptual Learning in Parkinson’s Disease Open
Introduction: Patients with Parkinson’s disease (PD) show impairments of motor and perceptual learning; however, their abilities to apply and generalize skills learned in one condition to new situations (learning transfer) remain unclear. …
View article: A case report of an individual with Creutzfeldt–Jakob disease characterized by prolonged isolated thalamic lesions and rare MM2-cortical-type pathology
A case report of an individual with Creutzfeldt–Jakob disease characterized by prolonged isolated thalamic lesions and rare MM2-cortical-type pathology Open
View article: 546. ESOPHAGEAL FUNCTION TESTS BEFORE AND AFTER LAPAROSCOPIC SLEEVE GASTRECTOMY FOR SEVERE OBESITY
546. ESOPHAGEAL FUNCTION TESTS BEFORE AND AFTER LAPAROSCOPIC SLEEVE GASTRECTOMY FOR SEVERE OBESITY Open
Background Gastroesophageal reflux disease is common in patients with severe obesity. However, changes in esophageal motility and gastroesophageal reflux in patients undergoing sleeve gastrectomy have not been well-studied. In this study, …
View article: Prolonged extracellular low sodium concentrations and subsequent their rapid correction modulate nitric oxide production dependent on NFAT5 in microglia
Prolonged extracellular low sodium concentrations and subsequent their rapid correction modulate nitric oxide production dependent on NFAT5 in microglia Open
Hyponatremia is the most common clinical electrolyte disorder. Chronic hyponatremia has been recently reported to be associated with falls, fracture, osteoporosis, neurocognitive impairment, and mental manifestations. In the treatment of c…
View article: Effects of hypernatremia on the microglia
Effects of hypernatremia on the microglia Open
Signs and symptoms of hypernatremia largely indicate central nervous system dysfunction. Acute hypernatremia can cause demyelinating lesions similar to that observed in osmotic demyelination syndrome (ODS). We have previously demonstrated …
View article: Astroglial connexin 43 is a novel therapeutic target for chronic multiple sclerosis model
Astroglial connexin 43 is a novel therapeutic target for chronic multiple sclerosis model Open
View article: Lateral olfactory tract usher substance (LOTUS), an endogenous Nogo receptor antagonist, ameliorates disease progression in amyotrophic lateral sclerosis model mice
Lateral olfactory tract usher substance (LOTUS), an endogenous Nogo receptor antagonist, ameliorates disease progression in amyotrophic lateral sclerosis model mice Open
View article: Reduced likelihood of the Poggendorff illusion in cerebellar strokes: a clinical and neuroimaging study
Reduced likelihood of the Poggendorff illusion in cerebellar strokes: a clinical and neuroimaging study Open
This study aimed to test our hypothesis that the cerebellum plays an important role in the generation of the optical-geometric illusion known as the Poggendorff illusion, the mechanism of which has been explained by accumulated experience …
View article: Is it meaningful to add mesh reinforcement to laparoscopic fundoplication for esophageal hiatal hernias?
Is it meaningful to add mesh reinforcement to laparoscopic fundoplication for esophageal hiatal hernias? Open
Background: While laparoscopic fundoplication is a standard surgical procedure for patients with esophageal hiatal hernias, the postoperative recurrence of esophageal hiatal hernias is a problem for patients with giant hernias, elderly pat…
View article: Phosphorylated CRMP1, axon guidance protein, is a component of spheroids and is involved in axonal pathology in amyotrophic lateral sclerosis
Phosphorylated CRMP1, axon guidance protein, is a component of spheroids and is involved in axonal pathology in amyotrophic lateral sclerosis Open
In amyotrophic lateral sclerosis (ALS), neurodegeneration is characterized by distal axonopathy that begins at the distal axons, including the neuromuscular junctions, and progresses proximally in a “dying back” manner prior to the degener…
View article: Inhibition of Crmp1 Phosphorylation at Ser522 Ameliorates Motor Function and Neuronal Pathology in Amyotrophic Lateral Sclerosis Model Mice
Inhibition of Crmp1 Phosphorylation at Ser522 Ameliorates Motor Function and Neuronal Pathology in Amyotrophic Lateral Sclerosis Model Mice Open
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive and fatal neurodegenerative disorder that affects upper and lower motor neurons; however, its pathomechanism has not been fully elucidated. Using a comprehensive phosphoproteomic…
View article: Sensory Ataxic Guillain-Barré Syndrome with Dysgeusia after mRNA COVID-19 Vaccination
Sensory Ataxic Guillain-Barré Syndrome with Dysgeusia after mRNA COVID-19 Vaccination Open
Guillain-Barré syndrome (GBS) has occasionally occurred in people who have received coronavirus disease 2019 (COVID-19) vaccines. Dysgeusia is rare symptom of GBS. We herein report a rare case of sensory ataxic GBS with dysgeusia just afte…
View article: Case Report: Takotsubo Cardiomyopathy in Bickerstaff Brainstem Encephalitis Triggered by COVID-19
Case Report: Takotsubo Cardiomyopathy in Bickerstaff Brainstem Encephalitis Triggered by COVID-19 Open
Takotsubo cardiomyopathy (TCM) is a stress-induced cardiomyopathy triggered by critical illness including severe neurological disorders. However, an association between TCM and Bickerstaff brainstem encephalitis (BBE) has rarely been descr…
View article: “COVID arm” detected by MR neurography
“COVID arm” detected by MR neurography Open
View article: Seen by a Glance, But Not by a Stare—A Case Study of a Patient With Simultanagnosia
Seen by a Glance, But Not by a Stare—A Case Study of a Patient With Simultanagnosia Open
Objective Simultanagnosia is a rare neuropsychological symptom characterized by difficulty recognizing global structures while preserving perception of local detail. The condition is classified into ventral and dorsal types. Clinical prese…
View article: Ablation of interleukin-19 improves motor function in a mouse model of amyotrophic lateral sclerosis
Ablation of interleukin-19 improves motor function in a mouse model of amyotrophic lateral sclerosis Open
View article: De novo ATP1A3 variants cause polymicrogyria
De novo ATP1A3 variants cause polymicrogyria Open
ATP1A3 , a mutated gene for AHC, RDP, and CAPOS, is also associated with polymicrogyria by different functional variants.
View article: SGTA associates with intracellular aggregates in neurodegenerative diseases
SGTA associates with intracellular aggregates in neurodegenerative diseases Open
View article: Interleukin-19 Abrogates Experimental Autoimmune Encephalomyelitis by Attenuating Antigen-Presenting Cell Activation
Interleukin-19 Abrogates Experimental Autoimmune Encephalomyelitis by Attenuating Antigen-Presenting Cell Activation Open
Interleukin-19 (IL-19) acts as a negative-feedback regulator to limit proinflammatory response of macrophages and microglia in autocrine/paracrine manners in various inflammatory diseases. Multiple sclerosis (MS) is a major neuroinflammato…
View article: Double percutaneous transesophageal gastrotubing precluded high risk surgery for intestinal malignant lymphoma
Double percutaneous transesophageal gastrotubing precluded high risk surgery for intestinal malignant lymphoma Open
Primary gastrointestinal lymphoma is relatively rare and typically treated by chemotherapy. In some cases, surgery for obstruction in the proximal small intestine is challenging and has a high risk for anastomotic leakage. An 80-year-old w…
View article: Case Report: Anti-MOG Antibody Seroconversion Accompanied by Dimethyl Fumarate Treatment
Case Report: Anti-MOG Antibody Seroconversion Accompanied by Dimethyl Fumarate Treatment Open
Here we report three cases of anti-myelin oligodendrocyte glycoprotein (MOG) antibody–associated disease (MOGAD) mimicking multiple sclerosis in which seropositivity for anti-MOG antibodies occurred during disease-modifying drug dimethyl f…
View article: Laparoscopic resection of a metachronous secondary lymph node metastasis in the mesentery of the ileum after surgery for sigmoid colon cancer with ileum invasion: a case report
Laparoscopic resection of a metachronous secondary lymph node metastasis in the mesentery of the ileum after surgery for sigmoid colon cancer with ileum invasion: a case report Open
View article: Neural mechanisms of foreign accent syndrome: Lesion and network analysis
Neural mechanisms of foreign accent syndrome: Lesion and network analysis Open
View article: Tonsillectomy Improved Therapeutic Response in Anti-SRP Myopathy With Chronic Tonsillitis
Tonsillectomy Improved Therapeutic Response in Anti-SRP Myopathy With Chronic Tonsillitis Open
Chronic tonsillitis has been attracted attention as a source of abnormal immune responses and a possible trigger of autoimmune diseases such as IgA nephritis, IgA vasculitis, palmoplantar pustulosis, psoriasis, rheumatoid arthritis, Behçet…